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1. 发明申请

WO2017145130A1 AN ARTIFICIAL BLADDER, AND A PROCESS FOR ITS MANUFACTURE 审中-公开
标题翻译：人造膀胱，及其制造过程
公开(公告)号：WO2017145130A1
公开(公告)日：2017-08-31
申请号：PCT/IB2017/051133
申请日：2017-02-27
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , PINZI, Novello
发明人： PINZI, Novello , RICOTTI, Leonardo , MAZZOCCHI, Tommaso , FONTANA, Rossella , MENCIASSI, Arianna , IACOVACCI, Veronica
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61F2210/0076 , A61F2230/005 , A61F2240/004
摘要： The present invention relates to an implantable medical device for collecting and discharging biological urinary fluids, for example an artificial bladder, which by virtue of a multilayer body having a particular shape of the inner surface, allows reproducing the natural organ tissue performance especially in terms of flexibility and consequent variability of the inner volume, further exhibiting high stability and urine resistance in the long term.
摘要翻译：本发明涉及用于收集和排出生物尿液的可植入医疗装置，例如人造膀胱，其借助具有特定形状的内表面的多层体允许再生天然器官组织的性能，特别是在灵活性和内部容积的随之变化方面，进一步表现出长期的高稳定性和尿液抵抗力。

2. 发明申请

WO2017145128A1 ARTIFICIAL BLADDER 审中-公开
标题翻译：人工膀胱
公开(公告)号：WO2017145128A1
公开(公告)日：2017-08-31
申请号：PCT/IB2017/051130
申请日：2017-02-27
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , PINZI, Novello
发明人： PINZI, Novello , RICOTTI, Leonardo , MAZZOCCHI, Tommaso , FONTANA, Rossella , MENCIASSI, Arianna , IACOVACCI, Veronica
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61F2210/0076
摘要： The present invention relates to an artificial bladder for collecting and discharging biological urinary fluids, provided with high stability and resistance to urine over the long periods, also being able to expand and contract with a variation of its inner volume, without the constituent material to be subject to stretching or deformation under the pressure of the urinary fluids.
摘要翻译：本发明涉及一种用于收集和排出生物尿液的人造膀胱，其长期具有高稳定性和耐尿性，并且能够随其内部的变化而膨胀和收缩体积，没有组成材料在尿液压力下受到拉伸或变形。

3. 发明申请

WO2022074632A1 A DEVICE FOR ENDOSCOPICALLY DELIVERING A THERAPEUTIC SUBSTANCE 审中-公开
公开(公告)号：WO2022074632A1
公开(公告)日：2022-04-14
申请号：PCT/IB2021/059279
申请日：2021-10-11
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA
发明人： RICOTTI, Leonardo , VANNOZZI, Lorenzo , MAZZOCCHI, Tommaso , SILIBERTO, Alessio , GUARNERA, Daniele
IPC分类号： A61B17/34 , A61M25/01 , A61M25/00
摘要： A device for endoscopically delivering at least one therapeutic substance includes a cannula (10) defining at least one extrusion channel (11) and comprises a proximal portion (19), a flexible distal portion (15) having an extrusion mouth (16), and a substantially rigid intermediate portion (17) between the flexible distal portion (15) and the proximal portion (19). The proximal portion (19) is configured to feed and push a therapeutic substance into the extrusion channel (11), so that the latter can pass through the extrusion channel (11) flowing through the intermediate portion (17) and through the flexible distal portion (15) and can exit from the extrusion mouth (16). The device also comprises at least one actuation cable (50, 50', 50") having a proximal end (59) operable at the proximal portion (19) and a distal end (55) connected to the flexible distal portion (15) at the extrusion mouth (16), and configured to pull the flexible distal portion (15) with a force transversal to the extrusion channel (11), bringing the flexible distal portion (15) from an undeformed conformation (A) to a deformed conformation (B). According to the invention, the substantially rigid intermediate portion (17) has a distal rigid edge (54) from which the flexible distal portion protrudes (15), and in which the distal rigid edge (54) has a passageway exit (53) of a passageway (56) for the actuation cable (50), the distal rigid edge (54) and the passageway exit (53) of the passageway arranged in such a way that only the flexible distal portion (15) of the cannula (10) can be brought, by the actuation cable (50, 50', 50"), from the undeformed conformation (A) to the deformed conformation (B) while the intermediate portion (17) remains undeformed.

4. 发明申请

WO2017051394A1 Sensorized coating for detection of pressures 审中-公开
标题翻译：用于检测压力的传感器涂层
公开(公告)号：WO2017051394A1
公开(公告)日：2017-03-30
申请号：PCT/IB2016/055751
申请日：2016-09-26
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA
发明人： CIUTI, Gastone , DIODATO, Alessandro , MAZZOCCHI, Tommaso , MENCIASSI, Arianna , VITIELLO, Nicola
IPC分类号： B25J9/16 , B25J19/02
CPC分类号： B25J13/084 , B25J9/1633 , B25J9/1676
摘要： A sensorized coating device (100) configured for measuring external pressures acting on it, said sensorized coating device (100) comprising a flexible sensor (110) having shape substantially laminar and comprising a plurality of sensitive areas A i,j , said flexible sensor (110) being configured for measuring, at said sensitive areas A i,j , the presence of corresponding external pressures P i, j EXT · The flexible sensor (110) comprises a first layer (111) comprising a number i of strips of conductive material (111') alternate to strips of non-conductive material (111'') and a second layer (112) comprising a number j of strips of conductive material (112') alternate to strips of non-conductive material (112''). The first layer (111) and said second layer (112) are arranged in a position such that the i strips of conductive material (112') of the second layer (112) overlap without physical contact to the j strips of conductive material (111') of the first layer (111) at the said sensitive areas A i,j . The strips of conductive material (111') of the first layer (111) and the strips of conductive material (112') of the second layer (112) are connected to an electrical circuit (115). The strips of conductive material (111') of the first layer (111) are arranged to come into electrical contact with the strips of conductive material (112') of the second layer (112) at determined sensitive areas A i,j in consequence of determined external pressures P i, j EXT acting on the determined sensitive areas A i,j , said electrical contact closing the electrical circuit (115) and generating a voltage at the ends of two strips of conductive material (111', 112') in electrical contact to each other, in order to generate contact signals reporting information about the presence of said external pressures P i, j EXT and their spatial position on the flexible sensor (110).
摘要翻译：传感涂层装置（100）被配置为测量作用在其上的外部压力，所述传感涂覆装置（100）包括柔性传感器（110），该柔性传感器具有基本上层流的形状，并且包括多个敏感区域Ai，j，所述柔性传感器）被配置用于在所述敏感区域Ai，j处测量是否存在相应的外部压力Pi，j EXT·柔性传感器（110）包括第一层（111），其包括数个导体材料条（111'），）与第二层（112）交替，所述第二层（112）包括与非导电材料（112“）的条带交替的多个导电材料条带（112'）。第一层（111）和所述第二层（112）被布置在使得第二层（112）的导电材料（112'）的条带重叠而不与导电材料（111）的j条物理接触的位置 '）在所述敏感区域Ai，j处的第一层（111）。第一层（111）的导电材料（111'）和第二层（112）的导电材料条（112'）的条带连接到电路（115）。第一层（111）的导电材料条（111'）布置成在确定的敏感区域Ai，j处与第二层（112）的导电材料（112'）的条带电接触，结果是确定的外部压力Pi，j EXT作用在确定的敏感区域Ai，j上，所述电气接触闭合电路（115）并且在电接触的两个导电材料条带（111'，112'）的端部处产生电压以产生报告关于在柔性传感器（110）上存在所述外部压力Pi，j EXT及其空间位置的信息的接触信号。

5. 发明申请

WO2019106581A2 URETHRAL ARTIFICIAL SPHINCTER WITH BISTABLE ACTUATION SYSTEM 审中-公开
公开(公告)号：WO2019106581A2
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059432
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL - ISTITUTO NAZIONALE PER L’ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo , LUCARINI, Gioia , MARZIALE, Leonardo , SACCHETTI, Rinaldo
IPC分类号： A61F2/00
CPC分类号： A61F2/0022 , A61F2/0036 , A61F2210/009 , A61F2250/0001 , A61F2250/0041
摘要： An artificial sphincter to be implanted in a urethra, in particular, for treating patients suffering from urinary incontinence, comprises a container (10) configured to be connected to a wall of a urethra (4), inside or outside it, a valve unit (20) housed within the container (10) and configured to move from a release configuration (R) to a block configuration (B) and vice-versa; an actuation magnet (66) movably (rotatably or slidably) arranged between a first and a second position in the container (10), and connected to the valve unit (20) in such a way that a predetermined (rotation or translation) movement (67', 67") of the actuation magnet (66) from a first towards a second position, or from the second towards the first position, under the effect of an external manoeuvre magnet (90), brings the valve unit (20) from the release configuration (R) to the block configuration (B), where the valve is stably maintained, and from the block configuration (B) to the release configuration (R), where the valve is stably maintained.

6. 发明申请

WO2019106581A3 URETHRAL ARTIFICIAL SPHINCTER WITH BISTABLE ACTUATION SYSTEM 审中-公开
公开(公告)号：WO2019106581A3
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059432
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL - ISTITUTO NAZIONALE PER L’ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo , LUCARINI, Gioia , MARZIALE, Leonardo , SACCHETTI, Rinaldo
IPC分类号： A61F2/00
摘要： An artificial sphincter to be implanted in a urethra, in particular, for treating patients suffering from urinary incontinence, comprises a container (10) configured to be connected to a wall of a urethra (4), inside or outside it, a valve unit (20) housed within the container (10) and configured to move from a release configuration (R) to a block configuration (B) and vice-versa; an actuation magnet (66) movably (rotatably or slidably) arranged between a first and a second position in the container (10), and connected to the valve unit (20) in such a way that a predetermined (rotation or translation) movement (67', 67") of the actuation magnet (66) from a first towards a second position, or from the second towards the first position, under the effect of an external manoeuvre magnet (90), brings the valve unit (20) from the release configuration (R) to the block configuration (B), where the valve is stably maintained, and from the block configuration (B) to the release configuration (R), where the valve is stably maintained.

7. 发明申请

WO2019106563A1 ROTATABLY-ACTUATED ENDOURETHRAL ARTIFICIAL SPHINCTER 审中-公开
公开(公告)号：WO2019106563A1
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059407
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL-ISTITUTO NAZIONALE PER L'ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo
IPC分类号： A61F2/00
CPC分类号： A61F2/0022 , A61F2/0018 , A61F2210/009
摘要： An endourethral artificial sphincter (101) comprises a container (10) configured to be blocked in the patient's urethra (4), a torsionally compliant tubular body (20) fixedly arranged within the container (10) with the longitudinal axis (29) parallel to that (19) of the container (10), comprising two end portions (21, 23) torsionally stiffer, of which the first one (21) is integrally connected to the container (10), and comprising also a torsionally more deformable central portion (22), an opening/closing torsional deformation (8,9) of which brings the torsionally compliant tubular body (20) from an open configuration (A) to a closed configuration (C), causing the inner walls of the central portion (22) to come into contact with each other thus blocking a passageway (24), or vice-versa, the endourethral artificial sphincter (101) also comprising a rotatable actuation cylinder (30) integrally connected to the second end portion (23) of the torsionally compliant body (20), and a magnetic actuation unit (60) having an actuation magnet (66) movably arranged within the container (10), connected to the rotatable actuation cylinder (30) in such a way that a movement (67', 67") of the latter induced by a manoeuvre magnet (90) positioned at a predetermined distance causes an integral rotation (68', 68") of the rotatable actuation cylinder (30) and of the second end portion (23), and twists the central portion (22), thus opening or closing it.

8. 发明申请

WO2013144770A3 A STRUCTURE OF ARTIFICIAL ENDO-URETHRAL SPHINCTER 审中-公开
公开(公告)号：WO2013144770A3
公开(公告)日：2013-10-03
申请号：PCT/IB2013/052156
申请日：2013-03-18
申请人： PINZI, Novello , MAZZOCCHI, Tommaso , GIULIANI, Giuseppe
发明人： PINZI, Novello , MAZZOCCHI, Tommaso , GIULIANI, Giuseppe
IPC分类号： A61F2/00
摘要： A structure (140) of artificial endo-urethral sphincter for treating the urinary incontinence comprising at least one hollow rigid body (71), configured for being fixed within the walls (3) of the urethral-bladder lumen of a patient, inside it being provided: a longitudinal channel (11'); a valve element (13) housed within the longitudinal channel (11'); a closure means for moving the valve element (13) between a closed configuration and an open configuration. In a first aspect of the invention, the structure comprises a safety element (16) arranged within the longitudinal channel (11') downstream of the valve element (13), also comprises a block means structured for turning between a block configuration and a release configuration, where the safety element (16) is configured for preventing an unwanted / allowing a massive flow of urine (99), respectively, through the valve element (13). The structure prevents unwanted urine leakage, in particular urine leakages due to a seal defect of the sphincter, or in the case of an uncontrolled increase of the intravesical pressure due to coughs and efforts of any other nature. In an exemplary embodiment, a safety abutment member (16) is provided on a valve element (13) comprising preferably shell- shaped (34) resilient walls, which in the release configuration is at a distance from the valve element (13) and enables the latter to open. A return elastic element (14) may be arranged for firmly keeping the safety element (16) in the block configuration. In a second aspect of the invention, the safety element (16) may comprise, at an own end (21,21'), a magnetically sensitive element (15), configured such that, by arranging an external (electro)magnetic element (17) with the same polarization direction, a magnetic coupling is formed of the two elements (15,17) and the safety element (16) turns to the release configuration.

9. 发明申请

WO2012120326A1 STRUCTURE OF ARTIFICIAL URINARY BLADDER 审中-公开
标题翻译：人造尿布结构
公开(公告)号：WO2012120326A1
公开(公告)日：2012-09-13
申请号：PCT/IB2011/001558
申请日：2011-07-04
申请人： PINZI, Novello , MAZZOCCHI, Tommaso , GIULIANI, Giuseppe
发明人： PINZI, Novello , MAZZOCCHI, Tommaso , GIULIANI, Giuseppe
IPC分类号： A61F2/00 , A61F2/04
CPC分类号： A61F2/042 , A61F2/0036 , A61F2210/009
摘要： A structure of artificial urinary bladder (1 ) comprises at least one inlet (11a and lib) that is adapted to be put in communication with a respective ureter (110a and 110b), and an outlet (13) that is adapted to be put in communication with the urethra (130) of the patient. The hollow container body (10) is made of a flexible material and is arranged to turn from an urine containing configuration (50) to a squeezed discharge configuration that causes a discharge of urine (50) through the outlet (13). A valve is provided (20) at the outlet (13) and actuating means (30) of the valve (20) is provided movable between a closed position for closing outlet (13), when the container (10) is in the urine containing configuration, and an open position, when the hollow flexible container body (10) is in the squeezed discharge configuration. Furthermore, a squeezing means (60) of the hollow container body (10) can be present that is adapted to pass from a rest position, simultaneously to the valve (20) staying in the closed position, to a position of squeezing the hollow container body (10), simultaneously to the valve (20) staying in the open position.
摘要翻译：人造尿囊（1）的结构包括适于与相应的输尿管（110a和110b）连通的至少一个入口（11a和11b）和适于放入与患者的尿道（130）通信。中空容器主体10由柔性材料制成，并被布置成从尿液构造（50）转向通过出口（13）排出尿液（50）的挤压排放构型。在出口（13）处设有阀门（20），阀门（20）的致动装置（30）设置为可在关闭出口（13）的关闭位置之间移动，当容器（10）在尿液中时构造和打开位置，当中空柔性容器主体（10）处于挤压排放构型时。此外，可以存在中空容器主体（10）的挤压装置（60），该挤压装置（60）适于从静止位置同时传递到保持在关闭位置的阀（20）到挤压中空容器的位置主体（10）同时到位于打开位置的阀门（20）。

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