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1. 发明申请

WO2012157921A3 COMPOSITION FOR TRANSDERMAL ADMINISTRATION, CONTAINING RIVASTIGMINE OR SALT THEREOF 审中-公开
标题翻译：含有盐酸盐或盐的超导管理组合物
公开(公告)号：WO2012157921A3
公开(公告)日：2013-03-21
申请号：PCT/KR2012003756
申请日：2012-05-14
申请人： SK CHEMICALS CO LTD , HWANG YONG-YOUN , CHOI WON-JAE , KIM JAE-SUN , YOUN WON-NO , PARK YEO-JIN , OJ JOON-GYO , IM JONGSEOB
发明人： HWANG YONG-YOUN , CHOI WON-JAE , KIM JAE-SUN , YOUN WON-NO , PARK YEO-JIN , OJ JOON-GYO , IM JONGSEOB
IPC分类号： A61K31/325 , A61K9/70 , A61K31/195 , A61P17/00
CPC分类号： A61K31/27 , A61K9/0014 , A61K31/192 , A61K2300/00
摘要： The present invention relates to a composition for transdermal administration with improved storage stability, containing rivastigmine or a salt thereof. The composition for transdermal administration of the present invention uses gentisic acid as a stabilizer of rivastigmine, wherein gentisic acid has greater rivastigmine stability than tocopherol, a formulation used on the market, is easy to handle and is commercially cheap. According to the present invention, the composition has improved stability, and thus can be stored for a long time as a drug for transdermal administration.
摘要翻译：本发明涉及具有改善的储存稳定性的透皮给药组合物，其含有利伐斯的明或其盐。用于本发明透皮给药的组合物使用龙胆酸作为利伐斯的明的稳定剂，其中龙胆酸具有比生育酚更好的利伐斯的明稳定性，市售上使用的制剂易于处理并且商业上便宜。根据本发明，组合物具有改善的稳定性，因此可以长时间作为透皮给药用药物储存。

2. 发明申请

WO2011102655A3 COMPOSITION FOR PERCUTANEOUS ADMINISTRATION OF TOLTERODINE WITH REDUCED SKIN IRRITATION 审中-公开
标题翻译：用于皮肤刺激减轻的多巴酚丁胺治疗组合物
公开(公告)号：WO2011102655A3
公开(公告)日：2012-01-19
申请号：PCT/KR2011001061
申请日：2011-02-17
申请人： SK CHEMICALS CO LTD , HWANG YONG YOUN , CHOI WON-JAE , KIM JAE-SUN , PARK YEO-JIN , OH JOON-GYO , RHEE HAE-IN , IM JONG-SEOB , LEE BONG-YONG
发明人： HWANG YONG YOUN , CHOI WON-JAE , KIM JAE-SUN , PARK YEO-JIN , OH JOON-GYO , RHEE HAE-IN , IM JONG-SEOB , LEE BONG-YONG
IPC分类号： A61K47/44 , A61K31/137 , A61P13/10
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/44
摘要： The present invention relates to a composition for percutaneous administration, in which an essential oil serving as an abirritant is mixed to minimize skin irritation caused by the composition for percutaneous administration, containing tolterodine. The composition for percutaneous administration according to the present invention reduces skin irritation caused by tolterodine, thereby making percutaneous preparations containing tolterodine commercially available.
摘要翻译：本发明涉及一种用于经皮给药的组合物，其中将用作刺激剂的精油混合以使包含托特罗定的经皮给药组合物引起的皮肤刺激最小化。根据本发明的用于经皮给药的组合物减少了托特罗定引起的皮肤刺激，由此制备了含有托特罗定的经皮制剂。

3. 发明申请

WO2011102657A3 COMPOSITION FOR PERCUTANEOUS ADMINISTRATION OF TOLTERODINE WITH IMPROVED SKIN PERMEATION 审中-公开
标题翻译：用于皮肤渗透性改善的多巴酚丁胺治疗组合物
公开(公告)号：WO2011102657A3
公开(公告)日：2012-01-12
申请号：PCT/KR2011001064
申请日：2011-02-17
申请人： SK CHEMICALS CO LTD , HWANG YONG YOUN , CHOI WON-JAE , KIM JAE-SUN , PARK YEO-JIN , OH JOON-GYO , IM JONG-SEOB , RHEE HAE-IN , LEE BONG-YONG
发明人： HWANG YONG YOUN , CHOI WON-JAE , KIM JAE-SUN , PARK YEO-JIN , OH JOON-GYO , IM JONG-SEOB , RHEE HAE-IN , LEE BONG-YONG
IPC分类号： A61K9/70 , A61K31/137 , A61P13/10
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/167 , A61K2300/00
摘要： The present invention relates to a composition for percutaneous administration, containing tolterodine, wherein the composition comprises lidocaine or pharmaceutically acceptable salts thereof so as to improve skin permeation. The composition for percutaneous administration according to the present invention improves skin permeation of tolterodine, thereby making percutaneous preparations of tolterodine commercially available.
摘要翻译：本发明涉及含有托特罗定的经皮给药组合物，其中组合物包含利多卡因或其药学上可接受的盐，以改善皮肤渗透。根据本发明的用于经皮给药的组合物改善了托特罗定的皮肤渗透，从而使得托特罗定的经皮制剂可商购。

4. 发明申请

WO2009066956A3 LYOPHILIZED PHARMACEUTICAL COMPOSITION WITH IMPROVED RECONSTITUTION TIME CONTAINING TAXANE DERIVATIVES AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：具有改进的包含TAXANE衍生物的重新构建时间的LYOPHILIZED药物组合物及其制备方法
公开(公告)号：WO2009066956A3
公开(公告)日：2009-07-16
申请号：PCT/KR2008006876
申请日：2008-11-21
申请人： SK CHEMICALS CO LTD , JANG WOO JAE , OH JOON-GYO , HWANG YONG YOUN , CHOI WON JAE , UM KEY AN
发明人： JANG WOO JAE , OH JOON-GYO , HWANG YONG YOUN , CHOI WON JAE , UM KEY AN
IPC分类号： A61K31/337
CPC分类号： A61K9/19 , A61K47/26 , A61K47/32
摘要： The present invention relates to a lyophilized composition with an improved reconstitution time comprising a taxoid and a method thereof. More specifically, the present invention relates to a lyophilized composition with an improved reconstitution time prepared by mixing and dissolving a taxoid; cyclodextrin(CD); a hydrophilic polymer selected from the group consisting of hydroxypropylmethyl CeIIuIoSe(HPMC), polyethylene glycol(PEG), and polyvinylpyrrolidone(PVP); and a bulking agent of saccharides in water for injection; and lyophilizing the mixture, and a method thereof.
摘要翻译：本发明涉及具有改进的重构时间的冻干组合物，其包含紫杉烷及其方法。更具体地，本发明涉及通过混合和溶解紫杉烷制备的具有改进的重构时间的冻干组合物; 环糊精（CD）; 选自羟丙基甲基CeIIuIoSe（HPMC），聚乙二醇（PEG）和聚乙烯吡咯烷酮（PVP）的亲水性聚合物; 和糖类在注射用水中的填充剂; 并将混合物冻干，及其方法。

5. 发明申请

WO2009066955A3 LYOPHILIZED PHARMACEUTICAL COMPOSITION WITH IMPROVED STABILITY CONTAINING TAXANE DERIVATIVES, AND METHOD OF MANUFACTURING THE SAME 审中-公开
公开(公告)号：WO2009066955A3
公开(公告)日：2009-05-28
申请号：PCT/KR2008/006875
申请日：2008-11-21
申请人： SK CHEMICALS CO., LTD. , HWANG, Yong Youn , JANG, Woo Jae , OH, Joon-Gyo , KIM, Nam Ho , KIM, Jae-Sun , UM, Key An
发明人： HWANG, Yong Youn , JANG, Woo Jae , OH, Joon-Gyo , KIM, Nam Ho , KIM, Jae-Sun , UM, Key An
IPC分类号： A61K9/19 , A61K31/337 , A61K9/127 , A61P35/00
摘要： The present invention relates to a lyophilized pharmaceutical composition for injection having superior storage stability comprising a taxoid, and a method thereof. More specifically, the present invention relates to a lyophilized pharmaceutical composition for injection having improved solubility and stability of dilution compared to the conventional preparations by dissolving a water-insoluble taxoid in distilled water added with a hydrophilic polymer such as hydroxypropylmethyl cellulose(HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone(PVP)cyclodextrin (CD), and lyophilizing the mixture and a method thereof.

6. 发明申请

WO2012161489A3 PATCH CONTAINING RIVASTIGMINE 审中-公开
标题翻译：包含RIVASTIGMINE的PATCH
公开(公告)号：WO2012161489A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012003986
申请日：2012-05-21
申请人： SK CHEMICALS CO LTD , HWANG YONG-YOUN , CHOI WON-JAE , KIM JAE-SUN , YOUN WON-NO , PARK YEO-JIN , OH JOON-GYO , IM JONGSEOB
发明人： HWANG YONG-YOUN , CHOI WON-JAE , KIM JAE-SUN , YOUN WON-NO , PARK YEO-JIN , OH JOON-GYO , IM JONGSEOB
IPC分类号： A61K9/70 , A61F13/02 , A61K31/325 , A61L15/44
CPC分类号： A61K31/325 , A61K9/7061 , A61K9/7084 , A61K31/27 , A61L15/44 , A61L15/58 , A61L2300/00
摘要： The present invention relates to a patch containing rivastigmine having improved storage stability and proper release properties.
摘要翻译：本发明涉及具有改善的储存稳定性和适当释放性质的利伐斯的明片。

7. 发明申请

WO2012064088A3 PHARMACEUTICAL COMPOSITION INCLUDING POLYMER MICROSPHERE CONTAINING OLANZAPINE AS ACTIVE INGREDIENT 审中-公开
标题翻译：包含含有作为活性成分的氯氮平的聚合物微球的药物组合物
公开(公告)号：WO2012064088A3
公开(公告)日：2012-07-19
申请号：PCT/KR2011008470
申请日：2011-11-08
申请人： SK CHEMICALS CO LTD , UNIV EWHA IND COLLABORATION , SAH HONG KEE , LEE KYU HO , HONG SEOK HYUN , LEE YOON-JUNG , OH JOON-GYO , UM KEY-AN , LEE BONG-YONG , HWANG YONG YOUN , YUN SUN KYU , KIM HONG-KEE
发明人： SAH HONG KEE , LEE KYU HO , HONG SEOK HYUN , LEE YOON-JUNG , OH JOON-GYO , UM KEY-AN , LEE BONG-YONG , HWANG YONG YOUN , YUN SUN KYU , KIM HONG-KEE
IPC分类号： A61K9/16 , A61K9/14 , A61K31/551 , A61P25/24
CPC分类号： A61K31/551 , A61K9/5021
摘要： The present invention relates to a pharmaceutical composition including a polymer microsphere that contains olanzapine as an active ingredient, and more particularly, to a pharmaceutical composition including a polymer microsphere containing olanzapine as an active ingredient, for treating or preventing a disease or a symptom thereof, the disease selected from a group comprised of schizophrenia and related mental illnesses, bipolar mania, bipolar disorder, seizure, obsessive/compulsive disorder, generalized anxiety disorder, post traumatic distress syndrome, extreme shyness, diabetic nerve pain, and depression, and to a method for preventing or treating, and usage thereof, and the pharmaceutical composition prepared by a method comprising the following steps: mixing a water insoluble organic solvent and a dispersion solvent; preparing a dispersion by mixing a polymer compound, olanzapine, and the water insoluble organic solvent; manufacturing an emulsion by mixing the dispersion with the dispersion solvent in which the water insoluble organic solvent while maintaining the temperature of the emulsion between 0°C to 10°C; and eliminating the water insoluble organic solvent from the emulsion by adding a base or an acid while maintaining the emulsion between 0°C to 10°C. The method for preparing of the present invention does not involve the existing steps of solvent evaporation or solvent extraction, uses little amount of water thereby minimizing waste water generation, while allowing for preparing the polymer microsphere including olanzapine in a swift and simple manner, maintains a low density of solvent remnants inside the polymer microsphere, and is effective for manufacturing sustained-release medicine including anastrozole, as the speed of releasing anastrozole in the body can be adjusted.
摘要翻译：本发明涉及包含含有奥氮平作为活性成分的聚合物微球的药物组合物，并且更具体地涉及包含含有奥氮平作为活性成分的聚合物微球的药物组合物，用于治疗或预防疾病或其症状，选自精神分裂症和相关精神疾病，双相躁狂症，双相性精神障碍，癫痫发作，强迫症，广泛性焦虑症，创伤后窘迫综合征，极度羞怯，糖尿病性神经痛和抑郁症的组的疾病以及方法用于预防或治疗，以及其用途，以及通过包括以下步骤的方法制备的药物组合物：混合水不溶性有机溶剂和分散溶剂; 通过混合聚合物化合物奥氮平和水不溶性有机溶剂来制备分散体; 通过将分散体与其中水不溶性有机溶剂在其中的分散溶剂混合，同时将乳液的温度保持在0℃至10℃之间来制备乳液; 并通过添加碱或酸从乳液中除去不溶于水的有机溶剂，同时保持乳液在0℃至10℃之间。本发明的制备方法不涉及溶剂蒸发或溶剂萃取的现有步骤，使用少量的水，从而使废水产生最小化，同时允许以快速和简单的方式制备包括奥氮平的聚合物微球，聚合物微球内部的溶剂残余物的密度低，并且因为可以调节体内释放阿那曲唑的速度，所以对于制造包括阿那曲唑的缓释药物是有效的。

8. 发明申请

WO2012011740A8 METHOD FOR PREPARING MICROSPHERES AND MICROSPHERES PRODUCED THEREBY 审中-公开
公开(公告)号：WO2012011740A8
公开(公告)日：2012-01-26
申请号：PCT/KR2011/005347
申请日：2011-07-20
申请人： SK CHEMICALS CO., LTD. , EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , SAH, Hong Kee , LEE, Bong-Yong , UM, Key-An , OH, Joon-gyo , HWANG, Yong Youn , KIM, Hong-Kee , LEE, Kyu Ho , HONG, Seok Hyun , LEE, Yoon-Jung
发明人： SAH, Hong Kee , LEE, Bong-Yong , UM, Key-An , OH, Joon-gyo , HWANG, Yong Youn , KIM, Hong-Kee , LEE, Kyu Ho , HONG, Seok Hyun , LEE, Yoon-Jung
IPC分类号： A61K9/14 , A61K9/22 , A61K31/57 , C08J3/12
摘要： The present invention relates to a method for preparing microsphere and microspheres produced by thereby. More particularly, the present invention relates to a method for preparing a polymeric microsphere comprising the steps of: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent so as to prepare an emulsion; and adding a base or an acid to the prepared emulsion so as to remove the water-insoluble organic solvent from the emulsion and a polymeric microsphere thereby, and a composition for drug delivery comprising the microspheres. In the inventive preparation method, it is possible to conveniently prepare a drug-containing polymeric microsphere within a short time using a small amount of water, with the generation of a minimized amount of waste solution without a requirement of a conventional solvent-evaporation or solvent-extract ion process. Also, since a low concentration of remaining solvent within a prepared polymeric microsphere can be maintained, it is effective in preparation in sustained-release type medicines.

9. 发明申请

WO2012011740A3 METHOD FOR PREPARING MICROSPHERES AND MICROSPHERES PRODUCED THEREBY 审中-公开
公开(公告)号：WO2012011740A3
公开(公告)日：2012-01-26
申请号：PCT/KR2011/005347
申请日：2011-07-20
申请人： SK CHEMICALS CO., LTD. , EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , SAH, Hong Kee , LEE, Bong-Yong , UM, Key-An , OH, Joon-gyo , HWANG, Yong Youn , KIM, Hong-Kee , LEE, Kyu Ho , HONG, Seok Hyun , LEE, Yoon-Jung
发明人： SAH, Hong Kee , LEE, Bong-Yong , UM, Key-An , OH, Joon-gyo , HWANG, Yong Youn , KIM, Hong-Kee , LEE, Kyu Ho , HONG, Seok Hyun , LEE, Yoon-Jung
IPC分类号： A61K9/14 , A61K9/22 , A61K31/57 , C08J3/12
摘要： The present invention relates to a method for preparing microsphere1- and microspheres produced by thereby. More particularly, the present invention relates to a method for preparing a polymeric microsphere comprising the steps of: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent so as to prepare an emulsion; and adding a base or an acid to the prepared emulsion so as to remove the water-insoluble organic solvent from the emulsion and a polymeric microsphere thereby, and a composition for drug delivery comprising the microspheres. In the inventive preparation method, it is possible to conveniently prepare a drug-containing polymeric microsphere within a short time using a small amount of water, with the generation of a minimized amount of waste solution without a requirement of a conventional solvent-evaporation or solvent-extract ion process. Also, since a low concentration of remaining solvent within a prepared polymeric microsphere can be maintained, it is effective in preparation in sustained-release type medicines.

10. 发明申请

WO2011002161A2 TRANSDERMAL COMPOSITION COMPRISING TOLTERODINE 审中-公开
标题翻译：包含托特罗定的透皮组合物
公开(公告)号：WO2011002161A2
公开(公告)日：2011-01-06
申请号：PCT/KR2010/003365
申请日：2010-05-27
申请人： SK CHEMICALS CO., LTD. , HWANG, Yong Youn , CHOI, Won-Jae , PARK, Yeo-jin , OH, Joon-gyo
发明人： HWANG, Yong Youn , CHOI, Won-Jae , PARK, Yeo-jin , OH, Joon-gyo
IPC分类号： A61K9/20 , A61P13/10 , A61K31/137 , A61K9/70
CPC分类号： A61K31/137 , A61K9/06 , A61K9/7061 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/38
摘要： A transdermal composition comprising tolterodine having improved storage stability is disclosed. The transdermal composition comprising tolterodine contains an antioxidant to stabilize tolterodine and can be stored for a long period of time.
摘要翻译：公开了包含具有改善的储存稳定性的托特罗定的透皮组合物。包含托特罗定的透皮组合物含有抗氧化剂以稳定托特罗定并且可以长时间储存。

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