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    • 1. 发明申请
      WO2012154362A1 DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS 审中-公开
    • DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS
    • 用于输送和/或取出流体和保存流体的装置和方法
    • WO2012154362A1
    • 2012-11-15
    • PCT/US2012/032846
    • 2012-04-10
    • SEVENTH SENSE BIOSYSEMS, INC. , BERNSTEIN, Howard , BLICHARZ, Timothy M.
    • BERNSTEIN, Howard , BLICHARZ, Timothy M.
    • A61B17/14 , A61B17/06 , A61B10/02
    • A61B5/1519 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15123 , A61B5/15125 , A61B50/30 , A61B2010/008 , A61M2037/0023
    • The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
    • 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽出或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 5. 发明申请
      WO2011094573A1 MONITORING OR FEEDBACK SYSTEMS AND METHODS 审中-公开
    • MONITORING OR FEEDBACK SYSTEMS AND METHODS
    • 监控或反馈系统和方法
    • WO2011094573A1
    • 2011-08-04
    • PCT/US2011/022967
    • 2011-01-28
    • SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Donald, E.
    • LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Donald, E.
    • G06F19/00
    • G06F19/3456 , G06F19/00 , Y02A90/26
    • The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
    • 本发明一般涉及用于监测和/或提供受试者所采取的药物或其他药物的反馈的系统和方法。 一方面，本发明涉及用于确定受试者皮肤内物种的装置和方法; 并根据物种的确定向对象产生反馈。 反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于物种的确定的信息可以被传输到另一个实体，例如医疗保健提供者，计算机， 相对等，其然后可以以某种方式向受试者提供反馈。 在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受物种影响的化合物是否为 存在等。然而，在一些实施例中，反馈也可以是间接的。 例如，受试者可以例如基于皮肤内物种的确定来呈现外部奖励。 例如，可以基于主体的合规级别来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。 本发明的其它方面通常涉及涉及这种装置的试剂盒（有或没有待监测的药物），促进这种系统的方法等。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 7. 发明申请
      WO2010151329A1 ASSAYS INVOLVING COLORIMETRIC SIGNALING 审中-公开
    • ASSAYS INVOLVING COLORIMETRIC SIGNALING
    • 涉及彩色信号的测定
    • WO2010151329A1
    • 2010-12-29
    • PCT/US2010/001820
    • 2010-06-24
    • SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , BLICHARZ, Timothy, M.
    • BERNSTEIN, Howard , CHICKERING, Donald, E. , BLICHARZ, Timothy, M.
    • G01N33/543
    • G01N33/54313 , G01N21/78 , G01N21/783 , G01N21/80 , G01N21/82 , G01N2021/7783 , G01N2021/7786
    • The present invention generally relates to particles and, in particular, to methods of determining binding involving particles, e.g., using colorimetric and other signaling techniques. In one aspect, a mixture of particles of different colors (e.g., at least a first color and a second color) is provided that exhibits a first collective color, e.g., due to the presence of the different colors of particles within the mixture. The mixture can then be exposed to a medium containing a binding partner able to preferentially bind to some of the particles, e.g., particles of a first color relative to particles of a second color. The bound particles can be separated in some fashion (e.g., filtration, gravity, magnetism, centrifugal separation, etc.), such that the mixture exhibits a second collective color, e.g., due to the presence of a greater number of particles of the second color relative to the number of particles of the first color. Accordingly, by visualizing or otherwise determining a color change, a binding event may be determined. Other aspects of the invention relate to kits involving such particles, methods of promoting the making or use of such particles, or the like.
    • 本发明一般涉及颗粒，特别是关于确定涉及颗粒的结合的方法，例如使用比色和其它信号传导技术。 在一个方面，提供了不同颜色（例如，至少第一颜色和第二颜色）的颗粒的混合物，其表现出第一集合颜色，例如由于在混合物内存在不同颜色的颗粒。 然后可以将混合物暴露于含有能够优先结合一些颗粒的结合配偶体的介质，例如相对于第二种颜色的颗粒的第一种颜色的颗粒。 结合的颗粒可以以某种方式分离（例如，过滤，重力，磁性，离心分离等），使得混合物呈现第二集合颜色，例如由于存在更多数量的第二 颜色相对于第一颜色的颗粒数。 因此，通过可视化或以其他方式确定颜色变化，可以确定结合事件。 本发明的其它方面涉及涉及这种颗粒的试剂盒，促进制造或使用这种颗粒的方法等。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 8. 发明申请
      WO2010101625A2 OXYGEN SENSOR 审中-公开
    • OXYGEN SENSOR
    • 氧传感器
    • WO2010101625A2
    • 2010-09-10
    • PCT/US2010/000630
    • 2010-03-02
    • SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard
    • LEVINSON, Douglas, A. , BERNSTEIN, Howard
    • A61B5/15 , A61B5/00 , G01N33/49 , G01N33/72
    • G01N33/84 , A61B5/021 , A61B5/14532 , A61B5/14542 , A61B5/411 , A61B2560/0412 , A61M5/14244 , G01N33/54366 , G01N33/72
    • The present invention generally relates to systems and methods for determining oxygen in a sample, or in a subject. In one aspect, the present invention is generally directed to an article exhibiting a determinable feature responsive to oxygen, such as oxygen-sensitive particles. The particles may exhibit a determinable change with a change in oxygen concentration, and such particles can accordingly be used to determine oxygen. For example, in one set of embodiments, the particles may be at least partially coated with a protein, such as hemoglobin, that is able to interact with oxygen. In some cases, the protein may aggregate under certain conditions (e.g., under relatively low oxygen concentrations), and such protein aggregation may be used, for example, to cause the particles to become aggregated, which can be determined in some way. In some cases, such aggregation may be irreversible; i.e., the degree of aggregation corresponds to the most extreme oxygen concentrations that the proteins were exposed to. Such articles may be used, for example, to determine oxygen within a sample, or within a subject, such as a human subject. For instance, the article may be formed as a skin patch, or administered to the skin of a subject, e.g., on the surface of the skin, within the dermis or epidermis, etc., to determine oxygen within the subject.
    • 本发明一般涉及用于测定样品或受试者中的氧的系统和方法。 一方面，本发明一般涉及一种表现出对氧敏感的颗粒有氧的可确定特征的物品。 颗粒可以随着氧浓度的变化而呈现可确定的变化，因此可以使用这样的颗粒来确定氧气。 例如，在一组实施方案中，颗粒可以至少部分地涂覆有能够与氧相互作用的蛋白质，例如血红蛋白。 在一些情况下，蛋白质可以在某些条件下（例如，在相对低的氧浓度下）聚集，并且可以使用这种蛋白质聚集，例如使颗粒变得聚集，这可以以某种方式确定。 在某些情况下，这种聚合可能是不可逆的; 即聚集度对应于蛋白质暴露于最极端的氧浓度。 例如，这样的制品可用于测定样品内或受试者（例如人类受试者）内的氧。 例如，制品可以形成为皮肤贴片，或者施用于受试者的皮肤，例如皮肤表面，真皮或表皮等内，以确定受试者内的氧。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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