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1. 发明申请

WO2005032523A1 INJECTABLE, ORAL, OR TOPICAL SUSTAINED RELEASE PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：可注射，口服或局部持续释放药物制剂
公开(公告)号：WO2005032523A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/031570
申请日：2004-09-27
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , HUANG, Eric, K. , NARASIMHAN, Sridhar , REESE, Shaina , STRAUB, Julie, A.
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , HUANG, Eric, K. , NARASIMHAN, Sridhar , REESE, Shaina , STRAUB, Julie, A.
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/1617
摘要： Pharmaceutical formulations and methods are provided for the sustained delivery of a pharmaceutical agent to a patient by injection, by oral administration or by topical administration. The injectable formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein upon injection of the formulation a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 24 hours. The oral formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 2 hours following oral administration. The topical formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 2 hours following topical administration.
摘要翻译：提供药物制剂和方法用于通过注射，口服给药或通过局部给药将药剂持续递送至患者。可注射制剂包括包含药剂和基质材料的多孔微粒，其中在注射制剂时，治疗或预防有效量的药剂从微粒释放至少24小时。口服制剂包括包含药剂和基质材料的多孔微粒，其中在口服给药后至少2小时将治疗或预防有效量的药剂从微粒释放至少2小时。局部制剂包括包含药剂和基质材料的多孔微粒，其中治疗或预防有效量的药剂在局部给药后从微粒释放至少2小时。

2. 发明申请

WO2007070843A2 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：口服给药的粒状药物制剂的制备方法
公开(公告)号：WO2007070843A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/062073
申请日：2006-12-14
申请人： ACUSPHERE, INC. , ALTREUTER, David , BERNSTEIN, Howard , BRITO, Luis, A. , BRITO, Shaina , CHICKERING, Donald, E., III , HUANG, Eric, K. , JAIN, Rajeev , NARASIMHAN, Sridhar , STRAUB, Julie, A.
发明人： ALTREUTER, David , BERNSTEIN, Howard , BRITO, Luis, A. , BRITO, Shaina , CHICKERING, Donald, E., III , HUANG, Eric, K. , JAIN, Rajeev , NARASIMHAN, Sridhar , STRAUB, Julie, A.
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20
CPC分类号： A61K9/145 , A61K9/0056 , A61K9/0095 , A61K9/2072 , A61K9/2077 , A61K9/2095
摘要： A method is provided for making an oral dosage form of a pharmaceutical agent which includes the steps of (a) providing particles which include a pharmaceutical agent; (b) blending the particles with particles of a pre-processed excipient to form a primary blend, wherein the pre-processed excipient is prepared by (i) dissolving a bulking agent (e.g., a sugar) and at least one non-friable excipient (e.g., a waxy or liquid surfactant) in a solvent to form an excipient solution, and (ii) removing the solvent from the excipient solution to form the pre-processed excipient in dry powder form; (c) milling the primary blend to form a milled pharmaceutical formulation blend that includes microparticles or nanoparticles of the pharmaceutical agent; and (d) processing the milled pharmaceutical formulation blend into a solid oral dosage form or liquid suspension for oral administration. The process yields formulations having improved wettability or dispersibility.
摘要翻译：提供了制备药剂口服剂型的方法，其包括以下步骤：（a）提供包含药剂的颗粒; （b）将所述颗粒与预加工的赋形剂的颗粒共混以形成主要共混物，其中所述预加工的赋形剂通过以下步骤制备：（i）将填充剂（例如糖）和至少一种不易碎的赋形剂（例如蜡质或液体表面活性剂）在溶剂中混合以形成赋形剂溶液，和（ii）从赋形剂溶液中除去溶剂以形成干粉形式的预处理赋形剂; （c）研磨所述主要共混物以形成包含所述药剂的微粒或纳米颗粒的研磨的药物制剂共混物; 和（d）将碾磨的药物制剂混合物加工成用于口服给药的固体口服剂型或液体悬浮液。该过程产生具有改进的润湿性或分散性的制剂。

3. 发明申请

WO2007070852A2 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PARENTERAL ADMINISTRATION 审中-公开
标题翻译：制备基于颗粒的药物制剂用于住院管理的方法
公开(公告)号：WO2007070852A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/062094
申请日：2006-12-14
申请人： ACUSPHERE, INC. , ALTREUTER, David , BERNSTEIN, Howard , BRITO, Luis , BRITO, Shaina , CARNEIRO, Olinda, C. , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , NARASIMHAN, Sridhar , PANDIT, Namrata , STRAUB, Julie, A.
发明人： ALTREUTER, David , BERNSTEIN, Howard , BRITO, Luis , BRITO, Shaina , CARNEIRO, Olinda, C. , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , NARASIMHAN, Sridhar , PANDIT, Namrata , STRAUB, Julie, A.
CPC分类号： A61K9/0019 , A61K9/145 , A61K9/146 , A61K9/19
摘要： A method is provided for making a parenteral dosage form of a pharmaceutical agent which Includes (a) providing particles of a pharmaceutical agent; (b) blending the particles with particles of at least one bulking agent to form a first powder blend, which does not include a surfactant; (c) milling the first powder blend to form a milled blend which comprises microparticles or nanopartides of the pharmaceutical agent; and (d) reconstituting the milled blend with a liquid vehicle, which includes at least one surfactant, for parenteral administration. A method also is provided which includes (a) providing particles of a pharmaceutical agent; (b) blending these particles with particles of an excipient to form a first blend; and (c) milling the first blend to form a milled blend that includes microparticles or tianopartÊcles, which exhibits a greater dispersibility, wettability, and suspcndability as compared to the particles of step (a) or the first blend.
摘要翻译：提供了制备药物的肠胃外剂型的方法，其包括（a）提供药剂的颗粒; （b）将颗粒与至少一种填充剂的颗粒混合以形成不包括表面活性剂的第一粉末混合物; （c）研磨第一粉末混合物以形成包含药剂的微粒或纳米颗粒的研磨混合物; 和（d）将研磨的共混物与包含至少一种表面活性剂的液体载体重组，用于肠胃外给药。还提供了一种方法，其包括（a）提供药剂的颗粒; （b）将这些颗粒与赋形剂的颗粒混合以形成第一共混物; 和（c）研磨第一共混物，以形成与步骤（a）或第一共混物的颗粒相比显示出更大的分散性，润湿性和悬浮性的微粒或天然配料的研磨混合物。

4. 发明申请

WO2007070851A2 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PULMONARY OR NASAL ADMINISTRATION 审中-公开
标题翻译：制备基于粒子的药物制剂用于肺癌或鼻咽管理的方法
公开(公告)号：WO2007070851A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/062093
申请日：2006-12-14
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , BRITO, Shaina , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , STRAUB, Julie, A.
发明人： BERNSTEIN, Howard , BRITO, Shaina , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , STRAUB, Julie, A.
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/0043 , A61K9/0073 , A61K9/143 , A61K9/145
摘要： Dry powder pharmaceutical formulations for pulmonary or nasal administration are made to provide an improved respired dose. These formulations may be blends of milled blends and may include a phospholipid, alone or Ên combination with other excipient materials. In one case, the process includes the steps of (a) providing particles which comprise a pharmaceutical agent; (b) blending the particles with particles of at least one first excipient to form a first powder blend; (c) railling the first powder blend to form a milled blend which comprises microparticies or nanoparticles of the pharmaceutical agent; and (d) blending the milled blend with particles of a second excipient to form a blended dry powder blend pharmaceutical formulation suitable for pulmonary or nasal administration.
摘要翻译：制备用于肺或鼻给药的干粉药物制剂以提供改善的呼吸剂量。这些制剂可以是研磨的共混物的混合物，并且可以包括单独的磷脂或与其它赋形剂材料组合的磷脂。在一种情况下，该方法包括以下步骤：（a）提供包含药剂的颗粒; （b）将颗粒与至少一种第一赋形剂的颗粒混合以形成第一粉末混合物; （c）冲击第一粉末混合物以形成包含药剂的微粒或纳米颗粒的研磨混合物; 和（d）将研磨的共混物与第二赋形剂的颗粒混合以形成适于肺或鼻施用的混合的干粉混合药物制剂。

5. 发明申请

WO2005120587A1 ULTRASOUND CONTRAST AGENT DOSAGE FORMULATION 审中-公开
标题翻译：超声对比剂剂量配方
公开(公告)号：WO2005120587A1
公开(公告)日：2005-12-22
申请号：PCT/US2004/017813
申请日：2004-06-04
申请人： ACUSPHERE, INC. , WALOVITCH, Richard , BERNSTEIN, Howard , CHICKERING, Donald, E, III , STRAUB, Julie
发明人： WALOVITCH, Richard , BERNSTEIN, Howard , CHICKERING, Donald, E, III , STRAUB, Julie
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： Clinical studies have been conducted and specific dosage formulations developed using polymeric microparticles having incorporated therein perfluorocarbon gases that provide significantly enhanced images of long duration. The dosage formulation includes microparticles formed of a biocompatible polymer, preferably including a lipid incorporated therein, and containing a perfluorocarbon that is a gas at body temperature. The microparticles are provided to a patient in an amount effective to enhance ultrasound imaging in the ventricular chambers for more than 5 minutes or in the mycocardium for more than a minute, in a dose ranging from 0.025 to 8.0 mg microparticles/kg body weight. Preferably the dose ranges from 0.05 to 4.0 mg microparticles/kg body weight. The dosage formulation typically is provided in a vial. A typical formulation is in the form of a dry powder that is reconstituted with sterile water prior to use by adding the water to the vial or syringe of the dry powder and shaking to yield an isosmotic or isotonic suspension of microparticles.
摘要翻译：已经进行了临床研究，并且使用其中掺入了全氟化碳气体的聚合物微粒开发出特定的剂量制剂，其提供长时间显着增强的图像。剂量制剂包括由生物相容性聚合物形成的微粒，其优选包括掺入其中的脂质，并且含有在体温下作为气体的全氟化碳。将微粒以有效量的方式提供给患者，剂量范围为0.025至8.0mg微粒/ kg体重的剂量，以在室室内超过5分钟或在心肌中增强超声成像超过一分钟。剂量范围优选为0.05至4.0mg微粒/ kg体重。剂型通常提供在小瓶中。典型的制剂是干粉的形式，其在使用前通过将水添加到干粉末的小瓶或注射器中并且摇动以产生微粒的等渗或等渗悬浮液而在使用前用无菌水重构。

6. 发明申请

WO2011053796A2 SYSTEMS AND METHODS FOR TREATING, SANITIZING, AND/OR SHIELDING THE SKIN OR DEVICES APPLIED TO THE SKIN 审中-公开
标题翻译：用于治疗，消毒和/或屏蔽皮肤或适用于皮肤的装置的系统和方法
公开(公告)号：WO2011053796A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054741
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for treating, sanitizing, and/or shielding blood on the surface of the skin or devices applied to the skin. In one set of embodiments, while blood is withdrawn from the skin of the subject, the blood is covered and/or shielded such that the blood is not seen by the subject. In another set of embodiments, any blood present on the skin may be altered or treated such that it no longer appears as blood, e.g., by exposing the blood to a chemical such as a peroxide that alters the color of the blood. In yet another set of embodiments, blood present on the skin is withdrawn or taken up by the device such that visible residual blood is not present in an amount visible to the unaided eye once the device is removed. In some cases, the same device may be used to sanitize the skin and deliver to and/or withdraw fluid from the skin and/or beneath the skin. The sanitization may be performed before, during, or after delivering to and/or withdrawing fluid from the skin and/or beneath the skin. Sanitization may be performed, for example, using a sanitizer such as hydrogen peroxide, ethyl alcohol, isopropyl alcohol, or the like.
摘要翻译：本发明在某些方面通常涉及用于治疗，消毒和/或屏蔽皮肤表面上的血液或施用于皮肤的装置的系统和方法。在一组实施方案中，当血液从受试者的皮肤中抽出时，血液被覆盖和/或被屏蔽，使得受试者看不到血液。在另一组实施方案中，存在于皮肤上的任何血液可以被改变或治疗，使得其不再像血液一样出现，例如通过将血液暴露于改变血液颜色的化学物质例如过氧化物。在另一组实施方案中，存在于皮肤上的血液被装置取出或吸收，使得一旦该装置被移除，可见的残留血液就不能以肉眼可见的量存在。在一些情况下，可以使用相同的装置来消毒皮肤并递送至/或从皮肤和/或皮肤下方排出流体。消毒可以在从皮肤和/或皮肤之下输送和/或从中释放流体之前，期间或之后进行。可以例如使用消毒剂如过氧化氢，乙醇，异丙醇等进行消毒。

7. 发明申请

WO2012149126A1 PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE 审中-公开
标题翻译：等离子体或血清生产和减少压力下的流体
公开(公告)号：WO2012149126A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035152
申请日：2012-04-26
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , HAGHGOOIE, Ramin , CHICKERING, Donald, E., III , DAVIS, Shawn , MICHELMAN, Mark , BERNSTEIN, Howard , HORTON, Kristin
发明人： HAGHGOOIE, Ramin , CHICKERING, Donald, E., III , DAVIS, Shawn , MICHELMAN, Mark , BERNSTEIN, Howard , HORTON, Kristin
IPC分类号： G01N33/49 , A61B5/145 , A61B5/151 , A61B5/154 , A61B5/15
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： The present application generally relates to the separation of blood within a device to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. In certain embodiments, plasma, serum, or other fluids may be removed from the device by inserting a needle into a portion of the device that has reduced pressure, expelling gas into the device through the needle, then receiving plasma, serum, or other fluids through the needle.
摘要翻译：本申请通常涉及在装置内分离血液以形成血浆或血清。例如，可以将装置应用于受试者的皮肤以从受试者接收血液，并将血液通过分离膜，该分离膜将血液分离成血浆，并将部分浓缩在血细胞中。作为另一个例子，血液或血浆可能被允许在装置内凝结，血清（未经切开的血液部分）可以从装置中取出。在一些情况下，该装置可以包含诸如预包装真空的真空源，以便于接收血液和/或使血液通过分离膜以产生血浆或血清。在某些实施方案中，血浆，血清或其它流体可以通过将针插入到具有减压的装置的一部分中而从装置中移除，通过针将气体排出到装置中，然后接收血浆，血清或其它流体通过针。

8. 发明申请

WO2010101621A1 DEVICES AND METHODS FOR THE ANALYSIS OF AN EXTRACTABLE MEDIUM 审中-公开
标题翻译：用于分析可萃取介质的装置和方法
公开(公告)号：WO2010101621A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/000624
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明总体上涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，该装置包括用于在进入位置处从受试者皮肤和/或穿过受试者的皮肤进入可提取介质的系统，以及由支撑结构支撑的压力调节器，其能够在访问站点的最少一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自受试者的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

9. 发明申请

WO2011163347A2 SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN 审中-公开
标题翻译：采用相关的轻度疼痛的装置和方法
公开(公告)号：WO2011163347A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041430
申请日：2011-06-22
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
发明人： CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
IPC分类号： A61M37/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。一方面，本发明一般涉及使用包括物质转移组件（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及存储室在接收血液之前具有小于大气压的内部压力。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

10. 发明申请

WO2008060934A2 FORMULATIONS OF TETRAHYDROPYRIDINE ANTIPLATELET AGENTS FOR PARENTERAL OR ORAL ADMINISTRATION 审中-公开
标题翻译：用于肠胃外或口服给药的四氢吡啶抗血小板药物的制剂
公开(公告)号：WO2008060934A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084040
申请日：2007-11-08
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , CARNEIRO, Olinda , JAIN, Rajeev A. , PANDIT, Namrata , RANE, Shveta , STRAUB, Julie Ann
发明人： BERNSTEIN, Howard , CARNEIRO, Olinda , JAIN, Rajeev A. , PANDIT, Namrata , RANE, Shveta , STRAUB, Julie Ann
IPC分类号： A61K9/00 , A61K9/107 , A61K9/16 , A61K31/4365
CPC分类号： A61K31/4365 , A61K9/0019 , A61K9/1075 , A61K9/1617 , A61K9/19
摘要： A pharmaceutical composition for the oral or parenteral administration of a compound of Formula (I) comprising an oil in water emulsion, wherein the oil phase comprises the free base of or a pharmaceutically acceptable salt thereof of a compound of Formula (I), and one or more surfactants which are soluble in the oil phase and/or the aqueous phase. The emulsion optionally contains one or more excipients that are soluble in the oil phase and/or the aqueous phase, such as pH modifying agents such as buffers, osmolality/tonicity modifying agents, emulsifying agents, water-soluble polymers, and preservatives. The compound of Formula (I) can be formulated as a solid material and stored until needed. Kits for forming the emulsion are provided. Prior to administration, the solid material can be reconstituted in an aqueous medium to form the emulsion.
摘要翻译：一种用于口服或肠胃外给药式（I）化合物的药物组合物，其包含水包油乳剂，其中所述油相包含化合物的游离碱或其药学上可接受的盐（I）的化合物和一种或多种可溶于油相和/或水相的表面活性剂。乳剂任选含有一种或多种可溶于油相和/或水相的赋形剂，例如pH调节剂如缓冲剂，渗透压/张力调节剂，乳化剂，水溶性聚合物和防腐剂。式（I）化合物可以配制成固体材料并储存直至需要。提供用于形成乳液的试剂盒。在给药之前，固体材料可以在水性介质中重构以形成乳液。

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