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1. 发明申请

WO2011015037A1 ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THERE OF CROSS REFERENCE TO RELATED APPLICATIONS 审中-公开
标题翻译：抗病毒化合物及其制备方法及其相关应用的交叉参考
公开(公告)号：WO2011015037A1
公开(公告)日：2011-02-10
申请号：PCT/CN2010/001187
申请日：2010-08-05
申请人： THE UNIVERSITY OF HONGKONG , KAO, Yitsun, Richard , YANG, Dan , YEUN, Kwokyung
发明人： KAO, Yitsun, Richard , YANG, Dan , YEUN, Kwokyung
IPC分类号： C07D413/12 , C07D295/00 , A61K31/497 , A61K31/44 , A61K31/42 , A61K31/00 , A61P31/16 , A61P31/12
CPC分类号： C07D261/18 , A61K31/42 , A61K31/422 , A61K31/496
摘要： Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
摘要翻译：本文描述了显示抗病毒活性，特别是针对流感病毒的化合物及其制备和使用方法。在一个实施方案中，化合物是含有哌嗪和异唑环并任选被一个或多个取代基取代的杂环酰胺。所述化合物可与一种或多种药学上可接受的赋形剂一起配制以形成适于肠胃外给药的组合物。该化合物优选用于治疗或预防流感毒素，例如H1N1，H2N2，H3N2，H5N1，H7N7，H1N2，H9N2，H7N2，H7N3和H10N7。

2. 发明申请

WO2011147199A1 COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译：化合物和治疗病毒感染的方法
公开(公告)号：WO2011147199A1
公开(公告)日：2011-12-01
申请号：PCT/CN2011/000914
申请日：2011-05-30
申请人： VERSITECH LIMITED , KAO, Yitsun Richard , YUEN, Kwokyung , YANG, Dan , HU, Lihong , CHEN, Guanhua , ZHENG, Bojian
发明人： KAO, Yitsun Richard , YUEN, Kwokyung , YANG, Dan , HU, Lihong , CHEN, Guanhua , ZHENG, Bojian
IPC分类号： C40B30/02 , G06F19/00 , C07D413/06 , C07D413/00 , A61K31/496 , A61K31/495 , A61P31/12
CPC分类号： C07D261/04 , C40B30/02
摘要： Disclosed are high throughput and virtual screening methods that can identify potential anti-viral agents. The said methods identify compounds that inhibit viral infection by binding to viral nucleoprotein. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, especially influenza A.
摘要翻译：公开了高通量和虚拟筛选方法，其可以鉴定潜在的抗病毒剂。所述方法通过结合病毒核蛋白鉴定抑制病毒感染的化合物。还公开了可用于治疗或预防病毒感染，特别是甲型流感的药物制剂。

3. 发明申请

WO2009121247A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES 审中-公开
标题翻译：用于检测反应物种的荧光探针和荧光探针
公开(公告)号：WO2009121247A1
公开(公告)日：2009-10-08
申请号：PCT/CN2009/000376
申请日：2009-04-07
申请人： VERSITECH LIMITED , MORNINGSIDE VENTURES LIMITED , YANG, Dan , PENG, Tao
发明人： YANG, Dan , PENG, Tao
IPC分类号： C07D493/10 , C07D405/00 , C07D491/00 , C07D405/14 , C07D311/82 , C07D311/00 , G01N21/64 , G01N21/77 , G01N33/533
CPC分类号： G01N21/6428 , C07D307/94 , C07D493/10 , G01N33/533
摘要： Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the fluorogenic probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite or hypochlorite in chemical and biological samples.
摘要翻译：本文提供了可用作测量，检测和/或筛选ROS或RNS如过氧亚硝酸盐或次氯酸盐的试剂的化合物或荧光探针。本文还提供了可用于直接或间接测量化学样品和生物样品中过氧亚硝酸盐或次氯酸盐的量的方法，例如活生物体中的细胞和组织。具体地，所述方法包括使本文公开的荧光探针与样品接触以形成一种或多种荧光化合物并测量荧光化合物的荧光性质的步骤。本文还提供了用于检测或筛选过氧亚硝酸盐或化合物的高通量筛选荧光方法，其可以增加或降低化学和生物样品中过氧亚硝酸盐或次氯酸盐的水平。

4. 发明申请

WO2005091697A2 THIOUREA COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： THIOUREA组合物及其用途
公开(公告)号：WO2005091697A2
公开(公告)日：2005-10-06
申请号：PCT/CN2005/000391
申请日：2005-03-28
申请人： THE UNIVERSITY OF HONG KONG , YANG, Dan , CHEN, Yingchun
发明人： YANG, Dan , CHEN, Yingchun
IPC分类号： C07C2/86 , C07C6/12 , C07C335/16 , C07D233/42 , C07D239/10 , C07D243/04 , C07D403/02 , C07F15/00
CPC分类号： C07D233/42 , C07C1/321 , C07C2/861 , C07C41/30 , C07C45/68 , C07C67/343 , C07C201/12 , C07C227/10 , C07C335/16 , C07C2531/22 , C07D239/10 , C07D243/04 , C07C15/14 , C07C15/50 , C07C15/52 , C07C49/784 , C07C49/796 , C07C47/546 , C07C69/618 , C07C69/76 , C07C69/65 , C07C69/738 , C07C229/44 , C07C205/06 , C07C205/11 , C07C205/56 , C07C43/215 , C07C43/205 , C07C43/225
摘要： The invention provides N,N'-disubstituted monothiourea or bisthiourea-Pd(0) complexes that are useful as catalysts for palladium-catalyzed Heck reaction of aryl iodides and bromides with olefins, and as catalysts for palladium catalyzed Suzuki reactions of organoboric compounds and aryl halides (Formula A).
摘要翻译：本发明提供了可用作芳基碘化物和溴化物与烯烃的钯催化Heck反应催化剂的N，N'-二取代一硫代硫脲或二硫代磷酸钯（0）络合物，以及作为有机硼化合物和芳基的钯催化Suzuki反应的催化剂卤化物（式A）。

5. 发明申请

WO2009117902A1 5-DEMETHOXYFUMAGILLOL AND DERIVATIVES THEREOF 审中-公开
标题翻译： 5-DEMETHOXYFUMAGILLOL及其衍生物
公开(公告)号：WO2009117902A1
公开(公告)日：2009-10-01
申请号：PCT/CN2009/000328
申请日：2009-03-27
申请人： VERSITECH LIMITED , MORNINGSIDE VENTURES LIMITED , YANG, Dan , LI, Cheng-Yong , CHEN, Shi-Wu
发明人： YANG, Dan , LI, Cheng-Yong , CHEN, Shi-Wu
IPC分类号： C07D339/08 , C07D319/06 , C07D301/03 , C07D303/32 , C07D403/08 , A61K31/336 , A61P35/00
CPC分类号： C07D303/16 , C07D339/08
摘要： Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities of the 5-demethoxyfumagillol and derivatives and methods of using same for treating diseases.
摘要翻译：本文提供5-脱甲氧基烟曲霉及其衍生物。本文还提供制备5-去甲氧基烟曲霉及其衍生物的方法。本文还提供了5-去甲氧基烟曲霉素及其衍生物的生物活性及其用于治疗疾病的方法。

6. 发明申请

WO2008074227A1 SYNTHETIC ION CHANNELS 审中-公开
标题翻译：合成离子通道
公开(公告)号：WO2008074227A1
公开(公告)日：2008-06-26
申请号：PCT/CN2007/003691
申请日：2007-12-19
申请人： VERSITECH LIMITED , YANG, Dan , LI, Xiang
发明人： YANG, Dan , LI, Xiang
IPC分类号： C07C239/14 , C07C239/20 , C07C217/48 , C07C217/46 , C07C217/42 , C07C225/08 , C07C225/14 , C07C225/16 , C07D213/63 , C07D213/79 , C07D213/81 , A61K31/16 , A61K31/215 , A61K31/4412 , A61P11/00 , A61P27/00 , A61P13/12 , A61P25/14 , A61P25/08 , A61P25/00 , A61P19/08
CPC分类号： C07C239/20 , C07D213/63 , C07D213/79 , C07D213/81
摘要： Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
摘要翻译：本文提供了可以在脂质双层或细胞膜中形成离子通道的自组装化合物和包含自组装化合物的离子通道形成组合物。还提供了制造和使用由多个自组装化合物分子形成的离子通道的方法。此外，提供了治疗或预防与离子通道功能障碍（包括氯化物通道）相关的病症和疾病的方法。

7. 发明申请

WO2006099019A2 METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
标题翻译：与基因表达VIVO成像相关的方法和组合
公开(公告)号：WO2006099019A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008374
申请日：2006-03-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , KUNDRA, Vikas , FANG, Bingliang , JI, Linx, X. , YANG, Dan
发明人： KUNDRA, Vikas , FANG, Bingliang , JI, Linx, X. , YANG, Dan
IPC分类号： C12N15/85 , C07K14/705 , A61K49/00
CPC分类号： C12N15/85 , A61K49/0002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.
摘要翻译：公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效偶联的非侵入性方法引入编码可体内报道物的核酸的核酸，涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。成像可以通过包括核医学在内的各种方法进行。

8. 发明申请

WO2022161490A1 TARGETED DELIVERY OF 1, 2, 4, 5-TETRAOXANE COMPOUNDS AND THEIR USES 审中-公开
公开(公告)号：WO2022161490A1
公开(公告)日：2022-08-04
申请号：PCT/CN2022/074975
申请日：2022-01-29
申请人： YANG, Dan , WONG, Ming Kwan
发明人： YANG, Dan , WONG, Ming Kwan
IPC分类号： C07D323/04 , A61K31/357 , A61P35/00
摘要： 1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.

9. 发明申请

WO2008110063A1 REAGENTS FOR DETECTION OF HYPOCHLOROUS ACID 审中-公开
标题翻译：用于检测嗜酸性粒细胞的试剂
公开(公告)号：WO2008110063A1
公开(公告)日：2008-09-18
申请号：PCT/CN2008/000449
申请日：2008-03-06
申请人： VERSITECH LIMITED , MORNINGSIDE VENTURES LIMITED , YANG, Dan , SUN, Zhen-Ning , CHEN, Yan , LIU, Fengqin
发明人： YANG, Dan , SUN, Zhen-Ning , CHEN, Yan , LIU, Fengqin
IPC分类号： C07F5/02 , G01N31/00
CPC分类号： C07F5/022 , G01N21/6428 , G01N31/22 , Y10T436/19
摘要： Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.
摘要翻译：本文提供了可用作直接或间接次氯酸或次氯酸盐的测量，检测和/或筛选试剂的化合物或次氯酸探针。本文还提供了可用于直接或间接测量化学样品和生物样品（如细菌和生物体组织）中次氯酸或次氯酸盐的量的方法。具体而言，该方法包括使本文公开的次氯酸探针与样品接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。本文还提供了用于检测或筛选次氯酸或化合物的高通量筛选荧光方法，其可以直接或间接地增加或减少化学和生物样品中次氯酸或次氯酸盐的含量。

10. 发明申请

WO2009121244A1 FLUOROPHORE COMPOUNDS 审中-公开
标题翻译：氟化合物
公开(公告)号：WO2009121244A1
公开(公告)日：2009-10-08
申请号：PCT/CN2009/000365
申请日：2009-04-03
申请人： VERSITECH LIMITED , MORNINGSIDE VENTURES LIMITED , YANG, Dan , PENG, Tao
发明人： YANG, Dan , PENG, Tao
IPC分类号： C07D311/96 , G01N21/77
CPC分类号： C07D493/10 , G01N33/582
摘要： Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell, tissue, drug, hormone, nucleotide, nucleic acid, polysaccharide or lipid in living organisms. Specifically, the methods include the steps of contacting any of the fluorophore compounds, rhodol compounds and rhodamine compounds disclosed herein with the biological species to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening biological species.
摘要翻译：本文提供了可用作荧光标记和/或荧光探针的罗丹明和罗丹明化合物的荧光团化合物及其制备方法。本文还提供了可用于跟踪，测量，检测或筛选生物物种如蛋白质，DNA，酶，抗体，细胞器，细胞，组织，药物，激素，核苷酸，核酸，多糖或脂质在生物中的方法生物。具体地说，这些方法包括使本文公开的任何荧光团化合物，罗丹明化合物和罗丹明化合物与生物物质接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。本文还提供了用于检测或筛选生物物种的高通量筛选荧光方法。

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