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1. 发明申请

WO2010151329A1 ASSAYS INVOLVING COLORIMETRIC SIGNALING 审中-公开
标题翻译：涉及彩色信号的测定
公开(公告)号：WO2010151329A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/001820
申请日：2010-06-24
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , BLICHARZ, Timothy, M.
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E. , BLICHARZ, Timothy, M.
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , G01N21/78 , G01N21/783 , G01N21/80 , G01N21/82 , G01N2021/7783 , G01N2021/7786
摘要： The present invention generally relates to particles and, in particular, to methods of determining binding involving particles, e.g., using colorimetric and other signaling techniques. In one aspect, a mixture of particles of different colors (e.g., at least a first color and a second color) is provided that exhibits a first collective color, e.g., due to the presence of the different colors of particles within the mixture. The mixture can then be exposed to a medium containing a binding partner able to preferentially bind to some of the particles, e.g., particles of a first color relative to particles of a second color. The bound particles can be separated in some fashion (e.g., filtration, gravity, magnetism, centrifugal separation, etc.), such that the mixture exhibits a second collective color, e.g., due to the presence of a greater number of particles of the second color relative to the number of particles of the first color. Accordingly, by visualizing or otherwise determining a color change, a binding event may be determined. Other aspects of the invention relate to kits involving such particles, methods of promoting the making or use of such particles, or the like.
摘要翻译：本发明一般涉及颗粒，特别是关于确定涉及颗粒的结合的方法，例如使用比色和其它信号传导技术。在一个方面，提供了不同颜色（例如，至少第一颜色和第二颜色）的颗粒的混合物，其表现出第一集合颜色，例如由于在混合物内存在不同颜色的颗粒。然后可以将混合物暴露于含有能够优先结合一些颗粒的结合配偶体的介质，例如相对于第二种颜色的颗粒的第一种颜色的颗粒。结合的颗粒可以以某种方式分离（例如，过滤，重力，磁性，离心分离等），使得混合物呈现第二集合颜色，例如由于存在更多数量的第二颜色相对于第一颜色的颗粒数。因此，通过可视化或以其他方式确定颜色变化，可以确定结合事件。本发明的其它方面涉及涉及这种颗粒的试剂盒，促进制造或使用这种颗粒的方法等。

2. 发明申请

WO2011088214A2 RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
标题翻译：快速交付和/或取消流体
公开(公告)号：WO2011088214A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021134
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. ,III , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A. , MICHELMAN, Mark
发明人： CHICKERING, Donald, E. ,III , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A. , MICHELMAN, Mark
IPC分类号： A61M5/178 , A61B5/151 , A61B5/145
CPC分类号： A61B5/6849 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明总体上涉及用于递送和/或从皮肤和/或皮肤下面的受试者递送和/或取出物质或诸如血液或间质液的物质的方法。在一个方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从皮肤和/或从皮肤下方抽取或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

3. 发明申请

WO2011088211A2 SAMPLING DEVICE INTERFACES 审中-公开
标题翻译：采样设备接口
公开(公告)号：WO2011088211A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021131
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A.
发明人： CHICKERING, Donald, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A.
IPC分类号： A61B5/151
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self- contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明总体上涉及用于从受试者（例如从皮肤和/或从皮肤下方）输送和/或排出一种或多种物质（例如血液或间质液）的系统和方法。在一个方面，本发明总体上涉及用于使用含有液体转运体的装置（例如，一个或多个微针）从受试者（例如从皮肤和/或皮肤下面）抽取或抽取血液的装置和方法）以及在接收血液之前具有小于大气压的内部压力的储存室。在某些情况下，该装置可以是自包含的，并且在某些情况下，该装置可以被施加到皮肤上，并且被激活以从受试者中抽取血液。该装置在某些情况下可以与外部设备连接以确定装置内包含的或被装置收集的流体内包含的分析物。例如，该装置可以被安装或接合在外部保持器上，该装置可以包括用于将流体输送出装置的端口，该装置可以包括用于询问容纳在装置内的流体的窗口等。然后可以处理装置或其一部分，以单独地或利用外部装置来确定血液和/或血液内的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽取血液（或其他体液，例如间质液）的其它装置，涉及这种装置的套件，制造这种装置的方法，使用这种装置的方法等。

4. 发明申请

WO2011053796A2 SYSTEMS AND METHODS FOR TREATING, SANITIZING, AND/OR SHIELDING THE SKIN OR DEVICES APPLIED TO THE SKIN 审中-公开
标题翻译：用于治疗，消毒和/或屏蔽皮肤或适用于皮肤的装置的系统和方法
公开(公告)号：WO2011053796A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054741
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for treating, sanitizing, and/or shielding blood on the surface of the skin or devices applied to the skin. In one set of embodiments, while blood is withdrawn from the skin of the subject, the blood is covered and/or shielded such that the blood is not seen by the subject. In another set of embodiments, any blood present on the skin may be altered or treated such that it no longer appears as blood, e.g., by exposing the blood to a chemical such as a peroxide that alters the color of the blood. In yet another set of embodiments, blood present on the skin is withdrawn or taken up by the device such that visible residual blood is not present in an amount visible to the unaided eye once the device is removed. In some cases, the same device may be used to sanitize the skin and deliver to and/or withdraw fluid from the skin and/or beneath the skin. The sanitization may be performed before, during, or after delivering to and/or withdrawing fluid from the skin and/or beneath the skin. Sanitization may be performed, for example, using a sanitizer such as hydrogen peroxide, ethyl alcohol, isopropyl alcohol, or the like.
摘要翻译：本发明在某些方面通常涉及用于治疗，消毒和/或屏蔽皮肤表面上的血液或施用于皮肤的装置的系统和方法。在一组实施方案中，当血液从受试者的皮肤中抽出时，血液被覆盖和/或被屏蔽，使得受试者看不到血液。在另一组实施方案中，存在于皮肤上的任何血液可以被改变或治疗，使得其不再像血液一样出现，例如通过将血液暴露于改变血液颜色的化学物质例如过氧化物。在另一组实施方案中，存在于皮肤上的血液被装置取出或吸收，使得一旦该装置被移除，可见的残留血液就不能以肉眼可见的量存在。在一些情况下，可以使用相同的装置来消毒皮肤并递送至/或从皮肤和/或皮肤下方排出流体。消毒可以在从皮肤和/或皮肤之下输送和/或从中释放流体之前，期间或之后进行。可以例如使用消毒剂如过氧化氢，乙醇，异丙醇等进行消毒。

5. 发明申请

WO2012149134A8 DEVICES AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS 审中-公开
公开(公告)号：WO2012149134A8
公开(公告)日：2012-11-01
申请号：PCT/US2012/035173
申请日：2012-04-26
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , DAVIS, Shawn , GONG, Ping , HORTON, Kristin , JAMES, Scott
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E. , DAVIS, Shawn , GONG, Ping , HORTON, Kristin , JAMES, Scott
IPC分类号： A61B5/15 , A61B5/151 , A61B10/00 , G01N27/30 , A61B5/145
摘要： The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed.

6. 发明申请

WO2011053787A2 SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY AND/OR PERCEPTION THEREOF 审中-公开
标题翻译：用于皮肤应用的系统和方法及其致动，传递和/或认知的控制
公开(公告)号：WO2011053787A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054723
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
发明人： CHICKERING, Donald, E. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
IPC分类号： A61M5/32 , A61B5/155 , A61B5/151
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150122 , A61B5/150129 , A61B5/150137 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150893 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.
摘要翻译：本发明在某些方面一般涉及用于皮肤的系统和方法，以及对其致动，传递和/或感知的控制。例如，本发明的某些方面通常涉及用于递送到和/或从流体或从受试者递送到皮肤和/或从皮肤下方的装置。在一个方面，流体的递送和/或排出至少部分地模糊。例如，遮蔽可以是时间，和/或通过感觉遮蔽（例如，通过提供触觉，嗅觉，听觉和/或视觉感觉）。本发明的某些方面通常涉及能够在活化后自动递送至皮肤和/或皮下的流体的装置，例如在流体被输送和/或取出而不需要任何额外干预的情况下。可以通过任何合适的技术来激活装置。在其他方面，装置可以包含在包装中，并且当从包装中取出时，可以构造和布置该装置，以便当该装置应用于皮肤时能够输送和/或抽出流体，并且在某些情况下，自动地和/或没有受试者或另一个人的进一步干预。

7. 发明申请

WO2012149126A1 PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE 审中-公开
标题翻译：等离子体或血清生产和减少压力下的流体
公开(公告)号：WO2012149126A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035152
申请日：2012-04-26
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , HAGHGOOIE, Ramin , CHICKERING, Donald, E., III , DAVIS, Shawn , MICHELMAN, Mark , BERNSTEIN, Howard , HORTON, Kristin
发明人： HAGHGOOIE, Ramin , CHICKERING, Donald, E., III , DAVIS, Shawn , MICHELMAN, Mark , BERNSTEIN, Howard , HORTON, Kristin
IPC分类号： G01N33/49 , A61B5/145 , A61B5/151 , A61B5/154 , A61B5/15
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： The present application generally relates to the separation of blood within a device to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. In certain embodiments, plasma, serum, or other fluids may be removed from the device by inserting a needle into a portion of the device that has reduced pressure, expelling gas into the device through the needle, then receiving plasma, serum, or other fluids through the needle.
摘要翻译：本申请通常涉及在装置内分离血液以形成血浆或血清。例如，可以将装置应用于受试者的皮肤以从受试者接收血液，并将血液通过分离膜，该分离膜将血液分离成血浆，并将部分浓缩在血细胞中。作为另一个例子，血液或血浆可能被允许在装置内凝结，血清（未经切开的血液部分）可以从装置中取出。在一些情况下，该装置可以包含诸如预包装真空的真空源，以便于接收血液和/或使血液通过分离膜以产生血浆或血清。在某些实施方案中，血浆，血清或其它流体可以通过将针插入到具有减压的装置的一部分中而从装置中移除，通过针将气体排出到装置中，然后接收血浆，血清或其它流体通过针。

8. 发明申请

WO2011094573A1 MONITORING OR FEEDBACK SYSTEMS AND METHODS 审中-公开
标题翻译：监控或反馈系统和方法
公开(公告)号：WO2011094573A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022967
申请日：2011-01-28
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Donald, E.
发明人： LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Donald, E.
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
摘要翻译：本发明一般涉及用于监测和/或提供受试者所采取的药物或其他药物的反馈的系统和方法。一方面，本发明涉及用于确定受试者皮肤内物种的装置和方法; 并根据物种的确定向对象产生反馈。反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于物种的确定的信息可以被传输到另一个实体，例如医疗保健提供者，计算机，相对等，其然后可以以某种方式向受试者提供反馈。在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受物种影响的化合物是否为存在等。然而，在一些实施例中，反馈也可以是间接的。例如，受试者可以例如基于皮肤内物种的确定来呈现外部奖励。例如，可以基于主体的合规级别来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。本发明的其它方面通常涉及涉及这种装置的试剂盒（有或没有待监测的药物），促进这种系统的方法等。

9. 发明申请

WO2011065972A2 PATIENT-ENACTED SAMPLING TECHNIQUE 审中-公开
标题翻译：以患者为对象的抽样技术
公开(公告)号：WO2011065972A2
公开(公告)日：2011-06-03
申请号：PCT/US2010/003045
申请日：2010-11-24
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas A. , BERNSTEIN, Howard , CHICKERING, Donald E. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： LEVINSON, Douglas A. , BERNSTEIN, Howard , CHICKERING, Donald E. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32 , A61B5/145
CPC分类号： A61B5/150984 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/74 , A61B10/0045 , A61B2010/008 , G06F19/00 , Y02A90/26
摘要： The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device.
摘要翻译：本发明总体上涉及用于从受试者采样流体的系统和方法。该流体可以是任何合适的体液，例如血液或间质液。在某些情况下，受试者是患者。受试者可以具有可以应用于受试者皮肤（例如，受试者或另一个人）的装置，并且该装置能够获得流体样本。流体可以存储在装置中的贮存器内，并且流体可以在任何方便的时间例如在家中远离医疗保健装置等从对象获得。在一些实施例中，装置或其一部分，可以返回到临床和/或实验室设置以分析存储在设备内的流体。

10. 发明申请

WO2010101621A1 DEVICES AND METHODS FOR THE ANALYSIS OF AN EXTRACTABLE MEDIUM 审中-公开
标题翻译：用于分析可萃取介质的装置和方法
公开(公告)号：WO2010101621A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/000624
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明总体上涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，该装置包括用于在进入位置处从受试者皮肤和/或穿过受试者的皮肤进入可提取介质的系统，以及由支撑结构支撑的压力调节器，其能够在访问站点的最少一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自受试者的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

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