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1. 发明申请

WO2009106294A8 METHODS AND SYSTEMS FOR UNIFORM ENRICHMENT OF GENOMIC REGIONS 审中-公开
公开(公告)号：WO2009106294A8
公开(公告)日：2009-09-03
申请号：PCT/EP2009/001307
申请日：2009-02-24
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG
发明人： KITZMAN, Jacob , ALBERT, Thomas , D'ASCENZO, Mark , JEDDELOH, Jeff , MIDDLE, Christina , RICHMOND, Todd , RODESCH, Matthew
IPC分类号： C12Q1/68
摘要： The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.

2. 发明申请

WO2012126793A1 WHOLE PROTEOME TILING MICROARRAYS 审中-公开
标题翻译：全面保护倾斜微波
公开(公告)号：WO2012126793A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054521
申请日：2012-03-15
申请人： ROCHE DIAGNOSTICS GmbH , F. HOFFMANN-LA ROCHE AG , NIMBLEGEN SYSTEMS GmbH
发明人： ALBERT, Thomas , BUEHLER, Jochen , RICHMOND, Todd , RODESCH, Matthew , STENGELE, Klaus-Peter
IPC分类号： G01N33/68 , C07K1/04
CPC分类号： G01N33/6842 , C07K1/047 , G01N33/6845 , G01N2570/00
摘要： The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm 2 where the oligopeptide features represent at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, at least 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm 2 . In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000, at least about 10,000, at least about 15,000, at least about 20,000, or at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents between about 5,000 and 50,000 expressed proteins, between about 10,000 and 50,000 expressed proteins, between about 15,000 and 50,000 expressed proteins, between about 20,000 and 50,000 expressed proteins, or between about 25,000 and 50,000 expressed proteins.
摘要翻译：本发明涉及一种微阵列，其包含每cm 2至少50,000个寡肽特征，其中寡肽特征表示至少50％，至少60％，至少70％，至少80％，至少90％，至少95％至少99％或100％的病毒或生物体的蛋白质组。本发明还涉及用于合成这种微阵列的方法以及使用每cm 2包含至少50,000个寡肽特征的微阵列的方法。在本发明的一个实施方案中，寡肽特征表示在相同物种中表达的蛋白质，其中寡肽特征呈平铺图案，代表至少约5,000，至少约10,000，至少约15,000，至少约20,000或至少约25,000个蛋白质在一个物种中表达。在一些实施方案中，寡肽微阵列特征表示在相同物种中表达的蛋白质，其中微阵列特征以平铺图案存在，其表示约5,000和50,000表达的蛋白质之间，约10,000和50,000表达的蛋白质之间，约15,000和50,000表达约20,000至50,000个表达蛋白质之间，或约25,000至50,000个表达蛋白质之间的蛋白质。

3. 发明申请

WO2012126788A1 METHODS FOR SYNTHESIS OF AN OLIGOPEPTIDE MICROARRAY 审中-公开
标题翻译：合成寡核苷酸微阵列的方法
公开(公告)号：WO2012126788A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054503
申请日：2012-03-15
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , NIMBLEGEN SYSTEMS GMBH
发明人： ALBERT, Thomas , BUELHER, Jochen , OTT, Markus , RICHMOND, Todd , RODESCH, Matthew , STENGELE, Klaus-Peter
IPC分类号： C07K17/06
CPC分类号： C07K17/06 , B01J19/0046 , B01J2219/00432 , B01J2219/00439 , B01J2219/00596 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C40B50/18
摘要： An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm2 and preferably at least about 50,000 oligopeptide features per cm 2 .
摘要翻译：提出了寡肽微阵列及其合成方法。还提出了一种固体支持物上的微阵列，其包含每cm 2至少约10,000个寡肽特征，优选每cm 2至少约50,000个寡肽特征。

4. 发明申请

WO2010091870A1 METHOD AND SYSTEMS FOR ENRICHMENT OF TARGET GENOMIC SEQUENCES 审中-公开
标题翻译：用于扩增目标基因组序列的方法和系统
公开(公告)号：WO2010091870A1
公开(公告)日：2010-08-19
申请号：PCT/EP2010/000858
申请日：2010-02-11
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
发明人： GERHARDT, Daniel , MARRIONE, Paul , ALBERT, Thomas , RODESCH, Matthew , RICHMOND, Todd , JEDDELOH, Jeffrey
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/6837 , C12Q2565/515 , C12Q2539/101 , C12Q2563/131 , C12Q2537/149
摘要： The present invention provides methods and systems for targeted nucleic acid sequence enrichment in a sample. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in hybridization assays by first depleting non-target nucleic acid sequences.
摘要翻译：本发明提供了样品中目标核酸序列富集的方法和系统。特别地，本发明提供了通过首先消耗非靶核酸序列在杂交测定中的杂交期间富集靶向的核酸序列。

5. 发明申请

WO2009053039A1 METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT AND ANALYSIS OF GENOMIC REGIONS 审中-公开
标题翻译：解决方案和系统基于序列的增长和基因组区域的分析
公开(公告)号：WO2009053039A1
公开(公告)日：2009-04-30
申请号：PCT/EP2008/008920
申请日：2008-10-22
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ALBERT, Thomas , RODESCH, Matthew
发明人： ALBERT, Thomas , RODESCH, Matthew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides novel methods and systems for capturing and enrichment of target nucleic acids for reducing the complexity of target nucleic acids, preferably a genomic sample, for further analysis such as direct DNA sequencing, resequencing or SNP calling. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
摘要翻译：本发明提供用于捕获和富集靶核酸以用于降低靶核酸（优选基因组样品）的复杂性的新颖方法和系统，用于进一步分析，例如直接DNA测序，重测序或SNP呼叫。特别地，本发明提供了以基于溶液的格式富集目标序列。

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