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1. 发明申请

WO2009096819A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 审中-公开
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：WO2009096819A1
公开(公告)日：2009-08-06
申请号：PCT/SE2008/000077
申请日：2008-01-28
申请人： ST.JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , ÖHLANDER, Malin , HEDBERG, Sven-Erik
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , ÖHLANDER, Malin , HEDBERG, Sven-Erik
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement comprising a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processing means where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value being a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可植入心脏刺激器，其可连接到电极装置，所述电极装置包括适于将刺激脉冲输送到对象的心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准将阻抗信号施加到处理信号的处理装置，并且在预定测量周期期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的量度。

2. 发明申请

WO2009078758A1 AN IMPLANTABLE HEART MONITORING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏监测装置，系统和方法
公开(公告)号：WO2009078758A1
公开(公告)日：2009-06-25
申请号：PCT/SE2007/001134
申请日：2007-12-19
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： The invention concerns an implantable heart monitoring device (10) comprising, inter alia, a control circuit (14) configured to be able to measure an impedance across at least part of an atrium, such that the variation of the impedance is related to the volume change of the atrium. The control circuit (14) is configured to carry out certain steps, and to store values at different occasions that indicate the rate of change of the meas¬ ured impedance. The stored values have been determined such that, when the device (10) is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial dias¬ tole. The invention also concerns a corresponding system and method.
摘要翻译：本发明涉及可植入心脏监测装置（10），其特别地包括控制电路（14），其被配置为能够测量穿过至少部分心房的阻抗，使得阻抗的变化与体积改变中庭。控制电路（14）被配置为执行某些步骤，并且在指示所测量的阻抗的变化率的不同场合存储值。存储的值已经被确定为使得当在生物体中使用装置（10）时，所存储的值的变化将与心房中的心脏充满血液的速度的变化有关托勒。本发明还涉及相应的系统和方法。

3. 发明申请

WO2009082284A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE. 审中-公开
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置。
公开(公告)号：WO2009082284A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001155
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61B5/053 , A61B5/0245 , A61N1/365
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device (100) comprises an impedance determiner (120) for determining a cardiogenic impedance signal (20, 30) based on electric signals sensed by connected electrodes. A parameter calculator (130) processes the impedance signal (20, 30) to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device (100) for monitoring acute decompensated heart failure status of a subject (1).
摘要翻译：可植入医疗装置（100）包括阻抗确定器（120），用于基于由连接的电极感测的电信号来确定心源阻抗信号（20,30）。参数计算器（130）处理阻抗信号（20,30）以计算与心脏循环的舒张期相关的代表心源阻抗的阻抗参数。该装置（100）然后使用该参数来监测对象（1）的急性失代偿性心力衰竭状态。

4. 发明申请

WO2008153450A1 AN IMPLANTABLE MEDICAL DEVICE AND A METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING VENTRICULAR TACHYARRHYTMIAS 审中-公开
标题翻译：一种可植入医疗装置和一种包含检测和分类静脉曲张虫的手段的方法
公开(公告)号：WO2008153450A1
公开(公告)日：2008-12-18
申请号：PCT/SE2007/000581
申请日：2007-06-13
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： The invention relates to ventricular tachyarrhythmia detection and classification. Upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：本发明涉及室性快速性心律失常检测和分类。在基于心电图信号检测到心室快速性心律失常时，收集代表心室体积动力学的心源阻抗数据，并用于将检测到的快速性心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

5. 发明申请

WO2008118041A1 AN IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于监测心血管疾病状态的可植入心脏装置和方法
公开(公告)号：WO2008118041A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000288
申请日：2007-03-23
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , ÖHLANDER, Malin , NOREN, Kjell , BLOMQVIST, Andreas , LJUNGSTRÖM, Karin
发明人： HOLMSTRÖM, Nils , ÖHLANDER, Malin , NOREN, Kjell , BLOMQVIST, Andreas , LJUNGSTRÖM, Karin
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device comprises a heart stimulator (10, 12) for electricly stimulating the heart of a patient, detecting means (2, 4) for measuring a physiologic parameter which is affected by the status of a cardiovascular disease associated with sympathetic activation, signal processing means (6) for determining at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and an analysor for analyzing the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detecting means comprise measuring means (2) arranged to measure, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator (10, 12) a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analysed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置包括用于电刺激患者心脏的心脏刺激器（10,12），用于测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测装置（2,4），信号用于确定所测量的参数中的低频，低频和极低频，伏尔伏特梅耶波分量中的至少一个的处理装置（6），以及用于相对于预定参考值分析所确定的梅尔波分量的分析器以确定心血管疾病的状况。检测装置包括测量装置（2），其被布置成根据所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器（10,12）的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，梅耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。测量心脏四个腔室中的至少一个的机械变化作为生理参数。

6. 发明申请

WO2007100276A1 Method and implantable medical device for classifying sensor signals 审中-公开
标题翻译：用于分类传感器信号的方法和可植入医疗装置
公开(公告)号：WO2007100276A1
公开(公告)日：2007-09-07
申请号：PCT/SE2006/000264
申请日：2006-02-28
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , ÖHLANDER, Malin
发明人： HOLMSTRÖM, Nils , ÖHLANDER, Malin
IPC分类号： A61N1/37 , A61B5/053 , A61N1/362
CPC分类号： A61N1/3627 , A61B5/0402 , A61B5/7264 , A61N1/36514 , A61N1/3702
摘要： The present invention relates to a method for creating hemodynamic sensor signal templates using an implantable medical device being connectable to a patient. A heart activity of a patient is sensed in order to identify a paced or sensed sequence of events of a heart cycle; hemodynamic sensor signals for consecutive heart cycles is sensed; and the sensed hemodynamic sensor signals for consecutive heart cycles is stored. Furthermore, sensed sensor signals are classified on basis of at least one predetermined heart event sequence condition and, for example, a template may be created using said classified sensor signals. The invention also relates to an implantable medical device for creating hemodynamic sensor signal templates, a computer program product, and a computer readable medium comprising instructions for bringing a computer to perform the method.
摘要翻译：本发明涉及使用可连接到患者的可植入医疗装置来产生血液动力学传感器信号模板的方法。感测患者的心脏活动以便识别心跳周期的起搏或感测的事件序列; 感测连续心脏周期的血流动力学传感器信号; 并且存储用于连续心脏周期的感测的血液动力学传感器信号。此外，感测的传感器信号基于至少一个预定的心脏事件序列条件进行分类，并且例如，可以使用所分类的传感器信号来创建模板。本发明还涉及用于产生血液动力学传感器信号模板的可植入医疗装置，计算机程序产品和包括用于使计算机执行该方法的指令的计算机可读介质。

7. 发明申请

WO2007001219A1 MEDICAL DEVICE FOR DETERMINING THE POSTURE OF PATIENT 审中-公开
标题翻译：用于确定患者症状的医疗装置
公开(公告)号：WO2007001219A1
公开(公告)日：2007-01-04
申请号：PCT/SE2005/001030
申请日：2005-06-29
申请人： ST. JUDE MEDICAL AB , ÖHLANDER, Malin , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： ÖHLANDER, Malin , HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61B5/053 , A61B5/103 , A61B5/11
CPC分类号： G06F19/34 , A61B5/0031 , A61B5/01 , A61B5/029 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/4561 , A61B5/686
摘要： The present invention relates to a method for determining the posture of a patient. The method comprises the steps of: initiating (50, 52) a patient posture determining session by performing an electrical bio-impedance measurement session in at least one of a number of different electrode configurations in order to measure an impedance value for the at least one configuration; obtaining reference impedance values (54) stored in advance for the at least one configuration and for at least one potential posture of the patient; comparing (54) the measured impedance value for the at least one configuration with corresponding stored reference impedance values for at least one potential posture of the patient; and determining (56) the present posture of the patient by using results from the comparison between measured impedance values and the stored reference impedance values. Furthermore, the invention relates to a medical device for determining the posture of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于确定患者姿势的方法。该方法包括以下步骤：通过在多个不同电极配置中的至少一个中执行电生物阻抗测量会话来启动（50,52）患者姿势确定会话，以便测量所述至少一个组态; 获得针对所述至少一个配置预先存储的参考阻抗值（54）和所述患者的至少一个潜在姿势; 将所述至少一个配置的测量阻抗值与所述患者的至少一个潜在姿势的相应存储的参考阻抗值进行比较（54）以及通过使用测量的阻抗值与存储的参考阻抗值之间的比较的结果来确定（56）患者的当前姿势。此外，本发明涉及一种用于确定患者的姿势的医疗装置和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

8. 发明申请

WO2006126918A1 A METHOD AND A MEDICAL DEVICE FOR EVALUATING THE PREVALENCE OF DIFFERENT POSTURES OF A PATIENT AND A COMPUTER READABLE MEDIUM FOR BRINGING A COMPUTER TO PERFORMING THE METHOD 审中-公开
标题翻译：用于评估患者不同症状的预防方法和医疗装置以及用于使计算机执行该方法的计算机可读介质
公开(公告)号：WO2006126918A1
公开(公告)日：2006-11-30
申请号：PCT/SE2005/000777
申请日：2005-05-24
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , ÖHLANDER, Malin
发明人： HOLMSTRÖM, Nils , ÖHLANDER, Malin
IPC分类号： A61B5/11 , A61B5/00 , A61B5/103 , A61N1/36
CPC分类号： A61B5/103 , A61B5/0205 , A61B5/1116 , A61B5/686 , A61B5/7264 , A61N1/3702
摘要： The present invention relates to a method for evaluating the prevalence of different postures of a patient. The method includes the steps of: sensing (60) signals indicating the posture of the patient during a monitoring period having a predetermined length; determining (60) specific body postures of the patient during the monitoring period using the signals; measuring (62) the amount of time the patient spends in each of the specific postures; storing (62) information regarding each specific posture and the amount of time spent in each posture; and evaluating (64) the prevalence of the different postures of the patient by classifying the stored information with respect of specific postures and the amount of time spent in corresponding postures. Furthermore, the invention relates to a medical device (20) for evaluating the prevalence of different postures of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种评估患者不同姿势流行率的方法。该方法包括以下步骤：在具有预定长度的监视期间内检测（60）指示患者姿势的信号; 在监测期间使用信号确定（60）患者的特定身体姿势; 测量（62）患者在每个特定姿势中花费的时间量; 存储关于每个特定姿势的信息和每个姿势花费的时间量; 并通过对存储的信息进行分类来评估（64）患者的不同姿势的流行率，以及在相应姿势中花费的时间量。此外，本发明涉及一种用于评估患者的不同姿势的患病率的医疗装置（20）和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

9. 发明申请

WO2006068566A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2006068566A1
公开(公告)日：2006-06-29
申请号：PCT/SE2004/002022
申请日：2004-12-23
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , ÖHLANDER, Malin , KALLING, Sven
发明人： HOLMSTRÖM, Nils , ÖHLANDER, Malin , KALLING, Sven
IPC分类号： A61B5/053 , A61N1/08
CPC分类号： A61B5/0535 , A61B5/0809 , A61N1/3627 , A61N1/3702
摘要： The present invention relates to a method for detecting a change of a condition of a patient, comprising the steps of: detecting a position of the patient; and measuring the impedance arranged to sense an electrical bio-impedance associated with said condition. The inventive method is characterized by the steps of: detecting a specific body position of said patient; and initiating an impedance measuring session in order to obtain substantially repeatable impedance signals, wherein a change of said condition can be derived from said impedance signals. Furthermore, the invention relates to a medical device for obtaining electrical bio-impedance signals in order to monitor or detect changes in a condition of the heart of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于检测患者状况变化的方法，包括以下步骤：检测患者的位置; 以及测量布置成感测与所述条件相关联的电生物阻抗的阻抗。本发明的方法的特征在于以下步骤：检测所述患者的特定身体位置; 以及启动阻抗测量会话以获得基本上可重复的阻抗信号，其中可以从所述阻抗信号导出所述条件的改变。此外，本发明涉及一种用于获得电生物阻抗信号的医疗装置，以便监测或检测患者心脏状况的改变以及包括用于使计算机执行本发明方法的指令的计算机可读介质。

10. 发明申请

WO2008105698A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：WO2008105698A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000855
申请日：2007-09-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
发明人： BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
IPC分类号： A61N1/372 , A61B5/0205 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： A device and method of a medical implant for monitoring progression of heart failure in a human heart. An activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法。活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将静脉氧含量的水平与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

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