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1. 发明申请

WO2016011281A1 FORMULATIONS OF AN ALBUMIN-hGH FUSION PROTEIN 审中-公开
标题翻译： ALBUMIN-hGH融合蛋白的制剂
公开(公告)号：WO2016011281A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040793
申请日：2015-07-16
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , BOCK, Jason , LIN, Yen-Huei , FENG, Ping
发明人： BOCK, Jason , LIN, Yen-Huei , FENG, Ping
IPC分类号： A61K38/00 , A61K38/27 , A61K38/38 , G01N33/74 , C07K14/61
CPC分类号： A61K38/27 , A61K9/0019 , A61K38/385 , A61K47/02 , A61K47/22 , A61K47/26 , A61K47/34 , C07K14/61 , C07K14/765 , C07K2319/31
摘要： A stable liquid pharmaceutical composition comprising an albumin-human growth hormone (hGH) fusion protein whose amino acid sequence is set forth as SEQ ID NO: 1 and a buffer, wherein the stable liquid pharmaceutical composition has a pH range of 5.5-6.5.
摘要翻译：一种稳定的液体药物组合物，其包含其氨基酸序列如SEQ ID NO：1所示的白蛋白 - 人生长激素（hGH）融合蛋白和缓冲液，其中所述稳定液体药物组合物的pH范围为5.5-6.5。

2. 发明申请

WO2014113358A1 LYOPHILIZATION PROCESS 审中-公开
标题翻译： LYOPHILATION过程
公开(公告)号：WO2014113358A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011399
申请日：2014-01-14
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , ZHAO, Qinghai , LUO, Xia , BOCK, Jason
发明人： ZHAO, Qinghai , LUO, Xia , BOCK, Jason
IPC分类号： A61J3/00 , A61K9/14 , A61K38/19
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/19 , A61K38/193 , A61K38/215 , A61K38/27 , A61K38/385 , A61K47/02 , A61K47/26 , C07K14/53 , C07K14/565 , C07K14/765 , C07K2319/31 , C12Y301/01008 , F26B5/06
摘要： The present invention provides a process for producing a lyophilized pharmaceutical composition containing a protein. The present invention further provides a product produced by the process. The present invention further provides a process for producing an injectable pharmaceutical composition. The present invention further provides a method of treating a patient with a therapeutic protein composition.
摘要翻译：本发明提供了含有蛋白质的冻干药物组合物的制造方法。本发明还提供了通过该方法生产的产品。本发明还提供了可注射药物组合物的制备方法。本发明还提供了治疗患有治疗性蛋白质组合物的患者的方法。

3. 发明申请

WO2014113359A1 FORMULATIONS OF ALBU-BCHE, PREPARATION AND USES THEREOF 审中-公开
标题翻译： ALBU-BCHE的制剂，其制备及其用途
公开(公告)号：WO2014113359A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011401
申请日：2014-01-14
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , ZHAO, Qinghai , LUO, Xia , BOCK, Jason
发明人： ZHAO, Qinghai , LUO, Xia , BOCK, Jason
IPC分类号： A61P25/36
CPC分类号： B65B3/04 , A61J1/00 , A61K38/385 , A61K38/465 , C07K2319/00
摘要： The present invention provides an aqueous pharmaceutical composition comprising the fusion protein whose amino acid sequence is set forth as SEQ ID NO:1 and an aqueous solution comprising 40 to 60 mM sodium phosphate. The present invention further provides lyophilized pharmaceutical composition, an reconstituted solution, a sealed package comprising the lyophilized pharmaceutical composition, and a vial comprising the lyophilized pharmaceutical or the reconstituted solution. The present invention also provides a method of producing the lyophilized pharmaceutical composition and the sealed package. The present invention also provides a method of treating a human having cocaine seeking behavior, and methods of using the aqueous pharmaceutical composition and lyophilized pharmaceutical composition.
摘要翻译：本发明提供包含其氨基酸序列如SEQ ID NO：1所示的融合蛋白和包含40-60mM磷酸钠的水溶液的水性药物组合物。本发明还提供了冻干药物组合物，重构溶液，包含冻干药物组合物的密封包装，以及包含冻干药物或重构溶液的小瓶。本发明还提供了制备冻干药物组合物和密封包装的方法。本发明还提供了治疗具有可卡因寻求行为的人的方法，以及使用含水药物组合物和冻干药物组合物的方法。

4. 发明申请

WO2015168284A1 ALBUMIN-BCHE IN DETOXIFICATION OF NEUROTOXINS 审中-公开
标题翻译： ALBUMIN-BCHE在脱氧神经毒素中的应用
公开(公告)号：WO2015168284A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028291
申请日：2015-04-29
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , BASSAN, Merav , GROSS, Aviva , SINGH, Mallika , SEAVEY, Matthew, M. , BOCK, Jason , ELIAZ, Rom, E.
发明人： BASSAN, Merav , GROSS, Aviva , SINGH, Mallika , SEAVEY, Matthew, M. , BOCK, Jason , ELIAZ, Rom, E.
IPC分类号： C12N9/18
CPC分类号： C12N9/18 , A61K31/15 , A61K38/465 , C07K2319/31 , C12Y301/01008 , A61K2300/00
摘要： The present invention provides the recombinant fusion protein of SEQ ID No :1. and a method of treating a mammal for exposure to a neurotoxin or for preventing or ameliorating the Neurotoxic Symptoms of exposure to neurotoxin which comprises administering an effective amount of the recombinant fusion protein of SEQ ID No :1. SEQ ID No:1 is a fully recombinant fusion polypeptide composed of the mature form of human serum albumin (HSA) fused at its amino terminus to the carboxy- terminus of a truncated and mutated human BChE.
摘要翻译：本发明提供了SEQ ID No：1的重组融合蛋白。以及治疗哺乳动物暴露于神经毒素或用于预防或改善暴露于神经毒素的神经毒性症状的方法，其包括施用有效量的SEQ ID No：1的重组融合蛋白。 SEQ ID No：1是由其血清白蛋白（HSA）的成熟形式组成的完全重组融合多肽，其在其氨基末端与截短和突变的人类BChE的羧基末端融合。

5. 发明申请

WO2010027584A3 POWER TRANSFER UNIT WITH DISCONNECTING INPUT SHAFT 审中-公开
公开(公告)号：WO2010027584A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/052138
申请日：2009-07-29
申请人： GKN DRIVELINE NORTH AMERICA, INC. , PALAZZOLO, Joseph , BOCK, Jason
发明人： PALAZZOLO, Joseph , BOCK, Jason
IPC分类号： B60K17/22 , B60K17/344 , F16H3/08
摘要： A power transfer unit assembly for a vehicle is provided comprising a first input shaft providing rotational drive. A second input shaft is in communication with a gear train assembly which is in communication with a propshaft. A selective engagement element is movable between an engagement position wherein the second input shaft is placed in rotational communication with the first input shaft and a disengagement position wherein the second input shaft is disengaged from the first input shaft. An actuator assembly moves the selective engagement element into the engagement position for all wheel drive mode and into the disengagement position for two wheel drive mode.

6. 发明申请

WO2013043202A1 LOW AXIAL BEARING ARRANGEMENT FOR STRADDLE MOUNTED HYPOID PINION 审中-公开
标题翻译：低轴向轴承安装用于扁平安装的高密封
公开(公告)号：WO2013043202A1
公开(公告)日：2013-03-28
申请号：PCT/US2011/053187
申请日：2011-09-25
申请人： GKN DRIVELINE NORTH AMERICA, INC. , PALAZZOLO, Joseph , BOCK, Jason
发明人： PALAZZOLO, Joseph , BOCK, Jason
IPC分类号： F16H48/08 , F16H1/14
CPC分类号： F16H1/145 , F16H48/08 , F16H2048/426
摘要： Disclosed is an exemplary differential axle assembly that includes a pinion gear attached to a pinion shaft for concurrent rotation therewith. The pinion gear includes a distal end and a proximal end. A bearing pocket is formed in the proximal end of the pinion gear. A first bearing member is mounted on the pinion shaft, and is configured to support a thrust load in a first axial direction. A second bearing member is mounted on the pinion shaft and is configured to support a thrust load in a second axial direction. A third bearing member disposed in the bearing pocket of the pinion gear and is configured to support a radial load.
摘要翻译：公开了一种示例性的差速器轴组件，其包括附接到小齿轮轴的小齿轮，用于与其同时旋转。小齿轮包括远端和近端。轴承槽形成在小齿轮的近端。第一轴承构件安装在小齿轮轴上，并且构造成在第一轴向方向上支撑推力载荷。第二轴承构件安装在小齿轮轴上并且构造成在第二轴向方向上支撑推力载荷。第三轴承构件，其设置在所述小齿轮的所述轴承槽中并构造成支撑径向载荷。

7. 发明申请

WO2012145580A1 POWER TRANSFER UNIT 审中-公开
标题翻译：电力传输单元
公开(公告)号：WO2012145580A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034371
申请日：2012-04-20
申请人： GKN DRIVELINE NEWTON, LLC , GREISS, Bernd , GERDING, Austin, R. , BOCK, Jason
发明人： GREISS, Bernd , GERDING, Austin, R. , BOCK, Jason
IPC分类号： B60K23/08
CPC分类号： F16H3/22 , B60K17/344 , B60K17/348 , B60K23/08 , B60K2023/0858 , Y10T74/19614
摘要： A power transfer unit for transferring a torque comprising a first shaft configured to receive the torque from a first device, a second shaft configured to output the torque to a second device, and an activating assembly for selectively transferring the torque from the first shaft to the second shaft. The activating assembly includes a sliding cam, a rotating cam, an actuator configured to selectively rotate the rotating cam relative to the sliding cam, and an engaging gear. The gear is configured to be moved by the sliding cam between a first engaged position where the torque is transferred from the first shaft to the second shaft through the gear and a second disengaged position where no torque is transferred to the second shaft. Relative rotation between the rotating earn and the sliding cam moves the sliding earn thereby moving the gear between the first engaged and second disengaged position.
摘要翻译：一种用于传递包括构造成从第一装置接收扭矩的第一轴的扭矩的动力传递单元，被配置为将扭矩输出到第二装置的第二轴以及用于选择性地将扭矩从第一轴传递到第二轴。激活组件包括滑动凸轮，旋转凸轮，被配置为相对于滑动凸轮选择性地旋转旋转凸轮的致动器和接合齿轮。所述齿轮被构造成通过所述滑动凸轮在所述扭矩从所述第一轴通过所述齿轮传递到所述第二轴的第一接合位置和没有扭矩传递到所述第二轴的第二分离位置之间移动。旋转槽和滑动凸轮之间的相对旋转移动滑动挣，从而在第一接合和第二脱离位置之间移动齿轮。

8. 发明申请

WO2007021494A2 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2007021494A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029391
申请日：2006-07-31
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig , BELL, Adam , MOORE, Paul , SHI, Yanggu , LAFLEUR, David , LAIRD, Michael , HASELTINE, William , WOODS, Douglas , BOCK, Jason , SUBRAMANIAN, Mani
发明人： ROSEN, Craig , BELL, Adam , MOORE, Paul , SHI, Yanggu , LAFLEUR, David , LAIRD, Michael , HASELTINE, William , WOODS, Douglas , BOCK, Jason , SUBRAMANIAN, Mani
IPC分类号： C07K14/765
CPC分类号： C07K14/765 , A61K47/643 , C07K2319/00
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，以及含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括含有白蛋白融合蛋白的药物组合物和使用本发明的白蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。

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