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    • 1. 发明申请
    • BIOCIDIC PACKAGING FOR COSMETICS AND FOODSTUFFS
    • 生物化学包装用于化妆品和食品
    • WO2008132719A2
    • 2008-11-06
    • PCT/IL2008000468
    • 2008-04-03
    • SURE INTERNAT VENTURES B VBUKSHPAN SHMUELZILBERSTEIN GLEB
    • BUKSHPAN SHMUELZILBERSTEIN GLEB
    • A01N61/00A01N25/10A01N25/34A01P1/00A23L3/00A61K8/00A61L2/16B65B55/00
    • A61L2/16A01N25/34A01N37/08A01N37/20A01N41/04A01N61/00A23L3/3463
    • The present invention presents a biocidic packaging for cosmetics and/or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The ackaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.
    • 本发明提出了一种用于化妆品和/或食品的生物杀伤剂包装,包括至少一种不溶性质子沉或源(PSS)。 提供了用于杀死活的靶细胞(LTC)或另外破坏所述LTC在接触时的重要的细胞内过程和/或细胞间相互作用的有效性。 PSS尤其包括(i)提供缓冲能力的质子源或接收器; 和(ii)提供质子传导性和/或电势的手段。 PSS有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用,同时有效地保持所述LTC的环境的pH。 本发明还公开了一种用于杀死活的靶细胞(LTC)或以其它方式破坏所述LTC在包装,特别是化妆品或食品包装中的细胞内过程和/或细胞间相互作用的方法。
    • 3. 发明申请
    • BIOCIDIC HOUSEHOLD CLEANSING MATERIALS
    • 生物化学家用清洁材料
    • WO2008132716A2
    • 2008-11-06
    • PCT/IL2008/000464
    • 2008-04-03
    • SURE INTERNATIONAL VENTURES B.V.BUKSHPAN, ShmuelZILBERSTEIN, Gleb
    • BUKSHPAN, ShmuelZILBERSTEIN, Gleb
    • C11D3/00A01N61/00
    • A01N61/00A61L2/22C11D3/48C11D17/049Y10T442/10Y10T442/60
    • The present invention discloses household cleaning materials comprising at least one insoluble proton sink or source (PSS) and to method for utilizing the PSS as a biocidic agent. The household cleaning materials are provided useful for killing living target cells (LTCs) or otherwise inhibiting LTCs growth, disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The household cleaning materials consisting of at least one PSS, comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of said LTC and/or disrupting vital intercellular interactions of said LTCs while efficiently preserving the pH of said LTCs' environment.
    • 本发明公开了包含至少一种不溶性质子沉或源(PSS)的家用清洁材料以及将PSS用作生物杀伤剂的方法。 家用清洁材料可用于杀死活细胞(LTC)或以其他方式抑制LTC的生长,破坏LTC在接触时的重要细胞内过程和/或细胞间相互作用。 由至少一个PSS组成的家用清洁材料尤其包括(i)提供缓冲能力的质子源或接收器; 和(ii)提供质子传导性和/或电势的手段。 PSS有效地破坏所述LTC的限定体积内的pH稳态和/或电平衡和/或破坏所述LTC的重要细胞间相互作用,同时有效地保持所述LTC的环境的pH。
    • 6. 发明申请
    • SEPARATION OF ANALYTES BY MOLECULAR MASS
    • 通过分子量分析分析
    • WO2007004225A2
    • 2007-01-11
    • PCT/IL2006/000777
    • 2006-07-05
    • BIOACTIVITY PARTNERSHIPBUKSHPAN, ShmuelZILBERSTEIN, Gleb
    • BUKSHPAN, ShmuelZILBERSTEIN, Gleb
    • G01N27/447
    • G01N27/44747
    • The present invention relates to a method and apparatus for the separation of analytes based on their molecular weight, by application of an electric field across a low-friction matrix (e.g., a polymeric gel, polymeric beads, highly viscous liquids or porous glass) modified with a charged separation agent. The matrix comprises charged regions ordered in a monotonous sequence distributed throughout the matrix so as to generate a charge density gradient. When an external electric field is applied to a sample of a charged analyte complex deposited at one end of the matrix, the complex will move through the different charged regions and focusing (immobilization by charge neutralization) of different analytes in different charge regions will occur. Since the analyte complex preserves the charge to mass ratio, the total charge of the complex is directly proportional to its weight. Therefore, analytes of different sizes will possess different charges and will migrate differently across the porous matrix. They systems are suitable for planar, capillary in-tube electrophoresis, as well as multi-channel arrays of capillaries filled with charge gradient gels, serial arrays of discrete compartments with charge density gradient, arrays in a chip format, pre-designed mass focusing arrays for specific protein masses in application for protein and DNA marker diagnostics, and multi compartment trapping devices for specific mass ranges.
    • 本发明涉及一种基于其分子量分离分析物的方法和装置,其通过在低摩擦基质(例如,聚合物凝胶,聚合物珠粒,高粘性液体或多孔玻璃)上施加电场而被修饰 带有电荷分离剂。 矩阵包括以分布在整个矩阵中的单调序列排列的带电区域,以产生电荷密度梯度。 当外部电场施加到沉积在基体一端的带电荷的分析物复合物的样品时,复合体将移动穿过不同的带电区域,并且将发生不同分析物在不同电荷区域的聚焦(通过电荷中和固定)。 由于分析物复合物保持了质量比,所以络合物的总电荷与其重量成正比。 因此,不同尺寸的分析物将具有不同的电荷,并将在多孔基质上不同地迁移。 它们的系统适用于平面,毛细管内电泳,以及填充有电荷梯度凝胶的多通道阵列的毛细管阵列,具有电荷密度梯度的离散隔室的串联阵列,芯片格式的阵列,预先设计的质量聚焦阵列 用于蛋白质和DNA标记诊断的特定蛋白质质量,以及用于特定质量范围的多隔室捕获装置。