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1. 发明申请

WO2019222536A1 CATHETERS WITH STRUCTURALLY SUPPORTED EXPANDABLE ELEMENTS AND METHODS FOR SAME 审中-公开
公开(公告)号：WO2019222536A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032719
申请日：2019-05-16
申请人： SURMODICS, INC.
发明人： MULLEN, Conleth A. , FINNERTY, Michael J. , MANNING, Colm C. , GATELY, Noel M. , FOX, Noel C. , LOCKWOOD, Nathan , SLAGER, Joram , TROCKE, Amy , GANSKE, Karl V.
IPC分类号： A61M25/10 , A61F2/82 , A61F2/958 , A61M25/00 , A61M25/04
摘要： A balloon catheter includes a catheter shaft extending between proximal and distal end portions along a shaft axis. The catheter shaft includes an inflation lumen, and at least one inflation port in communication with the inflation lumen. A balloon assembly is coupled with the catheter shaft and in communication with the at least one inflation port. The balloon assembly includes a balloon membrane having a balloon body, a balloon proximal nose and a balloon distal nose coupled with the catheter shaft. An interlaced jacket is coupled with the balloon membrane, the interlaced jacket includes interlaced filaments extending at diverging angles relative to the shaft axis.

2. 发明申请

WO2017218634A1 HEMOSTASIS SEALING DEVICE WITH CONSTRICTION RING 审中-公开
标题翻译：带限制环的模体密封装置
公开(公告)号：WO2017218634A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037410
申请日：2017-06-14
申请人： SURMODICS, INC.
发明人： SUTTON, Gregg Stuart
IPC分类号： A61M39/06 , A61M39/00
摘要： Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.
摘要翻译：本文的各方面涉及用于提供用于血管通路装置中的防漏密封件的医疗装置。在各种实施例中，包括用于血管通路止血的装置。该装置可以包括被配置成至少部分地接收医疗装置的外壳，该外壳限定腔体。外壳可以具有第一密封部分和第二密封部分，该空腔设置在第一密封部分和第二密封部分之间。该外壳可以包括第二密封部分，该第二密封部分包括分隔的隔膜密封。外壳可以包括与第二密封部分结构连通的筒。该装置可以包括设置在筒体周围的收缩环，该收缩环与第二密封部分连接以限制分开的隔膜密封的移动。

3. 发明申请

WO2014110407A2 CONDUCTIVE POLYMERS AND USES 审中-公开
标题翻译：导电聚合物和用途
公开(公告)号：WO2014110407A2
公开(公告)日：2014-07-17
申请号：PCT/US2014011096
申请日：2014-01-10
申请人： SURMODICS INC
发明人： JELLE BRUCE M , KURDYUMOV ALEKSEY V , MCGONIGLE JOSEPH SCHMIDT , HERGENROTHER ROBERT W , LOCKWOOD NATHAN A , VENTURA JOSEPH , STUCKE SEAN M
IPC分类号： A61B5/04
CPC分类号： A61L31/10 , A61B2562/125 , A61B2562/16 , A61L31/14 , A61N1/0404 , A61N1/05 , C07D495/04 , C07D519/00 , C08G61/02 , C08G61/124 , C08G61/126 , C08G73/0266 , C08G2261/1424 , C08G2261/1426 , C08G2261/1428 , C08G2261/143 , C08G2261/144 , C08G2261/145 , C08G2261/148 , C08G2261/3221 , C08G2261/3223 , C08G2261/3422 , C08G2261/43 , C08G2261/76 , C08G2261/77 , C08G2261/90 , C08G2261/94 , C09D5/24 , H01B1/127 , Y10T428/31507 , Y10T428/31533
摘要： Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers polymers are described and electrically conductive coatings that include activatable conductive polymers.
摘要翻译：本文公开了可激活的导电组合物和制备和使用可活化导电组合物的方法。特别地，描述了可激活的导电单体聚合物和包括可活化的导电聚合物的导电涂层。

4. 发明申请

WO2013142758A1 COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID 审中-公开
标题翻译：用于体液检测的组合物和方法，包括硫酸
公开(公告)号：WO2013142758A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/033429
申请日：2013-03-22
申请人： SURMODICS, INC. , OPPERMAN, Gary , NELSON, Wendy
发明人： OPPERMAN, Gary , NELSON, Wendy
IPC分类号： C12Q1/28 , G01N33/52 , G01N33/535 , G01N33/558 , G01N33/58
CPC分类号： G01N33/581 , C12Q1/28 , G01N21/78 , G01N33/52 , G01N33/535 , G01N33/558
摘要： The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.
摘要翻译：本发明提供用于进行比色分析的组合物，试剂盒和方法。使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

5. 发明申请

WO2012170706A2 PHOTO-VINYL LINKING AGENTS 审中-公开
标题翻译：紫胶连接剂
公开(公告)号：WO2012170706A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041381
申请日：2012-06-07
申请人： SurModics, Inc. , SWAN, Dale G. , KURDYUMOV, Aleksey V. , JELLE, Bruce M.
发明人： SWAN, Dale G. , KURDYUMOV, Aleksey V. , JELLE, Bruce M.
IPC分类号： C08J7/16 , A61L31/10
CPC分类号： C09D4/00 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2420/02 , C07F9/4078 , C08J7/16 , Y10T428/31938
摘要： Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Other embodiments are also included herein.
摘要翻译：本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。本文的实施方案还包括具有式R 1 -X-R 2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。本文还包括其它实施例。

6. 发明申请

WO2012092421A2 COMPOSITION FOR INTRAVASCULAR DELIVERY OF THERAPEUTIC COMPOSITION 审中-公开
标题翻译：用于治疗组合物的血管内输送的组合物
公开(公告)号：WO2012092421A2
公开(公告)日：2012-07-05
申请号：PCT/US2011/067717
申请日：2011-12-29
申请人： SURMODICS, INC. , CHAPPA, Ralph, A.
发明人： CHAPPA, Ralph, A.
IPC分类号： A61K47/22
CPC分类号： A61K47/22 , A61K9/0019 , A61K31/337 , A61K31/436 , A61L29/16 , A61L2300/416 , A61M25/0009 , A61M25/0026 , A61M25/0045 , A61M25/1011 , A61M25/1029 , A61M2025/1004 , A61M2025/1013 , A61M2025/105 , A61M2025/1088
摘要： The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.
摘要翻译：本发明涉及用于血管内递送治疗剂（例如紫杉醇，雷帕霉素或其类似物）的药物组合物。该组合物包含治疗剂和生物相容性溶剂，例如糖糠醛。该组合物可以帮助治疗剂渗透组织。保护药物组合物不受周围环境影响的导管组件可用于血管内输送。

7. 发明申请

WO2012006135A3 FLUORINATED POLYMERS AND LUBRICIOUS COATINGS 审中-公开
公开(公告)号：WO2012006135A3
公开(公告)日：2012-01-12
申请号：PCT/US2011/042282
申请日：2011-06-29
申请人： SURMODICS, INC. , ROLFES MEYERING, Emily R.
发明人： ROLFES MEYERING, Emily R.
IPC分类号： C08F226/10
摘要： The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.

8. 发明申请

WO2012003296A1 CATHETER ASSEMBLY 审中-公开
标题翻译：导管总成
公开(公告)号：WO2012003296A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042556
申请日：2011-06-30
申请人： SURMODICS, INC. , CHAPPA, Ralph, A.
发明人： CHAPPA, Ralph, A.
IPC分类号： A61M25/10
CPC分类号： A61M25/1034 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1093
摘要： A catheter assembly includes an expandable and collapsible structure (12) having an outer surface (22). The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A coating (32) is disposed on the outer surface of the expandable and collapsible structure. The coating includes a bioactive agent. A sleeve (14) is disposed over the coating. The sleeve is adapted to expand between a compressed state and an enlarged state and to return to the compressed state. The sleeve defines a plurality of openings (150) in the compressed state. An outer diameter of the coating is less than an outer diameter of the sleeve when the expandable and collapsible structure is in the contracted state and greater than the outer diameter of the sleeve when the expandable and collapsible structure is in the dilated state.
摘要翻译：导管组件包括具有外表面（22）的可膨胀和可折叠结构（12）。可膨胀和可折叠结构适于在收缩状态和膨胀状态之间膨胀。涂层（32）设置在可膨胀和可折叠结构的外表面上。涂层包括生物活性剂。套管（14）设置在涂层上方。套筒适于在压缩状态和放大状态之间膨胀并返回到压缩状态。套筒限定了处于压缩状态的多个开口（150）。当可膨胀和可折叠结构处于收缩状态时，当可膨胀和可折叠结构处于膨胀状态时，涂层的外径小于套筒的外径，并且大于套筒的外径。

9. 发明申请

WO2011082296A1 SILYL ETHER-MODIFIED HYDROPHILIC POLYMERS AND USES FOR MEDICAL ARTICLES 审中-公开
标题翻译： SILYL改性水解聚合物及其用于医疗文章的用途
公开(公告)号：WO2011082296A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062489
申请日：2010-12-30
申请人： SURMODICS, INC. , KURDYUMOV, Aleksey, V. , HERGENROTHER, Robert , JELLE, Bruce, M.
发明人： KURDYUMOV, Aleksey, V. , HERGENROTHER, Robert , JELLE, Bruce, M.
IPC分类号： A61L29/08 , A61L29/14
CPC分类号： C09D201/10 , A61L29/085 , A61L2400/10 , C09D143/04 , C08L101/10 , C08L39/06
摘要： Silane-functionalized hydrophilic polymers and polymeric matrices are described. Hydrophilic matrices can be formed from the polymers, and can be used in association with the preparation of implantable and injectable medical devices. Exemplary devices include those having a durable lubricious coating formed from the hydrophilic polymers.
摘要翻译：描述了硅烷官能化的亲水聚合物和聚合物基质。亲水基质可以由聚合物形成，并且可以与可植入和可注射的医疗装置的制备相结合使用。示例性的装置包括具有由亲水性聚合物形成的耐久润滑涂层的装置。

10. 发明申请

WO2010141553A1 SILANE-FUNCTIONALIZED HYDROPHOBIC a(1→4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION 审中-公开
标题翻译：硅烷官能化的疏水性（1→4）葡聚糖聚合物和用于植入或注射的聚合物
公开(公告)号：WO2010141553A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/037027
申请日：2010-06-02
申请人： SURMODICS, INC. , KURDYUMOV, Aleksey, V. , LOCKWOOD, Nathan, A. , SLAGER, Joram , SWAN, Dale, G. , HERGENROTHER, Robert
发明人： KURDYUMOV, Aleksey, V. , LOCKWOOD, Nathan, A. , SLAGER, Joram , SWAN, Dale, G. , HERGENROTHER, Robert
IPC分类号： C08B31/12 , C08B33/04 , C08B37/00
CPC分类号： C08B37/0009 , C08B31/12 , C08B33/04 , C08B37/0012
摘要： Silane-functionalized hydrophobic a(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic a(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
摘要翻译：描述了硅烷官能化的疏水性（1→4）吡喃葡萄糖聚合物和聚合物基质。可生物降解的基质可由疏水性（1→4）吡喃葡萄糖聚合物与反应性侧挂甲硅烷基基团形成。甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。

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