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1. 发明申请

WO2004098565A3 IMPLANTABLE CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 审中-公开
标题翻译：可植入控制释放生物体递送装置
公开(公告)号：WO2004098565A3
公开(公告)日：2005-03-03
申请号：PCT/US2004013327
申请日：2004-04-29
申请人： SURMODICS INC , ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译：本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯，）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。本发明还提供了所述组合物用于制备用于以控制释放方式将生物活性剂递送至患者的药物以及制备受控释放生物活性剂递送装置的方法的用途。

2. 发明申请

WO2006014484A3 METHODS AND DEVICES FOR THE TREATMENT OF OCULAR CONDITIONS 审中-公开
标题翻译：用于治疗眼睛病症的方法和设备
公开(公告)号：WO2006014484A3
公开(公告)日：2006-06-22
申请号：PCT/US2005023972
申请日：2005-07-05
申请人： SURMODICS INC , DE JUAN EUGENE , VARNER SIGNE E , LAWIN LAURIE R
发明人： DE JUAN EUGENE , VARNER SIGNE E , LAWIN LAURIE R
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61L27/54 , A61L2300/41 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2430/16
摘要： Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
摘要翻译：特征是一种将一种或多种生物活性剂滴入患者眼睛内用于治疗眼部病症的眼组织的方法，所述方法包括同时使用以下生物活性剂递送方法中的至少两种（A） - （C）（A）将包含一种或多种生物活性剂的持续释放递送装置植入眼睛的后部区域，使得其将一种或多种生物活性剂递送至眼睛的玻璃体液中; （B）将一种或多种生物活性剂灌注（例如注射或植入）和（C）将眼睛离子电渗疗法中的一种或多种生物活性剂灌注（例如，注射或递送）到眼睛的玻璃体液中。

3. 发明申请

WO2004028477A3 METHODS FOR TREATMENT AND/OR PREVENTION OF RETINAL DISEASE 审中-公开
标题翻译：治疗和/或预防感染性疾病的方法
公开(公告)号：WO2004028477A3
公开(公告)日：2005-03-03
申请号：PCT/US0330716
申请日：2003-09-29
申请人： SURMODICS INC , DE JUAN EUGENE , VARNER SIGNE E
发明人： DE JUAN EUGENE , VARNER SIGNE E
IPC分类号： A61K9/00 , A61K31/56 , A61K31/573
CPC分类号： A61K31/56 , A61K9/0048 , A61K31/573
摘要： Featured is a methodology for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. In particular embodiments, the therapeutic medium is disposed in a sub retinal space. Such instillation being accomplished by one of injection or implantation of the therapeutic medium sub-retinally or the sub-retinal space. In other aspects, the methodology further includes forming a limited retinal detachment so as to define the sub-retinal space as well as methods for treating an eye by sub-retinally administering a therapeutic medium.
摘要翻译：特色是一种用于向眼后段施用治疗性介质的方法，包括滴注或处置回顾性治疗介质。在具体实施方案中，将治疗介质设置在视网膜的视网膜空间中。这种滴注是通过注射或植入视网膜或视网膜下空间的治疗介质之一完成的。在其他方面，所述方法还包括形成有限的视网膜脱离以限定子视网膜空间以及通过次级再次施用治疗介质来治疗眼睛的方法。

4. 发明申请

WO2012019176A3 IMPLANTABLE THERAPEUTIC DEVICE 审中-公开
标题翻译：可植入的治疗装置
公开(公告)号：WO2012019176A3
公开(公告)日：2012-04-05
申请号：PCT/US2011046870
申请日：2011-08-05
申请人： FORSIGHT VISION4 INC , DE JUAN EUGENE , ALSTER YAIR , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E
发明人： DE JUAN EUGENE , ALSTER YAIR , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the fist side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译：释放治疗剂的治疗装置包括与包含储存器的容器偶联的多孔结构。所述储库包含一定体积，所述体积经设定尺寸以在连接到所述多孔结构并植入患者体内时释放治疗量的治疗剂达延长的时间。多孔结构可以包括连接到储存器的第一侧和连接到患者以释放治疗剂的第二侧。从第一侧延伸到第二侧的通道的长度可以包括大于从第一侧到第二侧穿过多孔结构的距离的有效长度。治疗装置可以包括可穿透的屏障，以在植入患者体内时将治疗剂注入该装置。

5. 发明申请

WO2008070592A3 METHODS AND APPARATUS FOR PREVENTION OF WOUND INCOMPETENCE ASSOCIATED WITH PHACOEMULSIFICATION 审中-公开
标题翻译：用于防止与光乳化相关的伤口不适的方法和装置
公开(公告)号：WO2008070592A3
公开(公告)日：2008-08-21
申请号：PCT/US2007086204
申请日：2007-12-01
申请人： DE JUAN EUGENE , NASERI AYMAN
发明人： DE JUAN EUGENE , NASERI AYMAN
IPC分类号： A61F9/01 , A61B17/32
CPC分类号： A61F9/0133 , A61F9/00736
摘要： Wound incompetence may increase the risk of endophthalmitis following cataract surgery. In phacoemulsification with corneal incisions, an inverted flap of posterior corneal tissue, a corneal tongue, may prevent normal anatomical apposition of the surgical wound edges leading to potential wound incompetence. Preventing or correcting inversion of corneal tissue into a corneal wound will prevent the corneal tissue from creating a barrier for tissue apposition during healing.
摘要翻译：创伤无力可能会增加白内障手术后眼内炎的风险。在角膜切口超声乳化术中，后角膜组织倒置皮瓣（角膜舌）可能会阻止手术伤口边缘的正常解剖对位，从而导致伤口无法适应。防止或纠正角膜组织倒入角膜伤口将防止角膜组织在愈合过程中形成用于组织并置的屏障。

6. 发明申请

WO2012019136A3 INJECTOR APPARATUS AND METHOD FOR DRUG DELIVERY 审中-公开
标题翻译：注射器装置和药物递送方法
公开(公告)号：WO2012019136A3
公开(公告)日：2012-06-07
申请号：PCT/US2011046812
申请日：2011-08-05
申请人： FORSIGHT VISION 4 INC , DE JUAN EUGENE , ALSTER YAIR , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E , DOUD DARREN , ERICKSON SIGNE , BARRETT MIKE , BATTEN DAVID , SKIELLER CHRISTINA
发明人： DE JUAN EUGENE , ALSTER YAIR , FARINAS KATHLEEN COGAN , MACFARLANE K ANGELA , REICH CARY J , CAMPBELL RANDOLPH E , DOUD DARREN , ERICKSON SIGNE , BARRETT MIKE , BATTEN DAVID , SKIELLER CHRISTINA
IPC分类号： A61M39/02
CPC分类号： A61F9/0017 , A61F9/0008 , A61M5/14276 , A61M5/178 , A61M5/31 , A61M5/32 , A61M5/46 , A61M39/0208 , A61M39/0247 , A61M2039/027 , A61M2039/0276
摘要： Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.
摘要翻译：方法和装置为植入体内的装置提供治疗流体，例如提供植入患者眼中的装置的容器。该方法和装置可以包括注射器，以增加注入植入眼中的装置中的治疗剂的量，或者在植入眼中的装置内接收治疗流体的结构，或其组合。植入眼中的装置可以包括具有密度与治疗流体不同的流体的储存器腔室，并且该装置可以适于至少部分地将储存腔室内的植入装置流体与治疗流体分开以增加放置在储存室中的治疗流体。

7. 发明申请

WO2009145842A9 THERAPEUTIC DEVICE FOR PAIN MANAGEMENT AND VISION 审中-公开
标题翻译：用于疼痛管理和视力的治疗设备
公开(公告)号：WO2009145842A9
公开(公告)日：2010-11-18
申请号：PCT/US2009002166
申请日：2009-04-06
申请人： FORSIGHT LABS LLC , DE JUAN EUGENE , REICH CARY J , BOYD STEPHEN , ALSTER YAIR , SIERRA DAVID , GIFFORD HANSON S , ALEJANDRO JOSE D , LINDSTROM RICHARD L , MACFARLANE K ANGELA , SUTTON DOUGLAS , SCHOLL JOHN ANTHONY
发明人： DE JUAN EUGENE , REICH CARY J , BOYD STEPHEN , ALSTER YAIR , SIERRA DAVID , GIFFORD HANSON S , ALEJANDRO JOSE D , LINDSTROM RICHARD L , MACFARLANE K ANGELA , SUTTON DOUGLAS , SCHOLL JOHN ANTHONY
IPC分类号： A61F2/14
CPC分类号： A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
摘要翻译：用于治疗上皮缺陷的治疗镜片包括设置在基质和/或鲍曼膜上的一层治疗材料，以抑制水从泪液流向基质和/或鲍曼膜，使得角膜失去光泽可以恢复到减少角膜肿胀和光散射。该层可以覆盖并保护神经纤维以减轻疼痛。该层可以包括折射率以抑制光从基质和/或鲍曼膜的前表面散射。该镜片可以包括弯曲的前表面，其在上皮再生时为患者提供功能性视力。治疗材料层可以以多种方式定位在眼睛上，例如用喷雾固化以将该层粘附到基质和/或鲍曼膜的暴露表面上。

8. 发明申请

WO2007040825A3 METHODS AND APPARATUS FOR INTRAOCULAR BRACHYTHERAPY 审中-公开
标题翻译：方法和装置用于室内BRACHYTHERAPY
公开(公告)号：WO2007040825A3
公开(公告)日：2009-04-30
申请号：PCT/US2006031004
申请日：2006-08-09
申请人： NEOVISTA INC , LARSEN CHARLES E , HILLSTEAD RICHARD , TRIP ROELOF , DE JUAN EUGENE , HUMAYUN MARK , FRITZ EBERHARD , PINTASKE RAINER
发明人： LARSEN CHARLES E , HILLSTEAD RICHARD , TRIP ROELOF , DE JUAN EUGENE , HUMAYUN MARK , FRITZ EBERHARD , PINTASKE RAINER
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1017 , A61N5/1049 , A61N2005/1058
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.
摘要翻译：公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。辐射源安装到具有柔性远端和较硬的近端的导线上。

9. 发明申请

WO2007087061A2 GLAUCOMA TREATMENT DEVICE 审中-公开
标题翻译： GLAUCOMA治疗装置
公开(公告)号：WO2007087061A2
公开(公告)日：2007-08-02
申请号：PCT/US2006049234
申请日：2006-12-22
申请人： TRANSCEND MEDICAL INC , DE JUAN EUGENE , BOYD STEPHEN , DEEM MARK E , GIFFORD HANSON S III , ROSENMAN DAN
发明人： DE JUAN EUGENE , BOYD STEPHEN , DEEM MARK E , GIFFORD HANSON S III , ROSENMAN DAN
IPC分类号： A61F11/00
CPC分类号： A61F9/00781 , A61B34/70 , A61B90/00 , A61F2/14 , A61F2/142 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F9/0133 , A61F11/00 , A61F2250/0001 , A61F2250/0096 , A61F2250/0097 , A61K9/0051 , A61M27/002 , A61M2202/04 , A61M2210/0612
摘要： Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.
摘要翻译：方法和装置适于植入眼睛。在眼睛的角膜中形成切口，并且通过切口将分路插入眼睛的前房。分流器包括流体通道。所述分流器沿着从所述前房通过所述眼睛的巩膜刺入所述脉管外空间的路径通过并且定位在第一位置，使得所述流体通道的第一部分与所述前房连通，并且所述流体通道的第二部分与脉管外空间连通，以在脉络膜上空间和前房之间提供流体通道。

10. 发明申请

WO2004066871A3 RESERVOIRS WITH SUBRETINAL CANNULA FOR SUBRETINAL DRUG DELIVERY 审中-公开
标题翻译：具有子宫颈瘘的储备用于子宫内膜药物递送
公开(公告)号：WO2004066871A3
公开(公告)日：2004-11-25
申请号：PCT/US2004002214
申请日：2004-01-26
申请人： DOHENY RETINA INST , HUMAYUN MARK , DE JUAN EUGENE
发明人： HUMAYUN MARK , DE JUAN EUGENE
IPC分类号： A61F20060101 , A61F2/16 , A61F9/00 , A61M5/142 , A61M31/00
CPC分类号： A61F9/0017 , A61F2/16 , A61F2250/0068 , A61M5/1428 , A61M2210/0612
摘要： Featured are devices and methods for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. Such instillation is accomplished by providing a reservoir (22) containing a therapeutic medium to which is fluidly coupled a cannula (30) and inserting a portion of the cannula (30) sub-retinally, whereby the therapeutic medium within the reservoir (22) is coupled to and dispersed subretinally via the cannula (30).
摘要翻译：特别是用于将治疗性介质施用于眼后段的装置和方法，包括滴注或处置回顾性治疗介质。通过提供容纳治疗介质的储存器（22）来实现这种滴注，储存器（22）流体地联接套管（30）并且插入套管（30）的一部分，其中储存器（22）内的治疗介质是通过插管（30）联接到和分散地分散。

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