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1. 发明申请

WO2004041435A3 METHODS OF MANIPULATING SMALL AMOUNTS OF SOLIDS 审中-公开
标题翻译：控制固体微量元素的方法
公开(公告)号：WO2004041435A3
公开(公告)日：2005-03-03
申请号：PCT/US0335169
申请日：2003-11-03
申请人： TRANSFORM PHARMACEUTICALS INC , KANE NATHAN , CIMA MICHAEL , GONZALEZ-ZUGASTI JAVIER , CHERNG JEAN-PEI , LEMMO ANTHONY V , GYORY J RICHARD , PRYCE-LEWIS WENDY , CHEN HONGMING
发明人： KANE NATHAN , CIMA MICHAEL , GONZALEZ-ZUGASTI JAVIER , CHERNG JEAN-PEI , LEMMO ANTHONY V , GYORY J RICHARD , PRYCE-LEWIS WENDY , CHEN HONGMING
IPC分类号： B01F3/18 , B01F7/00 , B01F7/18 , B01F11/00 , B01F13/00 , B01F13/02 , B01F13/08 , B01L3/02 , G01F11/02 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/28 , G01N1/36 , G01N35/00 , G01N1/10 , B01L3/00 , B32B27/04 , B32B27/12 , G01N31/00 , G01N33/00 , G01N35/08
CPC分类号： B01F3/18 , B01F7/00258 , B01F7/18 , B01F11/0065 , B01F13/0059 , B01F13/0272 , B01F13/08 , B01L3/0217 , B01L2200/0657 , G01F11/021 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/286 , G01N1/36 , G01N35/0099 , G01N2001/368 , Y10T436/2575
摘要： The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.
摘要翻译：本发明涉及用于操作少量固体的方法和装置。本发明的具体实施方案特别适用于少量固体的自动转移。在一个实施方案中，将均匀的粉末床轻轻地压制成粉末塞并分配。在另一个实施方案中，将固体置于液体载体中以形成浆液，分配，随后除去液体组分。在另一个实施方案中，使用粘合剂表面操纵固体。

2. 发明申请

WO2004102158A3 RAISED SURFACE ASSAY PLATE 审中-公开
标题翻译：升高的表面测试板
公开(公告)号：WO2004102158A3
公开(公告)日：2005-02-03
申请号：PCT/US2004014904
申请日：2004-05-13
申请人： TRANSFORM PHARMACEUTICALS INC , CIMA MICHAEL J , LEWIS WENDY PRYCE , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY V , MONAGLE JULIE
发明人： CIMA MICHAEL J , LEWIS WENDY PRYCE , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY V , MONAGLE JULIE
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/00 , C12Q1/24 , C12Q1/68 , G01N20060101
CPC分类号： B01L3/5085 , B01L3/5025 , B01L3/5088 , B01L2300/0609 , B01L2300/0819 , B01L2300/0829
摘要： The assay plate (100) includes a substrate (102) having an substrate surface (108) and at least one raised pad (104) extending from the substrate surface (108). The raised pad (104) includes a substantially planar sample receiving surface (200) configured for holding a sample (106) thereon for in situ experimentation. The sample receiving surface (200) preferably has at least one sharp edge (210) at the junction between a sidewall (208) coupling the sample receiving surface (200) to the substrate surface (108). The sample receiving surface (200) is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample (106). A method of using the above described assay plate (100) is also provided. Once a raised pad (104) extending from a substrate (102) is formed, a sample (106) is deposited on the raised pad (104). Experiments are subsequently performed using the sample (106) on the raised pad (104).
摘要翻译：测定板（100）包括具有衬底表面（108）和从衬底表面（108）延伸的至少一个凸起垫（104）的衬底（102）。凸起垫（104）包括基本平坦的样品接收表面（200），其被配置用于在其上保持样品（106）用于现场实验。样品接收表面（200）优选在连接到样品接收表面（200）与衬底表面（108）的侧壁（208）之间的接合处具有至少一个尖锐边缘（210）。样品接收表面（200）优选为尺寸适于保持样品（106）的预定体积的圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形。还提供了使用上述测定板（100）的方法。一旦形成从衬底（102）延伸的凸起垫（104），样品（106）沉积在凸起垫（104）上。随后使用凸起垫（104）上的样品（106）进行实验。

3. 发明申请

WO0151919A9 HIGH-THROUGHPUT FORMATION, IDENTIFICATION, AND ANALYSIS OF DIVERSE SOLID-FORMS 审中-公开
标题翻译：多元固体形成，识别和分析的高通量分析
公开(公告)号：WO0151919A9
公开(公告)日：2002-03-14
申请号：PCT/US0100531
申请日：2001-01-08
申请人： TRANSFORM PHARMACEUTICALS INC , LEVINSON DOUGLAS , CIMA MICHAEL J , LEMMO ANTHONY V , GALAKATOS NICHOLAS , PUTNAM DAVID A
发明人： LEVINSON DOUGLAS , CIMA MICHAEL J , LEMMO ANTHONY V , GALAKATOS NICHOLAS , PUTNAM DAVID A
IPC分类号： G01N23/04 , B01J19/00 , B01L3/00 , C07B61/00 , C07B63/00 , C07C227/42 , C07C229/08 , C12Q1/00 , C30B7/00 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N1/28 , G01N1/36 , G01N13/14 , G01N13/16 , G01N21/03 , G01N21/23 , G01N21/35 , G01N21/65 , G01N23/20 , G01N23/225 , G01N24/08 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/68 , G01N37/00 , G06F19/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00479 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/00659 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00756 , B01L3/5085 , B82Y30/00 , C30B7/00 , C30B29/58 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N21/23 , G01N33/6845
摘要： The invention concerns arrays of solid-forms of substances, such as compounds and rapid-screening methods therefor to identify solid-forms, particularly of pharmaceuticals, with enhanced properties. Such properties include improved bioavailability, solubility, stability, delivery, and processing and manufacturing characteristics. The invention relates to a practical and cost-effective method to rapidly screen hundreds to thousands of samples in parallel. The invention further provides methods for determining the conditions and/or ranges of conditions required to produce crystals with desired compositions, particle sizes, habits, or polymorphic forms. In a further aspect, the invention provides high-throughput methods to identify sets of conditions and/or combinations of components compatible with particular solid-forms, for example, conditions and/or components that are compatible with advantageous polymorphs of a particular pharmaceutical.
摘要翻译：本发明涉及固体形式的物质阵列，例如化合物及其快速筛选方法，以鉴定具有增强性质的固体形式，特别是药物。这些性质包括改进的生物利用度，溶解度，稳定性，递送以及加工和制造特性。本发明涉及一种用于并行快速筛选数百到数千个样本的实用且具有成本效益的方法。本发明还提供了用于确定产生具有所需组成，粒度，习惯或多晶形式的晶体所需条件和/或范围的方法。在另一方面，本发明提供了高通量方法来鉴定与特定固体形式相容的条件组合和/或组合，例如与特定药物的有利多晶型物相容的条件和/或组分。

4. 发明申请

WO0151919A2 HIGH-THROUGHPUT FORMATION, IDENTIFICATION, AND ANALYSIS OF DIVERSE SOLID-FORMS 审中-公开
标题翻译：高通量的形成，识别和分析不同的实体
公开(公告)号：WO0151919A2
公开(公告)日：2001-07-19
申请号：PCT/US0100531
申请日：2001-01-08
申请人： TRANSFORM PHARMACEUTICALS INC , LEVINSON DOUGLAS , CIMA MICHAEL J , LEMMO ANTHONY V , GALAKATOS NICHOLAS , PUTNAM DAVID A
发明人： LEVINSON DOUGLAS , CIMA MICHAEL J , LEMMO ANTHONY V , GALAKATOS NICHOLAS , PUTNAM DAVID A
IPC分类号： G01N23/04 , B01J19/00 , B01L3/00 , C07B61/00 , C07B63/00 , C07C227/42 , C07C229/08 , C12Q1/00 , C30B7/00 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N1/28 , G01N1/36 , G01N13/14 , G01N13/16 , G01N21/03 , G01N21/23 , G01N21/35 , G01N21/65 , G01N23/20 , G01N23/225 , G01N24/08 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/68 , G01N37/00 , G06F19/00 , G01N30/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00479 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/00659 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00756 , B01L3/5085 , B82Y30/00 , C30B7/00 , C30B29/58 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N21/23 , G01N33/6845
摘要： The invention concerns arrays of solid-forms of substances, such as compounds and rapid-screening methods therefor to identify solid-forms, particularly of pharmaceuticals, with enhanced properties. Such properties include improved bioavailability, solubility, stability, delivery, and processing and manufacturing characteristics. The invention relates to a practical and cost-effective method to rapidly screen hundreds to thousands of samples in parallel. The invention further provides methods for determining the conditions and/or ranges of conditions required to produce crystals with desired compositions, particle sizes, habits, or polymorphic forms. In a further aspect, the invention provides high-throughput methods to identify sets of conditions and/or combinations of components compatible with particular solid-forms, for example, conditions and/or components that are compatible with advantageous polymorphs of a particular pharmaceutical.
摘要翻译：本发明涉及固体形式的物质阵列，例如用于鉴定具有增强特性的固体形式，特别是药物的化合物和快速筛选方法。这些性质包括改善的生物利用度，溶解性，稳定性，递送以及加工和制造特性。本发明涉及一种实际并且成本有效的方法，用于并行快速筛选数百到数千个样本。本发明进一步提供了用于确定生产具有所需组成，粒径，习性或多晶型形式的晶体所需的条件和/或范围的方法。另一方面，本发明提供了高通量方法以鉴定与特定固体形式相容的组的条件和/或组合的组合，例如与特定药物的有利多晶形相容的条件和/或组分。

5. 发明申请

WO2012100205A3 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 审中-公开
标题翻译：具有纵向换能器和可更换毛细管的压电式分配器
公开(公告)号：WO2012100205A3
公开(公告)日：2012-12-27
申请号：PCT/US2012022091
申请日：2012-01-20
申请人： BIODOT INC , IVRI YEHUDA , TISONE THOMAS C , LEMMO ANTHONY V
发明人： IVRI YEHUDA , TISONE THOMAS C , LEMMO ANTHONY V
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01L2200/04 , B01L2200/0684 , B01L2400/0439
摘要： Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.
摘要翻译：提供了用于获取和分配预定体积的液体的系统，装置和方法，并且特别地，涉及一种独特的压电分配器，用于在DNA阵列和分析的自动或手动生产中采集和分配小体积流体，其中液滴是以单滴形式分配，体积范围可以从几皮升到几纳升。分配器可以有利地利用一次性毛细管组件，同时理想地保持压电致动器以用于随后的进一步使用，从而减轻流体交叉污染的可能性并且提供经济且节约成本的方法，其中压电致动器用于进一步操作，诸如各种要分配和转移的液体。独特的纵向传感器可以将径向管位移传递到管的受控轴向运动。

6. 发明申请

WO2008092116A3 NON-CONTACT POSITIVE DISPENSE SOLID POWDER SAMPLING APPARATUS AND METHOD 审中-公开
标题翻译：非接触式积极配方固体粉末取样装置及方法
公开(公告)号：WO2008092116A3
公开(公告)日：2008-10-23
申请号：PCT/US2008052112
申请日：2008-01-25
申请人： BIODOT INC , LEMMO ANTHONY V
发明人： LEMMO ANTHONY V
IPC分类号： B01L99/00 , G01N35/10
CPC分类号： B01L3/0289 , B01L3/0217 , B01L2200/0657 , B01L2200/141 , B01L2200/143 , B01L2400/0478 , B01L2400/0487 , G01N2035/00188 , Y10T436/2575
摘要： Systems and methods for non-contact positive dispense solid powder handling and/or manipulation are provided. Some embodiments advantageously provide the ability to pick up powders at either constant displacement (e.g., known powder depth) or constant pressure (e.g., powder height independent), thereby desirably providing enhanced versatility and options. In some embodiments, motorized aspiration (e.g., allows for variable fill height) is utilized in combination with pneumatic dispense (e.g., can permit better powder ejection). Again, this desirably permits flexible and optimized operation.
摘要翻译：提供了非接触式正分配固体粉末处理和/或操作的系统和方法。一些实施例有利地提供以均匀位移（例如，已知粉末深度）或恒定压力（例如，粉末高度独立）拾取粉末的能力，从而期望地提供增强的多功能性和选项。在一些实施例中，电动抽吸（例如，允许可变填充高度）与气动分配（例如，可以允许更好的粉末喷射）结合使用。同样，这样做期望地允许灵活和优化的操作。

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