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1. 发明申请

WO2012154362A1 DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS 审中-公开
标题翻译：用于输送和/或取出流体和保存流体的装置和方法
公开(公告)号：WO2012154362A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/032846
申请日：2012-04-10
申请人： SEVENTH SENSE BIOSYSEMS, INC. , BERNSTEIN, Howard , BLICHARZ, Timothy M.
发明人： BERNSTEIN, Howard , BLICHARZ, Timothy M.
IPC分类号： A61B17/14 , A61B17/06 , A61B10/02
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15123 , A61B5/15125 , A61B50/30 , A61B2010/008 , A61M2037/0023
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽出或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可将该装置应用于皮肤并被激活以从受试者中抽出血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

2. 发明申请

WO2010151329A1 ASSAYS INVOLVING COLORIMETRIC SIGNALING 审中-公开
标题翻译：涉及彩色信号的测定
公开(公告)号：WO2010151329A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/001820
申请日：2010-06-24
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , BLICHARZ, Timothy, M.
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E. , BLICHARZ, Timothy, M.
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , G01N21/78 , G01N21/783 , G01N21/80 , G01N21/82 , G01N2021/7783 , G01N2021/7786
摘要： The present invention generally relates to particles and, in particular, to methods of determining binding involving particles, e.g., using colorimetric and other signaling techniques. In one aspect, a mixture of particles of different colors (e.g., at least a first color and a second color) is provided that exhibits a first collective color, e.g., due to the presence of the different colors of particles within the mixture. The mixture can then be exposed to a medium containing a binding partner able to preferentially bind to some of the particles, e.g., particles of a first color relative to particles of a second color. The bound particles can be separated in some fashion (e.g., filtration, gravity, magnetism, centrifugal separation, etc.), such that the mixture exhibits a second collective color, e.g., due to the presence of a greater number of particles of the second color relative to the number of particles of the first color. Accordingly, by visualizing or otherwise determining a color change, a binding event may be determined. Other aspects of the invention relate to kits involving such particles, methods of promoting the making or use of such particles, or the like.
摘要翻译：本发明一般涉及颗粒，特别是关于确定涉及颗粒的结合的方法，例如使用比色和其它信号传导技术。在一个方面，提供了不同颜色（例如，至少第一颜色和第二颜色）的颗粒的混合物，其表现出第一集合颜色，例如由于在混合物内存在不同颜色的颗粒。然后可以将混合物暴露于含有能够优先结合一些颗粒的结合配偶体的介质，例如相对于第二种颜色的颗粒的第一种颜色的颗粒。结合的颗粒可以以某种方式分离（例如，过滤，重力，磁性，离心分离等），使得混合物呈现第二集合颜色，例如由于存在更多数量的第二颜色相对于第一颜色的颗粒数。因此，通过可视化或以其他方式确定颜色变化，可以确定结合事件。本发明的其它方面涉及涉及这种颗粒的试剂盒，促进制造或使用这种颗粒的方法等。

3. 发明申请

WO2011088214A2 RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
标题翻译：快速交付和/或取消流体
公开(公告)号：WO2011088214A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021134
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. ,III , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A. , MICHELMAN, Mark
发明人： CHICKERING, Donald, E. ,III , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A. , MICHELMAN, Mark
IPC分类号： A61M5/178 , A61B5/151 , A61B5/145
CPC分类号： A61B5/6849 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明总体上涉及用于递送和/或从皮肤和/或皮肤下面的受试者递送和/或取出物质或诸如血液或间质液的物质的方法。在一个方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从皮肤和/或从皮肤下方抽取或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

4. 发明申请

WO2011088211A2 SAMPLING DEVICE INTERFACES 审中-公开
标题翻译：采样设备接口
公开(公告)号：WO2011088211A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021131
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A.
发明人： CHICKERING, Donald, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A.
IPC分类号： A61B5/151
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self- contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明总体上涉及用于从受试者（例如从皮肤和/或从皮肤下方）输送和/或排出一种或多种物质（例如血液或间质液）的系统和方法。在一个方面，本发明总体上涉及用于使用含有液体转运体的装置（例如，一个或多个微针）从受试者（例如从皮肤和/或皮肤下面）抽取或抽取血液的装置和方法）以及在接收血液之前具有小于大气压的内部压力的储存室。在某些情况下，该装置可以是自包含的，并且在某些情况下，该装置可以被施加到皮肤上，并且被激活以从受试者中抽取血液。该装置在某些情况下可以与外部设备连接以确定装置内包含的或被装置收集的流体内包含的分析物。例如，该装置可以被安装或接合在外部保持器上，该装置可以包括用于将流体输送出装置的端口，该装置可以包括用于询问容纳在装置内的流体的窗口等。然后可以处理装置或其一部分，以单独地或利用外部装置来确定血液和/或血液内的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽取血液（或其他体液，例如间质液）的其它装置，涉及这种装置的套件，制造这种装置的方法，使用这种装置的方法等。

5. 发明申请

WO2011053796A2 SYSTEMS AND METHODS FOR TREATING, SANITIZING, AND/OR SHIELDING THE SKIN OR DEVICES APPLIED TO THE SKIN 审中-公开
标题翻译：用于治疗，消毒和/或屏蔽皮肤或适用于皮肤的装置的系统和方法
公开(公告)号：WO2011053796A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054741
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for treating, sanitizing, and/or shielding blood on the surface of the skin or devices applied to the skin. In one set of embodiments, while blood is withdrawn from the skin of the subject, the blood is covered and/or shielded such that the blood is not seen by the subject. In another set of embodiments, any blood present on the skin may be altered or treated such that it no longer appears as blood, e.g., by exposing the blood to a chemical such as a peroxide that alters the color of the blood. In yet another set of embodiments, blood present on the skin is withdrawn or taken up by the device such that visible residual blood is not present in an amount visible to the unaided eye once the device is removed. In some cases, the same device may be used to sanitize the skin and deliver to and/or withdraw fluid from the skin and/or beneath the skin. The sanitization may be performed before, during, or after delivering to and/or withdrawing fluid from the skin and/or beneath the skin. Sanitization may be performed, for example, using a sanitizer such as hydrogen peroxide, ethyl alcohol, isopropyl alcohol, or the like.
摘要翻译：本发明在某些方面通常涉及用于治疗，消毒和/或屏蔽皮肤表面上的血液或施用于皮肤的装置的系统和方法。在一组实施方案中，当血液从受试者的皮肤中抽出时，血液被覆盖和/或被屏蔽，使得受试者看不到血液。在另一组实施方案中，存在于皮肤上的任何血液可以被改变或治疗，使得其不再像血液一样出现，例如通过将血液暴露于改变血液颜色的化学物质例如过氧化物。在另一组实施方案中，存在于皮肤上的血液被装置取出或吸收，使得一旦该装置被移除，可见的残留血液就不能以肉眼可见的量存在。在一些情况下，可以使用相同的装置来消毒皮肤并递送至/或从皮肤和/或皮肤下方排出流体。消毒可以在从皮肤和/或皮肤之下输送和/或从中释放流体之前，期间或之后进行。可以例如使用消毒剂如过氧化氢，乙醇，异丙醇等进行消毒。

6. 发明申请

WO2008060934A2 FORMULATIONS OF TETRAHYDROPYRIDINE ANTIPLATELET AGENTS FOR PARENTERAL OR ORAL ADMINISTRATION 审中-公开
标题翻译：用于肠胃外或口服给药的四氢吡啶抗血小板药物的制剂
公开(公告)号：WO2008060934A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084040
申请日：2007-11-08
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , CARNEIRO, Olinda , JAIN, Rajeev A. , PANDIT, Namrata , RANE, Shveta , STRAUB, Julie Ann
发明人： BERNSTEIN, Howard , CARNEIRO, Olinda , JAIN, Rajeev A. , PANDIT, Namrata , RANE, Shveta , STRAUB, Julie Ann
IPC分类号： A61K9/00 , A61K9/107 , A61K9/16 , A61K31/4365
CPC分类号： A61K31/4365 , A61K9/0019 , A61K9/1075 , A61K9/1617 , A61K9/19
摘要： A pharmaceutical composition for the oral or parenteral administration of a compound of Formula (I) comprising an oil in water emulsion, wherein the oil phase comprises the free base of or a pharmaceutically acceptable salt thereof of a compound of Formula (I), and one or more surfactants which are soluble in the oil phase and/or the aqueous phase. The emulsion optionally contains one or more excipients that are soluble in the oil phase and/or the aqueous phase, such as pH modifying agents such as buffers, osmolality/tonicity modifying agents, emulsifying agents, water-soluble polymers, and preservatives. The compound of Formula (I) can be formulated as a solid material and stored until needed. Kits for forming the emulsion are provided. Prior to administration, the solid material can be reconstituted in an aqueous medium to form the emulsion.
摘要翻译：一种用于口服或肠胃外给药式（I）化合物的药物组合物，其包含水包油乳剂，其中所述油相包含化合物的游离碱或其药学上可接受的盐（I）的化合物和一种或多种可溶于油相和/或水相的表面活性剂。乳剂任选含有一种或多种可溶于油相和/或水相的赋形剂，例如pH调节剂如缓冲剂，渗透压/张力调节剂，乳化剂，水溶性聚合物和防腐剂。式（I）化合物可以配制成固体材料并储存直至需要。提供用于形成乳液的试剂盒。在给药之前，固体材料可以在水性介质中重构以形成乳液。

7. 发明申请

WO2005032523A1 INJECTABLE, ORAL, OR TOPICAL SUSTAINED RELEASE PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：可注射，口服或局部持续释放药物制剂
公开(公告)号：WO2005032523A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/031570
申请日：2004-09-27
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , HUANG, Eric, K. , NARASIMHAN, Sridhar , REESE, Shaina , STRAUB, Julie, A.
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , HUANG, Eric, K. , NARASIMHAN, Sridhar , REESE, Shaina , STRAUB, Julie, A.
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/1617
摘要： Pharmaceutical formulations and methods are provided for the sustained delivery of a pharmaceutical agent to a patient by injection, by oral administration or by topical administration. The injectable formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein upon injection of the formulation a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 24 hours. The oral formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 2 hours following oral administration. The topical formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 2 hours following topical administration.
摘要翻译：提供药物制剂和方法用于通过注射，口服给药或通过局部给药将药剂持续递送至患者。可注射制剂包括包含药剂和基质材料的多孔微粒，其中在注射制剂时，治疗或预防有效量的药剂从微粒释放至少24小时。口服制剂包括包含药剂和基质材料的多孔微粒，其中在口服给药后至少2小时将治疗或预防有效量的药剂从微粒释放至少2小时。局部制剂包括包含药剂和基质材料的多孔微粒，其中治疗或预防有效量的药剂在局部给药后从微粒释放至少2小时。

8. 发明申请

WO2012021792A2 CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES 审中-公开
标题翻译：临床和/或消费者技术和设备
公开(公告)号：WO2012021792A2
公开(公告)日：2012-02-16
申请号：PCT/US2011/047565
申请日：2011-08-12
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. III. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
发明人： CHICKERING, Donald, E. III. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
IPC分类号： A61M5/142
CPC分类号： A61M37/0015 , A61B5/117 , A61B5/14514 , A61B5/150984 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/96 , A61B90/98 , A61B2560/0412 , A61M5/14248 , A61M37/00 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/6009 , A61M2205/6072 , A61N1/30 , A61N1/325
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.
摘要翻译：本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。

9. 发明申请

WO2011163347A2 SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN 审中-公开
标题翻译：采用相关的轻度疼痛的装置和方法
公开(公告)号：WO2011163347A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041430
申请日：2011-06-22
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
发明人： CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
IPC分类号： A61M37/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。一方面，本发明一般涉及使用包括物质转移组件（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及存储室在接收血液之前具有小于大气压的内部压力。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

10. 发明申请

WO2011053788A2 RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：相对较小的装置适用于皮肤，模块化系统及其使用方法
公开(公告)号：WO2011053788A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054725
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32 , A61B5/151 , A61B5/157
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.
摘要翻译：在某些方面，本发明一般涉及应用于皮肤的相对较小的装置，模块化系统及其使用方法。在一些方面，该装置被构造并布置成具有多于一个模块。例如，该装置可以具有用于向皮肤和/或皮肤下方递送和/或抽出流体的模块和用于传输指示输送到皮肤和/或从皮肤抽出的流体的信号的模块，以及 /或在受试者的皮肤下方，用于分析从皮肤和/或受试者的皮肤下面抽出的流体的模块等。在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，连接和/或分离可在装置与对象接触时执行，例如在固定到对象时。在一些实施例中，该装置可以重复地适用于受试者的皮肤，以例如在相同的位置处或者在受试者的皮肤上的不同位置向受试者的皮肤和/或皮肤下方递送流体和/ 受试者的皮肤。在一些方面中，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，装置的尺寸可以是可穿戴的和/或能够由对象携带。例如，该装置可以具有允许装置被对象携带或佩戴不同时间段的质量和/或尺寸，例如至少约一小时，至少约一天，至少约一周等，或不超过约一小时，不超过约十分钟等。

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