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1. 发明申请

WO2005110488A1 STABLE PHARMACEUTICAL COMPOSITION CONTAINING BENZIMIDAZOLE DERIVATIVES AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：含有苯并咪唑衍生物的稳定的药物组合物及其制备方法
公开(公告)号：WO2005110488A1
公开(公告)日：2005-11-24
申请号：PCT/KR2005/001214
申请日：2005-04-27
申请人： SK CHEMICALS, CO., LTD. , KIM, Nam Ho , CHOI, Jin Young , KIM, Jae Sun , LEE, Nam Kyu , RYU, Je Ho , HWANG, Yong Youn , OH, Yong Ho , MIN, Dong Sun , UM, Key An , KWAK, Wie-Jong , KUM, Do Seung
发明人： KIM, Nam Ho , CHOI, Jin Young , KIM, Jae Sun , LEE, Nam Kyu , RYU, Je Ho , HWANG, Yong Youn , OH, Yong Ho , MIN, Dong Sun , UM, Key An , KWAK, Wie-Jong , KUM, Do Seung
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6951
摘要： The present invention relates to an inclusion complex containing a benzimidazole derivative with excellent storage stability and a method of its preparation. In particular, the present invention relates to an inclusion complex containing a benzimidazole derivative with improved storage stability and a method of its preparation, where an inclusion complex is manufactured by performing an inclusion reaction by combining a benzimidazole derivative, cyclodextrin and a water-soluble polymer in an aqueous alkali solution in order to be formulated after stabilizing an acid-unstable benzimidazole derivative.
摘要翻译：本发明涉及包含具有优异储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法。特别地，本发明涉及包含具有改进的储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法，其中通过将苯并咪唑衍生物，环糊精和水溶性聚合物组合进行包合反应来制备包合络合物在碱性水溶液中，为了在稳定酸不稳定的苯并咪唑衍生物后配制。

2. 发明申请

WO2005042485A1 ACID ADDED SALTS OF AMLODIPINE 审中-公开
标题翻译：酸添加的AMLODIPINE的盐
公开(公告)号：WO2005042485A1
公开(公告)日：2005-05-12
申请号：PCT/KR2004/002756
申请日：2004-10-29
申请人： SK CHEMICALS, CO., LTD. , KIM, Jae-Sun , CHOI, Jin Young , RYU, Je Ho , KIM, Nam ho , LEE, Nam Kyu , OH, Yong Ho , OH, Joon-Gyo , JANG, Woo Jae , KUM, Do Seung , UM, Key An , KWAK, Wie-Jong
发明人： KIM, Jae-Sun , CHOI, Jin Young , RYU, Je Ho , KIM, Nam ho , LEE, Nam Kyu , OH, Yong Ho , OH, Joon-Gyo , JANG, Woo Jae , KUM, Do Seung , UM, Key An , KWAK, Wie-Jong
IPC分类号： C07D211/90
CPC分类号： C07D211/90
摘要： The present invention relates to crystalline acid salts of amlodipine which exhibit excellent physicochemical properties such as high aqueous solubility, stability, non-hygroscopicity and anti-stiction property, thereby providing an effective therapeutic agent in the treatment of cardiovascular diseases including hypertension.
摘要翻译：本发明涉及氨氯地平的结晶酸盐，其具有优异的物理化学性质，例如高溶解性，稳定性，非吸湿性和抗静电性，从而提供治疗包括高血压在内的心血管疾病的有效治疗剂。

3. 发明申请

WO2009145368A1 IMPROVED PREPARING METHOD OF (S)-OMEPRAZOLE FROM OMEPRAZOLE RACEMATE USING OPTICAL RESOLUTION AGENT 审中-公开
标题翻译：使用光学分解剂改进从奥美拉唑的（S） - 甲基吡咯的制备方法
公开(公告)号：WO2009145368A1
公开(公告)日：2009-12-03
申请号：PCT/KR2008/002961
申请日：2008-05-27
申请人： SK CHEMICALS CO., LTD. , KIM, Jae-Sun , LEE, Jin Young , KIM, Sun Ho , KIM, Nam ho , LEE, Nam Kyu , PARK, Eun Ju , KUM, Do Seung
发明人： KIM, Jae-Sun , LEE, Jin Young , KIM, Sun Ho , KIM, Nam ho , LEE, Nam Kyu , PARK, Eun Ju , KUM, Do Seung
IPC分类号： C07D401/12 , C07D277/30 , A61K31/415 , A61K31/44
CPC分类号： C07D401/12
摘要： The present invention relates to an improved preparing method of ( S )-omeprazole from omeprazole racemate. In an exemplary embodiment, the preparing method according to the present invention comprises the steps of: a) reacting omeprazole racemate with optically active diethyl-D-tartrate and a titanium compound in an alcohol solvent to prepare an omeprazole racemic complex; b) reacting the omeprazole racemic complex with 1.5-3.0 molar equivalents of ( S )-(+)-mandelic acid as optical resolution agent to prepare an optically active ( S )-omeprazole complex; and c) dissociating the optically active ( S) -omeprazole complex with a basic solution to prepare an ( S )-omeprazole free base or reacting the ( S )- omeprazole free base with a metal salt to transfer to a metal salt or a metal salt hydrate of ( S )- omeprazole. With optical purity of 99.0 %ee or better, the ( S )-omeprazole, the metal salt thereof or the hydrate thereof prepared in accordance with the present invention is useful as a medicinal material.
摘要翻译：本发明涉及一种改善奥美拉唑外消旋物（S） - 奥美拉唑的制备方法。在一个示例性实施方案中，根据本发明的制备方法包括以下步骤：a）使奥美拉唑外消旋物与光学活性的D-酒石酸二乙酯和钛化合物在醇溶剂中反应以制备奥美拉唑外消旋体; b）将奥美拉唑外消旋配合物与1.5-3.0摩尔当量的（S） - （+） - 扁桃酸作为光学拆分剂反应，制备光学活性（S） - 奥美拉唑复合物; 和c）用碱性溶液解离光学活性（S） - 奥美拉唑复合物以制备（S） - 奥美拉唑游离碱或使（S） - 奥美拉唑游离碱与金属盐反应转移至金属盐或金属（S） - 奥美拉唑盐水合物。光学纯度为99.0％ee或更好，根据本发明制备的（S） - 奥美拉唑，其金属盐或其水合物可用作药用材料。

4. 发明申请

WO2002094301A1 HERBAL DRUG COMPOSITION FOR CARTILAGE PROTECTION 审中-公开
标题翻译：草药保护组合物
公开(公告)号：WO2002094301A1
公开(公告)日：2002-11-28
申请号：PCT/KR2002/000010
申请日：2002-01-04
申请人： SK CHEMICALS CO., LTD. , HAN, Chang-Kyun , KWAK, Wie-Jong , JOUNG, Ki Won , YOO, Hun Seung , KUM, Do Seung , CHO, Yong-Baik , RYU, Keun Ho , RHEE, Hae In , KIM, Taek Su , JUNG, In Ho , LEE, So Yoon , YI, Jung Bum , KIM, Joo Hyon , UM, Key An
发明人： HAN, Chang-Kyun , KWAK, Wie-Jong , JOUNG, Ki Won , YOO, Hun Seung , KUM, Do Seung , CHO, Yong-Baik , RYU, Keun Ho , RHEE, Hae In , KIM, Taek Su , JUNG, In Ho , LEE, So Yoon , YI, Jung Bum , KIM, Joo Hyon , UM, Key An
IPC分类号： A61K35/78
CPC分类号： A61K36/536 , A61K36/428 , A61K36/716 , A61K2300/00
摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.
摘要翻译：本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），三叶草（Trichosanthis Radix）和Prunellae Spica的植物提取物和迷迭香酸的最佳含量以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

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