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1. 发明申请

WO2008123756A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA 审中-公开
标题翻译：含有Lacton型吡啶衍生物的药物组合物作为预防和治疗异位症的有效成分
公开(公告)号：WO2008123756A1
公开(公告)日：2008-10-16
申请号：PCT/KR2008/002030
申请日：2008-04-10
申请人： SK CHEMICALS CO., LTD. , CHO, Yong-Baik , LEE, Junwon , YI, Jung Bum , LEE, Nam Kyu , LEE, Bong-Yong , HWANG, Ki-Chul , LIM, Soyeon , CHANG, Woochul , CHUNG, Ji Hyung , LEE, Byung Ho , SEO, Ho Won
发明人： CHO, Yong-Baik , LEE, Junwon , YI, Jung Bum , LEE, Nam Kyu , LEE, Bong-Yong , HWANG, Ki-Chul , LIM, Soyeon , CHANG, Woochul , CHUNG, Ji Hyung , LEE, Byung Ho , SEO, Ho Won
IPC分类号： A61K31/436
CPC分类号： A61K31/436
摘要： The present invention relates to a pharmaceutical composition comprising a lactone type pyridine derivative for the prevention and treatment of ischemic diseases, more particularly to a pharmaceutical composition for preventing and treating ischemic diseases comprising a lactone type pyridine derivative or a pharmaceutically acceptable salt thereof as an active ingredient, which provides superior cell-protecting effect and calcium homeostasis and HSP (heat shock protein) expression controlling effect.
摘要翻译：本发明涉及包含用于预防和治疗缺血性疾病的内酯型吡啶衍生物的药物组合物，更具体地，涉及用于预防和治疗缺血性疾病的药物组合物，其包含内酯型吡啶衍生物或其药学上可接受的盐作为活性物质成分，提供优异的细胞保护作用和钙稳态和HSP（热休克蛋白）表达控制作用。

2. 发明申请

WO2007073095A1 PROCESS FOR THE PREPARATION OF (S)-(+)-CLOPIDOGREL ON A SOLID-PHASE 审中-公开
标题翻译：在固体相上制备（S） - （+） - 螯合物的方法
公开(公告)号：WO2007073095A1
公开(公告)日：2007-06-28
申请号：PCT/KR2006/005602
申请日：2006-12-20
申请人： SK CHEMICALS CO., LTD. , LEE, Jin Young , KIM, Nam Ho , KIM, Jae-Sun , LEE, Nam Kyu
发明人： LEE, Jin Young , KIM, Nam Ho , KIM, Jae-Sun , LEE, Nam Kyu
IPC分类号： C07D495/04 , C07D513/08 , C07D498/02 , A61P7/02 , A61P9/10
CPC分类号： C07D495/04
摘要： The present invention relates to a process for preparing S-(+)-clopidogrel using a solid-phase reaction, and more particularly, to a process for preparing S-(+)- clopidogrel represented by the following formula 1 with high optical and chemical purity by carrying out a series of reactions and purifications more simply by a solid- phase synthetic approach using a polymer support.
摘要翻译：本发明涉及一种使用固相反应制备S - （+） - 氯吡格雷的方法，更具体地说，涉及一种用高光学和化学药物制备由下式1表示的S - （+） - 氯吡格雷的方法通过使用聚合物载体的固相合成方法更简单地进行一系列反应和纯化，从而获得纯度。

3. 发明申请

WO2006070984A1 NOVEL BENZOPYRAN DERIVATIVES HAVING INHIBITORY ACTIVITIES AGAINST LIVER FIBROSIS AND CIRRHOSIS AND THEIR PHARMACEUTICAL USES 审中-公开
标题翻译：具有抗肝纤维化和阻塞性疾病及其药物用途的抑制活性的新型苯并噻吩衍生物
公开(公告)号：WO2006070984A1
公开(公告)日：2006-07-06
申请号：PCT/KR2005/001833
申请日：2005-06-15
申请人： SK CHEMICALS, CO., LTD. , KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , GONG, Young-Dae , SEO, Jin-Soo , JEON, Moon-Kook , KWAK, Wie-Jong , CHO, Yong-Baik , LEE, Nam Kyu , LEE, Eun Ju , LEE, Jung Bum , LEE, Jun Won , LEE, Sukho , DONG, Mi-Sook , KIM, Jeong-Ran
发明人： GONG, Young-Dae , SEO, Jin-Soo , JEON, Moon-Kook , KWAK, Wie-Jong , CHO, Yong-Baik , LEE, Nam Kyu , LEE, Eun Ju , LEE, Jung Bum , LEE, Jun Won , LEE, Sukho , DONG, Mi-Sook , KIM, Jeong-Ran
IPC分类号： A61K31/353 , C07D311/04 , A61P1/16
CPC分类号： C07D311/70
摘要： The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof
摘要翻译：本发明涉及一种对TGF-β受体具有优异活性的新型苯并吡喃衍生物，可有效用作肝脏疾病的预防和治疗药物，以及若干纤维样天然酶，如肝纤维化，肝硬化，肺纤维化，皮肤硬化，肾小球纤维化等; 及其药物用途

4. 发明申请

WO2005077942A1 PROCESS FOR PREPARING SUBSTITUTED BENZOPYRAN COMPOUNDS 审中-公开
标题翻译：制备取代苯并噻吩化合物的方法
公开(公告)号：WO2005077942A1
公开(公告)日：2005-08-25
申请号：PCT/KR2005/000365
申请日：2005-02-07
申请人： SK CHEMICALS, CO., LTD. , LEE, Nam Kyu , LEE, Ju Young , KIM, Jae-Sun , JUNG, Jae Yoon , UM, Key An , OH, Yong Ho , SHIN, Ho Chul , JANG, Woo Jae , IM, Guang-Jin , KIM, Tae Kon
发明人： LEE, Nam Kyu , LEE, Ju Young , KIM, Jae-Sun , JUNG, Jae Yoon , UM, Key An , OH, Yong Ho , SHIN, Ho Chul , JANG, Woo Jae , IM, Guang-Jin , KIM, Tae Kon
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： The present invention relates to a novel method of synthesizing substituted benzopyran compounds, their novel intermediates and a method of their preparation thereof.
摘要翻译：本发明涉及一种合成取代苯并吡喃化合物的新方法及其新型中间体及其制备方法。

5. 发明申请

WO2003041014A1 APPARATUS AND METHOD FOR RECOGNIZING CODE 审中-公开
标题翻译：用于识别代码的装置和方法
公开(公告)号：WO2003041014A1
公开(公告)日：2003-05-15
申请号：PCT/KR2002/000886
申请日：2002-05-13
申请人： COLORZIP MEDIA, INC , CHEONG, Cheol-Ho , LEE, Nam-Kyu , HAN, Tack-Don
发明人： CHEONG, Cheol-Ho , LEE, Nam-Kyu , HAN, Tack-Don
IPC分类号： G06T1/00
CPC分类号： G06T1/0021
摘要： An apparatus and method for recognizing a code from a code image that is expressed physically or electronically and extracting data represented in the code image is provided. The method includes the steps of receiving a raw image in which a code image is contained, detecting a background image included in the raw image, extracting a code image region in which a background image is excluded, recognizing the shape and type of the code image and the color or shade represented in each of cells, converting the color or shade recognized from each of the cells into a corresponding character, number, or symbol and generating code data. The code image in which predetermined data are represented as colors or shades are received, and original colors or shades can be precisely discriminated regardless of an environment in which the code image is recognized.
摘要翻译：提供一种用于从物理或电子表示的代码图像中识别代码并提取代码图像中表示的数据的装置和方法。该方法包括以下步骤：接收包含代码图像的原始图像，检测原始图像中包括的背景图像，提取其中排除背景图像的代码图像区域，识别代码图像的形状和类型以及在每个单元格中表示的颜色或阴影，将从每个单元识别的颜色或阴影转换成相应的字符，数字或符号并生成代码数据。接收预定数据被表示为颜色或阴影的代码图像，并且无论识别代码图像的环境如何，都可以精确地识别原始颜色或阴影。

6. 发明申请

WO2008123755A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA 审中-公开
标题翻译：含有LACTAM型吡啶衍生物的药物组合物作为预防和治疗异位症的有效成分
公开(公告)号：WO2008123755A1
公开(公告)日：2008-10-16
申请号：PCT/KR2008/002029
申请日：2008-04-10
申请人： SK CHEMICALS CO., LTD. , CHO, Yong-Baik , LEE, Junwon , YI, Jung Bum , LEE, Nam Kyu , LEE, Bong-Yong , HWANG, Ki-Chul , LIM, Soyeon , CHANG, Woochul , CHUNG, Ji Hyung , LEE, Byung Ho , SEO, Ho Won
发明人： CHO, Yong-Baik , LEE, Junwon , YI, Jung Bum , LEE, Nam Kyu , LEE, Bong-Yong , HWANG, Ki-Chul , LIM, Soyeon , CHANG, Woochul , CHUNG, Ji Hyung , LEE, Byung Ho , SEO, Ho Won
IPC分类号： A61K31/4375
CPC分类号： A61K31/4375
摘要： The present invention relates to a pharmaceutical composition comprising a lactam type pyridine derivative for the prevention and treatment of ischemic diseases, more particularly to a pharmaceutical composition for preventing and treating ischemic diseases comprising a lactam type pyridine derivative or a pharmaceutically acceptable salt thereof as active ingredient, which provides superior cell-protecting effect and calcium homeostasis and HSP (heat shock protein) expression controlling effect.
摘要翻译：本发明涉及包含用于预防和治疗缺血性疾病的内酰胺型吡啶衍生物的药物组合物，更具体地涉及用于预防和治疗缺血性疾病的药物组合物，其包含内酰胺型吡啶衍生物或其药学上可接受的盐作为活性成分，提供优异的细胞保护作用和钙稳态和HSP（热休克蛋白）表达控制作用。

7. 发明申请

WO2008072836A1 INCLUSION COMPLEX COMPRISING CLOPIDOGREL 审中-公开
标题翻译：包含复合物包括CLOPIDOGREL
公开(公告)号：WO2008072836A1
公开(公告)日：2008-06-19
申请号：PCT/KR2007/005321
申请日：2007-10-26
申请人： SK CHEMICALS CO., LTD. , KIM, Jae-Sun , KIM, Nam Ho , LEE, Jin Young , LEE, Nam Kyu , OH, Joon Gyo , SHIN, Ji Young , KIM, Tae-Kon , YOON, Mi-Sun , SUNG, Jin-Heung , LEE, Yoon-Jung , PARK, Yeo-Jin , UM, Key An
发明人： KIM, Jae-Sun , KIM, Nam Ho , LEE, Jin Young , LEE, Nam Kyu , OH, Joon Gyo , SHIN, Ji Young , KIM, Tae-Kon , YOON, Mi-Sun , SUNG, Jin-Heung , LEE, Yoon-Jung , PARK, Yeo-Jin , UM, Key An
IPC分类号： A61K47/40 , A61K31/135 , C07D211/18 , A61K31/445
CPC分类号： A61K47/40 , C07D495/04
摘要： The present invention relates to an inclusion complex containing clopidogrel with superior storage stability, more particularly to a pharmaceutically stable and suitable inclusion complex obtained by reacting S-(+)-clopidogrel [methyl (+)-(S)-α- (o-chlorophenyl)-6/7-dihydrothieno[3/2-c]pyridin-5(4H)-acetate] represented by the formula (1) below with β-cyclodextrin at a specific equivalence ratio, and an antiplatelet agent composition comprising the same as an active ingredient:
摘要翻译：本发明涉及具有优异储存稳定性的含有氯吡格雷的包合络合物，更具体地涉及通过使S-（+） - 氯吡格雷[甲基（+） - （S）-α-（o- 氯苯基）-6,7-二氢噻吩并[3,2-c]吡啶-5（4H） - 乙酸酯]和具有特定当量比的β-环糊精的抗血小板剂组合物作为有效成分：

8. 发明申请

WO2007074995A1 PROCESS FOR THE PREPARATION OF S-(+)-CLOPIDOGREL BY OPTICAL RESOLUTION 审中-公开
标题翻译：通过光学分辨率制备S - （+） - 光滑石的方法
公开(公告)号：WO2007074995A1
公开(公告)日：2007-07-05
申请号：PCT/KR2006/005600
申请日：2006-12-20
申请人： SK CHEMICALS CO., LTD. , KIM, Nam Ho , LEE, Jin Young , KIM, Jae-Sun , LEE, Nam Kyu
发明人： KIM, Nam Ho , LEE, Jin Young , KIM, Jae-Sun , LEE, Nam Kyu
IPC分类号： C07D495/04 , C07D513/08 , C07D498/02 , A61P7/02 , A61P9/10
CPC分类号： C07D495/04
摘要： The present invention relates to a process for the preparation of S-(+)-clopidogrel by an optical resolution and, more particularly, to a process for the preparation of S-(+)-clopidogrel represented by the following formula 1 with high optical purity by converting a clopidogrel racemic carboxylic acid into a diastereomeric salt using a (+)-cinchonine for optical resolution, extracting an S-(+)-clopidogrel carboxylic acid from the diastereomeric salt using a suitable solvent under an acidic condition and then reacting the S-(+)-clopidogrel carboxylic acid with methanol.
摘要翻译：本发明涉及一种通过光学拆分制备S - （+） - 氯吡格雷的方法，更具体地说，涉及用高光学制备由下式1表示的S - （+） - 氯吡格雷的方法通过使用（+） - 辛可宁将氯吡格雷外消旋羧酸转化为非对映体盐进行光学拆分，使用合适的溶剂在酸性条件下从非对映异构体盐中提取S - （+） - 氯吡格雷羧酸，然后使 S - （+） - 氯吡格雷羧酸与甲醇。

9. 发明申请

WO2007049868A1 STABILIZED PHARMACEUTICAL ORAL PREPARATION CONTAINING CLOPIDOGREL BISULFATE 审中-公开
标题翻译：含有双歧杆菌的稳定的药物口服制剂
公开(公告)号：WO2007049868A1
公开(公告)日：2007-05-03
申请号：PCT/KR2006/004046
申请日：2006-10-09
申请人： SK CHEMICALS CO., LTD. , OH, Joon Gyo , SHIN, Dong-Chul , SHIN, Ji Young , YOUN, Won-No , UM, Key An , MIN, Dong-Sun , KIM, Jae-Sun , KIM, Nam Ho , LEE, Nam Kyu
发明人： OH, Joon Gyo , SHIN, Dong-Chul , SHIN, Ji Young , YOUN, Won-No , UM, Key An , MIN, Dong-Sun , KIM, Jae-Sun , KIM, Nam Ho , LEE, Nam Kyu
IPC分类号： A61K31/4365 , A61K9/14 , A61K9/20 , A61K9/48 , A61K47/36
CPC分类号： A61K9/2077 , A61K9/2866 , A61K31/4365
摘要： The present invention relates to a stabilized oral preparation comprising clopidogrel bisulfate, and in particular the oral preparation herein further comprises starch and cellulose along with the crystalline form 1 or form 2 clopidogrel bisulfate, which is susceptible to moisture and produces hydrated product-related impurities when formulated into oral preparations, thus showing storage stability even in the same dosage form with the conventional preparations.
摘要翻译：本发明涉及包含氯吡格雷硫酸氢盐的稳定的口服制剂，特别是本文的口服制剂还包括淀粉和纤维素以及结晶形式1或形式2的氯吡格雷硫酸氢盐，其易受潮湿并产生水合产物相关的杂质，当配制成口服制剂，因此即使以与常规制剂相同的剂型也显示出储存稳定性。

10. 发明申请

WO2007046616A1 PROCESS FOR PREPARATION OF CHIRAL AMLODIPINE GENTISATE 审中-公开
标题翻译：制备丙氨酸假丝酵母的方法
公开(公告)号：WO2007046616A1
公开(公告)日：2007-04-26
申请号：PCT/KR2006/004206
申请日：2006-10-17
申请人： SK CHEMICALS CO., LTD. , KIM, Jae-Sun , KIM, Nam Ho , LEE, Nam Kyu
发明人： KIM, Jae-Sun , KIM, Nam Ho , LEE, Nam Kyu
IPC分类号： C07D211/90 , C07D213/80 , C07D213/803
CPC分类号： C07D211/90
摘要： The present invention relates to a process for the preparation of optically pure amlodipine gentisate, more particularly to a continuous process for the preparation of optically pure amlodipine gentisate with good yield and high optical purity. The processes can be preformed by first reacting racemic ( R , S )-amlodipine and optically pure O,O'-dibenzoyltartaric acid in the presence of a solvent including isopropanol to prepare ( R )- or ( S )- amlodipine dibenzoyltartarate diastereomer or a solvate thereof, treating the prepared amlodipine diastereomeric salt or a solvate thereof with a base and then finally adding gentisic acid.
摘要翻译：本发明涉及一种制备光学纯氨氯地平龙胆酸盐的方法，更具体地说，涉及一种以高产率和高光学纯度制备光学纯氨氯地平龙胆酸盐的连续方法。该方法可以通过在包含异丙醇的溶剂存在下，首先使外消旋（R，S） - 氨氯地平和光学纯的O，O-二苯甲酰基酒石酸反应制备（R） - 或（S） - 氨氯地平二苯甲酰三酸盐非对映异构体或溶剂合物，用碱处理制备的氨氯地平非对映体盐或其溶剂合物，然后最后加入龙胆酸。

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