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1. 发明申请

WO2019106581A2 URETHRAL ARTIFICIAL SPHINCTER WITH BISTABLE ACTUATION SYSTEM 审中-公开
公开(公告)号：WO2019106581A2
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059432
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL - ISTITUTO NAZIONALE PER L’ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo , LUCARINI, Gioia , MARZIALE, Leonardo , SACCHETTI, Rinaldo
IPC分类号： A61F2/00
CPC分类号： A61F2/0022 , A61F2/0036 , A61F2210/009 , A61F2250/0001 , A61F2250/0041
摘要： An artificial sphincter to be implanted in a urethra, in particular, for treating patients suffering from urinary incontinence, comprises a container (10) configured to be connected to a wall of a urethra (4), inside or outside it, a valve unit (20) housed within the container (10) and configured to move from a release configuration (R) to a block configuration (B) and vice-versa; an actuation magnet (66) movably (rotatably or slidably) arranged between a first and a second position in the container (10), and connected to the valve unit (20) in such a way that a predetermined (rotation or translation) movement (67', 67") of the actuation magnet (66) from a first towards a second position, or from the second towards the first position, under the effect of an external manoeuvre magnet (90), brings the valve unit (20) from the release configuration (R) to the block configuration (B), where the valve is stably maintained, and from the block configuration (B) to the release configuration (R), where the valve is stably maintained.

2. 发明申请

WO2019106581A3 URETHRAL ARTIFICIAL SPHINCTER WITH BISTABLE ACTUATION SYSTEM 审中-公开
公开(公告)号：WO2019106581A3
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059432
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL - ISTITUTO NAZIONALE PER L’ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo , LUCARINI, Gioia , MARZIALE, Leonardo , SACCHETTI, Rinaldo
IPC分类号： A61F2/00
摘要： An artificial sphincter to be implanted in a urethra, in particular, for treating patients suffering from urinary incontinence, comprises a container (10) configured to be connected to a wall of a urethra (4), inside or outside it, a valve unit (20) housed within the container (10) and configured to move from a release configuration (R) to a block configuration (B) and vice-versa; an actuation magnet (66) movably (rotatably or slidably) arranged between a first and a second position in the container (10), and connected to the valve unit (20) in such a way that a predetermined (rotation or translation) movement (67', 67") of the actuation magnet (66) from a first towards a second position, or from the second towards the first position, under the effect of an external manoeuvre magnet (90), brings the valve unit (20) from the release configuration (R) to the block configuration (B), where the valve is stably maintained, and from the block configuration (B) to the release configuration (R), where the valve is stably maintained.

3. 发明申请

WO2012028557A1 SWALLOWABLE CAPSULE FOR INSUFFLATION OF GASTROINTESTINAL TRACT 审中-公开
标题翻译：用于消除胃肠道疾病的易吸收性胶囊
公开(公告)号：WO2012028557A1
公开(公告)日：2012-03-08
申请号：PCT/EP2011/064764
申请日：2011-08-26
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , VANDERBILT UNIVERSITY , VALDASTRI, Pietro , CIUTI, Gastone , MENCIASSI, Arianna , DARIO, Paolo , WEBSTER, Robert J. III , SMITH, Byron F. , TOENNIES, Jenna J.
发明人： VALDASTRI, Pietro , CIUTI, Gastone , MENCIASSI, Arianna , DARIO, Paolo , WEBSTER, Robert J. III , SMITH, Byron F. , TOENNIES, Jenna J.
IPC分类号： A61B1/32 , A61B1/04 , A61B1/12
CPC分类号： A61M13/003 , A61B1/00158 , A61B1/015 , A61B1/041
摘要： A system for insufflating a body cavity comprising a swallowable capsule comprising a chamber (11) containing a fluid capable to generate biocompatible gas or vapour by phase transition or chemical reaction, the chamber (11) being formed with at least one orifice (7) for placing it in communication with the outside. The orifice (7) is blocked by a shutter (4, 6; 26) made of magnetic material and there are provided elastic means (8) able to generate an elastic force sufficient to keep said shutter sealingly engaged in the orifice. The system further comprises magnetic actuating means (12; 34) external to the body cavity for generating a magnetic force having strength sufficient to overcome the elastic force of the elastic means disengaging the shutter from the orifice.
摘要翻译：一种用于吹入体腔的系统，包括可吞咽胶囊，其包括容纳能够通过相变或化学反应产生生物相容性气体或蒸汽的流体的腔室（11），所述腔室（11）形成有至少一个孔口（7），用于将其与外部通信。孔（7）被由磁性材料制成的活门（4,6; 26）阻挡，并且设置有弹性装置（8），该弹性装置能够产生足以使所述活门密封地接合在孔口中的弹性力。该系统还包括在体腔外部的磁性致动装置（12; 34），用于产生具有足以克服弹性装置将闸板从孔口分离的弹力的强度的磁力。

4. 发明申请

WO2011135503A1 ROBOTIC APPARATUS FOR MINIMALLY INVASIVE SURGERY 审中-公开
标题翻译：微型手术手术器械
公开(公告)号：WO2011135503A1
公开(公告)日：2011-11-03
申请号：PCT/IB2011/051772
申请日：2011-04-22
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , SCARFOGLIERO, Umberto , QUAGLIA, Claudio , PICCIGALLO, Marco , TOGNARELLI, Selene , VALDASTRI, Pietro , MENCIASSI, Arianna , DARIO, Paolo
发明人： SCARFOGLIERO, Umberto , QUAGLIA, Claudio , PICCIGALLO, Marco , TOGNARELLI, Selene , VALDASTRI, Pietro , MENCIASSI, Arianna , DARIO, Paolo
IPC分类号： A61B19/00 , A61B1/313
CPC分类号： A61B19/2203 , A61B34/30 , A61B2017/2906 , A61B2034/305 , Y10T74/19907 , Y10T74/20305 , Y10T74/20335
摘要： A robotic arm (101, 102; 201, 202) especially suited for laparoscopic surgery, comprising a torsional joint (6) and a flexural joint (5) serially arranged, said joints (5, 6) providing respective degrees of freedom for said arm, the robotic arm receiving drive means (38, 39) for said flexural (5) and torsional (6) joints. The robotic arm further comprises transmission means (340, 350, 34-36) placed between the drive means (38, 39) and the joints (5, 6). The transmission means comprise a first (340) and a second (350) assembly of three gear wheels, preferably of the conical type, and a train of three additional gear wheels (34-36) preferably straight-cut gear wheels, which couple the first (340) and second (350) assembly to form a differential mechanism.
摘要翻译：特别适用于腹腔镜手术的机械臂（101,102; 201,202）包括扭转关节（6）和串联地设置的弯曲关节（5），所述关节（5,6）为所述臂提供相应的自由度所述机械手臂接收用于所述弯曲（5）和扭转（6）接头的驱动装置（38,39）。机器手臂还包括放置在驱动装置（38,39）和接头（5,6）之间的传动装置（340,350,34-36）。传动装置包括优选为锥形的三个齿轮的第一（340）和第二（350）组件，以及三个附加齿轮（34-36）的列，优选为直切齿轮，其连接第一（340）和第二（350）组件以形成差速机构。

5. 发明申请

WO2017145130A1 AN ARTIFICIAL BLADDER, AND A PROCESS FOR ITS MANUFACTURE 审中-公开
标题翻译：人造膀胱，及其制造过程
公开(公告)号：WO2017145130A1
公开(公告)日：2017-08-31
申请号：PCT/IB2017/051133
申请日：2017-02-27
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , PINZI, Novello
发明人： PINZI, Novello , RICOTTI, Leonardo , MAZZOCCHI, Tommaso , FONTANA, Rossella , MENCIASSI, Arianna , IACOVACCI, Veronica
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61F2210/0076 , A61F2230/005 , A61F2240/004
摘要： The present invention relates to an implantable medical device for collecting and discharging biological urinary fluids, for example an artificial bladder, which by virtue of a multilayer body having a particular shape of the inner surface, allows reproducing the natural organ tissue performance especially in terms of flexibility and consequent variability of the inner volume, further exhibiting high stability and urine resistance in the long term.
摘要翻译：本发明涉及用于收集和排出生物尿液的可植入医疗装置，例如人造膀胱，其借助具有特定形状的内表面的多层体允许再生天然器官组织的性能，特别是在灵活性和内部容积的随之变化方面，进一步表现出长期的高稳定性和尿液抵抗力。

6. 发明申请

WO2017051394A1 Sensorized coating for detection of pressures 审中-公开
标题翻译：用于检测压力的传感器涂层
公开(公告)号：WO2017051394A1
公开(公告)日：2017-03-30
申请号：PCT/IB2016/055751
申请日：2016-09-26
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA
发明人： CIUTI, Gastone , DIODATO, Alessandro , MAZZOCCHI, Tommaso , MENCIASSI, Arianna , VITIELLO, Nicola
IPC分类号： B25J9/16 , B25J19/02
CPC分类号： B25J13/084 , B25J9/1633 , B25J9/1676
摘要： A sensorized coating device (100) configured for measuring external pressures acting on it, said sensorized coating device (100) comprising a flexible sensor (110) having shape substantially laminar and comprising a plurality of sensitive areas A i,j , said flexible sensor (110) being configured for measuring, at said sensitive areas A i,j , the presence of corresponding external pressures P i, j EXT · The flexible sensor (110) comprises a first layer (111) comprising a number i of strips of conductive material (111') alternate to strips of non-conductive material (111'') and a second layer (112) comprising a number j of strips of conductive material (112') alternate to strips of non-conductive material (112''). The first layer (111) and said second layer (112) are arranged in a position such that the i strips of conductive material (112') of the second layer (112) overlap without physical contact to the j strips of conductive material (111') of the first layer (111) at the said sensitive areas A i,j . The strips of conductive material (111') of the first layer (111) and the strips of conductive material (112') of the second layer (112) are connected to an electrical circuit (115). The strips of conductive material (111') of the first layer (111) are arranged to come into electrical contact with the strips of conductive material (112') of the second layer (112) at determined sensitive areas A i,j in consequence of determined external pressures P i, j EXT acting on the determined sensitive areas A i,j , said electrical contact closing the electrical circuit (115) and generating a voltage at the ends of two strips of conductive material (111', 112') in electrical contact to each other, in order to generate contact signals reporting information about the presence of said external pressures P i, j EXT and their spatial position on the flexible sensor (110).
摘要翻译：传感涂层装置（100）被配置为测量作用在其上的外部压力，所述传感涂覆装置（100）包括柔性传感器（110），该柔性传感器具有基本上层流的形状，并且包括多个敏感区域Ai，j，所述柔性传感器）被配置用于在所述敏感区域Ai，j处测量是否存在相应的外部压力Pi，j EXT·柔性传感器（110）包括第一层（111），其包括数个导体材料条（111'），）与第二层（112）交替，所述第二层（112）包括与非导电材料（112“）的条带交替的多个导电材料条带（112'）。第一层（111）和所述第二层（112）被布置在使得第二层（112）的导电材料（112'）的条带重叠而不与导电材料（111）的j条物理接触的位置 '）在所述敏感区域Ai，j处的第一层（111）。第一层（111）的导电材料（111'）和第二层（112）的导电材料条（112'）的条带连接到电路（115）。第一层（111）的导电材料条（111'）布置成在确定的敏感区域Ai，j处与第二层（112）的导电材料（112'）的条带电接触，结果是确定的外部压力Pi，j EXT作用在确定的敏感区域Ai，j上，所述电气接触闭合电路（115）并且在电接触的两个导电材料条带（111'，112'）的端部处产生电压以产生报告关于在柔性传感器（110）上存在所述外部压力Pi，j EXT及其空间位置的信息的接触信号。

7. 发明申请

WO2012070016A1 PROCESS FOR THE PREPARATION OF BIOCOMPATIBLE, FREE-STANDING NANOFILMS OF CONDUCTIVE POLYMERS 审中-公开
标题翻译：制备生物降解的自由基导电聚合物纳米微粒的方法
公开(公告)号：WO2012070016A1
公开(公告)日：2012-05-31
申请号：PCT/IB2011/055288
申请日：2011-11-24
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA , GRECO, Francesco , MATTOLI, Virgilio , DARIO, Paolo , MENCIASSI, Arianna , ZUCCA, Alessandra
发明人： GRECO, Francesco , MATTOLI, Virgilio , DARIO, Paolo , MENCIASSI, Arianna , ZUCCA, Alessandra
IPC分类号： C08J7/02 , B82Y30/00
CPC分类号： C08J7/02 , B82Y30/00 , C08J7/08 , Y10T428/31533
摘要： The invention concerns a process for the preparation of nanofilms of conductive polymers, through the formation of support layers of other polymers. The present process has advantageous properties such as cost-effectiveness, speed of execution and use of relatively simple instruments; and it also allows to obtain free-standing nanofilms, i.e. nanofilms that are stable and able to support themselves without the need for any support. The present nanofilms al so have further advantageous characteristics, such as strength, flexibility, ability to adhere to different substrates, and high biocompatibility, which make them suitable for numerous different technological applications, in particular in the biomedical field.
摘要翻译：本发明涉及通过形成其它聚合物的支撑层来制备导电聚合物的纳米膜的方法。本方法具有成本效益，执行速度和使用相对简单的仪器等优点; 并且它还允许获得独立的纳米薄膜，即稳定且能够支持自身而不需要任何支撑物的纳米薄膜。本发明的纳米薄膜具有更强的特性，例如强度，柔韧性，粘附于不同基材的能力以及高生物相容性，这使得它们适用于许多不同的技术应用，特别是生物医学领域。

8. 发明申请

WO2012035157A1 MAGNETIC LEVITATION ENDOSCOPIC DEVICE 审中-公开
标题翻译：磁感应内窥镜装置
公开(公告)号：WO2012035157A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/066149
申请日：2011-09-16
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , SIMI, Massimiliano , VALDASTRI, Pietro , MENCIASSI, Arianna , DARIO, Paolo
发明人： SIMI, Massimiliano , VALDASTRI, Pietro , MENCIASSI, Arianna , DARIO, Paolo
IPC分类号： A61B1/005 , A61B1/313 , A61B1/00
CPC分类号： A61B1/313 , A61B1/00158 , A61B1/0055
摘要： Endoscopic system, comprising an endoscopic device 1 moved by a magnetic levitation system comprising a first 2 and a second 3 module connected by means of a flexible joint 4 and each bearing one or more permanent magnets 21, 22, 31, 32, the second module 3 further being provided with a motor 34 for the actuation of the internal magnets 31, 32 thereof; and means 61, 62, 7 for generating a first and a second external magnetic field, adapted to respectively interact with the magnets of the first and of the second module with the aim of producing a desired magnetic field surrounding the second module 3 for an efficient working of the levitation system in orienting the second module 3 with respect to the first module 2.
摘要翻译：内窥镜系统，包括由磁悬浮系统移动的内窥镜装置1，该磁悬浮系统包括通过柔性关节4连接的第一和第二模块，并且每个轴承具有一个或多个永磁体21,22,31,32，第二模块 3还设置有用于致动其内部磁体31,32的马达34; 以及用于产生适于分别与第一和第二模块的磁体相互作用的第一和第二外部磁场的装置61,62,7，目的是产生围绕第二模块3的期望的磁场，用于有效地悬挂系统在使第二模块3相对于第一模块2定向时的工作。

9. 发明申请

WO2017145128A1 ARTIFICIAL BLADDER 审中-公开
标题翻译：人工膀胱
公开(公告)号：WO2017145128A1
公开(公告)日：2017-08-31
申请号：PCT/IB2017/051130
申请日：2017-02-27
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , PINZI, Novello
发明人： PINZI, Novello , RICOTTI, Leonardo , MAZZOCCHI, Tommaso , FONTANA, Rossella , MENCIASSI, Arianna , IACOVACCI, Veronica
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61F2210/0076
摘要： The present invention relates to an artificial bladder for collecting and discharging biological urinary fluids, provided with high stability and resistance to urine over the long periods, also being able to expand and contract with a variation of its inner volume, without the constituent material to be subject to stretching or deformation under the pressure of the urinary fluids.
摘要翻译：本发明涉及一种用于收集和排出生物尿液的人造膀胱，其长期具有高稳定性和耐尿性，并且能够随其内部的变化而膨胀和收缩体积，没有组成材料在尿液压力下受到拉伸或变形。

10. 发明申请

WO2012164517A1 ROBOTIC PLATFORM FOR MINI-INVASIVE SURGERY 审中-公开
标题翻译：微型手术机器人平台
公开(公告)号：WO2012164517A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052739
申请日：2012-05-31
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , VALDASTRI, Pietro , DI NATALI, Christian , SIMI, Massimiliano , RANZANI, Tommaso , MENCIASSI, Arianna , DARIO, Paolo
发明人： VALDASTRI, Pietro , DI NATALI, Christian , SIMI, Massimiliano , RANZANI, Tommaso , MENCIASSI, Arianna , DARIO, Paolo
IPC分类号： A61B19/00
CPC分类号： A61B34/30 , A61B17/00234 , A61B34/71 , A61B90/30 , A61B2017/00464 , A61B2017/00477 , A61B2017/00876 , A61B2034/302 , A61B2034/731 , G05B15/02
摘要： Robotic platform for mini-invasive surgery comprising robotic arms (4a, 4b) suitable to be placed in the body of a patient, introduced through a single access port, which are an extension of external robotic manipulators (19). The continuity between external (1) and internal (4a, 4b) robotic arms is guaranteed by means of a trans- abdominal magnetic connection (6) between the internal robotic arm integral with the external one. The trans-abdominal magnetic coupling not only guarantees a stable anchoring, but most of all it transfers degrees of freedom to the internal robotic arms, inducing the motion of internal magnets by means of the automatized motion of external magnets. It is also possible to reposition the internal robotic arms without requiring having to additionally perform incisions on the abdomen. Using the external robotic arms allows translating the internal ones on the entire abdomen thus providing a working space not bound to the point of insertion and theoretically unlimited.
摘要翻译：用于微创手术的机器人平台包括适于放置在患者体内的机器人臂（4a，4b），通过作为外部机器人操纵器（19）的延伸部的单个进入口引入。外部（1）和内部（4a，4b）机械手臂之间的连续性通过与外部机械臂整合的内部机械手臂之间的腹部磁性连接（6）来保证。跨腹磁耦合不仅可以保证稳定的锚固，而且最重要的是将内部机械臂的自由度转移，通过外部磁体的自动化运动来引起内部磁体的运动。也可以重新定位内部机器人手臂，而无需另外在腹部进行切口。使用外部机器人手臂允许翻译整个腹部的内部机器人手臂，从而提供不限于插入点的理论上无限制的工作空间。

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