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    • 1. 发明申请
    • METHOD AND APPARATUS FOR TREATING DISEASED OR FRACTURED BONE
    • 用于治疗疾病或骨折的方法和设备
    • WO2005027734A3
    • 2005-05-26
    • PCT/US2004030771
    • 2004-09-17
    • SYNECOR LLCWILLIAMS MICHAEL SSMITH JEFFERY ASTACK RICHARD SHOLBROOK KEVIN DGLENN RICHARD A
    • WILLIAMS MICHAEL SSMITH JEFFERY ASTACK RICHARD SHOLBROOK KEVIN DGLENN RICHARD A
    • A61B20060101A61B17/00A61B17/70A61F2/00A61F2/44
    • A61B17/8858A61B17/70A61B2017/00867
    • An apparatus according to the invention may comprise one or more expandable structural support pylons (140), means for deploying said one or more structural support pylons (138, 141), and one or more therapeutic substances. Structural support pylons (20) may comprise an elastomeric core (22), or may comprise one or more suitable metals, and may be deployed by shortening the length and increasing the height of the pylon. Alternatively, scaffold (200) may comprise a delivery configuration in which first unit (202) and second unit (204) he generally end to end, and a deployed configuration in which superior surfaces (216) and (218) exert an upward force and inferior surfaces (220) and (222) exert a downward force on superior and inferior vertebral surfaces respectively. A method according to the invention may comprise accessing an interior of a diseased or injured bone in a minimally invasive manner, creating a semi-circular path within said bone, deploying one or more structural support pylons within said interior, introducing structural reinforcement material, and if desired, repeating with one or more subsequent structural support pylons.
    • 根据本发明的装置可以包括一个或多个可膨胀结构支撑塔架(140),用于展开所述一个或多个结构支撑塔架(138,141)以及一种或多种治疗物质的装置。 结构支撑塔架(20)可以包括弹性体芯(22),或者可以包括一种或多种适合的金属,并且可以通过缩短长度并增加塔架的高度来展开。 或者,支架(200)可以包括输送构造,其中第一单元(202)和第二单元(204)通常首尾相接,以及展开构造,其中上表面(216)和(218)施加向上的力,并且 下表面(220)和(222)分别向上和下椎骨表面施加向下的力。 根据本发明的方法可以包括以微创方式进入患病或受损骨骼的内部,在所述骨内创建半圆形路径,在所述内部中布置一个或多个结构支撑柱,引入结构增强材料,以及 如果需要,用一个或多个随后的结构支撑塔重复。
    • 7. 发明申请
    • CATHETER SYSTEM FOR ACUTE NEUROMODULATION
    • 用于急性神经修复的导管系统
    • WO2013022543A3
    • 2013-10-03
    • PCT/US2012046332
    • 2012-07-11
    • SYNECOR LLCRANSBURY TERRANCESANDERS WILLIAM ESTACK RICHARD SMASSON STEPHEN C
    • RANSBURY TERRANCESANDERS WILLIAM ESTACK RICHARD SMASSON STEPHEN C
    • A61N1/36A61B18/14A61B18/18A61M25/04A61N1/362
    • A61N1/36114A61N1/0551A61N1/056A61N1/36053A61N1/36135A61N1/36139
    • A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning with in a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts - so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is con figured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.
    • 神经调节系统包括适于定位在上腔静脉内的第一治疗元件和适于定位在肺动脉中的第二治疗元件。 第一治疗元件承载在第一细长柔性轴上,并且第二治疗元件承载在第二细长柔性轴上。 第一和第二轴中的一个可滑动地容纳在第一和第二轴中的另一个的内腔中,使得第二治疗元件可相对于第一治疗元件在身体内前进。 刺激器被配置为激活第一血管内的第一治疗元件,以将治疗递送至布置在上腔静脉外部的第一神经纤维,并激励肺动脉内的第二治疗元件以向第二神经递送交感神经治疗 纤维布置在肺动脉外部。 为了治疗心力衰竭,第一神经纤维可能是迷走神经,第二神经纤维可能是交感神经纤维。
    • 8. 发明申请
    • NEUROMODULATION SYSTEMS AND METHODS FOR TREATING ACUTE HEART FAILURE SYNDROMES
    • 神经系统和治疗急性心力衰竭综合征的方法
    • WO2012149511A3
    • 2013-02-28
    • PCT/US2012035712
    • 2012-04-28
    • SYNECOR LLCRANSBURY TERRANCESANDERS WILLIAM ESTACK RICHARD SSTACK COLLEEN
    • RANSBURY TERRANCESANDERS WILLIAM ESTACK RICHARD SSTACK COLLEEN
    • A61N1/362A61B17/34A61B18/00A61M25/088A61N1/04
    • A61N1/3621A61B5/01A61B5/0215A61B5/024A61M25/0074A61M25/0125A61M25/0147A61M25/04A61M2025/0175A61N1/056A61N1/057A61N1/36114A61N1/3627
    • A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan- Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.
    • 用于治疗急性心力衰竭综合征的神经调节系统包括具有适于定位在诸如上腔静脉的第一血管内的副交感神经治疗元件的第一导管和适于与第二不同血液定位的第二导管交感神经治疗元件 血管如肺动脉。 导管包括其中一个导管可滑动地设置在另一个导管上的系统。 系统还可以可滑动地设置在第三细长元件(例如可定位在肺动脉内的Swan-Ganz导管)之上,使得Swan-Ganz可用于监测神经调节治疗期间的血压和心输出量等参数。 副交感神经治疗元件被激励以将神经调节治疗递送到副交感神经纤维例如迷走神经,而交感神经治疗元件通电以将神经调节治疗递送至交感神经纤维如交感神经纤维。 对于急性心力衰竭综合征的治疗,神经调节治疗可用于降低心率并增加心脏内向性。
    • 10. 发明申请
    • SYSTEM AND METHOD FOR NEUROMODULATION
    • 神经修复的系统和方法
    • WO2013028274A3
    • 2014-07-17
    • PCT/US2012046329
    • 2012-07-11
    • INTERVENTIONAL AUTONOMICS CORPSANDERS WILLIAM EMASSON STEPHEN CRANSBURY TERRANCESTACK RICHARD S
    • SANDERS WILLIAM EMASSON STEPHEN CRANSBURY TERRANCESTACK RICHARD S
    • A61N1/36A61N1/05A61N1/08
    • A61N1/36114A61N1/0551A61N1/056A61N1/36053A61N1/36135A61N1/36139
    • A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed in a superior vena cava of the patient to deliver therapy to a parasympathetic nerve fiber such as a vagus nerve, and energizing a second therapeutic element disposed within the superior vena cava to deliver therapy to a sympathetic cardiac nerve fiber. A neuromodulation system includes a parasympathetic therapy element adapted for positioning within a blood vessel, a sympathetic therapy element adapted for positioning with the blood vessel; and a stimulator configured to energize the parasympathetic therapy element to deliver parasympathetic therapy to a parasympathetic nerve fiber disposed external to the blood vessel and energize the sympathetic therapy element within the blood vessel to deliver sympathetic therapy to a sympathetic nerve fiber disposed external to the blood vessel. Delivery of the parasympathetic and sympathetic therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.
    • 一种治疗患者自主性不平衡的方法包括激励设置在患者上腔静脉中的第一治疗元件,以将治疗递送至副交感神经纤维如迷走神经,以及激励位于上腔静脉内的第二治疗元件 为交感神经纤维提供治疗。 神经调节系统包括适于定位在血管内的副交感神经治疗元件,适于与血管定位的交感治疗元件; 以及刺激器,其构造成激励所述副交感神经治疗元件以将副交感神经治疗递送至设置在所述血管外部的副交感神经纤维,并且激励所述血管内的所述交感神经治疗元件,以向位于所述血管外部的交感神经纤维递送交感神经治疗 。 副交感神经和交感神经治疗的交付减少患者的心率,提高或维持患者的血压。