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1. 发明申请

WO2012109388A1 VASO-OCCLUSIVE DEVICE 审中-公开
标题翻译： VASO-OCCLUSIVE设备
公开(公告)号：WO2012109388A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024377
申请日：2012-02-08
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED , CHEN, Hancun , MURPHY, Richard , DAO, Jimmy
发明人： CHEN, Hancun , MURPHY, Richard , DAO, Jimmy
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215
摘要： A vaso-occlusive device includes a first wire having a first cross-sectional geometry and a second wire having a second cross-sectional geometry, where the first cross-sectional geometry is different from the second cross-sectional geometry. The first wire may be wound to form a first coil, where the second wire is wound to form a second coil defining a lumen therein, and where the first coil is disposed at least partially in the lumen. The first wire and the second wire may be co-wound to form a single coil.
摘要翻译：血管闭塞装置包括具有第一横截面几何形状的第一线和具有第二横截面几何形状的第二线，其中第一横截面几何形状不同于第二横截面几何形状。第一线可以被缠绕以形成第一线圈，其中第二线被缠绕以形成在其中限定内腔的第二线圈，并且其中第一线圈至少部分地设置在内腔中。第一线和第二线可以共同缠绕以形成单个线圈。

2. 发明申请

WO2012109367A1 VASO-OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译： VASO-OCCLUSIVE设备交付系统
公开(公告)号：WO2012109367A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024349
申请日：2012-02-08
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED , CHEN, Hancun , MURPHY, Richard
发明人： CHEN, Hancun , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/12063
摘要： A vaso-occlusive device delivery system includes a delivery wire assembly having a core wire disposed in a delivery wire lumen, and a vaso-occlusive device having a tapered proximal end and defining a vaso-occlusive device lumen, wherein a tether is disposed in the lumen and secured to the core wire. A link may be attached to each of the core wire, the proximal end of the vaso-occlusive device, and the tether. Alternatively, the system may include a transition member attached to the vaso-occlusive device and secured to the core wire.
摘要翻译：血管闭塞装置递送系统包括具有布置在输送丝腔内的芯线的输送线组件和具有锥形近端并限定血管闭塞装置内腔的血管闭塞装置，其中系绳设置在内腔并固定在芯线上。连接件可以连接到芯线，血管闭塞装置的近端和系绳中的每一个。或者，系统可以包括附接到血管闭塞装置并固定到芯线的过渡构件。

3. 发明申请

WO2013039829A1 VASO-OCCLUSIVE DEVICE 审中-公开
标题翻译： VASO-OCCLUSIVE设备
公开(公告)号：WO2013039829A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054428
申请日：2012-09-10
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED , MURPHY, Richard , CHEN, Hancun
发明人： MURPHY, Richard , CHEN, Hancun
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12145 , A61B17/1215
摘要： A vaso-occlusive device includes a coil made from coil wire, wherein the coil wire includes a core containing a core material having a first electrical potential covered by a coating containing a coating material having a second electrical potential, wherein the second electrical potential is less than the first electrical potential. A method of manufacturing a vaso-occlusive device includes cladding a core with a magnesium containing coating to form a wire, wrapping the wire around a mandrel to form a coil, and heat-setting the coiled wire. A method of occluding a body cavity with a vaso-occlusive device includes delivering the vaso-occlusive device to a body cavity and inducing a reduction reaction in the body cavity and adjacent the vaso-occlusive device, wherein the reduction reaction reduces infections and promotes cell proliferation in the body cavity.
摘要翻译：一种血管闭塞装置包括由线圈线制成的线圈，其中所述线圈线包括芯，所述芯包含具有由包含具有第二电位的涂层材料的涂层覆盖的第一电位的芯材料，其中所述第二电势较小比第一个电位。制造血管闭塞装置的方法包括用含镁涂层包覆芯以形成线，将线围绕心轴缠绕以形成线圈，并对线圈进行热定型。用血管闭塞装置闭塞体腔的方法包括将血管闭塞装置输送到体腔并在体腔内和邻近血管闭塞装置处引起还原反应，其中还原反应减少感染并促进细胞体腔增生。

4. 发明申请

WO2012161953A2 VASO-OCCLUSIVE DEVICES WITH IN-SITU STIFFENING 审中-公开
标题翻译： VASO-OCCLUSIVE设备，具有现场强化功能
公开(公告)号：WO2012161953A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/036894
申请日：2012-05-08
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED , CHEN, Hancun , MURPHY, Richard
发明人： CHEN, Hancun , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00867
摘要： A vaso-occlusive device includes a first coil made from a first substantially non-expansile material, and a second coil at least partially co-wound with the first coil and made from a second expansile material. The second coil has a contracted state and an expanded state, in which the second coil expands radially and/or longitudinally. The vaso-occlusive device has increased stiffness when the second coil is in its expanded state.
摘要翻译：一种血管闭塞装置包括由第一基本上不可膨胀的材料制成的第一线圈和至少部分地与第一线圈共同缠绕并由第二可膨胀材料制成的第二线圈。第二线圈具有收缩状态和膨胀状态，其中第二线圈径向和/或纵向膨胀。当第二线圈处于其扩张状态时，血管闭塞装置具有增加的刚度。

5. 发明申请

WO2010120653A1 DELIVERY WIRE FOR OCCLUSIVE DEVICE DELIVERY SYSTEM AND METHOD OF MANUFACTURE 审中-公开
标题翻译：用于交付设备传送系统的交付线及其制造方法
公开(公告)号：WO2010120653A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030620
申请日：2010-04-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
发明人： CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B2017/12063 , Y10T29/49826
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature includes a delivery wire conduit having a proximal tubular portion coupled to a distal coil portion, the respective tubular and coil portions defining a conduit lumen, a plug at least partially seated in the conduit lumen and coupled to an interior surface of the coil portion so as to form a substantially fluid tight seal of the conduit lumen, and a core wire disposed in the conduit lumen, the core wire having a distal end extending through the plug and coupled to an occlusive device.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括输送线导管，其具有联接到远端线圈部分的近端管状部分，相应的管状部分和线圈部分限定导管管腔，塞子至少部分地位于导管管腔中并联接到线圈部分的内表面，以便形成导管管腔的基本上流体密封的密封，以及设置在导管管腔中的芯线，芯线具有延伸穿过插塞的远端并耦合到闭塞装置。

6. 发明申请

WO2010117883A1 DELIVERY WIRE FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：用于交付设备传送系统的交付线
公开(公告)号：WO2010117883A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/029700
申请日：2010-04-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
发明人： CHEN, Hancun , DAO, Jimmy , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B90/39 , A61B2017/12063 , A61B2017/12068 , A61M2025/09133 , A61M2025/0915
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature includes a delivery wire conduit having a proximal tubular portion connected to a distal coil portion, and a conduit lumen extending through the proximal tubular portion and the distal coil portion. The delivery wire assembly also includes a core wire disposed in the conduit lumen and having a distal end coupled to an occlusive device. The distal coil portion of the delivery wire assembly includes a plurality of zones and the plurality of zones decrease in stiffness distally along the length of the distal coil portion of the delivery wire assembly.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括输送线导管，其具有连接到远侧线圈部分的近端管状部分和延伸穿过近端管状部分和远端线圈部分的管腔。输送线组件还包括设置在导管管腔中并且具有联接到闭塞装置的远端的芯线。输送线组件的远端线圈部分包括多个区域，并且多个区域沿着输送线组件的远端线圈部分的长度向远侧减小。

7. 发明申请

WO2011060128A2 DELIVERY WIRE ASSEMBLY FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：交付设备传送系统的交付线组件
公开(公告)号：WO2011060128A2
公开(公告)日：2011-05-19
申请号：PCT/US2010/056330
申请日：2010-11-11
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , MURPHY, Richard , DAO, Jimmy
发明人： CHEN, Hancun , MURPHY, Richard , DAO, Jimmy
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/0088 , A61B2017/12063 , A61B2018/00083
摘要： A core wire of a delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature, includes a wire having a polyimide coating, with a polymer jacket disposed around the polyimide coating, and a hypotube disposed around the polymer jacket. The delivery wire assembly further comprises a delivery wire conduit including a coil disposed around the wire, wherein a proximal end of the coil is connected to a distal end of the hypotube. The polyimide coating may be enhanced with a nano-particle or micro-fiber ceramic, such as yttria-stabilized zirconia.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件的芯线包括具有聚酰亚胺涂层的线，聚酰亚胺涂层周围设置聚合物护套，以及设置在聚合物护套周围的海波管。输送线组件还包括输送线导管，其包括设置在线周围的线圈，其中线圈的近端连接到海波管的远端。聚酰亚胺涂层可以用纳米颗粒或微纤维陶瓷如氧化钇稳定的氧化锆来增强。

8. 发明申请

WO2010120694A1 ELECTRICAL CONTACT FOR OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译：电气设备输送系统的电气接触
公开(公告)号：WO2010120694A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/030753
申请日：2010-04-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, Hancun , GUO, Lantao , DAO, Jimmy , VO, Justin , WILLIAMS, Michael , MURPHY, Richard
发明人： CHEN, Hancun , GUO, Lantao , DAO, Jimmy , VO, Justin , WILLIAMS, Michael , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61B2017/12063
摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature includes a delivery wire conduit having a proximal tubular portion coupled to a distal coil portion, the respective tubular and coil portions defining a conduit lumen. A core wire is disposed in the conduit lumen and having a distal end coupled to an occlusive device, wherein an elongate electrical contact body at least partially seated in the conduit lumen and coupled to a proximal end of the core wire, the electrical contact body and the proximal tubular portion forming a junction. A coil collar is disposed around the electrical contact body near the junction.
摘要翻译：用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括输送线导管，其具有联接到远端线圈部分的近端管状部分，相应的管状部分和线圈部分限定导管腔。芯线布置在导管管腔中并且具有联接到闭塞装置的远端，其中细长电接触体至少部分地位于导管管腔中并且联接到芯线的近端，电接触体和近端管状部分形成结。在接头附近的电接触体周围设置线圈套圈。

9. 发明申请

WO2015026576A1 VASO-OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译： VASO-OCCLUSIVE设备交付系统
公开(公告)号：WO2015026576A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/050755
申请日：2014-08-12
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED
发明人： CHEN, Hancun , MURPHY, Richard , DAO, Jimmy , VO, Justin
IPC分类号： A61B17/12 , A61B17/00 , A61B19/00
CPC分类号： A61B17/12113 , A61B17/12109 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00199 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61B2017/12068 , A61B2090/3966
摘要： A vaso-occlusive delivery system (10) includes a vaso-occlusive coil (300), delivery wire assembly (200), and a link (500). The vaso-occlusive coil defines a coil lumen (306) and has first and second coil windings (308) defining a coil opening (314) therebetween. The delivery wire assembly defines a delivery wire lumen (212), and includes an electrolytic detachment zone (260), a delivery wire conduit (214), and a delivery wire (252) attached to the delivery wire conduit and extending through the delivery wire lumen distal of the delivery wire conduit. The link defines a link lumen (510) and has link body (506) including a proximal end of the link body defines an link opening (512) in communication with the link lumen and a distal end of the link body includes a link detent (514) extending radially from the link body, through the coil opening, securing the link body and the delivery wire assembly to the vaso-occlusive coil.
摘要翻译：血管闭塞递送系统（10）包括血管闭塞线圈（300），输送线组件（200）和连杆（500）。血管闭塞线圈限定线圈腔（306），并且具有在其间限定线圈开口（314）的第一和第二线圈绕组（308）。输送线组件限定输送线管腔（212），并且包括电解脱离区（260），输送线导管（214）和输送线（252），输送线（252）连接到输送线导管并延伸穿过输送线输送线管道的内腔远端。连杆限定了连接腔（510）并且具有连接体（506），其包括链节主体的近端，限定与连杆腔相连通的连杆开口（512），并且连杆本体的远端包括连杆制动器 514），其从连接体径向延伸通过线圈开口，将连接体和输送线组件固定到血管闭塞线圈。

10. 发明申请

WO2014159606A1 VASO-OCCLUSIVE DEVICE DELIVERY SYSTEM 审中-公开
标题翻译： VASO-OCCLUSIVE设备交付系统
公开(公告)号：WO2014159606A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/024399
申请日：2014-03-12
申请人： STRYKER CORPORATION , STRYKER NV OPERATIONS LIMITED
发明人： CHEN, Hancun , TEOH, Clifford , GUO, Lantao , ODELL, Timothy , MURPHY, Richard
IPC分类号： A61B17/12
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/12068
摘要： A vaso-occlusive device delivery assembly includes a pusher assembly (200) having a proximal end, a distal end, and a pusher lumen (212) extending therebetween; a vaso-occlusive device (300); and a tubular member (238) mechanically connecting the pusher assembly to the vaso-occlusive device, the tubular member having a proximal end, a distal end, a tube lumen extending therebetween, and a detach zone (244), wherein the proximal end of the tubular member extends into the pusher assembly lumen at the distal end of the pusher assembly. A heat generating member (210) is disposed in the tube lumen, such that, when activated, the heat generating member generates heat that melts or otherwise thermally degrades the tubular member at the detach zone, thereby detaching the vaso- occlusive device from the pusher assembly.
摘要翻译：血管闭塞装置输送组件包括具有近端，远端和在其间延伸的推动器腔（212）的推动器组件（200）血管闭塞装置（300）; 以及将所述推动器组件机械地连接到所述血管闭塞装置的管状构件（238），所述管状构件具有近端，远端，在其间延伸的管腔和分离区（244），其中，管状构件在推动器组件的远端处延伸到推动器组件内腔中。发热构件（210）设置在管腔中，使得当被激活时，发热构件产生在分离区域处熔化或以其它方式热管降低管的构件的热量，从而将血管闭塞装置从推动器部件。

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