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1. 发明申请

WO2006102461A3 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：WO2006102461A3
公开(公告)日：2007-07-26
申请号：PCT/US2006010491
申请日：2006-03-22
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , GE QING , EISEN HERMAN N
发明人： CHEN JIANZHU , GE QING , EISEN HERMAN N
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2320/11 , C12N2320/32 , C12N2799/021 , C12N2310/3521
摘要： The present invention provides compositions comprising an RNAi-inducing entity targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for inhibiting a biological activity of an influenza virus and/or for treatment or prevention of influenza. The invention provides target portion sequences that are favorably conserved for RNAi across a plurality of influenza virus A strains isolated from human hosts and/or avian hosts and RNAi-inducing entities, e.g., siRNAs and shRNAs, targeted to such favorably conserved target portions. The invention provides a variety of nucleic acids comprising sequences identical or complementary to at least a portion of one or more of these favorably conserved target portion sequences. The invention further provides methods and compositions for delivering RNAi-inducing agents to an organ or tissue of a mammalian subject, e.g., to the lung. Methods of diagnosing influenza and determining the susceptibility of an influenza virus to inhibition by an RNAi-inducing agent are also provided. Transgenic animals that express an RNAi-inducing agent targeted to an influenza gene are another aspect of the invention.
摘要翻译：本发明提供了包含针对流感病毒转录物的RNAi诱导实体和各种递送试剂中的任一种的组合物。本发明还包括使用该组合物抑制流感病毒的生物活性和/或用于治疗或预防流感的方法。本发明提供了靶向部分序列，其针对分离自人宿主和/或禽类宿主和RNAi诱导实体（例如siRNA和shRNA）分离的多个流感病毒A的RNAi被有针对性地保守，靶向这些有利的保守靶部分。本发明提供了多种核酸，其包含与这些有利保守的靶部分序列中的一种或多种的至少一部分相同或互补的序列。本发明进一步提供了用于将RNAi诱导剂递送至哺乳动物受试者的器官或组织例如肺的方法和组合物。还提供了诊断流感并确定流感病毒对RNAi诱导剂抑制的易感性的方法。表达针对流感基因的RNAi诱导剂的转基因动物是本发明的另一方面。

2. 发明申请

WO2004029213A3 COMPOSITIONS AND METHODS FOR DELIVERY OF SHORT INTERFERING RNA AND SHORT HAIRPIN RNA 审中-公开
标题翻译：用于递送短干扰RNA和短发夹RNA的组合物和方法
公开(公告)号：WO2004029213A3
公开(公告)日：2004-09-16
申请号：PCT/US0330508
申请日：2003-09-29
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/09 , C12N15/63
CPC分类号： C12N15/1131 , A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides compositions comprising an RNAi-inducing entity any of a variety of different delivery agents. Preferred RNAi-inducing agents include siRNA, shRNA, and RNAi-inducing vectors. Preferred delivery agents include cationic polymers, modified cationic polymers, lipids, and surfactants suitable for introduction into the lung. The invention further provides methods of inhibiting expression of a target 10 transcript in a mammal and methods of treating or preventing a disease or condition in a mammal by administration of the compositions.
摘要翻译：本发明提供了包含RNAi诱导实体的组合物，所述组合物包含多种不同递送剂中的任一种。优选的RNAi诱导剂包括siRNA，shRNA和RNAi诱导载体。优选的递送剂包括阳离子聚合物，改性阳离子聚合物，脂质和适用于引入肺中的表面活性剂。本发明进一步提供了抑制哺乳动物中靶转录物表达的方法以及通过施用组合物治疗或预防哺乳动物的疾病或病症的方法。

3. 发明申请

WO2005085443A3 RNAI-BASED THERAPEUTICS FOR ALLERGIC RHINITIS AND ASTHMA 审中-公开
标题翻译：基于RNAI的过敏性胃炎和哮喘的治疗方法
公开(公告)号：WO2005085443A3
公开(公告)日：2006-03-16
申请号：PCT/US2005006445
申请日：2005-03-01
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K31/713 , A61P11/00 , A61P11/06 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32
摘要： The present invention provides compositions comprising one or more RNAi agents (e.g., siRNAs, shRNAs, or RNAi vectors) for the treatment of conditions and diseases mediated by (e.g., featuring IgE-mediated hypersensitivity), as well as systems for identifying RNAi agents effective for this purpose. The compositions are suitable for the treatment of allergic rhinitis and/or asthma. In certain embodiments of the invention the RNAi agent is targeted to a transcript that encodes a protein selected from the group consisisting of the FCeRIa chain, the FCeRIß chain, c-Kit, Lyn, Syk, ICOS, OX40L, CD40, CD80, CD86, RelA, RelB, 4-1BB ligand, TLR1, TLR2, TLR3,TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, CD83, SLAM, common ? chain, and COX-2. In addition, the invention provides RNAi agent/delivery agent compositions and methods of use. In certain embodiments of the invention compositions comprising an RNAi agent are delivered by the respiratory route.
摘要翻译：本发明提供包含用于治疗由（例如，特征为IgE介导的超敏反应）介导的病症和疾病的一种或多种RNAi试剂（例如siRNA，shRNA或RNAi载体）的组合物，以及用于鉴定有效的RNAi试剂的系统以此目的。该组合物适用于治疗过敏性鼻炎和/或哮喘。在本发明的某些实施方案中，RNAi试剂靶向编码选自FCeRIa链，FCeRIβ链，c-Kit，Lyn，Syk，ICOS，OX40L，CD40，CD80，CD86， RelA，RelB，4-1BB配体，TLR1，TLR2，TLR3，TLR4，TLR5，TLR6，TLR7，TLR8，TLR9，CD83，SLAM，链和COX-2。此外，本发明提供RNAi剂/递送剂组合物和使用方法。在本发明的某些实施方案中，包含RNAi试剂的组合物通过呼吸途径递送。

4. 发明申请

WO2004028471A3 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：WO2004028471A3
公开(公告)日：2006-03-09
申请号：PCT/US0330502
申请日：2003-09-29
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C07H21/04 , A61K35/00 , C12Q1/70
CPC分类号： C12N15/1131 , A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.
摘要翻译：本发明提供了用于基于RNA干扰（RNAi）现象抑制流感感染和/或复制的方法和组合物以及用于鉴定用于抑制流感病毒的有效siRNA和shRNA以及用于研究流感病毒感染机制的系统的系统。本发明还提供用于抑制感染，致病性和/或其他感染因子的复制的方法和组合物，特别是感染可以从身体外部直接接近的细胞的感染，例如皮肤细胞或粘膜细胞的方法和组合物。此外，本发明提供了包含RNAi诱导实体的组合物，例如靶向流感病毒转录物的siRNA，shRNA或RNAi诱导载体和各种递送试剂中的任一种。本发明还包括使用该组合物治疗流感的方法。

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