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1. 发明申请

WO2012099635A2 ELECTRON BEAM PROCESSING WITH CONDENSED ICE 审中-公开
标题翻译：电子束加工冷凝冰
公开(公告)号：WO2012099635A2
公开(公告)日：2012-07-26
申请号：PCT/US2011/057805
申请日：2011-10-26
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRANTON, Daniel , HAN, Anpan , GOLOVCHENKO, Jene, A.
发明人： BRANTON, Daniel , HAN, Anpan , GOLOVCHENKO, Jene, A.
IPC分类号： H01L21/027
CPC分类号： G03F7/2059 , B81C1/00531 , B81C2201/0143 , B81C2201/0159 , B82Y10/00 , B82Y40/00 , G01N23/2251 , H01J37/3174 , H01J2237/004 , H01J2237/022 , H01J2237/2002 , H01J2237/2803 , H01J2237/2809 , H01J2237/31796 , H01L21/0331 , H01L22/12 , H01L51/0014 , H01L51/0048
摘要： In a method for imaging a solid state substrate, a vapor is condensed to an amorphous solid water condensate layer on a surface of a solid state substrate. Then an image of at least a portion of the substrate surface is produced by scanning an electron beam along the substrate surface through the water condensate layer. The water condensate layer integrity is maintained during electron beam scanning to prevent electron-beam contamination from reaching the substrate during electron beam scanning. Then one or more regions of the layer can be locally removed by directing an electron beam at the regions. A material layer can be deposited on top of the water condensate layer and any substrate surface exposed at the one or more regions, and the water condensate layer and regions of the material layer on top of the layer can be removed, leaving a patterned material layer on the substrate.
摘要翻译：在固态基板成像方法中，将蒸气冷凝成固态基板表面的无定形固体水凝结物层。然后通过沿着衬底表面扫描电子束通过水凝结层产生衬底表面的至少一部分的图像。在电子束扫描期间维持水凝结层的完整性，以防止电子束扫描期间电子束污染到达衬底。然后可以通过在该区域处引导电子束来局部地去除该层的一个或多个区域。材料层可以沉积在水冷凝物层的顶部和在一个或多个区域暴露的任何基底表面，并且水凝结物层和该层顶部上的材料层的区域可以被去除，留下图案化的材料层在基板上。

2. 发明申请

WO2009045472A1 CAPTURE, RECAPTURE, AND TRAPPING OF MOLECULES WITH A NANOPORE 审中-公开
标题翻译：捕获，克隆和捕获分子与NANOPORE
公开(公告)号：WO2009045472A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011412
申请日：2008-10-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GERSHOW, Marc H. , GOLOVCHENKO, Jene A. , BRANTON, Daniel
发明人： GERSHOW, Marc H. , GOLOVCHENKO, Jene A. , BRANTON, Daniel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6869 , G01N33/48721 , C12Q2565/631 , C12Q2565/607
摘要： In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
摘要翻译：在分子分析系统中，提供了包括纳米孔和第一和第二流体储层的结构。两个储存器通过纳米孔流体连接。连接检测器以检测纳米孔的分子物质易位，从两个流体储存器中的一个到两个流体储存器中的另一个。连接控制器以产生控制信号以在纳米孔上产生条件以诱导分子种类在易位纳米孔之后至少一次地转移纳米孔。这使得分子分析方法能够通过分子物质在被结构分离的两个流体储存器之间的结构中的纳米孔中多次转位。

3. 发明申请

WO2011046706A1 BARE SINGLE-LAYER GRAPHENE MEMBRANE HAVING A NANOPORE ENABLING HIGH-SENSITIVITY MOLECULAR DETECTION AND ANALYSIS 审中-公开
标题翻译：具有纳米光亮度的单层单层石墨膜启动高灵敏度分子检测和分析
公开(公告)号：WO2011046706A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/049238
申请日：2010-09-17
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , SLAVEN, Garaj , BRANTON, Daniel , GOLOVCHENKO, Jene, A.
发明人： SLAVEN, Garaj , BRANTON, Daniel , GOLOVCHENKO, Jene, A.
IPC分类号： G01N33/487 , C12Q1/68 , G01N27/447
CPC分类号： G01N33/48721 , B82Y30/00 , C12Q2565/631 , G01N15/1056 , G01N15/12 , G01N2015/0038
摘要： There is provided a substantially bare, single-layer graphene membrane including a nanopore extending through a thickness of the graphene membrane from a first to a second membrane surface opposite the first graphene membrane surface. A connection from the first graphene membrane surface to a first reservoir provides, at the first graphene membrane surface, a species in an ionic solution to the nanopore, and a connection from the second graphene membrane surface to a second reservoir is provided to collect the species and ionic solution after translocation of the species and ionic solution through the nanopore from the first graphene membrane surface to the second graphene membrane surface. An electrical circuit is connected on opposite sides of the nanopore to measure flow of ionic current through the nanopore in the graphene membrane.
摘要翻译：提供了基本上裸露的单层石墨烯膜，其包括从第一至第二膜表面延伸穿过石墨烯膜的厚度的纳米孔，第一膜表面与第一石墨烯膜表面相对。从第一石墨烯膜表面到第一储存器的连接在第一石墨烯膜表面提供离子溶液中的物质到纳米孔，并且提供从第二石墨烯膜表面到第二储存器的连接以收集物种离子溶液通过纳米孔从第一个石墨烯膜表面转移到第二个石墨烯膜表面。电路连接在纳米孔的相对两侧，以测量通过石墨烯膜中的纳米孔的离子电流的流动。

4. 发明申请

WO2012125770A2 CONTROLLED FABRICATION OF NANOPORES IN NANOMETRIC SOLID STATE MATERIALS 审中-公开
标题翻译：纳米材料在纳米固体状态材料中的控制制备
公开(公告)号：WO2012125770A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029132
申请日：2012-03-14
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , RUSSO, Christopher, J. , GOLOVCHENKO, Jene, A. , BRANTON, Daniel
发明人： RUSSO, Christopher, J. , GOLOVCHENKO, Jene, A. , BRANTON, Daniel
IPC分类号： B81C1/00
CPC分类号： B81B1/002 , B81B2201/0214 , B81B2203/0127 , B81B2207/056 , B81C1/00087 , G01N33/48721
摘要： In a method of forming a nanopore in a nanometric material, a nanopore nucleation site is formed at a location that is interior to lateral edges of the nanometric material by directing a first energetic beam, selected from the group of ion beam and neutral atom beam, at the interior location for a first time duration that imposes a first beam dose which causes removal of no more than five interior atoms from the interior location to produce at the interior location a nanopore nucleation site having a plurality of edge atoms. A nanopore is then formed at the nanopore nucleation site by directing a second energetic beam, selected from the group consisting of electron beam, ion beam, and neutral atom beam, at the nanopore nucleation site with a beam energy that removes edge atoms at the nanopore nucleation site but does not remove bulk atoms from the nanometric material.
摘要翻译：在纳米孔内形成纳米孔的方法中，通过引导选自离子束和中性原子束组的第一能量束，在纳米材料的横向边缘内部的位置处形成纳米孔成核位点，在内部位置处施加第一束剂量，其引起从内部位置移除不超过五个内部原子，以在内部位置处产生具有多个边缘原子的纳米孔成核位点。然后在纳米孔成核位置通过在纳米孔成核位置引入从由电子束，离子束和中性原子束组成的组中选择的第二能量束，以纳米孔成核位点形成纳米孔，该束能量去除纳米孔上的边缘原子但不能从纳米材料中去除体原子。

5. 发明申请

WO2009045473A3 CARBON NANOTUBE SYNTHESIS FOR NANOPORE DEVICES 审中-公开
公开(公告)号：WO2009045473A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/011413
申请日：2008-10-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRANTON, Daniel , GOLOVCHENKO, Jene, A. , GARAJ, Slaven , VLASSAREV, Dimitar, M. , SADKI, El-Hadi, S.
发明人： BRANTON, Daniel , GOLOVCHENKO, Jene, A. , GARAJ, Slaven , VLASSAREV, Dimitar, M. , SADKI, El-Hadi, S.
IPC分类号： B81C1/00
摘要： In a process for fabricating a nanopore device, at least one carbon nanotube catalyst region is formed on a structure. A plurality of nanopores is formed in the structure at a distance from the catalyst region that is no greater than about an expected length for a carbon nanotube synthesized from the catalyst region. Then at least one carbon nanotube is synthesized from the catalyst region. This fabrication sequence enables the in situ synthesis of carbon nanotubes at the site of nanopores, whereby one or more nanotubes articulate one or more nanopores without requiring manual positioning of the nanotubes.

6. 发明申请

WO2012005857A1 NANOPORE DEVICE WITH GRAPHENE SUPPORTED ARTIFICIAL LIPID MEMBRANE 审中-公开
标题翻译：具有石墨支撑的人造脂膜的纳米设备
公开(公告)号：WO2012005857A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/039621
申请日：2011-06-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GARAJ, Slaven , BRANTON, Daniel
发明人： GARAJ, Slaven , BRANTON, Daniel
IPC分类号： G01N33/487
CPC分类号： G01N27/44791 , G01N27/447 , G01N27/453 , G01N33/48721 , Y10S977/734
摘要： The invention features the use of graphene, a one atom thick planar sheet of bonded carbon atoms, in the formation of artificial lipid membranes. The invention also features the use of these membranes to detect the properties of polymers (e.g., the sequence of a nucleic acid) and identify transmembrane protein-interacting compounds.
摘要翻译：本发明的特征在于在形成人造脂膜中使用石墨烯（一个原子厚的键合碳原子的平板）。本发明还特征在于使用这些膜来检测聚合物的性质（例如，核酸的序列）并鉴定跨膜蛋白相互作用的化合物。

7. 发明申请

WO2006028508A2 METHODS AND APPARATUS FOR CHARACTERIZING POLYNUCLEOTIDES 审中-公开
标题翻译：用于表征多核苷酸的方法和装置
公开(公告)号：WO2006028508A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/009702
申请日：2005-03-23
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , REGENTS OF THE UNIVERSITY OF CALIFORNIA , AGILENT TECHNOLOGIES, INC. , AKESON, Mark , BRANTON, Daniel , DEAMER, David, W. , SAMPSON, Jeffrey, R.
发明人： AKESON, Mark , BRANTON, Daniel , DEAMER, David, W. , SAMPSON, Jeffrey, R.
IPC分类号： C12Q1/68
CPC分类号： G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2300/0896 , B01L2400/0475 , B82Y5/00 , B82Y30/00 , C12Q1/6869 , C12Q2565/631 , C12Q2521/543
摘要： Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.
摘要翻译：提供了用于分析聚合物的系统和方法，例如多核苷酸。该系统能够以指定的速率分析聚合物。一个这样的分析系统包括具有纳米孔孔的结构和邻近纳米孔孔的分子马达，例如聚合酶。

8. 发明申请

WO2006052882A1 FORMATION OF EDDIES IN CONSTRAINED FLUIDIC CHANNELS AND USES THEREOF 审中-公开
标题翻译：形成流体流体通道中的EDD和其用途
公开(公告)号：WO2006052882A1
公开(公告)日：2006-05-18
申请号：PCT/US2005/040282
申请日：2005-11-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , PARK, Stella , RUSSO, Chris , BRANTON, Daniel , STONE, Howard
发明人： PARK, Stella , RUSSO, Chris , BRANTON, Daniel , STONE, Howard
IPC分类号： B01L3/00 , B01F13/00 , B01J19/00
CPC分类号： B01F13/0076 , B01F5/0682 , B01F5/0688 , B01J19/0093 , B01J2219/00286 , B01J2219/00479 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00864 , B01J2219/00889 , B01J2219/0093 , B01J2219/00934 , B01J2219/0097 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2400/0418 , B82Y30/00 , G01N15/1484 , G01N33/48707
摘要： The invention features devices that enable the formation of eddies in fluidic channels. In general, the devices include a fluidic channel having one or more constrictions (i.e., regions of reduced cross-sectional area), and the application of an EOF induces eddy formation proximal to a constriction. Eddy formation may be used in a variety of applications including fluidic mixing, sensors, and reactors.
摘要翻译：本发明的特征在于能够在流体通道中形成涡流的装置。通常，这些装置包括具有一个或多个收缩部（即横截面积减小的区域）的流体通道，并且EOF的应用引起接近收缩部的涡流形成。涡流形成可用于各种应用，包括流体混合，传感器和反应器。

9. 发明申请

WO2003000920A3 METHODS FOR CHARACTERIZATION OF NUCLEIC ACID MOLECULES 审中-公开
公开(公告)号：WO2003000920A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/019766
申请日：2002-06-21
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , AGILENT TECHNOLOGIES, INC.
发明人： BRANTON, Daniel , WANG, Hui , LADERMAN, Stephen , SAMPSON, Jeffrey , YAKHANI, Zohar
IPC分类号： C12Q1/68
摘要： To probe the characteristics of a target nucleic acid molecule or a population of target nucleic acid molecules, a local cross-sectional area, local charge, or local chemistry of a molecule is modified. The modified nucleic acid is contacted with a substrate that includes a detector that is responsive to the modification in the local cross-sectional area, local charge, or local chemistry of the nucleic acid molecule. The modified nucleic acid molecule traverses a defined and preferably molecular dimensioned volume on the substrate so that nucleotides of the modified nucleic acid molecule interact with the detector in sequential order, whereby data correlating with the cross-sectional area, local charge, or local chemistry of the nucleic acid molecule are obtained. The nucleic acid molecule may be modified in a number of locations along the molecule's length. Because the individual nucleotides of the nucleic acid molecule interact with the detector in sequential order, information regarding the location and composition of a plurality of modified sites along a single molecule can be obtained.

10. 发明申请

WO2007084163A2 MOLECULAR CHARACTERIZATION WITH CARBON NANOTUBE CONTROL 审中-公开
标题翻译：用碳纳米管控制分子表征
公开(公告)号：WO2007084163A2
公开(公告)日：2007-07-26
申请号：PCT/US2006/012800
申请日：2006-04-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： GOLOVCHENKO, Jene , BRANTON, Daniel
IPC分类号： G01N27/00 , C12Q1/68
CPC分类号： G01N27/44791 , B82Y15/00 , C12Q1/6869 , G01N27/44743 , G01N33/48721 , Y10S977/762 , C12Q2565/631
摘要： There is provided a first reservoir containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution including a molecule that has been characterized. A solid state support structure is provided including an aperture having a molecular entrance providing a fluidic connection to the first reservoir and a molecular exit providing a fluidic connection to the second reservoir. First and second electron transport probes are each disposed on the support structure with a surface abutting a perimeter of the aperture. At least one of the probes comprises a fullerene structure, e.g., a carbon nanotube. A voltage source is connected between the probes to apply a voltage bias across the aperture. An electrical current monitor is connected between the probes for monitoring changes in electron transport between the probes corresponding to translocation of a molecule through the aperture.
摘要翻译：提供了一种包含液态溶液的第一储存器，该液体溶液包括要表征的分子和用于容纳包含已经表征的分子的液体溶液的第二储存器。提供了一种固态支撑结构，包括具有提供与第一储存器的流体连接的分子入口和提供与第二储存器的流体连接的分子出口的孔。第一和第二电子传输探针各自设置在支撑结构上，表面邻接孔的周边。至少一个探针包括富勒烯结构，例如碳纳米管。探针之间连接一个电压源，以在该孔径上施加电压偏置。探针之间连接有一个电流监测器，用于监测对应于分子通过孔的易位的探针之间的电子传输变化。

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