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1. 发明申请

WO2010090441A3 PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：用于预防和治疗可重复使用的BOWEL综合症的药物组合物
公开(公告)号：WO2010090441A3
公开(公告)日：2010-12-29
申请号：PCT/KR2010000658
申请日：2010-02-03
申请人： SK CHEMICALS CO LTD , SUN WON SUCK , KIM TAEK SU , RYU KEUN HO , UM KEY AN , JEON HYO JIN , MIN DONG SUN , PARK YANG HAE , SON HYUN JOO , LEE BONG YONG , PYO SUNG SOO
发明人： SUN WON SUCK , KIM TAEK SU , RYU KEUN HO , UM KEY AN , JEON HYO JIN , MIN DONG SUN , PARK YANG HAE , SON HYUN JOO , LEE BONG YONG , PYO SUNG SOO
IPC分类号： A61K36/896 , A23L1/30 , A61P1/10 , A61P1/12
CPC分类号： A61K36/896 , A23L33/105
摘要： Disclosed is a pharmaceutical composition for the prevention and treatment of irritable bowel syndrome including Liriopis tuber (tuber of Liriope platyphylla Wang et Tang, Ophiopogon japonicus Ker-Gawler or related plants of the same genuses) extract as an active ingredient. The Liriopis tuber extract has an excellent effect of suppressing visceral hypersensitivity and may be used for pharmaceutical compositions and health functional foods for the prevention and treatment of.
摘要翻译：公开了用于预防和治疗肠易激综合征的药物组合物，其包括Liriois tuber（Liriope platyphylla Wang et Tang，Ophiopogon japonicus Ker-Gawler或相同属的相关植物）提取物作为活性成分。 Liriopis块茎提取物具有抑制内脏超敏反应的优异效果，可用于药物组合物和保健功能食品的预防和治疗。

2. 发明申请

WO2007049868A1 STABILIZED PHARMACEUTICAL ORAL PREPARATION CONTAINING CLOPIDOGREL BISULFATE 审中-公开
标题翻译：含有双歧杆菌的稳定的药物口服制剂
公开(公告)号：WO2007049868A1
公开(公告)日：2007-05-03
申请号：PCT/KR2006/004046
申请日：2006-10-09
申请人： SK CHEMICALS CO., LTD. , OH, Joon Gyo , SHIN, Dong-Chul , SHIN, Ji Young , YOUN, Won-No , UM, Key An , MIN, Dong-Sun , KIM, Jae-Sun , KIM, Nam Ho , LEE, Nam Kyu
发明人： OH, Joon Gyo , SHIN, Dong-Chul , SHIN, Ji Young , YOUN, Won-No , UM, Key An , MIN, Dong-Sun , KIM, Jae-Sun , KIM, Nam Ho , LEE, Nam Kyu
IPC分类号： A61K31/4365 , A61K9/14 , A61K9/20 , A61K9/48 , A61K47/36
CPC分类号： A61K9/2077 , A61K9/2866 , A61K31/4365
摘要： The present invention relates to a stabilized oral preparation comprising clopidogrel bisulfate, and in particular the oral preparation herein further comprises starch and cellulose along with the crystalline form 1 or form 2 clopidogrel bisulfate, which is susceptible to moisture and produces hydrated product-related impurities when formulated into oral preparations, thus showing storage stability even in the same dosage form with the conventional preparations.
摘要翻译：本发明涉及包含氯吡格雷硫酸氢盐的稳定的口服制剂，特别是本文的口服制剂还包括淀粉和纤维素以及结晶形式1或形式2的氯吡格雷硫酸氢盐，其易受潮湿并产生水合产物相关的杂质，当配制成口服制剂，因此即使以与常规制剂相同的剂型也显示出储存稳定性。

3. 发明申请

WO2006049433A1 SOLID DISPERSION COMPOSITION OF PRANLUKAST WITH IMPROVED BIOAVAILIBILITY AND THE METHOD OF PREPARING THE SOLID DISPERSION 审中-公开
标题翻译：具有改善生物利用度的固体分散组合物和制备固体分散体的方法
公开(公告)号：WO2006049433A1
公开(公告)日：2006-05-11
申请号：PCT/KR2005/003686
申请日：2005-11-03
申请人： SK CHEMICALS, CO., LTD. , OH, Joon-Gyo , OH, Yong Ho , SHIN, Ho Chul , JUNG, Ji Sun , UM, Key-An , MIN, Dong Sun , LEE, Nam Kyu , LEE, Ju Young , IM, Guang-Jin , KIM, Tae Kon , KIM, Jeong Tae , JANG, Woo Jae , SHIN, Dong Chul , KIM, Woong-Sik
发明人： OH, Joon-Gyo , OH, Yong Ho , SHIN, Ho Chul , JUNG, Ji Sun , UM, Key-An , MIN, Dong Sun , LEE, Nam Kyu , LEE, Ju Young , IM, Guang-Jin , KIM, Tae Kon , KIM, Jeong Tae , JANG, Woo Jae , SHIN, Dong Chul , KIM, Woong-Sik
IPC分类号： A61K47/32 , A61K31/352 , A61K31/166
CPC分类号： A61K31/352 , A61K9/146 , A61K31/166
摘要： Disclosed is a pranlukast solid dispersion composition with an improved and a method of manufacturing the same. More particularly, the present invention provides a pranlukast solid dispersion manufactured by a hot-melting process using a composition comprising pranlukast and at least one water-soluble polymer selected from the group consisting of polyvinylpyrrolidone vinylacetate copolymer, polyvinylpyrrolidone and polyvinylalcohol, which has greatly improved dissolution rate and bioavailability as compared to those prepared by the conventional spray-drying method, thus enabling to obtain the equivalent pharmaceutical effects with less amount of a drug.
摘要翻译：公开了具有改进的普兰司特固体分散体组合物及其制造方法。更具体地说，本发明提供了一种通过使用包含普鲁司特和至少一种选自聚乙烯吡咯烷酮乙酸乙烯酯共聚物，聚乙烯吡咯烷酮和聚乙烯醇的至少一种水溶性聚合物的热熔融方法制造的普拉克司特固体分散体，其具有极大改善的溶解度速率和生物利用度与通过常规喷雾干燥方法制备的那些相比，因此能够以较少量的药物获得等效的药物作用。

4. 发明申请

WO2013009073A3 COMPOSITION COMPRISING PSORALEA CORYLIFOLIA L. EXTRACTS 审中-公开
标题翻译：包含PSORALEA CORYLIFOLIA L.提取物的组合物
公开(公告)号：WO2013009073A3
公开(公告)日：2013-04-11
申请号：PCT/KR2012005464
申请日：2012-07-10
申请人： SK CHEMICALS CO LTD , CHOI WON RACK , NAMGUNG HO JIN , KIM TAEK SU , RYU KEUN HO , MIN DONG SUN , LEE SO YOUNG , PARK YANG HAE , KIM MYUNG HWAN , LEE SOO HUN
发明人： CHOI WON RACK , NAMGUNG HO JIN , KIM TAEK SU , RYU KEUN HO , MIN DONG SUN , LEE SO YOUNG , PARK YANG HAE , KIM MYUNG HWAN , LEE SOO HUN
IPC分类号： A61K36/487 , A61P13/10
CPC分类号： A61K36/487
摘要： The present invention relates to a composition comprising Psoralea corylifolia L. extracts or fractions thereof, and to uses thereof. More particularly, provided are the Psoralea corylifolia L. extracts or fractions thereof, and the composition comprising the Psoralea corylifolia L. extracts or fractions thereof as active ingredients for preventing, ameliorating, or treating overactive bladder syndrome.
摘要翻译：本发明涉及一种组合物，其包含茄科植物提取物或其部分，以及其用途。更具体地，提供了补骨脂提取物或其部分，并且包含茯苓茯苓提取物或其部分作为预防，改善或治疗膀胱过度活动症综合征的活性成分的组合物。

5. 发明申请

WO2010134769A2 COMPOSITION FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：用于预防或治疗可疑玻璃体综合征的组合物
公开(公告)号：WO2010134769A2
公开(公告)日：2010-11-25
申请号：PCT/KR2010003197
申请日：2010-05-20
申请人： SK CHEMICALS CO LTD , SUN WON SUCK , KIM TAEK-SU , KIM WOONG SIK , KUM DO-SEUNG , RYU KEUN-HO , LEE HAE-IN , JEON HYO JIN , MIN DONG SUN , PARK YANG HAE , SON HYUN-JOO , PARK EUN-JU , LEE BONG-YONG , NAMGUNG HO JIN , PARK MINSEOK , OH EUICHAUL
发明人： SUN WON SUCK , KIM TAEK-SU , KIM WOONG SIK , KUM DO-SEUNG , RYU KEUN-HO , LEE HAE-IN , JEON HYO JIN , MIN DONG SUN , PARK YANG HAE , SON HYUN-JOO , PARK EUN-JU , LEE BONG-YONG , NAMGUNG HO JIN , PARK MINSEOK , OH EUICHAUL
IPC分类号： A61K36/284 , A23L1/30 , A61P1/00 , A61P1/12
CPC分类号： A61K36/284 , A23L33/105 , A23V2002/00 , A23V2200/3204 , A23V2250/21
摘要： The present invention relates to a composition useful for preventing or treating irritable bowel syndrome, and to a method for treating or preventing irritable bowel syndrome. The present invention uses an Atractylodes japonica rhizome extract, preferably an Atractylodes japonica rhizome extract using an aqueous ethanol solution, and more preferably an Atractylodes japonica rhizome extract using an aqueous ethanol solution of 35 to 65 v/v%, as an active ingredient to treat or prevent irritable bowel syndrome. The Atractylodes japonica extract exhibits superior effects of inhibiting bowel irritation and enhancement for dyschezia caused by stresses or irritable bowel.
摘要翻译：本发明涉及可用于预防或治疗肠易激综合征的组合物，以及治疗或预防肠易激综合征的方法。本发明使用含水乙醇溶液，更优选使用35〜65v / v％的乙醇水溶液作为有效成分的白术提取物，优选使用水提糖提取物，更优选使用Atractylodes japonica Rhizome提取物作为活性成分进行处理或预防肠易激综合征。 Atractylodes japonica提取物显示出优异的抑制肠道刺激和增强由应激或肠易激惹引起的运动障碍的作用。

6. 发明申请

WO2010021506A3 ESCALATOR HANDRAIL STERILIZER 审中-公开
标题翻译： ESCALATOR扶手杀菌器
公开(公告)号：WO2010021506A3
公开(公告)日：2010-06-03
申请号：PCT/KR2009004653
申请日：2009-08-20
申请人： KIM HYUN KWANG , YUN IN KI , KIM YOUNG MAN , MIN DONG SUN
发明人： KIM HYUN KWANG , YUN IN KI , KIM YOUNG MAN , MIN DONG SUN
IPC分类号： B66B23/24
CPC分类号： B66B31/02
摘要： The present invention is an escalator handrail sterilizer which is installed close to an inlet or outlet of an escalator handrail, and cleans and sterilizes the handrail moving in or out. The sterilizer comprises a case which is prepared for surrounding the escalator handrail, a chemical spray unit which is prepared in one end inside the case to spray chemicals on the handrail moving in, an ultraviolet ray irradiation unit which is prepared in the other end inside the case to project ultraviolet rays on the chemical-sprayed handrail, a drying unit which dries the chemicals sprayed on the handrail, a control unit which controls the chemical spray unit, the ultraviolet ray irradiation unit and the drying unit, and a cover which is prepared in both ends of the case in order to prevent foreign materials from flowing into the case.
摘要翻译：本发明是一种自动扶梯扶手消毒器，其安装在自动扶梯扶手的进口或出口附近，并清洁和消毒扶手移入或移出。该灭菌器包括：准备用于包围扶梯扶手的箱体;化学喷射单元，其一端设置在箱体内部，以便将化学物质喷射到扶手移动的内部;紫外线照射单元，将化学喷雾的扶手上的紫外线照射的情况;干燥喷雾在扶手上的药液的干燥单元;控制化学喷射单元，紫外线照射单元和干燥单元的控制单元; 在外壳的两端，以防止异物流入外壳。

7. 发明申请

WO2005110488A1 STABLE PHARMACEUTICAL COMPOSITION CONTAINING BENZIMIDAZOLE DERIVATIVES AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：含有苯并咪唑衍生物的稳定的药物组合物及其制备方法
公开(公告)号：WO2005110488A1
公开(公告)日：2005-11-24
申请号：PCT/KR2005/001214
申请日：2005-04-27
申请人： SK CHEMICALS, CO., LTD. , KIM, Nam Ho , CHOI, Jin Young , KIM, Jae Sun , LEE, Nam Kyu , RYU, Je Ho , HWANG, Yong Youn , OH, Yong Ho , MIN, Dong Sun , UM, Key An , KWAK, Wie-Jong , KUM, Do Seung
发明人： KIM, Nam Ho , CHOI, Jin Young , KIM, Jae Sun , LEE, Nam Kyu , RYU, Je Ho , HWANG, Yong Youn , OH, Yong Ho , MIN, Dong Sun , UM, Key An , KWAK, Wie-Jong , KUM, Do Seung
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6951
摘要： The present invention relates to an inclusion complex containing a benzimidazole derivative with excellent storage stability and a method of its preparation. In particular, the present invention relates to an inclusion complex containing a benzimidazole derivative with improved storage stability and a method of its preparation, where an inclusion complex is manufactured by performing an inclusion reaction by combining a benzimidazole derivative, cyclodextrin and a water-soluble polymer in an aqueous alkali solution in order to be formulated after stabilizing an acid-unstable benzimidazole derivative.
摘要翻译：本发明涉及包含具有优异储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法。特别地，本发明涉及包含具有改进的储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法，其中通过将苯并咪唑衍生物，环糊精和水溶性聚合物组合进行包合反应来制备包合络合物在碱性水溶液中，为了在稳定酸不稳定的苯并咪唑衍生物后配制。

8. 发明申请

WO2010090441A2 PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：药物组合物用于预防和治疗肠易激综合征
公开(公告)号：WO2010090441A2
公开(公告)日：2010-08-12
申请号：PCT/KR2010/000658
申请日：2010-02-03
申请人： SK CHEMICALS CO., LTD. , SUN, Won Suck , KIM, Taek Su , RYU, Keun Ho , UM, Key An , JEON, Hyo Jin , MIN, Dong Sun , PARK, Yang Hae , SON, Hyun Joo , LEE, Bong Yong , PYO, Sung Soo
发明人： SUN, Won Suck , KIM, Taek Su , RYU, Keun Ho , UM, Key An , JEON, Hyo Jin , MIN, Dong Sun , PARK, Yang Hae , SON, Hyun Joo , LEE, Bong Yong , PYO, Sung Soo
IPC分类号： A61K36/896 , A61P1/10 , A61P1/12 , A23L1/30
CPC分类号： A61K36/896 , A23L33/105
摘要： Disclosed is a pharmaceutical composition for the prevention and treatment of irritable bowel syndrome including Liriopis tuber (tuber of Liriope platyphylla Wang et Tang, Ophiopogon japonicus Ker-Gawler or related plants of the same genuses) extract as an active ingredient. The Liriopis tuber extract has an excellent effect of suppressing visceral hypersensitivity and may be used for pharmaceutical compositions and health functional foods for the prevention and treatment of.
摘要翻译：公开了一种用于预防和治疗肠易激综合征的药物组合物，所述肠易激综合征包括Liriopis tuber（Liriope platyphylla Wang et Tang，麦冬或相同植物的相关植物）提取物作为活性成分。 Liriopis块茎提取物具有抑制内脏过敏症的优异效果，并且可用于预防和治疗药物组合物和保健功能性食品。

9. 发明申请

WO2010062046A1 COMPOSITION FOR PREVENTION AND TREATMENT OF IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：用于预防和治疗可疑牙刷综合征的组合物
公开(公告)号：WO2010062046A1
公开(公告)日：2010-06-03
申请号：PCT/KR2009/006381
申请日：2009-11-02
申请人： SK CHEMICALS CO., LTD. , SUN, Won Suck , JEON, Hyo Jin , KIM, Taek Su , RYU, Keun Ho , MIN, Dong Sun , PARK, Yang Hae , SON, Hyun Joo , KANG, Sang Hwan , PYO, Sung Soo , UM, Key An , LEE, Bong Yong
发明人： SUN, Won Suck , JEON, Hyo Jin , KIM, Taek Su , RYU, Keun Ho , MIN, Dong Sun , PARK, Yang Hae , SON, Hyun Joo , KANG, Sang Hwan , PYO, Sung Soo , UM, Key An , LEE, Bong Yong
IPC分类号： A61K36/185 , A61P1/00
CPC分类号： A61K36/185
摘要： Disclosed is a composition for the prevention and treatment of irritable bowel syndrome, comprising a Myristicae Semen extract as an active ingredient. Being superior in suppressing visceral hypersensitivity and improving stress- or hypersensitivity-induced bowel abnormalities, the Myristicae Semen extract can be used in pharmaceutical compositions and health foods to be effective in the prevention and treatment of irritable bowel syndrome.
摘要翻译：公开了用于预防和治疗肠易激综合征的组合物，其包含肉豆蔻精液提取物作为活性成分。在抑制内脏超敏反应和改善压力或超敏反应引起的肠道异常方面优越，肉豆蔻精液提取物可用于药物组合物和保健食品中，以有效预防和治疗肠易激综合征。

10. 发明申请

WO2007024123A1 PHARMACEUTICAL COMPOSITION OF PRANLUKAST SOLID-DISPERSION WITH IMPROVED INITIAL DISSOLUTION RATE AND THE METHOD OF PREPARING THE SAME 审中-公开
标题翻译：具有改进的初始溶解速率的预抛光固体分散体的药物组合物及其制备方法
公开(公告)号：WO2007024123A1
公开(公告)日：2007-03-01
申请号：PCT/KR2006/003368
申请日：2006-08-25
申请人： SK CHEMICALS CO., LTD. , OH, Joon Gyo , OH, Yong Ho , SHIN, Ho Chul , JUNG, Jisun , UM, Key An , MIN, Dong-Sun , KIM, Woong Sik
发明人： OH, Joon Gyo , OH, Yong Ho , SHIN, Ho Chul , JUNG, Jisun , UM, Key An , MIN, Dong-Sun , KIM, Woong Sik
IPC分类号： A61K9/14
CPC分类号： A61K9/1641 , A61K9/2031 , A61K31/41
摘要： The present invention relates to a pharmaceutical composition of pranlukast solid-dispersion with an improved initial dissolution rate and the preparation method thereof. More particularly, it relates to a pharmaceutical composition of pranlukast solid-dispersion prepared by mixing pranlukast solid-dispersion and anticoagulation agent with a certain range of HLB at a elevated temperature, which can be further granulated and capsulated, thus enabling to improve initial dissolution rate of pranlukast by solving the serious problem of pranlukast solid-dispersion to stick to capsule walls and, to improve bioavailability because it shows superior Cmax and AUC based on the same administration dose, as comared to the commercial pharmaceutical composition of pranlukast formulated by conventional method, along with the preparation method thereof.
摘要翻译：本发明涉及具有改善的初始溶解速度的普鲁司特固相分散体的药物组合物及其制备方法。更具体地说，本发明涉及通过在高温下将普鲁司特固体分散体和抗凝血剂与一定范围的HLB混合而制备的普鲁司特固体分散体的药物组合物，其可进一步造粒和包封，从而能够改善初始溶解速率通过解决pranlukast固相分散粘附在胶囊壁上的严重问题，并提高生物利用度，因为与通过常规方法配制的普鲁卡司特的市售药物组合物相比，基于相同的给药剂量显示出优异的C max和AUC，以及其制备方法。

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