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1. 发明申请

WO2005019230A3 PROCESS FOR THE PREPARATION OF N-PHOSPHONO-METHYLGLYCINE AND DERIVATIVES THEREOF 审中-公开
标题翻译：制备N-膦酰基甲基甘氨酸及其衍生物的方法
公开(公告)号：WO2005019230A3
公开(公告)日：2005-08-04
申请号：PCT/US2004027413
申请日：2004-08-23
申请人： MONSANTO TECHNOLOGY LLC , COLEMAN JAMES P , EBNER JERRY R , HAUPFEAR ERIC A , LENNON PATRICK J , SCHAPER JOSEPH A , TREMONT SAMUEL J , WOLFSON SERGE G , BRODSKY PHILIP H
发明人： COLEMAN JAMES P , EBNER JERRY R , HAUPFEAR ERIC A , LENNON PATRICK J , SCHAPER JOSEPH A , TREMONT SAMUEL J , WOLFSON SERGE G , BRODSKY PHILIP H
IPC分类号： C07F9/28 , C07F9/38
CPC分类号： C07F9/3813 , Y02P20/582
摘要： N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.
摘要翻译： N-膦酰基甲基胺通过胺底物与卤代甲基膦酸或其盐，羟甲基膦酸或其盐，或羟甲基膦酸的脱水自酯二聚物，三聚物或低聚物反应而生成。可以根据该方法制备的产品是N-膦酰基甲基氨基羧酸，例如（例如）草甘膦，N-膦酰基甲基氨基链烷醇例如羟基乙基氨基甲基膦酸和N-酰基氨基甲基膦酸例如N-氨基甲酰基氨基甲基膦酸。用大量过量的胺反应物进行某些反应以驱动转化，同时避免过量形成双（N-膦酰基甲基）胺副产物。其他反应使用仲胺底物（如亚氨基二乙酸），并且可以以基本上等摩尔比例的卤代甲基氨基甲基膦酸或羟基氨基甲基膦酸与仲胺反应物进行反应，而不显着形成双（膦酰基甲基）胺副产物。还公开了通过共沸脱水制备羟甲基膦酸自酯二聚体，三聚体和低聚体的方法。

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