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1. 发明申请

WO2006099019A3 METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
标题翻译：与基因表达VIVO成像相关的方法和组合
公开(公告)号：WO2006099019A3
公开(公告)日：2007-04-05
申请号：PCT/US2006008374
申请日：2006-03-09
申请人： UNIV TEXAS , KUNDRA VIKAS , FANG BINGLIANG , JI LINX X , YANG DAN
发明人： KUNDRA VIKAS , FANG BINGLIANG , JI LINX X , YANG DAN
IPC分类号： C12N15/85 , A61K49/00 , C07K14/705
CPC分类号： C12N15/85 , A61K49/0002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.
摘要翻译：公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效连接的非侵入性方法引入编码可体内报道物的核酸的核酸，涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。成像可以通过包括核医学在内的各种方法进行。

2. 发明申请

WO2006099019A2 METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
标题翻译：与基因表达VIVO成像相关的方法和组合
公开(公告)号：WO2006099019A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008374
申请日：2006-03-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , KUNDRA, Vikas , FANG, Bingliang , JI, Linx, X. , YANG, Dan
发明人： KUNDRA, Vikas , FANG, Bingliang , JI, Linx, X. , YANG, Dan
IPC分类号： C12N15/85 , C07K14/705 , A61K49/00
CPC分类号： C12N15/85 , A61K49/0002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.
摘要翻译：公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效偶联的非侵入性方法引入编码可体内报道物的核酸的核酸，涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。成像可以通过包括核医学在内的各种方法进行。

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