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1. 发明申请

WO2004058762A1 MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS 审中-公开
标题翻译：激素激活蛋白激酶激酶蛋白激酶-2抑制化合物
公开(公告)号：WO2004058762A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/040811
申请日：2003-12-19
申请人： PHARMACIA CORPORATION , ANDERSON, David, R. , MAHONEY, Matthew, W. , PHILLION, Dennis, P. , ROGERS, Thomas, E. , MEYERS, Marvin, J. , PODA, Gennadiy , HEGDE, Shridhar, G. , SINGH, Megh , REITZ, David, B. , WU, Kun, K. , BUCHLER, Ingrid, P. , XIE, Jin , VERNIER, William, F.
发明人： ANDERSON, David, R. , MAHONEY, Matthew, W. , PHILLION, Dennis, P. , ROGERS, Thomas, E. , MEYERS, Marvin, J. , PODA, Gennadiy , HEGDE, Shridhar, G. , SINGH, Megh , REITZ, David, B. , WU, Kun, K. , BUCHLER, Ingrid, P. , XIE, Jin , VERNIER, William, F.
IPC分类号： C07D471/06
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D471/14 , C07D487/04 , C07D513/04 , C07D519/00
摘要： Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of using such compounds for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNFα, are described, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Therapeutic compositions, pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
摘要翻译：描述了抑制丝裂原活化蛋白激酶活化蛋白激酶-2（MK-2）的化合物。描述了使用这些化合物抑制MK-2以及用于预防或治疗由TNFα介导的疾病或病症的方法，其中所述方法涉及向受试者施用本发明的MK-2抑制化合物发明。还描述了含有本发明的MK-2抑制化合物的治疗组合物，药物组合物和试剂盒。

2. 发明申请

WO0242272A8 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开
标题翻译：用于选择性抑制凝聚剂CASCADE的取代的多环芳烃和异丁基吡啶
公开(公告)号：WO0242272A8
公开(公告)日：2003-10-23
申请号：PCT/US0143280
申请日：2001-11-20
申请人： PHARMACIA CORP , SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG-CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
发明人： SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG-CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K45/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , A61P43/00 , C07D213/74 , C07D213/89 , C07D401/10 , C07D409/04 , C07D213/77 , C07D213/90 , C07D237/20 , C07D239/36 , C07D239/42 , C07D241/20 , C07D253/04 , C07D253/06 , C07D265/02 , C07D417/12
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

3. 发明申请

WO0047568A3 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES 审中-公开
标题翻译：用于治疗高致病性疾病的1,2-苯二氮
公开(公告)号：WO0047568A3
公开(公告)日：2000-12-14
申请号：PCT/US0002503
申请日：2000-02-10
申请人： SEARLE & CO , TOLLEFSON MICHAEL B , KOLODZIEJ STEVE A , REITZ DAVID B
发明人： TOLLEFSON MICHAEL B , KOLODZIEJ STEVE A , REITZ DAVID B
IPC分类号： A61K31/554 , A61P3/06 , A61P9/10 , C07D281/02 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D521/00 , C07F9/36 , C07F9/38 , C07F9/54 , A61K31/55
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D281/02 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07F9/36 , C07F9/3808 , C07F9/5407
摘要： Novel 1,1-dioxido-1,2-benzothiazepines, derivatives and analogs thereof, pharmaceutical compositions containing them, and their use in medicine, particularly in the prophylaxis and/or treatment of hyperlipidemic diseases, conditions and/or disorders, such as those associated with atherosclerosis and/or hypercholesterolemia.
摘要翻译：新的1,1-二氧化-1,2-苯并硫氮杂，其衍生物和类似物，含有它们的药物组合物及其在药物中的用途，特别是用于预防和/或治疗高脂血症，病症和/或病症，例如与动脉粥样硬化和/或高胆固醇血症相关。

4. 发明申请

WO1992018092A2 1-ARYLHETEROARYLALKYL SUBSTITUTED-1H-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS 审中-公开
标题翻译：用于治疗循环障碍的1-ARYLHETEROARYLALKYL取代的1 H-1,2,4-三唑类化合物
公开(公告)号：WO1992018092A2
公开(公告)日：1992-10-29
申请号：PCT/US1992002801
申请日：1992-04-10
申请人： G.D. SEARLE & CO. , REITZ, David, B.
发明人： G.D. SEARLE & CO.
IPC分类号： A61K0
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/10 , C07D401/14
摘要： A class of 1-arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are angiotensin II antagonists of the formula (I) wherein A is selected from (1, 2, 3, 4, 5 and 6), wherein m is one; wherein R1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, phenyl, benzyl, phenethyl, 2-ethylbutyl, 1,1-difluorobutyl, N-methylamido, N-methyl-N-tertbutylamido, 2-methylphenyl, 2-isopropylphenyl, 2-methoxyphenyl, 2-chlorophenyl, 2,6-difluorophenyl, cyclohexyl, cyclohexylmethyl, 2-butenyl, 3-butenyl, 2-butynyl, 3-butynyl and 2-hydroxybutyl; wherein R2 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, ethylbutyl, n-pentyl, 1-oxo-2-phenylethyl, 1-oxo-2-cyclohexylethyl, 1,1-difluoro-2-phenylethyl, 1,1-difluoro-2-cyclohexylethyl, 2-cyclohexylethyl, 1,1-difluoro-3-cyclohexylpropyl, 1,1-dimethoxybutyl, 1,1-difluoroethyl, 1,1-difluoropropyl, 1,1-difluorobutyl, 1,1-difluoropentyl, phenyl, benzyl, 2-phenylethyl, 1,1-difluoro-3-phenylpropyl, cyclohexylmethyl, cyclohexanoyl, N-methylamido, N-methyl-N-tertbutylamido, 2-methylphenyl, 2-isopropylphenyl, 2-methoxyphenyl, 2-chlorophenyl, 2,6-difluorophenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-butynyl, 2-butynyl, 3-butynyl, propylthio and buthylthio; wherein R5 is an acidic group selected from CO¿2?H and tetrazole radicals; or a tautomer thereof or a pharmaceutically-acceptable salt thereof.

5. 发明申请

WO1992011255A1 N-SUBSTITUTED N-('alpha'-TRIAZOLYL-TOLUYL)PYRROLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS 审中-公开
标题翻译： N-取代的N-（α-三唑基 - 叔丁基）吡咯烷化合物，用于治疗循环障碍
公开(公告)号：WO1992011255A1
公开(公告)日：1992-07-09
申请号：PCT/US1991008726
申请日：1991-11-26
申请人： G.D. SEARLE & CO. , BOVY, Philippe, R. , REITZ, David, B. , MANNING, Robert, E.
发明人： G.D. SEARLE & CO.
IPC分类号： C07D403/14
CPC分类号： C07D403/10 , C07D403/14
摘要： A class of N-substituted N-(α-triazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of formula (I), wherein m is one; wherein R1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, cyclohexanoyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, propylthio, butylthio, and hydroxyalkyl; wherein each of R?3, R4, R5, R6, R7, R8, R9 and R10¿ is independently selected from hybrido, halo, nitro, trifluoromethyl, hydroxy, alkoxy, cyano, carboxyl and methoxycarbonyl; with the proviso that at least one of R?5 and R8¿ must be selected from COOH, SH, PO¿3?H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, a), b) and c) wherein each of R?42 and R43¿ is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl; or a tautomer thereof or a pharmaceutically acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.

6. 发明申请

WO1995011883A1 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的1,2-二环戊烯化合物
公开(公告)号：WO1995011883A1
公开(公告)日：1995-05-04
申请号：PCT/US1994008047
申请日：1994-07-21
申请人： G.D. SEARLE & CO. , REITZ, David, B. , LI, Jinglin
发明人： G.D. SEARLE & CO.
IPC分类号： C07C317/14
CPC分类号： C07C311/16 , C07C317/14 , C07C317/22 , C07C317/44 , C07C323/65
摘要： A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (III), wherein each of R and R is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkoxycarbonyl and carboxyl; wherein R is selected from alkylsulfonyl, haloalkylsulfonyl and sulfamyl; and wherein B is phenyl or pyridyl, wherein B is optionally substituted at a substitutable position with alkyl, halo, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl and alkoxyalkyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类1,2-二芳基环戊烯基化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式（III）定义，其中R 1和R 2各自独立地选自烷基，羟基，羟基烷基，卤素，卤代烷基，烷氧基羰基和羧基; 其中R 5选自烷基磺酰基，卤代烷基磺酰基和氨磺酰基; 并且其中B是苯基或吡啶基，其中B任选在可取代的位置被烷基，卤素，烷硫基，氰基，卤代烷基，烷氧基，羟基烷基和烷氧基烷基取代; 或其药学上可接受的盐。

7. 发明申请

WO1991018888A1 N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：用于治疗心血管疾病的N-取代的1,2,4-三唑酮化合物
公开(公告)号：WO1991018888A1
公开(公告)日：1991-12-12
申请号：PCT/US1991003449
申请日：1991-05-23
申请人： G.D. SEARLE & CO. , MANNING, Robert, E. , REITZ, David, B. , HUANG, Horng-Chih
发明人： G.D. SEARLE & CO.
IPC分类号： C07D249/12
CPC分类号： C07D403/10 , C07D249/12
摘要： A class of N-substituted-1,2,4-triazolone compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of formula (I), wherein R is selected from 2-oxo-2-(tricyclo[3.3.1.1. ]dec-2-yl)ethyl, 3-phenylpropyl, 2-oxo-2-phenylethyl, 2-hyroxy-2-phenylethyl, 1,1-dimethylethyloxycarbonylmethyl, hexyl, ethoxycarbonylmethyl, carboxymethyl, 1-naphthalenylmethyl, 2-cyclohexylethyl, pentyl, ethoxycarbonylmethoxyethyl substituted with phenyl, carboxymethoxyethyl substituted with phenyl, 3,5,5-trimethylhexyl, (2-phenylmethoxy)-1-(phenylmethyl)-E-ethenyl, 1-benzoyl-2-phenylethyl, 1-oxobutyl, 2-(2,5-dimethyoxyphenyl)-2-oxoethyl, 2-phenyl-2-(phenylmethoxyethyl, 2-(2,5-dimethioxy-phenyl)-2-hydroxyethyl, 2-naphthalenylmethyl, methoxycarbonyl-butyl, ethoxycarbonylethyl substituted with benzoyl, 1-benzyoyl-1-methylethyl, 1-pentanoic acid, cyclopropylmethyl, 3-phenyl-2E-propenyl and 3-acetonitrile; wherein R is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl, neopentyl, 1-cyanobutyl, propylthio and butylthio; wherein each of R through R is hydrido with the proviso that at least one of R and R must be selected from COOH, SH, PO3H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, (a), (b) and (c), wherein each of R and R is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
摘要翻译：描述了一类用于治疗心血管疾病的N-取代的1,2,4-三唑酮化合物。特别感兴趣的化合物是式（I）的血管紧张素II拮抗剂，其中R 1选自2-氧代-2-（三环[3.3.1.1.33.2]癸-2-基）乙基，3-苯基丙基，2-氧代-2-苯基乙基，2-羟基-2-苯基乙基，1,1-二甲基乙氧基羰基甲基，己基，乙氧基羰基甲基，羧甲基，1-萘基甲基，2-环己基乙基，戊基，被苯基取代的乙氧基羰基甲氧基乙基，被苯基取代的羧基甲氧基乙基，，5,5-三甲基己基，（2-苯基甲氧基）-1-（苯基甲基）-E-乙烯基，1-苯甲酰基-2-苯基乙基，1-氧代丁基，2-（2,5-二甲氧基苯基）-2-氧代乙基，2 - 苯基-2-（苯基甲氧基乙基，2-（2,5-二甲氧基 - 苯基）-2-羟乙基，2-萘基甲基，甲氧基羰基 - 丁基，苯甲酰基取代的乙氧基羰基乙基，1-苯甲酰基-1-甲基乙基，1-戊酸，环丙基甲基，3-苯基-2-丙烯基和3-乙腈;其中R 2选自乙基，正丙基，异丙基，正丁基，仲丁基，异丁基，4-甲基丁基，叔丁基，戊基，新戊基，1-氰基乙硫基，丁硫基; 其中R 3至R 11各自为氢，条件是R 5和R 9中的至少一个必须选自COOH，SH，PO 3 H 2，SO 3 H，CONHNH 2，CONHNHSO 2 CF 3，OH，（ a），（b）和（c），其中R 42和R 43各自独立地选自氯，氰基，硝基，三氟甲基，甲氧基羰基和三氟甲基磺酰基。这些化合物特别可用于治疗或控制高血压和充血性心力衰竭。

8. 发明申请

WO1991017148A1 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开
标题翻译： 1H-取代的1,2,4-三唑化合物用于治疗心血管疾病
公开(公告)号：WO1991017148A1
公开(公告)日：1991-11-14
申请号：PCT/US1991002926
申请日：1991-05-06
申请人： G.D. SEARLE & CO. , REITZ, David, B.
发明人： G.D. SEARLE & CO.
IPC分类号： C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/10 , C07D403/10
摘要： A class of 1H-substituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders, especially cardiovascular disorders. Compounds of interest are angiotensin II antagonists of formula (II), wherein R1 is selected from hydroxy, formyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, carboxyethyl, phenyl, benzyl, phenethyl, cyclopentyl, cyclohexyl, cyclopentylmethyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, adamantyl, adamantylmethyl, 1-oxoethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl, dimethoxymethyl, diethoxymethyl, 1,1-dimethoxypropyl, 1,1-dimethoxybutyl, 1,1-dimethoxypentyl, hydroxypropyl, halo, monofluoromethyl, difluoromethyl, 1,1-difluoroethyl, 1,1-difluoropropyl, 1,1-difluorobutyl, 1,1-difluoropentyl, pentafluoroethyl, heptafluoropropyl, phenylacetyl, phenyldifluoroethyl, aminomethyl, aminoethyl, aminopropyl, acetylaminomethyl, t-butoxycarbonylaminoethyl, glutamic acid methyl ester and glutamic acid ethyl ester; wherein R2 is selected from carboxyethyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl and neopentyl; wherein each of R3 through R11 is hydrido with the proviso that at least one of R?5 and R9¿ must be selected from COOH, SH, PO¿3?H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, (III), (IV) and (V), wherein each of R?40 and R41¿ is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.

9. 发明申请

WO2005009370A3 BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS 审中-公开
标题翻译： β-环糊精化合物及其类似物及其用作活化蛋白激酶的蛋白激酶蛋白激酶-2抑制剂
公开(公告)号：WO2005009370A3
公开(公告)日：2005-10-20
申请号：PCT/US2004023350
申请日：2004-07-22
申请人： PHARMACIA CORP , MEYERS MARVIN J , TRUJILLO JOHN I , VERNIER WILLIAM F , ANDERSON DAVID R , REITZ DAVID B , BUCHLER INGRID P , HEGDE SHRIDHAR G , MAHONEY MATTHEW W , WU KUN K
发明人： MEYERS MARVIN J , TRUJILLO JOHN I , VERNIER WILLIAM F , ANDERSON DAVID R , REITZ DAVID B , BUCHLER INGRID P , HEGDE SHRIDHAR G , MAHONEY MATTHEW W , WU KUN K
IPC分类号： A61K20060101 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/4745 , A61K31/55 , C07D209/82 , C07D209/94 , C07D471/02 , C07D471/14
CPC分类号： A61K31/40 , C07D471/04 , C07D471/14 , C07D471/18
摘要： Novel methods and compositions are described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject. The method involves administering to the subject a beta-carboline MK-2 inhibiting compound, or a pharmaceutically acceptable salt, or isomer thereof. The novel compositions are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof. Pharmaceutical compositions and kits that include these compounds are also described.
摘要翻译：描述了用于抑制受试者中丝裂原活化蛋白激酶激活蛋白激酶-2的新方法和组合物。该方法包括给受试者施用β-咔啉MK-2抑制化合物或其药学上可接受的盐或其异构体。新型组合物能够抑制丝裂原活化蛋白激酶活化蛋白激酶-2及其类似物。还描述了包括这些化合物的药物组合物和试剂盒。

10. 发明申请

WO1995033734A1 SUBSTITUTED DIBENZOXAZEPINE AND DIBENZTHIAZEPINE CARBAMATES USEFUL AS PROSTAGLANDIN ANTAGONISTS 审中-公开
标题翻译：取代二苯并氮杂和二苯胺吖啶酸盐可用作PROSTAGLANDIN ANTAGONISTS
公开(公告)号：WO1995033734A1
公开(公告)日：1995-12-14
申请号：PCT/US1995006888
申请日：1995-06-08
申请人： G.D. SEARLE & CO. , COLLINS, Joe, Terrel , HANSEN, Donald, Willis, Jr. , PETERSON, Karen, Berenice , PITZELE, Barnett, Sylvain , REITZ, David, B.
发明人： G.D. SEARLE & CO.
IPC分类号： C07D267/20
CPC分类号： C07D267/20 , C07D281/16
摘要： The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula (I) which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula (I) in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula (I) to the animal.
摘要翻译：本发明提供了可用作治疗疼痛的止痛剂的式（I）的取代二苯并氮杂和二苯并吖庚因化合物，药物组合物包含治疗有效量的式（I）化合物与药学上可接受的载体以及消除或改善动物疼痛的方法，包括向动物施用治疗有效量的式（I）化合物。

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