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1. 发明申请

WO2019106563A1 ROTATABLY-ACTUATED ENDOURETHRAL ARTIFICIAL SPHINCTER 审中-公开
公开(公告)号：WO2019106563A1
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059407
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL-ISTITUTO NAZIONALE PER L'ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo
IPC分类号： A61F2/00
CPC分类号： A61F2/0022 , A61F2/0018 , A61F2210/009
摘要： An endourethral artificial sphincter (101) comprises a container (10) configured to be blocked in the patient's urethra (4), a torsionally compliant tubular body (20) fixedly arranged within the container (10) with the longitudinal axis (29) parallel to that (19) of the container (10), comprising two end portions (21, 23) torsionally stiffer, of which the first one (21) is integrally connected to the container (10), and comprising also a torsionally more deformable central portion (22), an opening/closing torsional deformation (8,9) of which brings the torsionally compliant tubular body (20) from an open configuration (A) to a closed configuration (C), causing the inner walls of the central portion (22) to come into contact with each other thus blocking a passageway (24), or vice-versa, the endourethral artificial sphincter (101) also comprising a rotatable actuation cylinder (30) integrally connected to the second end portion (23) of the torsionally compliant body (20), and a magnetic actuation unit (60) having an actuation magnet (66) movably arranged within the container (10), connected to the rotatable actuation cylinder (30) in such a way that a movement (67', 67") of the latter induced by a manoeuvre magnet (90) positioned at a predetermined distance causes an integral rotation (68', 68") of the rotatable actuation cylinder (30) and of the second end portion (23), and twists the central portion (22), thus opening or closing it.

2. 发明申请

WO2022074632A1 A DEVICE FOR ENDOSCOPICALLY DELIVERING A THERAPEUTIC SUBSTANCE 审中-公开
公开(公告)号：WO2022074632A1
公开(公告)日：2022-04-14
申请号：PCT/IB2021/059279
申请日：2021-10-11
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA
发明人： RICOTTI, Leonardo , VANNOZZI, Lorenzo , MAZZOCCHI, Tommaso , SILIBERTO, Alessio , GUARNERA, Daniele
IPC分类号： A61B17/34 , A61M25/01 , A61M25/00
摘要： A device for endoscopically delivering at least one therapeutic substance includes a cannula (10) defining at least one extrusion channel (11) and comprises a proximal portion (19), a flexible distal portion (15) having an extrusion mouth (16), and a substantially rigid intermediate portion (17) between the flexible distal portion (15) and the proximal portion (19). The proximal portion (19) is configured to feed and push a therapeutic substance into the extrusion channel (11), so that the latter can pass through the extrusion channel (11) flowing through the intermediate portion (17) and through the flexible distal portion (15) and can exit from the extrusion mouth (16). The device also comprises at least one actuation cable (50, 50', 50") having a proximal end (59) operable at the proximal portion (19) and a distal end (55) connected to the flexible distal portion (15) at the extrusion mouth (16), and configured to pull the flexible distal portion (15) with a force transversal to the extrusion channel (11), bringing the flexible distal portion (15) from an undeformed conformation (A) to a deformed conformation (B). According to the invention, the substantially rigid intermediate portion (17) has a distal rigid edge (54) from which the flexible distal portion protrudes (15), and in which the distal rigid edge (54) has a passageway exit (53) of a passageway (56) for the actuation cable (50), the distal rigid edge (54) and the passageway exit (53) of the passageway arranged in such a way that only the flexible distal portion (15) of the cannula (10) can be brought, by the actuation cable (50, 50', 50"), from the undeformed conformation (A) to the deformed conformation (B) while the intermediate portion (17) remains undeformed.

3. 发明申请

WO2020174395A1 MATERIAL AND SYSTEM FOR THE THERAPEUTIC TREATMENT OF JOINTS 审中-公开
公开(公告)号：WO2020174395A1
公开(公告)日：2020-09-03
申请号：PCT/IB2020/051603
申请日：2020-02-25
申请人： VIMEX SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (VIMEX) , H&D WIRELESS AB , PLASMACHEM PRODUKTIONS UND HANDEL GMBH , IMAGE GUIDED THERAPY SA , ISTITUTO ORTOPEDICO RIZZOLI , BAR ILAN UNIVERSITY , SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA
发明人： RICOTTI, Leonardo , VANNOZZI, Lorenzo , CAFARELLI, Andrea , NESSIM, Gilbert Daniel , LISIGNOLI, Gina , WECHSLER, Aharon , DUMONT, Erik Jean-Claude , JOST, Carsten , GAPINSKI, Tomasz , BERGSTEN, Pär , GABUSI, Elena , FINI, Milena , TSCHON, Matilde , RUSSO, Alessandro , ZAFFAGNINI, Stefano , MELICONI, Riccardo , FEDUTIK, Yirij , LENARTOWICZ, Krzysztof Stanislaw , JERNBERGER, Åke , SHACHAF, Yonatan , ERIKSSON, Magnus
IPC分类号： A61L27/38 , A61L27/44 , A61L27/52 , A61M37/00 , A61N1/20 , A61N1/32 , B82Y5/00
摘要： A system for the therapeutic treatment of joints comprising a composite material (10) arranged to the therapeutic treatment of joints, said composite material (10) comprising a biodegradable polymer matrix (11) and a plurality of piezoelectric particles (12) adapted to generate local electric charges in response to an external stimulation made by means of ultrasound, said plurality of piezoelectric particles (12) being dispersed in the matrix. The composite material (10) also comprises a plurality of stamina cells (13) dispersed in the biodegradable polymer matrix (11) and a plurality of carbon-based particles. The system also comprises a releasing device (20), arranged to deposit the composite material (10) in a joint cavity at predetermined areas of the cartilage, and a stimulator device (30) arranged to emit ultrasound at a predetermined frequency, a predetermined intensity and for a predetermined time of application, in such a way that, when the device is located near a joint wherein the composite material (10) has been deposited, said ultrasound stimulate the plurality of piezoelectric particles (12).

4. 发明申请

WO2017145130A1 AN ARTIFICIAL BLADDER, AND A PROCESS FOR ITS MANUFACTURE 审中-公开
标题翻译：人造膀胱，及其制造过程
公开(公告)号：WO2017145130A1
公开(公告)日：2017-08-31
申请号：PCT/IB2017/051133
申请日：2017-02-27
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , PINZI, Novello
发明人： PINZI, Novello , RICOTTI, Leonardo , MAZZOCCHI, Tommaso , FONTANA, Rossella , MENCIASSI, Arianna , IACOVACCI, Veronica
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61F2210/0076 , A61F2230/005 , A61F2240/004
摘要： The present invention relates to an implantable medical device for collecting and discharging biological urinary fluids, for example an artificial bladder, which by virtue of a multilayer body having a particular shape of the inner surface, allows reproducing the natural organ tissue performance especially in terms of flexibility and consequent variability of the inner volume, further exhibiting high stability and urine resistance in the long term.
摘要翻译：本发明涉及用于收集和排出生物尿液的可植入医疗装置，例如人造膀胱，其借助具有特定形状的内表面的多层体允许再生天然器官组织的性能，特别是在灵活性和内部容积的随之变化方面，进一步表现出长期的高稳定性和尿液抵抗力。

5. 发明申请

WO2019106581A2 URETHRAL ARTIFICIAL SPHINCTER WITH BISTABLE ACTUATION SYSTEM 审中-公开
公开(公告)号：WO2019106581A2
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059432
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL - ISTITUTO NAZIONALE PER L’ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo , LUCARINI, Gioia , MARZIALE, Leonardo , SACCHETTI, Rinaldo
IPC分类号： A61F2/00
CPC分类号： A61F2/0022 , A61F2/0036 , A61F2210/009 , A61F2250/0001 , A61F2250/0041
摘要： An artificial sphincter to be implanted in a urethra, in particular, for treating patients suffering from urinary incontinence, comprises a container (10) configured to be connected to a wall of a urethra (4), inside or outside it, a valve unit (20) housed within the container (10) and configured to move from a release configuration (R) to a block configuration (B) and vice-versa; an actuation magnet (66) movably (rotatably or slidably) arranged between a first and a second position in the container (10), and connected to the valve unit (20) in such a way that a predetermined (rotation or translation) movement (67', 67") of the actuation magnet (66) from a first towards a second position, or from the second towards the first position, under the effect of an external manoeuvre magnet (90), brings the valve unit (20) from the release configuration (R) to the block configuration (B), where the valve is stably maintained, and from the block configuration (B) to the release configuration (R), where the valve is stably maintained.

6. 发明申请

WO2017145128A1 ARTIFICIAL BLADDER 审中-公开
标题翻译：人工膀胱
公开(公告)号：WO2017145128A1
公开(公告)日：2017-08-31
申请号：PCT/IB2017/051130
申请日：2017-02-27
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , PINZI, Novello
发明人： PINZI, Novello , RICOTTI, Leonardo , MAZZOCCHI, Tommaso , FONTANA, Rossella , MENCIASSI, Arianna , IACOVACCI, Veronica
IPC分类号： A61F2/04
CPC分类号： A61F2/042 , A61F2210/0076
摘要： The present invention relates to an artificial bladder for collecting and discharging biological urinary fluids, provided with high stability and resistance to urine over the long periods, also being able to expand and contract with a variation of its inner volume, without the constituent material to be subject to stretching or deformation under the pressure of the urinary fluids.
摘要翻译：本发明涉及一种用于收集和排出生物尿液的人造膀胱，其长期具有高稳定性和耐尿性，并且能够随其内部的变化而膨胀和收缩体积，没有组成材料在尿液压力下受到拉伸或变形。

7. 发明申请

WO2023281428A1 A SYSTEM FOR THE CONTROLLED ADMINISTRATION OF A SUBSTANCE WITH AN IMPLANTABLE INFUSION DEVICE PROVIDED WITH AN IMPROVED DOCKING GROUP FOR RELIABLY DOCKING AN INGESTIBLE SUBSTANCE CARRIER 审中-公开
公开(公告)号：WO2023281428A1
公开(公告)日：2023-01-12
申请号：PCT/IB2022/056271
申请日：2022-07-07
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , LIFECARE LABORATORY GMBH
发明人： AL-HADDAD, Hind , IZADYAR TAMADON, Izadyar , GUARNERA, Daniele , MENCIASSI, Arianna , DARIO, Paolo , PFÜTZNER, Andreas , VISTOLI, Fabio , IACOVACCI, Veronica , RICOTTI, Leonardo
IPC分类号： A61M5/142 , A61M5/172
摘要： The present invention generally regards the controlled administration of substances through infusion devices implanted in the human body and more particularly has as object an improved system for the controlled administration of a substance such as a drug, a hormone or a hormone complex and the like for which other administration modes result unsatisfactory or ineffective. More specifically, the invention is directed to such a system comprising an implanted infusion device provided with an improved docking group for reliably docking an ingestible substance carrier. The invention also relates with a special construction of the carrier.

8. 发明申请

WO2022172299A1 DEVICE FOR NOSE POST-TREATMENT REPAIR 审中-公开
公开(公告)号：WO2022172299A1
公开(公告)日：2022-08-18
申请号：PCT/IT2021/000005
申请日：2021-02-12
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , UNIVERSITA' DEGLI STUDI DI FERRARA
发明人： CAMPACCI, Federica , CIUTI, Gastone , RICOTTI, Leonardo , VICINI, Claudio
IPC分类号： A61F5/08 , A61B17/12 , A61F5/058 , A61M29/02
摘要： A device for nose post-treatment repair comprises a medial portion (20) supporting the nasal septum and a lateral portion (30) contacting the turbinates of the nasal wall, wherein the medial portion (20) comprises a foil element (21) to one side of which is connected a tubular element forming an airway (22), and the lateral portion (30) comprises a tamponade body (31) associated with the medial portion (20) on the same side on which the tubular element (22) is located. The tamponade body (31) comprises within it at least one air chamber (32) provided with inflation organs (33) to modulate the pressure of the tamponade body against the turbinates of the nasal wall, and a drainage duct (34) crossing it longitudinally and representing a way for cleaning the nasal cavity, decreasing the risk of post-operative fluid stagnation and infections, by constituting not only an outflow route in resting conditions, but also a conduit for injection and absorption of substances by means of a standard syringe.

9. 发明申请

WO2019106581A3 URETHRAL ARTIFICIAL SPHINCTER WITH BISTABLE ACTUATION SYSTEM 审中-公开
公开(公告)号：WO2019106581A3
公开(公告)日：2019-06-06
申请号：PCT/IB2018/059432
申请日：2018-11-28
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , INAIL - ISTITUTO NAZIONALE PER L’ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： MAZZOCCHI, Tommaso , MENCIASSI, Arianna , RICOTTI, Leonardo , LUCARINI, Gioia , MARZIALE, Leonardo , SACCHETTI, Rinaldo
IPC分类号： A61F2/00
摘要： An artificial sphincter to be implanted in a urethra, in particular, for treating patients suffering from urinary incontinence, comprises a container (10) configured to be connected to a wall of a urethra (4), inside or outside it, a valve unit (20) housed within the container (10) and configured to move from a release configuration (R) to a block configuration (B) and vice-versa; an actuation magnet (66) movably (rotatably or slidably) arranged between a first and a second position in the container (10), and connected to the valve unit (20) in such a way that a predetermined (rotation or translation) movement (67', 67") of the actuation magnet (66) from a first towards a second position, or from the second towards the first position, under the effect of an external manoeuvre magnet (90), brings the valve unit (20) from the release configuration (R) to the block configuration (B), where the valve is stably maintained, and from the block configuration (B) to the release configuration (R), where the valve is stably maintained.

10. 发明申请

WO2015056204A1 APPARATUS FOR PERFORMING PECTUS EXCAVATUM REPAIR 审中-公开
标题翻译：执行PECTUS EXCAVATUM修理的装置
公开(公告)号：WO2015056204A1
公开(公告)日：2015-04-23
申请号：PCT/IB2014/065360
申请日：2014-10-16
申请人： SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA , UNIVERSITA' DEGLI STUDI DI FIRENZE
发明人： CIUTI, Gastone , RICOTTI, Leonardo , MENCIASSI, Arianna , GHIONZOLI, Marco , MESSINEO, Antonio
IPC分类号： A61B17/68 , A61L31/12 , A61L31/14 , A61B17/80 , C08L67/04
CPC分类号： A61B17/68 , A61B17/8076 , A61L27/446 , A61L27/58 , A61L31/128 , A61L31/148 , C08L67/04
摘要： An apparatus for performing correction of the pathology of pectus excavatum comprises at least one elongated bar and means of suture suitable to constrain the elongated bar in the vicinity of its first and second ends, in body tissues, either directly or by means of suitable stabilizers. The elongated bar, which must have certain mechanical characteristics of breaking load, yield strength and elasticity to withstand the stresses imposed by the chest, is made of a composite material made from a bioresorbable polymer matrix in which are disposed elongated metal. A method of removing the apparatus provides for performing an incision on one side of the chest, and then pull out one by one the elongated metal, taking advantage of the high flexibility of the foregoing.
摘要翻译：用于进行挖掘孔的病理学矫正的装置包括至少一个细长杆和缝合装置，其适合于直接地或通过适当的稳定器在体组织中约束其第一和第二端附近的细长杆。必须具有断裂载荷的某些机械特性的伸长杆由屈服强度和弹性来承受由胸部施加的应力，由复合材料制成，该复合材料由生物可再吸收的聚合物基体制成，其中设置有细长的金属。移除该装置的方法提供了在胸部的一侧进行切口，然后利用上述的高柔性来逐个拉出细长的金属。

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