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1. 发明申请

WO2010085775A2 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING WIDE-FIELD SUPERRESOLUTION MICROSCOPY 审中-公开
标题翻译：用于提供宽场超分辨显微镜的系统，方法和计算机可访问介质
公开(公告)号：WO2010085775A2
公开(公告)日：2010-07-29
申请号：PCT/US2010/022034
申请日：2010-01-26
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YUAN, Jing
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YUAN, Jing
IPC分类号： G01N23/04 , G01N33/483 , G01N21/62
CPC分类号： G01N21/6458 , G02B21/0032 , G02B21/0072 , G02B21/0076 , G02B21/16 , G02B27/48
摘要： Exemplary embodiments of apparatus, system, method and computer-accessible medium using which at least one first pulsed electro-magnetic radiation is generated. Such radiation depletes at least one excited state of at least one molecule. Further, it is possible to generate at least one second electro-magnetic radiation based on the first pulsed electro-magnetic radiation(s). For example, the second electro-magnetic radiation(s) can have a pattern with a plurality of spots.
摘要翻译：使用其生成至少一个第一脉冲电磁辐射的设备，系统，方法和计算机可访问介质的示例性实施例。这种辐射消耗至少一种分子的至少一种激发态。此外，可以基于第一脉冲电磁辐射产生至少一个第二电磁辐射。例如，第二电磁辐射可以具有带有多个点的图案。

2. 发明申请

WO2011109818A2 SYSTEM, METHODS AND COMPUTER- ACCESSIBLE MEDIUM WHICH PROVIDE MICOSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
标题翻译：系统，方法和计算机可访问的介质，其在特定分辨率下提供至少一个解剖结构的微观图像
公开(公告)号：WO2011109818A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027421
申请日：2011-03-07
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo , MCLEOD, Robert, R.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo , MCLEOD, Robert, R.
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.
摘要翻译：可以提供装置，系统和方法的示例性实施例，以向至少一个样品提供至少一个电磁辐射。例如，可以提供多个波导装置，其被配置为（i）提供电磁辐射，和（ii）在每个波导装置的发射点处，引起相位每个电磁辐射具有预定值。示例性装置可以是探针的一部分。此外，示例性装置可以包括与探针连接和/或成为探针的一部分提供的干涉装置。

3. 发明申请

WO2008115965A1 APPARATUS AND METHOD FOR PROVIDING A NONINVASIVE DIAGNOSIS OF INTERNAL BLEEDING 审中-公开
标题翻译：提供非内在诊断的装置和方法
公开(公告)号：WO2008115965A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057450
申请日：2008-03-19
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , VELMAHOS, George , BOUMA, Brett, E. , VAKOC, Benjamin, J.
发明人： TEARNEY, Guillermo, J. , VELMAHOS, George , BOUMA, Brett, E. , VAKOC, Benjamin, J.
IPC分类号： A61B5/00 , G01B9/02
CPC分类号： A61B5/0059 , A61B5/0066 , A61B5/0095 , A61B5/416
摘要： Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.
摘要翻译：可以提供示例性的装置和过程来确定解剖结构的至少一个特征。例如，可以使用光声布置在解剖结构中产生声波。然后可以检测声波并确定至少一个血液池是否存在于解剖结构中或解剖结构中，作为声波的至少一个属性。此外，可以将至少一个第一电磁辐射转发到解剖结构的至少一个组织，基于在所述至少一个组织中的运动或在所述至少一个组织内检测从所述至少一个组织提供的至少一个第二电磁辐射至少一个组织以产生检测数据，并且基于检测数据确定至少一个部分的至少一个特性。

4. 发明申请

WO2007109540A2 ARRANGEMENT, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR IDENTIFYING CHARACTERISTICS OF AT LEAST A PORTION OF A BLOOD VESSEL CONTAINED WITHIN A TISSUE USING SPECTRAL DOMAIN LOW COHERENCE INTERFEROMETRY 审中-公开
标题翻译：装置，方法和计算机可访问介质，用于识别使用光谱域低相干干涉的组织中包含的血管的一部分的特征
公开(公告)号：WO2007109540A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/064174
申请日：2007-03-16
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E.
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/0062 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/103 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/6848 , A61B5/6852 , A61B10/0045 , A61B10/0283 , A61B2017/00022 , A61B2017/00061 , A61B2562/228 , G01N21/23 , G01N21/4795 , G01N2021/1787
摘要： An apparatus, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue can be provided. For example, it is possible to utilize a radiation source configured to provide a radiation to the tissue. In addition, a probe can be provided which may be adapted to receive the radiation returned from the tissue; Further, a system may be utilized which can be configured to process data relating to the tissue. The data can indicate whether the blood vessel is in a vicinity of an end portion of the probe.
摘要翻译：可以提供用于识别包含在组织内的血管的至少一部分的特征的装置，方法和计算机可访问介质。例如，可以利用被配置为向组织提供辐射的辐射源。此外，可以提供可以适于接收从组织返回的辐射的探针; 此外，可以使用可以被配置为处理与组织有关的数据的系统。数据可以指示血管是否在探针的端部附近。

5. 发明申请

WO2007084995A2 METHODS AND SYSTEMS FOR OPTICAL IMAGING OF EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 审中-公开
标题翻译：通过光束扫描对上皮细胞的光学成像的方法和系统
公开(公告)号：WO2007084995A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060787
申请日：2007-01-19
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , SHISHKOV, Milen , BOUMA, Brett, E. , VAKOC, Benjamin, J. , NISHIOKA, Norman, S.
发明人： TEARNEY, Guillermo, J. , SHISHKOV, Milen , BOUMA, Brett, E. , VAKOC, Benjamin, J. , NISHIOKA, Norman, S.
IPC分类号： A61B1/04 , A61B5/00 , A61B1/12
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了安排，装置，系统和系统以获得至少一个管腔或空心样品中的至少一个部分的数据。该装置，系统或装置可以（可经由患者的口或鼻中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可视）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

6. 发明申请

WO2006024014A2 PROCESS, SYSTEM AND SOFTWARE ARRANGEMENT FOR MEASURING A MECHANICAL STRAIN AND ELASTIC PROPERTIES OF A SAMPLE 审中-公开
标题翻译：用于测量机械应变和样品的弹性特性的过程，系统和软件安排
公开(公告)号：WO2006024014A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/030294
申请日：2005-08-24
申请人： THE GENERAL HOSPITAL CORPORATION , BOUMA, Brett, E. , CHAN, Raymond, C. , TEARNEY, Guillermo, J.
发明人： BOUMA, Brett, E. , CHAN, Raymond, C. , TEARNEY, Guillermo, J.
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/02007
摘要： A system, process and software arrangement are provided to determining data associated with at least one structural change of tissue. In particular, a first optical coherence tomography ("OCT”) signal which contains first information regarding the tissue at a first stress level, and a second OCT signal which contains second information regarding the tissue at a second stress level are received. The first and second information are compared to produce comparison information. The data associated with the at least one structural change is determined as a function of the comparison information and further information associated with (i) at least one known characteristics of the tissue and/or (ii) characteristics of an OCT system. Further, at least one optical coherence tomography ("OCT”) signal which contains information regarding the tissue can be received, and the modulus of the tissue may be determined as a function of the received at least one OCT signal.
摘要翻译：提供系统，过程和软件布置以确定与组织的至少一个结构变化相关联的数据。特别地，接收包含关于第一应力水平的组织的第一信息的第一光学相干断层摄影（“OCT”）信号和包含关于第二应力水平的组织的第二信息的第二OCT信号。比较第一和第二信息以产生比较信息。与至少一个结构变化相关联的数据被确定为比较信息和与（i）组织的至少一个已知特征和/或（ii）OCT系统的特征相关联的进一步信息的函数。此外，可以接收包含关于组织的信息的至少一个光学相干断层摄影（“OCT”）信号，并且可以根据所接收的至少一个OCT信号来确定组织的模量。

7. 发明申请

WO2011149972A2 SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS 审中-公开
标题翻译：用于提供结构和组成的光学成像的系统，设备，方法，装置和计算机可访问介质
公开(公告)号：WO2011149972A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037785
申请日：2011-05-24
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YOO, Hongki , SHISHKOV, Milen , GARDECKI, Joseph , SHUBOCHKIN, Roman , MORSE, Theodore , JAFFER, Amin, Farouc
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YOO, Hongki , SHISHKOV, Milen , GARDECKI, Joseph , SHUBOCHKIN, Roman , MORSE, Theodore , JAFFER, Amin, Farouc
IPC分类号： A61B5/00 , G01N21/64 , G01B9/02
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译：描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。例如，一种布置可以向解剖结构提供至少一个电磁辐射。这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

8. 发明申请

WO2011044301A2 APPARATUS AND METHODS FOR IMAGING PARTICULAR CELLS INCLUDING EOSINOPHILS 审中-公开
标题翻译：用于成像特异性细胞（包括嗜酸性粒细胞）的装置和方法
公开(公告)号：WO2011044301A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051715
申请日：2010-10-06
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , KANG, Dongkyun , YOO, Hongki
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , KANG, Dongkyun , YOO, Hongki
IPC分类号： A61B5/055 , A61B5/00
CPC分类号： A61B5/411 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/037 , A61B5/4233 , A61B5/68 , A61B5/6852 , A61B5/6853 , G02B21/0064 , G02B21/0076
摘要： An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.
摘要翻译：可以提供根据本公开的装置和方法的示例性实施例。例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。此外，使用至少三分之一布置，可以基于第二电磁辐射将部分中的至少一种特定的嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或营养细胞与其他细胞区分开。

9. 发明申请

WO2011008822A3 APPARATUS, SYSTEMS AND METHODS FOR MEASURING FLOW AND PRESSURE WITHIN A VESSEL 审中-公开
公开(公告)号：WO2011008822A3
公开(公告)日：2011-01-20
申请号：PCT/US2010/041923
申请日：2010-07-14
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , SUTER, Melissa , BOUMA, Brett, E. , JAFFER, Farouc, A.
发明人： TEARNEY, Guillermo, J. , SUTER, Melissa , BOUMA, Brett, E. , JAFFER, Farouc, A.
IPC分类号： A61B5/021 , A61B5/02 , A61B5/027
摘要： Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.

10. 发明申请

WO2010090837A2 ENDOSCOPIC BIOPSY APPARATUS, SYSTEM AND METHOD 审中-公开
标题翻译：内窥镜生物仪器，系统和方法
公开(公告)号：WO2010090837A2
公开(公告)日：2010-08-12
申请号：PCT/US2010/021514
申请日：2010-01-20
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , KANG, Dongkyun , SUTER, Melissa, J.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , KANG, Dongkyun , SUTER, Melissa, J.
IPC分类号： A61B1/04
CPC分类号： A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0086
摘要： Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.
摘要翻译：可以提供用于确定生物组织上或生物组织中的位置的装置，方法和系统的示例性实施例。例如，使用这样的示例性实施例，可以控制光学成像探针的焦点。在另一个示例性实施例中，可以与光学成像探头一起实现标记设备，根据一个示例性实施例，可以（使用一个或多个布置）接收与使用光学成像技术获得的生物组织的至少一部分的至少一个图像相关联的信息。此外，可以基于该信息，使用至少一个电磁辐射在该部分的至少位置上或至少位置处引起可见的变化。

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