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1. 发明申请

WO2011163347A3 SAMPLING DEVICES INVOLVING RELATIVELY LITTLE PAIN 审中-公开
标题翻译：涉及相对轻度疼痛的采样装置
公开(公告)号：WO2011163347A3
公开(公告)日：2012-03-29
申请号：PCT/US2011041430
申请日：2011-06-22
申请人： SEVENTH SENSE BIOSYSTEMS INC , CHICKERING DONALD E III , BERNSTEIN HOWARD , DAVIS SHAWN , HAGHGOOIE RAMIN , LEVINSON DOUGLAS A , MICHELMAN MARK , GONG PING
发明人： CHICKERING DONALD E III , BERNSTEIN HOWARD , DAVIS SHAWN , HAGHGOOIE RAMIN , LEVINSON DOUGLAS A , MICHELMAN MARK , GONG PING
IPC分类号： A61M37/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。一方面，本发明一般涉及使用包括物质转移组件（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及储存室在接收血液之前具有小于大气压的内部压力。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

2. 发明申请

WO2011163347A2 SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN 审中-公开
标题翻译：采用相关的轻度疼痛的装置和方法
公开(公告)号：WO2011163347A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041430
申请日：2011-06-22
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
发明人： CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
IPC分类号： A61M37/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。一方面，本发明一般涉及使用包括物质转移组件（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及存储室在接收血液之前具有小于大气压的内部压力。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

3. 发明申请

WO2012149134A1 DEVICES AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS 审中-公开
标题翻译：用于收集和/或处理血液或其他体液的装置和方法
公开(公告)号：WO2012149134A1
公开(公告)日：2012-11-01
申请号：PCT/US2012035173
申请日：2012-04-26
申请人： SEVENTH SENSE BIOSYSTEMS INC , BERNSTEIN HOWARD , CHICKERING DONALD E , DAVIS SHAWN , GONG PING , HORTON KRISTIN , JAMES SCOTT
发明人： BERNSTEIN HOWARD , CHICKERING DONALD E , DAVIS SHAWN , GONG PING , HORTON KRISTIN , JAMES SCOTT
IPC分类号： A61B5/15 , A61B5/145 , A61B5/151 , A61B10/00 , G01N27/30
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： The present application directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood.
摘要翻译：本申请涉及使用包括物质转移组分（其可以包含例如一个或多个微针）和将血液引导到基质上的装置从例如皮肤接收血液的装置和方法，例如，用于吸收血液。

4. 发明申请

WO2012149134A8 DEVICES AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS 审中-公开
公开(公告)号：WO2012149134A8
公开(公告)日：2012-11-01
申请号：PCT/US2012/035173
申请日：2012-04-26
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , DAVIS, Shawn , GONG, Ping , HORTON, Kristin , JAMES, Scott
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E. , DAVIS, Shawn , GONG, Ping , HORTON, Kristin , JAMES, Scott
IPC分类号： A61B5/15 , A61B5/151 , A61B10/00 , G01N27/30 , A61B5/145
摘要： The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed.

5. 发明申请

WO2010088240A1 CAPACITIVE MORPHOLINO DIAGNOSTICS FOR ANALYSIS OF NUCLEIC ACIDS 审中-公开
标题翻译：用于核酸分析的电容性多元醇诊断
公开(公告)号：WO2010088240A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022178
申请日：2010-01-27
申请人： POLYTECHNIC INSTITUTE OF NYU , LEVICKY, Rastislav , TERCERO, Napoleon , WANG, Kang , GONG, Ping , SHEPARD, Kenneth
发明人： LEVICKY, Rastislav , TERCERO, Napoleon , WANG, Kang , GONG, Ping , SHEPARD, Kenneth
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , Y10T436/143333 , C12Q2525/113
摘要： Surface hybridization, a reaction in which nucleic acid molecules in solution react with nucleic acid partners immobilized on a surface, is widely practiced in life science research. In these applications the immobilized partner, or "probe", is typically single-stranded DNA. Because DNA is strongly charged, high salt conditions are required to enable binding between analyte nucleic acids ("targets") in solution and the DNA probes. High salt, however, compromises prospects for label-free monitoring or control of the hybridization reaction through surface electric fields, as well as stabilizes secondary structure in target species that can interfere with probe-target recognition. In this work, initial steps toward addressing these challenges are taken by introducing Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports can be fabricated with methods similar to those employed with DNA, and are shown to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organ ization are analyzed with electrochem ical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Interestingly, positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm-2 range.
摘要翻译：表面杂交，其中溶液中的核酸分子与固定在表面上的核酸对象反应的反应在生命科学研究中广泛应用。在这些应用中，固定化的配偶体或“探针”通常是单链DNA。由于DNA是强电荷的，因此需要高盐条件才能使溶液中的分析物核酸（“靶”）与DNA探针结合。然而，高盐不利于通过表面电场进行无标记监测或控制杂交反应的前景，以及稳定可能干扰探针 - 目标识别的靶物种中的二级结构。在这项工作中，通过引入Morpholinos（一类不带电荷的DNA类似物）进行表面杂交应用，来解决这些挑战的初步步骤。可以用与DNA一起使用的方法类似的方法制备金载体上的Morpholino探针的单层，并且显示出与靶链有效地并且序列特异性地杂交。用电化学方法分析杂交诱导的界面电荷组织变化，并比较Morpholino和DNA探针单层。通过与数值泊松 - 玻尔兹曼计算进行比较，可以确定和解释将表面杂交态与界面电容连接的分子机制。有趣的是，取决于由施加电位控制的移动离子的表面种群，杂交的阳性和负电容反应（对比反转）是可能的。表面电容与目标覆盖（目标/面积）的定量比较显示近似线性关系，并显示pg mm-2范围内的灵敏度（定量限度）。

6. 发明申请

WO2009082706A1 ACTIVE CMOS SENSOR ARRAY FOR ELECTROCHEMICAL BIOMOLECULAR DETECTION 审中-公开
标题翻译：用于电化学生物分子检测的有源CMOS传感器阵列
公开(公告)号：WO2009082706A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/087773
申请日：2008-12-19
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LEVINE, Peter, M. , SHEPARD, Kenneth, L. , GONG, Ping , RASTISLAV, Levicky
发明人： LEVINE, Peter, M. , SHEPARD, Kenneth, L. , GONG, Ping , RASTISLAV, Levicky
IPC分类号： C12M3/00
CPC分类号： G01N27/3277 , C12Q1/6825 , G01N27/48 , H01L23/5226 , H01L23/5283 , H01L23/53261
摘要： Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-μm CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described. Demonstrations showing example operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and quantitative and specific DNA hybridization detection in real time.
摘要翻译：生物分子的电化学感测消除了对传统基于荧光的感测测定所需的庞大的光学仪器的需要。传感器接口电极和主动电化学检测电路在CMOS基板上的集成使传感平台小型化，增强了点对点应用的便携性，同时实现了高吞吐量，高度平行的分析。一个实施例包括用于在标准0.25μmCMOS工艺中多路复用电化学生物分子检测的四乘四活性传感器阵列。集成的恒电位仪，包括控制放大器和双斜率ADC，可激发电化学电池，并检测流经芯片表面上生物分子反应的每个传感器位置的片上金电极的电流。描述了用于在CMOS中制造可承受恶劣电化学环境中的操作的生物相容的表面电极阵列的后处理技术。显示用于生物分子检测的有源CMOS阵列的示例操作的演示包括可逆氧化还原物质的循环伏安法，DNA探针密度表征和实时定量和特异性DNA杂交检测。

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