专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9840375A2 COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS 审中-公开
标题翻译：联合治疗使用ILEAL BILE ACID运输抑制苯扎硫酯和HMG联合还原酶抑制剂
公开(公告)号：WO9840375A2
公开(公告)日：1998-09-17
申请号：PCT/US9803792
申请日：1998-03-10
申请人： SEARLE & CO , REITZ DAVID B , LEE LEN F , LI JINGLIN J , HUANG HORNG CHIH , TREMONT SAMUEL J , MILLER RAYMOND E , BANERIEE SHYAMAL C , MANNING ROBERT E , GLENN KEVIN C , KELLER BRADLEY T
发明人： REITZ DAVID B , LEE LEN F , LI JINGLIN J , HUANG HORNG-CHIH , TREMONT SAMUEL J , MILLER RAYMOND E , BANERIEE SHYAMAL C , MANNING ROBERT E , GLENN KEVIN C , KELLER BRADLEY T
IPC分类号： C07D337/08 , A61K31/19 , A61K31/22 , A61K31/366 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/4025 , A61K31/4035 , A61K31/405 , A61K31/4178 , A61K31/437 , A61K31/4375 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/498 , A61K31/4995 , A61K31/502 , A61K31/5377 , A61K31/55 , A61K31/67 , A61K45/06 , A61P3/06 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D337/00
CPC分类号： A61K45/06 , A61K31/22 , A61K31/366 , A61K31/405 , A61K2300/00
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
摘要翻译：提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。还提供了使用回肠胆汁酸转运抑制剂和HMG Co-A还原酶抑制剂联合治疗高脂血症的组合物和方法。

2. 发明申请

WO0001687A9 BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE 审中-公开
标题翻译：具有作为ILEAL BILE ACID TRACSPORT和TAUROCHOLATE摄取的抑制剂的活性的BENZOTHIEPINES
公开(公告)号：WO0001687A9
公开(公告)日：2000-07-20
申请号：PCT/US9912828
申请日：1999-06-29
申请人： SEARLE & CO , LEE LEN F , BANERJEE SHYAMAL C , HUANG HORNG CHIH , LI JINGLIN J , MILLER RAYMOND E , REITZ DAVID B , TREMONT SAMUEL J
发明人： LEE LEN F , BANERJEE SHYAMAL C , HUANG HORNG-CHIH , LI JINGLIN J , MILLER RAYMOND E , REITZ DAVID B , TREMONT SAMUEL J
IPC分类号： A61K31/00 , A61K31/38 , A61K31/4035 , A61K31/41 , A61K31/4178 , A61K31/4433 , A61K31/4436 , A61K31/4709 , A61K31/4995 , A61K31/662 , A61K31/67 , A61P1/16 , A61P3/06 , A61P9/10 , A61P43/00 , C07B53/00 , C07C319/14 , C07C323/12 , C07C323/18 , C07C323/19 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/653 , C07F9/6553 , C07K5/06 , C07K5/068 , C08G65/329
CPC分类号： A61K31/38 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
摘要： Novel benzothiepines, derivatives, and analogs thereof; methods of preparing such compounds; pharmaceutical compositions containing such compounds; and methods of using these compounds and compositions in the preparation of a medicament, particularly medicaments for use in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译：新的苯并噻庚因衍生物及其类似物; 制备这些化合物的方法; 含有这些化合物的药物组合物; 以及使用这些化合物和组合物制备药物，特别是用于预防和治疗哺乳动物中与高血脂症状相关的高脂血症或与高胆固醇血症有关的药物的方法。

3. 发明申请

WO0168096A2 COMBINATION THERAPY FOR THE PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS AND DISORDERS 审中-公开
标题翻译：预防和治疗高血压病症和疾病的联合治疗
公开(公告)号：WO0168096A2
公开(公告)日：2001-09-20
申请号：PCT/US0107505
申请日：2001-03-08
申请人： PHARMACIA CORP , KELLER BRADLEY T , TREMONT SAMUEL J , GLENN KEVIN C , MANNING ROBERT E
发明人： KELLER BRADLEY T , TREMONT SAMUEL J , GLENN KEVIN C , MANNING ROBERT E
IPC分类号： A61K31/235 , A61K31/38 , A61K31/495 , C07D337/08 , C07D409/12 , C07D487/08
CPC分类号： C07D409/12 , A61K31/235 , A61K31/38 , A61K31/495 , C07D337/08 , C07D487/08 , A61K2300/00
摘要： Novel methods and combinations for the treatment and/or prophylaxis of a hyperlipidemic condition or disorder in a subject, wherein the methods comprise the administration of one or more HMG Co-A reductase inhibitors and one or more ASBT inhibitors selected from the specific group of compounds described herein, and the combinations comprise one or more HMG Co-A reductase inhibitors and one or more of said apical sodium co-dependent bile acid transport inhibitors.
摘要翻译：用于治疗和/或预防受试者的高脂血症病症或病症的新方法和组合，其中所述方法包括施用一种或多种HMG Co-A还原酶抑制剂和一种或多种选自特定化合物组的ASBT抑制剂并且组合包含一种或多种HMG Co-A还原酶抑制剂和一种或多种所述顶端钠依赖性胆汁酸转运抑制剂。

4. 发明申请

WO9844951A3 HYDROLYSABLE DELIVERY SYSTEM USING CROSS-LINKED POLYMERIC RESINS AS VEHICLES 审中-公开
标题翻译：使用交联聚合树脂作为车辆的可水解输送系统
公开(公告)号：WO9844951A3
公开(公告)日：1999-01-07
申请号：PCT/US9806144
申请日：1998-03-30
申请人： MONSANTO CO , TREMONT SAMUEL J
发明人： TREMONT SAMUEL J
IPC分类号： A61K47/48 , C08F8/00
CPC分类号： C08F8/32 , A61K47/58 , C08F8/30 , C08F112/14
摘要： This invention provides a method of preparing a polymeric delivery system for active ingredients. The delivery system is formed either by attaching the active ingredient to a linker through a hydrolyzable covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a cross-linked polymer, or by attaching a linker to a portion of the subunits of a cross-linked polymer, then attaching the active ingredient to the polymer-linker combination through a hydrolyzable covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through a hydrolyzale covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a cross-linked polymer.
摘要翻译：本发明提供了制备用于活性成分的聚合物递送系统的方法。递送系统通过将活性成分连接到可通过可水解共价键的接头形成，然后在接头与交联聚合物的一部分亚单位之间形成共价键，或通过将接头连接到亚单位的一部分的交联聚合物，然后通过可水解共价键将活性成分连接到聚合物 - 连接体组合。本发明还提供一种递送系统，其包含通过可水解共价键共价键合到接头的活性成分，其接着共价键合到交联聚合物的一部分亚单位。

5. 发明申请

WO0208211A3 BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS 审中-公开
标题翻译：苯并噻嗪及其作为抗生素使用
公开(公告)号：WO0208211A3
公开(公告)日：2002-08-08
申请号：PCT/US0123533
申请日：2001-07-26
申请人： SEARLE LLC , TREMONT SAMUEL J , KOELLER KEVIN J , NEUMANN WILLIAM L
发明人： TREMONT SAMUEL J , KOELLER KEVIN J , NEUMANN WILLIAM L
IPC分类号： A61P3/06 , C07D281/10 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/04 , C07D521/00 , C07F9/6536 , C07F9/6558 , A61K31/554 , A61K31/675 , A61K31/7052 , C07H15/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D281/10 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/04 , C07F9/6536 , C07F9/65583
摘要： Compounds, pharmaceutical compositions, and methods for the treatment of a hyperlipidemic condition in a subject. The compounds of the present invention are apical sodium co-dependent bile acid transport inhibitors and are 1,4-benzothiazepine and 1,5-benzothiazepine compounds corresponding to Formula (I): wherein j, m ,Y, Z, R , R , R , R and R are as defined in the specification.
摘要翻译：用于治疗受试者中高脂血症的化合物，药物组合物和方法。本发明的化合物是顶端钠依赖性胆汁酸转运抑制剂，是对应于式（I）的1,4-苯并硫氮杂和1,5-苯并硫氮杂化合物：其中j，m，Y，Z，R 1A， R 1B，R 2A，R 2B和R 6如说明书中所定义。

6. 发明申请

WO0168637A3 METHOD FOR THE PREPARATION OF TETRAHYDROBENZOTHIEPINES 审中-公开
标题翻译：制备四氢生物素的方法
公开(公告)号：WO0168637A3
公开(公告)日：2003-01-09
申请号：PCT/US0107421
申请日：2001-03-08
申请人： PHARMACIA CORP , BABIAK KEVIN A , CARPENTER ANDREW , CHOU SHINE , COLSON PIERRE-JEAN , FARID PAYMAN , HETT ROBERT , HUBER CHRISISTIAN H , KOELLER KEVIN J , LAWSON JON P , LI JAMES , MAR EDUARDO K , MILLER LAWRENCE M , ORLOVSKI VLADISLAV , PETERSON JAMES C , POZZO MARK J , PRZYBYLA CLAIRE A , TREMONT SAMUEL J , TRIVEDI JAY S , WAGNER GRACE M , WEISENBURGER GERALD A , ZHI BENXIN
发明人： BABIAK KEVIN A , CARPENTER ANDREW , CHOU SHINE , COLSON PIERRE-JEAN , FARID PAYMAN , HETT ROBERT , HUBER CHRISISTIAN H , KOELLER KEVIN J , LAWSON JON P , LI JAMES , MAR EDUARDO K , MILLER LAWRENCE M , ORLOVSKI VLADISLAV , PETERSON JAMES C , POZZO MARK J , PRZYBYLA CLAIRE A , TREMONT SAMUEL J , TRIVEDI JAY S , WAGNER GRACE M , WEISENBURGER GERALD A , ZHI BENXIN
IPC分类号： C07D317/18 , A61K31/235 , A61K31/38 , A61K31/495 , A61K31/4995 , A61P3/06 , A61P43/00 , C07B53/00 , C07B55/00 , C07B57/00 , C07B61/00 , C07C201/12 , C07C205/35 , C07C315/02 , C07C315/04 , C07C317/24 , C07C317/36 , C07C319/14 , C07C321/28 , C07D337/08 , C07D409/12 , C07D487/08 , C07C31/36 , C07C45/29 , C07C47/14 , C07C69/63 , C07D317/24 , C07D317/36
CPC分类号： C07D409/12 , A61K31/235 , A61K31/38 , A61K31/495 , C07D337/08 , C07D487/08 , A61K2300/00
摘要： Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
摘要翻译：在其几个实施方案中，本发明提供了一种制备四氢苯并噻吩一-1,1-二氧化物化合物的改进方法; 提供了由这种化合物的单一非对映异构体制备四氢苯并噻吩一-1,1-二氧化物化合物的非对映体混合物的方法; 提供了制备3-溴-2-取代的丙醛化合物的方法; 并提供了制备3-硫代-2-取代的丙醛化合物的方法。

7. 发明申请

WO2005019230A3 PROCESS FOR THE PREPARATION OF N-PHOSPHONO-METHYLGLYCINE AND DERIVATIVES THEREOF 审中-公开
标题翻译：制备N-膦酰基甲基甘氨酸及其衍生物的方法
公开(公告)号：WO2005019230A3
公开(公告)日：2005-08-04
申请号：PCT/US2004027413
申请日：2004-08-23
申请人： MONSANTO TECHNOLOGY LLC , COLEMAN JAMES P , EBNER JERRY R , HAUPFEAR ERIC A , LENNON PATRICK J , SCHAPER JOSEPH A , TREMONT SAMUEL J , WOLFSON SERGE G , BRODSKY PHILIP H
发明人： COLEMAN JAMES P , EBNER JERRY R , HAUPFEAR ERIC A , LENNON PATRICK J , SCHAPER JOSEPH A , TREMONT SAMUEL J , WOLFSON SERGE G , BRODSKY PHILIP H
IPC分类号： C07F9/28 , C07F9/38
CPC分类号： C07F9/3813 , Y02P20/582
摘要： N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.
摘要翻译： N-膦酰基甲基胺通过胺底物与卤代甲基膦酸或其盐，羟甲基膦酸或其盐，或羟甲基膦酸的脱水自酯二聚物，三聚物或低聚物反应而生成。可以根据该方法制备的产品是N-膦酰基甲基氨基羧酸，例如（例如）草甘膦，N-膦酰基甲基氨基链烷醇例如羟基乙基氨基甲基膦酸和N-酰基氨基甲基膦酸例如N-氨基甲酰基氨基甲基膦酸。用大量过量的胺反应物进行某些反应以驱动转化，同时避免过量形成双（N-膦酰基甲基）胺副产物。其他反应使用仲胺底物（如亚氨基二乙酸），并且可以以基本上等摩尔比例的卤代甲基氨基甲基膦酸或羟基氨基甲基膦酸与仲胺反应物进行反应，而不显着形成双（膦酰基甲基）胺副产物。还公开了通过共沸脱水制备羟甲基膦酸自酯二聚体，三聚体和低聚体的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式