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1. 发明申请

WO2008120219A3 COMPOSITIONS AND METHODS FOR CELL KILLING 审中-公开
标题翻译：细胞杀伤的组合物和方法
公开(公告)号：WO2008120219A3
公开(公告)日：2009-06-25
申请号：PCT/IL2008000465
申请日：2008-04-03
申请人： SURE INTERNAT VENTURES B V , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
IPC分类号： A01N61/00 , A01N25/10 , A01N25/34 , A01P1/00 , A01P15/00 , A61K45/00 , A61L2/16 , A61L27/34
CPC分类号： A01N61/00 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04
摘要： The present invention discloses an insoluble proton sink or source (PSS), useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment. The invention also provides articles of manufacture comprises the PSS and presents an effective method for killing the LTCs.
摘要翻译：本发明公开了一种不溶性质子沉或源（PSS），其用于杀死活细胞（LTC），或以其他方式破坏接触时LTC的细胞内过程和/或细胞间相互作用。 PSS包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。本发明还提供包括PSS的制品，并提出了杀死LTC的有效方法。

2. 发明申请

WO2008132716A3 BIOCIDIC HOUSEHOLD CLEANSING MATERIALS 审中-公开
标题翻译：生物化学家用清洁材料
公开(公告)号：WO2008132716A3
公开(公告)日：2009-06-04
申请号：PCT/IL2008000464
申请日：2008-04-03
申请人： SURE INTERNAT VENTURES B V , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
IPC分类号： C11D3/00 , A01N61/00
CPC分类号： A01N61/00 , A61L2/22 , C11D3/48 , C11D17/049 , Y10T442/10 , Y10T442/60
摘要： The present invention discloses household cleaning materials comprising at least one insoluble proton sink or source (PSS) and to method for utilizing the PSS as a biocidic agent. The household cleaning materials are provided useful for killing living target cells (LTCs) or otherwise inhibiting LTCs growth, disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The household cleaning materials consisting of at least one PSS, comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of said LTC and/or disrupting vital intercellular interactions of said LTCs while efficiently preserving the pH of said LTCs' environment.
摘要翻译：本发明公开了包含至少一种不溶性质子沉或源（PSS）的家用清洁材料以及将PSS用作生物杀伤剂的方法。家用清洁材料可用于杀死活细胞（LTC）或以其他方式抑制LTC的生长，破坏LTC在接触时的重要细胞内过程和/或细胞间相互作用。由至少一个PSS组成的家用清洁材料尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏所述LTC的限定体积内的pH稳态和/或电平衡和/或破坏所述LTC的重要细胞间相互作用，同时有效地保持所述LTC的环境的pH。

3. 发明申请

WO2008132717A2 BIOFILM DETERRENCE IN WATER SUPPLY SYSTEMS 审中-公开
标题翻译：水供应系统中的生物灭绝
公开(公告)号：WO2008132717A2
公开(公告)日：2008-11-06
申请号：PCT/IL2008000466
申请日：2008-04-03
申请人： SURE INTERNAT VENTURES B V , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
IPC分类号： A01N61/00 , A01N25/10 , A01N25/34 , A01P1/00 , A61L2/16 , C02F1/50
CPC分类号： A61L2/16 , A01N25/34 , A01N37/08 , A01N41/04 , A01N61/00 , C02F1/50 , C02F2303/20
摘要： Means and methods for deterring biofilm in water supply systems, comprising at least one insoluble proton sink or source (PSS). The means and methods for deterring biofilm is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
摘要翻译：在供水系统中阻止生物膜的方法和方法，包括至少一种不溶性质子沉或源（PSS）。用于阻止生物膜的方法和方法可用于杀死活细胞（LTC）或以其他方式破坏LTC在接触时的重要的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。

4. 发明申请

WO2008132719A2 BIOCIDIC PACKAGING FOR COSMETICS AND FOODSTUFFS 审中-公开
标题翻译：生物化学包装用于化妆品和食品
公开(公告)号：WO2008132719A2
公开(公告)日：2008-11-06
申请号：PCT/IL2008000468
申请日：2008-04-03
申请人： SURE INTERNAT VENTURES B V , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
IPC分类号： A01N61/00 , A01N25/10 , A01N25/34 , A01P1/00 , A23L3/00 , A61K8/00 , A61L2/16 , B65B55/00
CPC分类号： A61L2/16 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04 , A01N61/00 , A23L3/3463
摘要： The present invention presents a biocidic packaging for cosmetics and/or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The ackaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.
摘要翻译：本发明提出了一种用于化妆品和/或食品的生物杀伤剂包装，包括至少一种不溶性质子沉或源（PSS）。提供了用于杀死活的靶细胞（LTC）或另外破坏所述LTC在接触时的重要的细胞内过程和/或细胞间相互作用的有效性。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持所述LTC的环境的pH。本发明还公开了一种用于杀死活的靶细胞（LTC）或以其它方式破坏所述LTC在包装，特别是化妆品或食品包装中的细胞内过程和/或细胞间相互作用的方法。

5. 发明申请

WO2010137014A2 PHOTOCATALYTICALLY ASSISTED ELECTROLYSIS AND FUEL CELLS 审中-公开
标题翻译：光电辅助电解质和燃料电池
公开(公告)号：WO2010137014A2
公开(公告)日：2010-12-02
申请号：PCT/IL2010000413
申请日：2010-05-25
申请人： H4 LTD , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
CPC分类号： H01M14/005 , H01M4/8657 , H01M4/8825 , Y02P20/133
摘要： An apparatus and methods for improvement of photoelectrolysis and fuel cells are disclosed. The aforesaid apparatus comprises (a) a container filled by a compound to be electrolyzed; (b) photocatalytic electrodes positioned in the container; the electrodes are connectable to a source of voltage; and (c) illuminating means adapted to provide illumination to the electrodes. The electrodes are coated with metal nanoparticles operable for localized surface plasmon resonance induced by the illumination being incident onto electrolysis electrode surfaces coated with metal nanoparticles.
摘要翻译：公开了改进光电解和燃料电池的装置和方法。上述装置包括（a）由待电解化合物填充的容器; （b）位于容器中的光催化电极; 电极可连接到电压源; 和（c）适于向电极提供照明的照明装置。电极被涂覆有金属纳米颗粒，其可操作用于由照射入射到涂覆有金属纳米颗粒的电解电极表面上的局部表面等离子体共振。

6. 发明申请

WO2012104844A2 IMPROVED BIOCIDAL ZEOLITES 审中-公开
标题翻译：改进的杀菌分子
公开(公告)号：WO2012104844A2
公开(公告)日：2012-08-09
申请号：PCT/IL2012000064
申请日：2012-02-06
申请人： OPLON PURE SCIENCE LTD , ZILBERSTEIN GLEB , BUKSHPAN SHMUEL , SHANI AVI
发明人： ZILBERSTEIN GLEB , BUKSHPAN SHMUEL , SHANI AVI
IPC分类号： A01N41/04 , A01N25/10 , A01N25/34 , A01N55/10 , A01P1/00 , B82Y99/00 , C08F14/26
CPC分类号： C08L23/06 , A01N37/02 , A01N59/00 , A01N61/00 , A23C3/085 , A23L3/3508 , A61L2/232 , C08L23/0853 , C08L77/00 , A01N25/08 , A01N25/10 , A01N2300/00
摘要： Methods and compositions for controlling the population of microorganisms within a predetermined volume are disclosed. The methods comprise exposing the microorganisms to a biocidal zeolite that does not contain significant quantities of heavy metals, ions or salts thereof, or antibiotics. In preferred embodiments, the biocidal zeolite comprises an acidic zeolite, a basic zeolite, or a mixture of the two. In other preferred embodiments, the biocidal zeolite is immobilized within a polymer matrix. In various embodiments, the methods keep the population of microorganisms static, provide a 1 - 5 log reduction in the population of microorganisms within the predetermined volume, or eliminate the microbial population and prevent microbial growth within the predetermined volume.
摘要翻译：公开了用于控制预定体积内的微生物群体的方法和组合物。该方法包括使微生物暴露于不含有显着量的重金属，离子或其盐或抗生素的杀生物沸石。在优选的实施方案中，杀生物沸石包含酸性沸石，碱性沸石或两者的混合物。在其他优选的实施方案中，杀生物沸石被固定在聚合物基质内。在各种实施方案中，所述方法保持微生物群体静止，在预定体积内的微生物群体中提供1-5个对数减少，或消除微生物群体并防止微生物在预定体积内生长。

7. 发明申请

WO2010137015A3 METHOD AND SYSTEM FOR THE PRODUCTION OF A BIOACTIVE CONTAINER, AND SUCH A BIOACTIVE CONTAINER 审中-公开
标题翻译：用于生产活性容器的方法和系统，以及这样的生物容器
公开(公告)号：WO2010137015A3
公开(公告)日：2011-03-03
申请号：PCT/IL2010000414
申请日：2010-05-25
申请人： OPLON BV , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB , HALAVEE URIEL , SHANI AVI
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB , HALAVEE URIEL , SHANI AVI
IPC分类号： B29C49/24 , B05B13/06 , B65D81/28
CPC分类号： B29C49/24 , B05B1/14 , B05B13/0618 , B05B13/069 , B29B2911/14053 , B29B2911/1408 , B29B2911/14093 , B29C2049/027 , B29K2105/0011 , B29K2105/258 , B29L2031/7158 , B65D81/28
摘要： A method is disclosed for providing a container (20) with a bioactive material, said method comprising one or more steps of spraying, irrigating, gluing, imbedding, melting, evaporating, immersing, doping, immobilizing, entrapping, coating, directing, or otherwise f acilitatedly flowing at least one bioactive material within a container and/or a preform thereof such that at least one layer (40) of bioactive material is provided within at least one portion of the container's lumen. Containers are also disclosed the inner surface of which is at least partially coated with a bioactive material. In preferred embodiments, the bioactive material comprises a highly-charged biocidic polymer that preserves the pH of the contents of the container.
摘要翻译：公开了一种用于向容器（20）提供生物活性材料的方法，所述方法包括一个或多个步骤，其中一个或多个步骤是喷雾，灌溉，胶合，嵌入，熔化，蒸发，浸渍，掺杂，固定，捕获，涂覆，引导或以其它方式 f将至少一种生物活性材料流动到容器和/或其预型体内，使得在容器的内腔的至少一部分内提供至少一层生物活性材料层（40）。还公开了容器，其内表面至少部分地涂覆有生物活性材料。在优选的实施方案中，生物活性材料包含保持容器内容物的pH的高度充电的生物活性聚合物。

8. 发明申请

WO2011067762A2 EXTENDED SHELF-LIFE LIQUIDS AND METHOD THEREOF 审中-公开
标题翻译：延长寿命的液体及其方法
公开(公告)号：WO2011067762A2
公开(公告)日：2011-06-09
申请号：PCT/IL2010001016
申请日：2010-12-02
申请人： OPLON BV , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
CPC分类号： A01N25/10 , A01N33/12 , A01N41/04 , A23L2/44 , A23L3/3463 , A23L3/3526 , A23L3/3535
摘要： A method of producing a liquid substantially free of beverage spoiling microorganisms, characterized in that said method comprises steps of: (a) obtaining a liquid; (b) obtaining a bioactive material that does not affect a predetermined set of organoleptic parameters of said liquid upon contact with said concentrate for a predetermined length of time; and, (c) treating said liquid with said bioactive material until the concentration of beverage-spoiling microorganism falls below a predetermined threshold.
摘要翻译：一种生产基本上不含饮料破坏微生物的液体的方法，其特征在于所述方法包括以下步骤：（a）获得液体; （b）获得生物活性材料，所述生物活性材料在与所述浓缩物接触预定长度的时间后不影响所述液体的预定组感官参数; 和（c）用所述生物活性材料处理所述液体，直到饮料破坏微生物的浓度降到预定阈值以下。

9. 发明申请

WO2007010532A3 COMPOSITIONS FOR ONE STEP COLORIMETRIC ANALYSIS AND METHODS OF USING SAME 审中-公开
标题翻译：一步彩色分析的组合物及其使用方法
公开(公告)号：WO2007010532A3
公开(公告)日：2008-01-10
申请号：PCT/IL2006000830
申请日：2006-07-18
申请人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
IPC分类号： C12Q1/68 , G01N33/00 , G01N33/566
CPC分类号： G01N33/68 , G01N33/6803
摘要： The present invention provides compositions and kits comprising porous substrates that retain staining solutions, wherein the staining solutions comprise one or more staining agents that form visible complexes with proteins or other molecular species of interest in a gel. The invention further provides methods for identifying biological moieties in a sample, using the compositions and kits of the invention, with superior signal to noise ratios that do not require destaining procedures.
摘要翻译：本发明提供了包含保留染色溶液的多孔底物的组合物和试剂盒，其中染色溶液包含一种或多种在凝胶中与蛋白质或其它分子物质形成可见复合物的染色剂。本发明还提供了使用本发明的组合物和试剂盒来鉴定样品中生物部分的方法，具有优异的不需要脱色程序的信噪比。

10. 发明申请

WO2007046103A2 SYSTEM FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF POLYMERIC AGENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于聚合物的绝缘超导传输系统及其使用方法
公开(公告)号：WO2007046103A2
公开(公告)日：2007-04-26
申请号：PCT/IL2006001206
申请日：2006-10-19
申请人： PERF ACTION TECHNOLOGIES LTD , BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
发明人： BUKSHPAN SHMUEL , ZILBERSTEIN GLEB
IPC分类号： F16K23/00
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： The present invention relates to a system for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent or of a polypeptide useful for delivery of high molecular weight cosmetic or therapeutic agents. Particularly, the present invention relates to a system comprising an iontophoresis device comprising a pharmaceutical composition comprising a non-peptidic polymeric cosmetic or therapeutic agent together with a peptide, polypeptide or protein and a pharmaceutically acceptable carrier having a pH below or above the isoelectric pH of the peptide, polypeptide or protein.
摘要翻译：本发明涉及用于非肽聚合物化妆品或治疗剂或可用于递送高分子量化妆品或治疗剂的多肽的离子电渗透皮递送系统。特别地，本发明涉及包含离子电渗装置的系统，该离子电渗装置包含药物组合物，其包含非肽聚合物化妆品或治疗剂以及肽，多肽或蛋白质以及药学上可接受的载体，其pH低于或高于肽，多肽或蛋白质。

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