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1. 发明申请

WO2011163262A2 ULTRA-HIGH PHOTOSENSITIVITY VERTICAL NANOWIRE ARRAYS FOR RETINAL PROSTHESIS 审中-公开
标题翻译：超高光敏性垂直纳米阵列
公开(公告)号：WO2011163262A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041293
申请日：2011-06-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , KHRAICHE, Massoud L. , SILVA, Gabriel A. , CAUWENBERGHS, Gert , LO, Yu-Hwa , WANG, Deli , FREEMAN, William
发明人： KHRAICHE, Massoud L. , SILVA, Gabriel A. , CAUWENBERGHS, Gert , LO, Yu-Hwa , WANG, Deli , FREEMAN, William
IPC分类号： A61F2/14 , A61F9/00 , A61N1/02 , A61L27/14
CPC分类号： A61N1/36046 , A61F2/14 , A61L27/18 , A61L2400/12 , A61L2430/16 , A61N1/0543 , H01L31/035227 , H01L31/035236 , C08L83/04 , C08L65/04
摘要： A prosthetic retina for implantation in an eye having a defective retina is formed from an array of nanowires having a predetermined spatial distribution, density, size and shape implanted in close proximity to the retina. An electrical conductor is formed at a first end of all nanowires in the array of nanowires and placed in contact with a bias source which biases the array. A plurality of electrodes is located on a second end of each of one nanowire or a bundle of nanowires in the array. Each nanowire produces a photocurrent at a corresponding electrode in response to detection of light impinging on the array of nanowires and the photocurrent stimulates one or more neurons adapted for visual perception. In the preferred embodiment, the predetermined spatial distribution mimics a distribution of rods and cones in a normal eye.
摘要翻译：用于植入具有缺陷视网膜的眼睛中的假视网膜由具有植入在视网膜附近的预定空间分布，密度，大小和形状的纳米线阵列形成。电导体形成在纳米线阵列中的所有纳米线的第一端，并与偏置源接触，偏置源偏置阵列。多个电极位于阵列中的一个纳米线或纳米线束中的每一个的第二端上。每个纳米线响应于入射到纳米线阵列上的光而在对应的电极处产生光电流，并且光电流刺激一个或多个适于视觉感知的神经元。在优选实施例中，预定空间分布模拟正常眼睛中的棒和锥体的分布。

2. 发明申请

WO2010045406A3 CAMERA SYSTEM WITH AUTONOMOUS MINIATURE CAMERA AND LIGHT SOURCE ASSEMBLY AND METHOD FOR IMAGE ENHANCEMENT 审中-公开
公开(公告)号：WO2010045406A3
公开(公告)日：2010-04-22
申请号：PCT/US2009/060745
申请日：2009-10-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LO, Yu-Hwa , MINTZ, Yoav , NGUYEN, Truong , TZENG, Jack
发明人： LO, Yu-Hwa , MINTZ, Yoav , NGUYEN, Truong , TZENG, Jack
IPC分类号： A61B17/00 , A61B19/00 , A61B1/05 , A61B1/06
摘要： The present Invention relates to a camera system suitable for use in minimally invasive surgery (MIS ), among other applications. In at least one embodiment, the camera system includes an autonomous miniature camera, a light source assembly providing features such as steerable illumination and a variable radiation angle, and a control and processing unit for processing images acquired by the camera Io generate improved images having reduced blurring using a deblurring algorithm.

3. 发明申请

WO2007051170A2 APPARATUS AND METHOD FOR IMPROVED OPTICAL DETECTION OF PARTICLES IN FLUID 审中-公开
标题翻译：用于改进流体中颗粒的光学检测的装置和方法
公开(公告)号：WO2007051170A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/060313
申请日：2006-10-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LO, Yu-Hwa , LIEN, Victor, Jie , CHEN, Chun Hao, Randy
发明人： LO, Yu-Hwa , LIEN, Victor, Jie , CHEN, Chun Hao, Randy
IPC分类号： C12M3/00
CPC分类号： G01N15/1429 , B01L3/502707 , B01L3/502715 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2400/0424 , B01L2400/0487 , G01N15/1434 , G01N15/1484 , G01N21/05 , G01N21/49 , G01N21/53 , G01N21/6408 , G01N2021/0346 , Y10T29/49124
摘要： A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfiuidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fiuidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process.
摘要翻译：本文公开了许多用于允许光学检测的流体 - 光子器件，采用这种器件的系统以及这些器件的操作和制造的相关方法。在至少一些实施例中，所述装置可以充当流式细胞术装置和/或采用微流体通道。而且，在至少一些实施例中，所述装置是流体 - 光子集成电路（FPIC）装置，其采用流体通道和能够接收和/或传递光的一个或多个波导，并且可以使用聚合物材料制造。至少一些实施例中的流体光子装置能够具有诸如片上激发，飞行时间测量之类的功能，并且可以体验增强的荧光检测灵敏度。在至少一些实施例中，这些装置采用通过波导解复用器连接的检测波导。在另外的实施例中，可以使用各种技术来处理经由波导接收的信息，包括迭代互相关处理。

4. 发明申请

WO2006088514A2 FLUIDIC ADAPTIVE LENS SYSTEMS WITH PUMPING SYSTEMS 审中-公开
标题翻译：具有泵送系统的流体自适应镜头系统
公开(公告)号：WO2006088514A2
公开(公告)日：2006-08-24
申请号：PCT/US2005/039774
申请日：2005-11-04
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JUSTIC, Nicole, B. , ZHANG, De-Ying , LO, Yu-Hwa
发明人： JUSTIC, Nicole, B. , ZHANG, De-Ying , LO, Yu-Hwa
IPC分类号： G02B1/06
CPC分类号： G02B26/005 , G02B3/14
摘要： The present invention in various embodiments relates to a variety of different types of fluidic adaptive lens systems, pumping systems for implementation in such lens systems, other systems employing such lens systems, and related methods of fabrication. In at least some embodiments, the present invention relates to a lens system that includes a reservoir having at least one flexible wall, a first actuator coupled in relation to the reservoir, and a terminal at which is located at least one of an integrated fluidic lens and a port configured to be coupled to an external fluidic lens. The terminal is coupled to at least one of the reservoir and the actuator, and at least one of the actuator and a first pumping system including the actuator is capable of causing fluid to be moved at least one of from the reservoir toward the terminal, and from the terminal toward the reservoir.
摘要翻译：各种实施例中的本发明涉及各种不同类型的流体自适应透镜系统，用于在这种透镜系统中实现的泵送系统，使用这种透镜系统的其它系统以及相关的制造方法。在至少一些实施例中，本发明涉及一种透镜系统，其包括具有至少一个柔性壁的储存器，相对于储存器联接的第一致动器，以及位于集成流体透镜中的至少一个的端子以及被配置为联接到外部流体透镜的端口。所述端子联接到所述储存器和所述致动器中的至少一个，并且所述致动器和包括所述致动器的第一泵送系统中的至少一个能够使流体从所述储存器中的至少一个向所述端子移动，以及从码头到水库。

5. 发明申请

WO2022256352A1 HIGH SPEED AND HIGH TIMING RESOLUTION CYCLING EXCITATION PROCESS (CEP) SENSOR ARRAY FOR NIR LIDAR 审中-公开
公开(公告)号：WO2022256352A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/031659
申请日：2022-05-31
申请人： NANOVISION BIOSCIENCES, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yu-Hwa , LIU, Yu-Hsin , THACKER, Hiren, D.
IPC分类号： H01L31/0264 , H01L31/0304 , H01L31/0336 , H01L31/20 , H01L27/14
摘要： High speed, and high timing resolution photon detecting systems and methods are presented with multiplication and self-quenching and self-recovering functions.

6. 发明申请

WO2016054293A1 IMAGING FLOW CYTOMETER USING SPATIAL-TEMPORAL TRANSFORMATION 审中-公开
标题翻译：使用空间转换的成像流量计
公开(公告)号：WO2016054293A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/053368
申请日：2015-09-30
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yu-Hwa , HAN, Yuanyuan
IPC分类号： G01F17/00 , G01N15/14 , G01N21/53
CPC分类号： G01N15/147 , G01F17/00 , G01N2015/1006 , G01N2015/1447 , G01N2015/145 , G02B21/002
摘要： Methods, systems, and devices are disclosed for imaging particles and/or cells using flow cytometry. In one aspect, a method includes transmitting a light beam at a fluidic channel carrying a fluid sample containing particles; optically encoding scattered or fluorescently-emitted light at a spatial optical filter, the spatial optical filter including a surface having a plurality of apertures arranged in a pattern along a transverse direction opposite to particle flow and a longitudinal direction parallel to particle flow, such that different portions of a particle flowing over the pattern of the apertures pass different apertures at different times and scatter the light beam or emit fluorescent light at locations associated with the apertures; and producing image data associated with the particle flowing through the fluidic channel based on the encoded optical signal, in which the produced image data includes information of a physical characteristic of the particle.
摘要翻译：公开了使用流式细胞术来成像颗粒和/或细胞的方法，系统和装置。一方面，一种方法包括在携带含有颗粒的流体样品的流体通道上传输光束; 光学地编码空间光学滤光器上的散射或荧光发射的光，该空间光学滤光器包括具有多个孔的表面，该多个孔沿着与颗粒流相反的横向方向排列成图案，并且平行于颗粒流动的纵向方向，流过孔的图案的颗粒的部分在不同时间通过不同的孔，并在与孔相关联的位置处散射光束或发射荧光; 并且基于编码的光信号产生与流过流体通道的粒子相关联的图像数据，其中所生成的图像数据包括粒子的物理特性的信息。

7. 发明申请

WO2022266310A1 LABEL-FREE IMAGE-ENCODED MICROFLUIDIC CELL SORTER WITH A SCANNING HIGH FOCAL DEPTH BEAM 审中-公开
公开(公告)号：WO2022266310A1
公开(公告)日：2022-12-22
申请号：PCT/US2022/033770
申请日：2022-06-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yu-Hwa , CHEN, Xinyu , WALLER, Lauren , CHEN, Jiajie
IPC分类号： G01N15/02 , G01N15/10 , B01L3/00
摘要： Disclosed are devices, systems and methods for label-free, image-encoded, microfluidics-based cell sorting. In some aspects, an image-based particle sorting system includes an optical imaging system; a data processing system to process the image data obtained by the optical imaging device and determine one or more properties associated with the individual particles flowing in the carrier fluid and to produce a control command based on a comparison of the determined one or more properties with a sorting criteria; and a particle sorting system including a particle flow device that comprises a substrate including the particle-flow channel and a plurality of output channels branching from the particle-flow channel to receive, in one output channel of the plurality of output channels, sorted particles directed by an actuator device based on the control command.

8. 发明申请

WO2021108678A1 UNCOOLED INFRARED PHOTODETECTORS 审中-公开
公开(公告)号：WO2021108678A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062382
申请日：2020-11-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yu-Hwa , ZHOU, Jiayun , MIAH, Mohammad Abu Raihan , ZHANG, Yong
IPC分类号： H01L31/105 , H01L27/146 , H01L31/0203 , H01L31/0304 , G01J5/20 , C23C16/02
摘要： Methods, apparatus and systems are described that relate to uncooled long-wave infrared (LWIR) photodetectors capable of operating at room temperature and having a simple structure that can be manufactured at low cost. One example LWIR photodetector includes a layer of amorphous silicon (a-Si) disposed on a silicon substrate and a layer of amorphous germanium (a-Ge) disposed on the a-Si layer, wherein the a-Ge layer is operable to absorb infrared light and provide photoconductive gain, and the a-Si layer is operable to produce carrier multiplication via cycling excitation process.

9. 发明申请

WO2015061362A1 ENRICHMENT AND DETECTION OF NUCLEIC ACIDS WITH ULTRA-HIGH SENSITIVITY 审中-公开
标题翻译：增强和检测具有超高灵敏度的核酸
公开(公告)号：WO2015061362A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/061639
申请日：2014-10-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , COMPLIANCE DECISIONS, INC.
发明人： LO, Yu-Hwa , QIAO, Wen , ZHANG, Tiantian , LIAN, Ian , YEN, Tony, Minghung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0819 , B01L2300/0887 , B01L2300/161 , B01L2300/166 , C12Q1/6825 , C12Q1/6837 , C12Q2600/178 , C12Q2563/159 , C12Q2565/501 , C12Q2565/607
摘要： Methods, systems, and devices are disclosed for enrichment and detection of molecules of a target biomarker. In one aspect, In one aspect, a biosensor device for enriching and detecting biomarker molecules include a substrate, and a microarray of hydrophilic islands disposed on the substrate. A sensing area on each of the microarray hydrophilic islands is structured to anchor bio-molecular probes of at least one type for detecting molecules of a target biomarker and to attract an array of nanodroplets of a biomarker solution that includes the target biomarker molecules. A hydrophobic surface disposed to surround the microarray of hydrophilic islands.
摘要翻译：公开了用于浓缩和检测靶标生物标志物分子的方法，系统和装置。一方面，一方面，用于富集和检测生物标志物分子的生物传感器装置包括底物和设置在基底上的亲水岛的微阵列。每个微阵列亲水岛上的感测区域被构造成锚定至少一种类型的生物分子探针，用于检测靶生物标志物的分子，并吸引包括靶生物标志物分子的生物标志物溶液的一系列纳米质滴。设置成围绕亲水岛的微阵列的疏水表面。

10. 发明申请

WO2014113614A1 LABEL FREE MOLECULAR DETECTION METHODS, SYSTEMS AND DEVICES 审中-公开
标题翻译：标签免费分子检测方法，系统和设备
公开(公告)号：WO2014113614A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011942
申请日：2014-01-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yu-Hwa , QIAO, Wen , SONG, Junlan , CHEN, Longchuan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6825 , C12Q2563/143 , C12Q2563/149 , C12Q2565/501 , C12Q2565/629
摘要： Methods, systems, and devices are disclosed for capturing, concentrating, isolating, and detecting molecules. In one aspect, a molecular probe device includes a molecular probe having a complimentary base pair region initially zipped and structured to include a binding agent to chemically attach the molecular probe to an outer surface of a magnetic bead, and a binding molecule to chemically attach the molecular probe to a substrate of a microfluidic device, in which the complimentary base pair region is configured to hybridize to a complementary nucleic acid sequence of a DNA or RNA molecule.
摘要翻译：公开了捕获，浓缩，分离和检测分子的方法，系统和装置。在一个方面，分子探针装置包括分子探针，其具有最初拉链的互补碱基对区域，并被构建成包括将分子探针化学连接到磁珠的外表面的结合剂，以及结合分子，以化学连接分子探针到微流体装置的底物，其中互补碱基对区被配置为与DNA或RNA分子的互补核酸序列杂交。

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