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1. 发明申请

WO00005569A1 IMAGING SYSTEM FOR LUMINESCENCE ASSAYS 审中-公开
标题翻译：成像系统用于发光测定
公开(公告)号：WO00005569A1
公开(公告)日：2000-02-03
申请号：PCT/GB1999/002348
申请日：1999-07-20
IPC分类号： G01N21/64 , G01N21/76
CPC分类号： G01N21/6452 , G01N21/76 , G01N2021/6421 , G01N2021/6484 , G01N2201/0826 , G01N2201/0833 , G01N2201/0866
摘要： Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fibre bundle. The cross-sectional area of the optical fibre bundle corresponds to the area of the sample, the end of which is located close to the sample for detecting any light emitted therefrom, and selected fibres (30) of those making up the bundle are separated from the remainder and extend to a source of excitation radiation (76) and serve to convey excitation radiation (if required) directly to a corresponding plurality of points distributed over the area of the end face of the bundle and therefore over the area of the sample. The remaining fibres (32, 38) of the bundle serve to collect emitted light (whether generated by fluorescence caused by excitation or otherwise) and provide a light path to the charge coupled device camera, wherein the ends of the excitation fibres and the ends of the emitted light collecting fibres are distributed uniformly over the area of the fibre bundle presented to the reaction site.
摘要翻译：提供了用于检测由测定样品发射的光的装置，其中由样品发射的光被收集以通过光纤束传输到电荷耦合器件照相机（74）。光纤束的横截面积对应于样品的面积，其端部靠近样品，用于检测从其发出的任何光，并且构成束的那些选定的纤维（30）从剩余部分并延伸到激发辐射源（76）并且用于将激发辐射（如果需要）直接传送到分布在束的端面的区域上并因此在样品的区域上的对应的多个点。束的剩余纤维（32,38）用于收集发射的光（无论是由激发产生的还是由激发产生的），并且向电荷耦合器件照相机提供光路，其中激发光纤的端部和发射的聚光纤维均匀地分布在呈现给反应部位的纤维束的区域上。

2. 发明申请

WO2011149972A3 SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS 审中-公开
标题翻译：用于提供结构和组成的光学成像的系统，设备，方法，装置和计算机可访问介质
公开(公告)号：WO2011149972A3
公开(公告)日：2012-01-19
申请号：PCT/US2011037785
申请日：2011-05-24
申请人： GEN HOSPITAL CORP , TEARNEY GUILLERMO J , BOUMA BRETT E , YOO HONGKI , SHISHKOV MILEN , GARDECKI JOSEPH , SHUBOCHKIN ROMAN , MORSE THEODORE , JAFFER AMIN FAROUC
发明人： TEARNEY GUILLERMO J , BOUMA BRETT E , YOO HONGKI , SHISHKOV MILEN , GARDECKI JOSEPH , SHUBOCHKIN ROMAN , MORSE THEODORE , JAFFER AMIN FAROUC
IPC分类号： A61B5/00 , G01B9/02 , G01N21/64
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译：描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。例如，一种布置可以向解剖结构提供至少一个电磁辐射。这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。光纤芯和包层之间的区域可以具有与光学芯和包层的折射率不同的折射率。该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

3. 发明申请

WO2013148360A1 PHASE CONTRAST MICROSCOPY WITH OBLIQUE BACK-ILLUMINATION 审中-公开
标题翻译：相对对比度显微镜与背光照明
公开(公告)号：WO2013148360A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/032517
申请日：2013-03-15
申请人： TRUSTEES OF BOSTON UNIVERSITY
发明人： MERTZ, Jerome, Charles , FORD, Timothy, Nehiley , CHU, Kengyeh, Ken
IPC分类号： G02B21/00 , G01N21/00 , G01N33/483
CPC分类号： G06T5/009 , A61B1/00009 , A61B1/00172 , A61B1/04 , G01N21/255 , G01N21/27 , G01N21/4795 , G01N2021/4797 , G01N2201/062 , G01N2201/0866 , G02B21/0012 , G02B21/06 , G02B21/14 , G06T2207/10068 , G06T2207/20208 , G06T2207/20221
摘要： A method of creating a phase contrast image is provided. In some embodiments the method comprises illuminating the target region of a sample with a first light source to provide a first oblique back illumination of the target region of the sample, and detecting a first phase contrast image from light originating from the first light source and back illuminating the target region of the sample. In some embodiments the method further comprises illuminating the sample with a second light source to provide a second oblique back illumination of the target region of the sample, and detecting a second phase contrast image from light originating from the second light source and back illuminating the target region of the sample. In some embodiments a difference image of the target region of the sample is created by subtracting the second phase contrast image of the target region of the sample from the first phase contrast image of the target region of the sample. Apparatus for carrying out the methods are also provided. The methods and apparatus find use, for example, in endoscopy.
摘要翻译：提供了创建相位对比图像的方法。在一些实施例中，该方法包括用第一光源照射样品的目标区域，以提供样品的目标区域的第一倾斜背照射，以及从源自第一光源和背部的光检测第一相位对比图像照亮样品的目标区域。在一些实施例中，该方法还包括用第二光源照亮样品以提供样品的目标区域的第二倾斜背照射，以及从源自第二光源的光检测第二相位对比图像，并且反射照射目标样品区域。在一些实施例中，通过从样本的目标区域的第一相位对比图像中减去样本的目标区域的第二相位对比图像来创建样本的目标区域的差异图像。还提供了用于执行方法的装置。该方法和装置可用于例如内窥镜检查。

4. 发明申请

WO1993006459A1 DUAL-WAVELENGTH PHOTOMETER AND FIBER OPTIC SENSOR PROBE 审中-公开
标题翻译：双波长光电测量仪和光纤传感器探头
公开(公告)号：WO1993006459A1
公开(公告)日：1993-04-01
申请号：PCT/US1992007883
申请日：1992-09-17
申请人： IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人： IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , PORTER, Marc, D. , JONES, Thomas, P.
IPC分类号： G01N21/31
CPC分类号： G01N21/7703 , G01J2001/1636 , G01N21/80 , G01N2021/3181 , G01N2021/772 , G01N2201/062 , G01N2201/084 , G01N2201/0866
摘要： A dual wavelength optical sensor for measuring the optical characteristics of sensing films which are responsive to a particular quantity to be measured. The optical sensor includes a light source (16, 18) for producing light outputs at two distinct wavelengths and transmitting twin components of light to first and second outputs. A time-shared optical fiber (26) receives the two distinct wavelengths of light from the first output and carries the light on a time-shared basis to a sensor probe (14). A sample detector (30) receives the two distinct wavelengths of light transmitted from the thin sensing film. A reference detector (34) receives the two distinct wavelengths of light from the second output and monitors the output intensity of the light source. A signal processing system (35) combines the measurements of the optical characteristics of the thin sensing film in response to each of the two distinct wavelengths to provide measurements which account for changes in the optical properties of the thin sensing film.
摘要翻译：一种双波长光学传感器，用于测量响应于要测量的特定量的感测膜的光学特性。光学传感器包括用于产生两个不同波长的光输出的光源（16,18），并将光的双分量传输到第一和第二输出。时分共享的光纤（26）从第一输出接收两个不同波长的光，并将时间共享的光传送到传感器探头（14）。样本检测器（30）接收从薄感测膜传输的两种不同波长的光。参考检测器（34）接收来自第二输出端的两个不同波长的光，并监视光源的输出强度。信号处理系统（35）响应于两个不同波长中的每一个组合了薄感测膜的光学特性的测量，以提供考虑薄感测膜的光学性质变化的测量。

5. 发明申请

WO2017139657A1 SIMPLE MONOLITHIC OPTICAL ELEMENT FOR FORWARD-VIEWING SPECTRALLY ENCODED ENDOSCOPY 审中-公开
标题翻译：用于前瞻性光谱编码内窥镜的简单单片光学元件
公开(公告)号：WO2017139657A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/017488
申请日：2017-02-10
申请人： CANON U.S.A., INC. , THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo J.
发明人： TEARNEY, Guillermo J. , DO, Dukho , KANG, Dongkyun , IKUTA, Mitsuhiro
IPC分类号： A61B1/06 , A61B1/005 , A61B1/045 , A61B1/07
CPC分类号： G01J3/0218 , A61B1/00009 , A61B1/00096 , A61B1/00165 , A61B1/00167 , A61B1/005 , A61B1/045 , A61B1/051 , A61B1/0638 , A61B1/0669 , A61B1/07 , G01J3/18 , G01J3/2823 , G01N21/27 , G01N2201/0866 , H04N5/2256 , H04N2005/2255
摘要： Exemplary spectrally encoded probes are provided having forward view capabilities. These probes are configured such that the detection element comprises a plurality of light collecting components, where the distal ends at least partially surround the illumination element and the proximal ends form a linear array that is optically connected to a dispersive component.
摘要翻译：提供了具有前向观看能力的示例性频谱编码探针。这些探针被配置成使得检测元件包括多个光收集部件，其中远端至少部分地围绕照明元件，并且近端形成光学连接到色散部件的线性阵列。

6. 发明申请

WO2011149972A2 SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS 审中-公开
标题翻译：用于提供结构和组成的光学成像的系统，设备，方法，装置和计算机可访问介质
公开(公告)号：WO2011149972A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037785
申请日：2011-05-24
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YOO, Hongki , SHISHKOV, Milen , GARDECKI, Joseph , SHUBOCHKIN, Roman , MORSE, Theodore , JAFFER, Amin, Farouc
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YOO, Hongki , SHISHKOV, Milen , GARDECKI, Joseph , SHUBOCHKIN, Roman , MORSE, Theodore , JAFFER, Amin, Farouc
IPC分类号： A61B5/00 , G01N21/64 , G01B9/02
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译：描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。例如，一种布置可以向解剖结构提供至少一个电磁辐射。这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

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