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1. 发明申请

WO2011139107A2 PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：吡啶酰胺和嘧啶-4-羧酰胺化合物，其制备方法和包含其的药物组合物
公开(公告)号：WO2011139107A2
公开(公告)日：2011-11-10
申请号：PCT/KR2011/003362
申请日：2011-05-04
申请人： SK Chemicals Co.,Ltd. , RYU, Je Ho , KIM, Shin Ae , RYU, Keun Ho , KIM, Jae Sun , KIM, Nam Ho , HAN, Hye Young , KIM, Yong Hyuk , YOUN, Won-No , LEE, Yoon-Jung , SON, Hyun Joo , LEE, Bong-yong , PARK, Sung Hoon , LEE, Ju Young , LEE, Hyun Jung , JUNG, Hoe Chul , SHIN, Young Ah , LEE, Jung A , LEE, Bo Ram , SA, Joon Ho
发明人： RYU, Je Ho , KIM, Shin Ae , RYU, Keun Ho , KIM, Jae Sun , KIM, Nam Ho , HAN, Hye Young , KIM, Yong Hyuk , YOUN, Won-No , LEE, Yoon-Jung , SON, Hyun Joo , LEE, Bong-yong , PARK, Sung Hoon , LEE, Ju Young , LEE, Hyun Jung , JUNG, Hoe Chul , SHIN, Young Ah , LEE, Jung A , LEE, Bo Ram , SA, Joon Ho
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , A61K31/444 , A61K31/496 , A61P3/10 , A61P3/06
CPC分类号： C07D401/04 , C07D213/81 , C07D239/557 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要： Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LAD A), insulin tolerance syndromes, obesity, impaired glucose tolerane (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
摘要翻译：提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途化合物对11β-HSD1酶的选择性抑制活性。本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11β-HSD1酶的选择性抑制剂，可用于预防，调节和治疗与糖皮质激素调节有关的疾病的药剂，其中人源性11β- 涉及HSD1酶，例如代谢综合征，例如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成人（LAD A），胰岛素耐受综合征，肥胖症，葡萄糖耐量降低（IGT），空腹血糖受损 IFG），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。

2. 发明申请

WO2005110488A1 STABLE PHARMACEUTICAL COMPOSITION CONTAINING BENZIMIDAZOLE DERIVATIVES AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：含有苯并咪唑衍生物的稳定的药物组合物及其制备方法
公开(公告)号：WO2005110488A1
公开(公告)日：2005-11-24
申请号：PCT/KR2005/001214
申请日：2005-04-27
申请人： SK CHEMICALS, CO., LTD. , KIM, Nam Ho , CHOI, Jin Young , KIM, Jae Sun , LEE, Nam Kyu , RYU, Je Ho , HWANG, Yong Youn , OH, Yong Ho , MIN, Dong Sun , UM, Key An , KWAK, Wie-Jong , KUM, Do Seung
发明人： KIM, Nam Ho , CHOI, Jin Young , KIM, Jae Sun , LEE, Nam Kyu , RYU, Je Ho , HWANG, Yong Youn , OH, Yong Ho , MIN, Dong Sun , UM, Key An , KWAK, Wie-Jong , KUM, Do Seung
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6951
摘要： The present invention relates to an inclusion complex containing a benzimidazole derivative with excellent storage stability and a method of its preparation. In particular, the present invention relates to an inclusion complex containing a benzimidazole derivative with improved storage stability and a method of its preparation, where an inclusion complex is manufactured by performing an inclusion reaction by combining a benzimidazole derivative, cyclodextrin and a water-soluble polymer in an aqueous alkali solution in order to be formulated after stabilizing an acid-unstable benzimidazole derivative.
摘要翻译：本发明涉及包含具有优异储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法。特别地，本发明涉及包含具有改进的储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法，其中通过将苯并咪唑衍生物，环糊精和水溶性聚合物组合进行包合反应来制备包合络合物在碱性水溶液中，为了在稳定酸不稳定的苯并咪唑衍生物后配制。

3. 发明申请

WO2008020674A1 A CENTRIFUGAL DEHYDRATOR 审中-公开
标题翻译：离心脱水机
公开(公告)号：WO2008020674A1
公开(公告)日：2008-02-21
申请号：PCT/KR2007/002075
申请日：2007-04-27
申请人： HWA YANG MACHINERY CO. LTD , KIM, Jae Sun
发明人： KIM, Jae Sun
IPC分类号： C02F11/12
CPC分类号： C02F11/127 , B04B1/20 , B04B1/2016 , B04B2001/205 , B04B2001/2083 , B04B2001/2091
摘要： The present invention is related to a centrifugal dehydrator for sludge extraction which does not use a coagulant. The centrifugal dehydrator of the present invention comprises a bowl having an inner surface in which at least one crush unit is disposed; and a screw conveyor disposed inside the bowl, and having a fan making a certain gap with the crush unit. The crush unit disposed above may be four (4) or eight (8), which may be disposed with a same space in the inner surface of the bowl, and the gap between the fan and the crush unit may be no more than 1mm. Also, the gap between the fan and the inner side of the bowl may be in the range of 1mm to 3mm.
摘要翻译：本发明涉及一种不使用凝结剂的污泥提取离心脱水机。本发明的离心脱水机包括：碗，其内表面设有至少一个挤压单元; 以及设置在所述碗内的螺旋传送器，并且具有与所述挤压单元形成一定间隙的风扇。设置在上方的挤压单元可以是四（4）或八（8），其可以在碗的内表面中以相同的空间设置，并且风扇和挤压单元之间的间隙可以不大于1mm。此外，风扇和碗内侧之间的间隙可以在1mm至3mm的范围内。

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