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1. 发明申请

WO2005000398A2 INTRAVASCULAR ELECTROPHYSIOLOGICAL SYSTEM AND METHODS 审中-公开
标题翻译：血管内电生理系统和方法
公开(公告)号：WO2005000398A2
公开(公告)日：2005-01-06
申请号：PCT/US2004017650
申请日：2004-06-04
申请人： SYNECOR , RANSBURY TERRANCE , WILLIAMS MICHAEL S , GLENN RICHARD A , FIFER DAN , HOLBROOK KEVIN
发明人： RANSBURY TERRANCE , WILLIAMS MICHAEL S , GLENN RICHARD A , FIFER DAN , HOLBROOK KEVIN
IPC分类号： A61N1/372 , A61N1/375
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes an intravascular implantable pacing and/or defibrillation system. The described system includes a pulse generator that is implantable within a blood vessel and proportioned to blood flow through the blood vessel, and at least one electrode attachable to the pulse generator. During implantation, the pulse generator is introduced into a patient's vasculature, advanced to a desired vessel and anchored in place within the vessel. The electrode or electrodes are placed within the heart or surrounding vessels as needed to deliver electrical pulses to the appropriate location.
摘要翻译：本申请描述了血管内植入式起搏和/或除颤系统。所描述的系统包括一个脉冲发生器是在血管内植入和比例，以通过血管的血流量，以及至少一个电极附接到所述脉冲发生器。在植入期间，脉冲发生器被引入患者的脉管系统，前进到期望的血管并锚定在血管内。根据需要将一个或多个电极放置在心脏或周围血管内，以将电脉冲输送到适当的位置。

2. 发明申请

WO2005077450A3 INTRAVASCULAR DELIVERY SYSTEM FOR THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的血管内输送系统
公开(公告)号：WO2005077450A3
公开(公告)日：2006-11-23
申请号：PCT/US2005004063
申请日：2005-02-10
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , HOLBROOK KEVIN , RANSBURY TERRANCE
发明人： WILLIAMS MICHAEL S , HOLBROOK KEVIN , RANSBURY TERRANCE
IPC分类号： A61M5/00 , A61B5/00 , A61B5/0215 , A61F2/00 , A61F2/82 , A61K9/22 , A61K9/24 , A61M5/142 , A61M5/172 , A61M25/04 , A61M31/00
CPC分类号： A61M25/04 , A61B5/0215 , A61B5/145 , A61B5/14532 , A61F2/82 , A61F2250/0068 , A61M5/14216 , A61M5/14232 , A61M5/14236 , A61M5/14276 , A61M5/172 , A61M2205/3523
摘要： Described herein is a system for intravascular drug delivery system, which includes a reservoir implantable a blood vessel, an intravascular pump fluidly coupled to the reservoir and an anchor expandable into contact with a wall of the blood vessel to retain the system within the vasculature. Delivery conduits may be extend from the reservoir and are positionable at select locations within the vasculature for target drug delivery to select organs or tissues.
摘要翻译：本文描述了一种用于血管内药物递送系统，其包括可植入血管的血管，流体耦合到储器的血管内泵，以及可膨胀成与血管壁接触以将系统保持在脉管系统内的锚固体。输送管道可以从储存器延伸并且可定位在脉管系统内的选定位置，以用于靶向药物递送以选择器官或组织。

3. 发明申请

WO2005077450A9 INTRAVASCULAR DELIVERY SYSTEM FOR THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的血管内输送系统
公开(公告)号：WO2005077450A9
公开(公告)日：2005-09-29
申请号：PCT/US2005004063
申请日：2005-02-10
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , HOLBROOK KEVIN , RANSBURY TERRANCE
发明人： WILLIAMS MICHAEL S , HOLBROOK KEVIN , RANSBURY TERRANCE
IPC分类号： A61B5/00 , A61B5/0215 , A61F2/00 , A61F2/82 , A61K9/22 , A61K9/24 , A61M5/00 , A61M5/142 , A61M5/172 , A61M25/04 , A61M31/00
CPC分类号： A61M25/04 , A61B5/0215 , A61B5/145 , A61B5/14532 , A61F2/82 , A61F2250/0068 , A61M5/14216 , A61M5/14232 , A61M5/14236 , A61M5/14276 , A61M5/172 , A61M2205/3523
摘要： Described herein is a system for intravascular drug delivery system, which includes a reservoir implantable a blood vessel, an intravascular pump fluidly coupled to the reservoir and an anchor expandable into contact with a wall of the blood vessel to retain the system within the vasculature. Delivery conduits may be extend from the reservoir and are positionable at select locations within the vasculature for target drug delivery to select organs or tissues.
摘要翻译：本文描述了一种用于血管内药物递送系统，其包括可植入血管的血管，流体耦合到储器的血管内泵，以及可膨胀成与血管壁接触以将系统保持在脉管系统内的锚固体。输送管道可以从储存器延伸并且可定位在脉管系统内的选定位置，以用于靶向药物递送以选择器官或组织。

4. 发明申请

WO2005081878A3 POLYMERIC ENDOPROSTHESES WITH ENHANCED STRENGTH AND FLEXIBILITY AND METHODS OF MANUFACTURE 审中-公开
标题翻译：具有增强强度和柔韧性的制备聚合物的方法及制备方法
公开(公告)号：WO2005081878A3
公开(公告)日：2005-11-24
申请号：PCT/US2005005299
申请日：2005-02-22
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , HOLBROOK KEVIN D , GLENN RICHARD A
发明人： WILLIAMS MICHAEL S , HOLBROOK KEVIN D , GLENN RICHARD A
IPC分类号： A61F2/02 , A61F2/82 , A61L29/12 , A61L29/18 , A61L31/12 , A61L31/18 , B32B1/08 , F16L11/00 , A61F2/04 , A61F2/06
CPC分类号： A61F2/82 , A61L29/126 , A61L29/18 , A61L31/128 , A61L31/18
摘要： Improved polymeric endoprostheses and methods of manufacturing endoprostheses are disclosed herein. The endoprostheses may comprise one or more polymers wherein the polymer chains are substantially aligned circumferentially, and comprising increased radial strength and flexibility. An endoprosthesis according to the invention may comprise a smooth surface. Endoprostheses disclosed herein may be used in the treatment of strictures in lumens of the body. Alternatively, endoprostheses disclosed herein may be used as anchors to secure medical devices within lumens of the body. The endoprostheses disclosed herein may comprise one or more erodible polymer.
摘要翻译：本文公开了改进的聚合物内用假体和制造内用假体的方法。内用假体可以包含一种或多种聚合物，其中聚合物链基本上对齐地对齐，并且包括增加的径向强度和柔性。根据本发明的内用假体可以包括光滑表面。本文公开的内假体可以用于治疗身体内腔的狭窄。或者，本文公开的假体可以用作锚固件以将身体内腔内的医疗装置固定。本文公开的内用假体可以包含一种或多种可侵蚀的聚合物。

5. 发明申请

WO2005027734A3 METHOD AND APPARATUS FOR TREATING DISEASED OR FRACTURED BONE 审中-公开
标题翻译：用于治疗疾病或骨折的方法和设备
公开(公告)号：WO2005027734A3
公开(公告)日：2005-05-26
申请号：PCT/US2004030771
申请日：2004-09-17
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , SMITH JEFFERY A , STACK RICHARD S , HOLBROOK KEVIN D , GLENN RICHARD A
发明人： WILLIAMS MICHAEL S , SMITH JEFFERY A , STACK RICHARD S , HOLBROOK KEVIN D , GLENN RICHARD A
IPC分类号： A61B20060101 , A61B17/00 , A61B17/70 , A61F2/00 , A61F2/44
CPC分类号： A61B17/8858 , A61B17/70 , A61B2017/00867
摘要： An apparatus according to the invention may comprise one or more expandable structural support pylons (140), means for deploying said one or more structural support pylons (138, 141), and one or more therapeutic substances. Structural support pylons (20) may comprise an elastomeric core (22), or may comprise one or more suitable metals, and may be deployed by shortening the length and increasing the height of the pylon. Alternatively, scaffold (200) may comprise a delivery configuration in which first unit (202) and second unit (204) he generally end to end, and a deployed configuration in which superior surfaces (216) and (218) exert an upward force and inferior surfaces (220) and (222) exert a downward force on superior and inferior vertebral surfaces respectively. A method according to the invention may comprise accessing an interior of a diseased or injured bone in a minimally invasive manner, creating a semi-circular path within said bone, deploying one or more structural support pylons within said interior, introducing structural reinforcement material, and if desired, repeating with one or more subsequent structural support pylons.
摘要翻译：根据本发明的装置可以包括一个或多个可膨胀结构支撑塔架（140），用于展开所述一个或多个结构支撑塔架（138,141）以及一种或多种治疗物质的装置。结构支撑塔架（20）可以包括弹性体芯（22），或者可以包括一种或多种适合的金属，并且可以通过缩短长度并增加塔架的高度来展开。或者，支架（200）可以包括输送构造，其中第一单元（202）和第二单元（204）通常首尾相接，以及展开构造，其中上表面（216）和（218）施加向上的力，并且下表面（220）和（222）分别向上和下椎骨表面施加向下的力。根据本发明的方法可以包括以微创方式进入患病或受损骨骼的内部，在所述骨内创建半圆形路径，在所述内部中布置一个或多个结构支撑柱，引入结构增强材料，以及如果需要，用一个或多个随后的结构支撑塔重复。

6. 发明申请

WO2004045653A3 POLYMERIC ENDOPROSTHESIS AND METHOD OF MANUFACTURE 审中-公开
标题翻译：聚合物内切酶及其制备方法
公开(公告)号：WO2004045653A3
公开(公告)日：2004-09-23
申请号：PCT/US0335805
申请日：2003-11-12
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , HOLBROOK KEVIN D , GLENN RICHARD A , SMITH JEFFREY A , DESIMONE JOSEPH M
发明人： WILLIAMS MICHAEL S , HOLBROOK KEVIN D , GLENN RICHARD A , SMITH JEFFREY A , DESIMONE JOSEPH M
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： B29C47/06 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2250/0014 , A61F2250/0068 , B29C35/0805 , B29C35/0894 , B29C47/0023 , B29C47/0033 , B29C2035/0827 , B29K2995/0044 , B29K2995/0059 , B29K2995/006 , B29L2031/7542
摘要： Improved polymeric endoprostheses and methods of making endoprostheses are disclosed. Said endoprostheses exhibit improved overall compliance, selective regional compliance, and selective radial strength without varying the geometries of selected regions. Numerous other physical characteristics of said endoprostheses may be selectively varied during manufacture. Some embodiments may comprise one or more erodible material. Some embodiments may comprise one or more therapeutics incorporated into said endoprosthesis via a solvent in a supercritical state.
摘要翻译：公开了改进的聚合物内用假体和制造内用假体的方法。所述内假体表现出改善的整体顺应性，选择性区域依从性和选择性径向强度，而不改变所选区域的几何形状。所述内用假体的许多其它物理特性可以在制造期间选择性地变化。一些实施例可以包括一种或多种可侵蚀材料。一些实施方案可以包含通过超临界状态的溶剂并入所述内用假体的一种或多种治疗剂。

7. 发明申请

WO2004045450A2 IMPROVED ENDOPROSTHESES AND METHODS OF MANUFACTURE 审中-公开
标题翻译：改进的内窥镜和制造方法
公开(公告)号：WO2004045450A2
公开(公告)日：2004-06-03
申请号：PCT/US0335951
申请日：2003-11-10
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , GLENN RICHARD A , SMITH JEFFREY A , HOLBROOK KEVIN D , DESIMONE JOSEPH M
发明人： WILLIAMS MICHAEL S , GLENN RICHARD A , SMITH JEFFREY A , HOLBROOK KEVIN D , DESIMONE JOSEPH M
IPC分类号： A61F2/00 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2/915 , A61F
CPC分类号： A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2220/005 , A61F2220/0058 , A61F2250/0014 , A61F2250/0068
摘要： Improved endoprostheses comprising a delivery configuration and a deployed configuration and methods of manufacture are disclosed. Some embodiments according to the invention comprise woven tubular structures and means for maintaining said structures in their expanded configurations. In one embodiment of the invention, locking elements (12, 14) disposed on one or more fibers (15, 17) maintain said endoprosthesis in its deployed configuration. In alternative embodiments, one or more axial members may maintain said endoprosthesis in its deployed configuration. In yet additional alternative embodiments, a chemical bond or thermocouple may maintain said endoprosthesis in its deployed configuration. Some embodiments according to the invention may comprise erodible material.
摘要翻译：公开了包括递送配置和部署配置以及制造方法的改进的内置假体。根据本发明的一些实施例包括织造管状结构和用于将所述结构保持在其展开构型的装置。在本发明的一个实施例中，布置在一根或多根纤维（15,17）上的锁定元件（12,14）将所述人造内修管维持在其展开构型中。在替代实施例中，一个或多个轴向构件可以将所述内置假体维持在其展开构型中。在另外的可选实施例中，化学粘合剂或热电偶可以将所述内置假体维持在其展开构型中。根据本发明的一些实施例可以包括易蚀材料。

8. 发明申请

WO2005051228A2 ARTIFICIAL INTERVERTEBRAL DISC 审中-公开
标题翻译：人造椎间盘
公开(公告)号：WO2005051228A2
公开(公告)日：2005-06-09
申请号：PCT/US2004038933
申请日：2004-11-19
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , SMITH JEFFREY A , HOLBROOK KEVIN D
发明人： WILLIAMS MICHAEL S , SMITH JEFFREY A , HOLBROOK KEVIN D
IPC分类号： A61F20060101 , A61F2/00 , A61F2/30 , A61F2/44 , A61F
CPC分类号： A61F2/442 , A61F2/3094 , A61F2/441 , A61F2002/30016 , A61F2002/30069 , A61F2002/30092 , A61F2002/30448 , A61F2002/30457 , A61F2002/30574 , A61F2002/30576 , A61F2002/30583 , A61F2002/30586 , A61F2002/30971 , A61F2002/444 , A61F2002/4495 , A61F2210/0014 , A61F2210/0085 , A61F2220/005 , A61F2220/0058 , A61F2250/0019 , A61F2310/00365
摘要： Devices and methods for manufacturing devices for treating degenerated and/or traumatized intervertebral discs are disclosed. Artificial discs and components of discs may include an artificial nucleus and/or an artificial annulus and may be comprised of shape memory materials synthesized to achieve desired mechanical and physical properties. An artificial nucleus and/or annulus according to the invention may comprise a hollow body that may be filled with a curable material for deployment. A hollow body according to the invention may comprise one or more partitions to define one or more chambers and may comprise means for directing the flow of material within said hollow body.
摘要翻译：公开了用于制造用于治疗退化和/或创伤性椎间盘的装置的装置和方法。人造盘和盘的组件可以包括人造核和/或人造环，并且可以由合成以实现期望的机械和物理性质的形状记忆材料组成。根据本发明的人造核和/或环可以包括可以填充用于展开的可固化材料的中空体。根据本发明的中空体可以包括一个或多个隔板以限定一个或多个室，并且可以包括用于将材料流引导在所述中空体内的装置。

9. 发明申请

WO2008036384A3 STOMACH WALL CLOSURE DEVICES 审中-公开
标题翻译： STOMACH墙关闭装置
公开(公告)号：WO2008036384A3
公开(公告)日：2008-07-24
申请号：PCT/US2007020440
申请日：2007-09-21
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , ORTH GEOFFREY A , GLENN RICHARD A , SMITH JEFFREY A
发明人： WILLIAMS MICHAEL S , ORTH GEOFFREY A , GLENN RICHARD A , SMITH JEFFREY A
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00278 , A61B2017/00292 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00637
摘要： In a method for sealing an incision in an interior body wall such as a gastrotomy opening in a stomach, a closure device (10) is positioned within the incision. The closure device includes a seal (12b) and an anchor (12a) coupled to the seal. The seal is positioned in sealing contact against a first surface surface of the body wall, and the anchor is positioned against the second surface of the body wall such that a portion of the closure device is positioned. The closure device seals the incision while healing takes place. Once the incision is significantly healed, the closure device bioerodes.
摘要翻译：在用于密封内部体壁（例如胃中的胃切口）的切口的方法中，闭合装置（10）位于切口内。闭合装置包括密封件（12b）和联接到密封件的锚固件（12a）。密封件被定位成与主体壁的第一表面表面密封接触，并且锚定件抵靠主体壁的第二表面定位，使得封闭装置的一部分被定位。闭合装置在愈合发生时密封切口。一旦切口明显愈合，关闭装置就会生物反应。

10. 发明申请

WO2009035650A3 DEVICE FOR MINIMALLY INVASIVE SURGICAL PROCEDURES 审中-公开
标题翻译：用于微创外科手术的设备
公开(公告)号：WO2009035650A3
公开(公告)日：2009-07-02
申请号：PCT/US2008010640
申请日：2008-09-12
申请人： SYNECOR LLC , ATHAS WILLIAM L , MILLER THOMAS B , PRYOR AURORA , ORTH GEOFFREY A , WILLIAMS MICHAEL S , SMITH JEFFREY A , GLENN RICHARD A , FIFER DANIEL W
发明人： ATHAS WILLIAM L , MILLER THOMAS B , PRYOR AURORA , ORTH GEOFFREY A , WILLIAMS MICHAEL S , SMITH JEFFREY A , GLENN RICHARD A , FIFER DANIEL W
IPC分类号： A61B17/34 , A61B17/00
CPC分类号： A61B17/3421 , A61B18/1477 , A61B18/1482 , A61B2017/003 , A61B2017/00349 , A61B2017/320044 , A61B2017/320048 , A61B2017/320056 , A61B2017/3445 , A61B2017/3447 , A61B2018/00214 , A61B2018/1407 , A61B2018/144
摘要： A system for minimally invasive medical procedures includes an elongate tubular access cannula comprising an elongate tubular member having a rigid proximal portion and an articulating portion. The tubular member has a first branch and a tubular bifurcation extending from the first branch, allowing simultaneous use of multiple instruments. A dissector suitable for use with the access cannula, or other access devices, for implantation of gastric bands or for other procedures includes a pre-curved distal portion having a dissection element such as a monopolar RF conductor and/or a dissection balloon, as well as a snare. In one method, the dissector is advanced around the posterior side of the stomach to form a tunnel in the connective tissue, and the snare is then extended from the dissector to engage a portion of the band and withdraw it through the tunnel.
摘要翻译：用于微创医疗程序的系统包括细长管状进入套管，其包括具有刚性近端部分和铰接部分的细长管状构件。管状构件具有从第一分支延伸的第一分支和管状分叉，允许同时使用多个仪器。适合与入口插管或其他进入装置一起用于植入胃束带或用于其他程序的解剖器包括具有解剖元件的预弯曲远侧部分，例如单极RF导体和/或解剖气囊，以及作为一个圈套在一种方法中，解剖器在胃的后部周围前进，以在结缔组织中形成隧道，然后将圈套从解剖器延伸以接合带的一部分并将其从隧道中取出。

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