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1. 发明申请

WO1995031228A1 METHOD OF INHIBITING BLOOD COAGULATION DURING EXTRACORPOREAL BLOOD CIRCULATION AND DEVICE FOR RELEASING ANTITHROMBOTIC DRUG USED THEREIN 审中-公开
标题翻译：在超声波血液循环期间抑制血液凝聚的方法和用于释放其使用的抗真菌药物的装置
公开(公告)号：WO1995031228A1
公开(公告)日：1995-11-23
申请号：PCT/JP1995000917
申请日：1995-05-12
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , OTSUKA PHARMACEUTICAL CO., LTD. , IGUCHI, Seiichiro , HIGASHINO, Rika , YAMATO, Minoru , YAMAMOTO, Hiroaki , INAI, Masatoshi
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC. , OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61M01/14
CPC分类号： A61M1/3672
摘要： A method of inhibiting the coagulation of blood during the extracorporeal circulation thereof by bringing a member for releasing an antithrombotic drug, prepared by dispersing a difficulty water-soluble antithrombotic drug in a macromolecular material, into contact with the circulating blood. A device for releasing an antithrombotic drug to be used in the above method comprises either the drug releasing member contained in a vessel provided with blood inlet and outlet ports at the respective ends thereof or the drug releasing member constituting at least the inner wall surface of the vessel. As the antithrombotic agent can be released sustainedly from the drug releasing member, the blood coagulation in the blood circuit can be inhibited as a result of the contact of the blood with the member during the extracorporeal circulation.
摘要翻译：通过将通过将难溶性水溶性抗血栓形成药物分散在高分子材料中而制备的抗血栓药物的释放部件与循环血液接触来抑制体外循环期间的血液凝固的方法。用于释放在上述方法中使用的抗血栓药物的装置包括容纳在容器中的药物释放构件，所述容器设置有各自的血液入口和出口，或者至少构成至少内壁表面的药物释放构件船只。由于可以从药物释放部件持续释放抗血栓形成剂，所以血液循环中的血液凝固可以通过在体外循环期间血液与构件的接触而被抑制。

2. 发明申请

WO1996021448A1 RESIN PARTICLE, MEDICAL MATERIAL AND PHARMACEUTICAL PREPARATION CONTAINING SAID RESIN PARTICLE 审中-公开
标题翻译：树脂颗粒，含有树脂颗粒的医用材料和药物制剂
公开(公告)号：WO1996021448A1
公开(公告)日：1996-07-18
申请号：PCT/JP1996000004
申请日：1996-01-04
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC. , IGUCHI, Seiichiro , HIGASHINO, Rika , YAMATO, Minoru , YAMAMOTO, Hiroaki , KIMURA, Yuzo , NAKAGAWA, Shinsuke , YAMADA, Keigo , NAKAMURA, Toshio
发明人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： A61K31/47
CPC分类号： A61K9/1694 , A61K9/1635 , A61K31/4709
摘要： A resin particle is provided which comprises an ethylene vinyl alcohol copolymer and 5 to 90 % by weight of cilostazol incorporated therein, and has a particle size of not greater than 2,000 mu m. The resin particle, upon being administered orally, allows the concentration of cilostazol in blood to be kept constant over an extended period of time and, therefore, remarkably alleviates side effects such as pain and headache which may otherwise be caused by rapid release of cilostazol into a body.
摘要翻译：提供了一种树脂颗粒，其包含乙烯乙烯醇共聚物和5至90重量％的西洛他唑，其粒径不大于2000微米。通过口服给药，树脂粒子能够使长时间保持血液中西洛他唑的浓度保持恒定，因此显着地减轻副作用，例如由于西洛他唑迅速释放引起的疼痛和头痛，身体。

3. 发明申请

WO1995003075A1 MEDICAL MATERIAL AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：医疗材料及其制造方法
公开(公告)号：WO1995003075A1
公开(公告)日：1995-02-02
申请号：PCT/JP1994001162
申请日：1994-07-13
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , OTSUKA PHARMACEUTICAL CO., LTD. , IGUCHI, Seiichiro , HIGASHINO, Rika
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC. , OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A61L33/00
CPC分类号： A61L29/16 , A61L27/54 , A61L31/16 , A61L33/0005 , A61L33/0011 , A61L2300/42
摘要： A medical material comprising a polymer or copolymer of a polar vinyl derivative and containing an antithrombocytic agent. Since it can release the antithrombocytic agent in an effective concentration for long, it has a high anticoagulant effect and the effect of preventing platelet loss by activating the same.
摘要翻译：包含极性乙烯基衍生物的聚合物或共聚物并含有抗血栓形成剂的医疗材料。由于能够长时间有效地释放抗血栓形成剂，因此具有高的抗凝血作用和通过活化其预防血小板丧失的作用。

4. 发明申请

WO1997048365A1 PACKAGE FOR CONTAINER OF LIQUID MEDICINE CONTAINING BICARBONATE AND pH INDICATOR 审中-公开
标题翻译：含有BICARBONATE和pH指示剂的液体药物容器的包装
公开(公告)号：WO1997048365A1
公开(公告)日：1997-12-24
申请号：PCT/JP1997002040
申请日：1997-06-13
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , IGUCHI, Seiichiro , SHINOMIYA, Shino , HAMAMOTO, Rika , ABE, Akiyo , INAI, Masatoshi , KAWAKAMI, Keiichi
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： A61J01/00
CPC分类号： A61J1/05 , A61J1/1462 , A61J1/16 , B65D79/02
摘要： A package for a container of liquid medicine in which a gas permeable plastic container having sealed therein liquid medicine containing bicarbonate is packaged by a gas impermeable plastic packaging material, wherein a space between the plastic container and the plastic packaging material is made to be a carbonic acid gas atmosphere, wherein a pH indicator is disposed in the space in which liquid containing bicarbonate and a pH indicator adapted to change its color in accordance with change in pH of the liquid are sealed in a gas permeable plastic small container. According to the package, it is possible to easily conduct a visual confirmation of the pH change in the liquid caused by long-time preservation or troubles generation of pin holes in a secondary packaging material and deterioration of the liquid attributed to the pH change.
摘要翻译：一种用于液体药物容器的包装，其中密封有含有碳酸氢钠的液体药物的透气塑料容器由不透气的塑料包装材料包装，其中塑料容器和塑料包装材料之间的空间被制成碳酸酸性气体气氛，其中pH指示剂设置在其中含有碳酸氢盐和pH指示剂的液体根据液体的pH变化而变色的空间中，将其密封在透气塑料小容器中。根据该包装，可以容易地进行二次包装材料中由于长时间保存或针孔产生困难引起的液体pH变化的视觉确认，以及由pH变化导致的液体劣化。

5. 发明申请

WO1993023374A1 INDOLE DERIVATIVE 审中-公开
公开(公告)号：WO1993023374A1
公开(公告)日：1993-11-25
申请号：PCT/JP1993000560
申请日：1993-04-28
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , INAI, Masatoshi , SHIBUTANI, Tadanao , KANAYA, Jun , MORITAKE, Masako , TANAKA, Akie
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： C07D209/10
CPC分类号： C07D401/12 , C07D209/10
摘要： An indole derivative represented by general formula (1). It has a potent antiestrogenic effect and hence is useful for treating estrogen-dependent diseases such as anovular infertility, prostatomegaly, osteoporosis, breast cancer, endometrial cancer and melanoma.
摘要翻译：由通式（1）表示的吲哚衍生物。它具有有效的抗雌激素作用，因此可用于治疗雌激素依赖性疾病，如无性生殖不全，前列腺肥大，骨质疏松症，乳腺癌，子宫内膜癌和黑素瘤。

6. 发明申请

WO1992017604A1 ANTI-EDA MONOCLONAL ANTIBODY 审中-公开
标题翻译：抗EDA单克隆抗体
公开(公告)号：WO1992017604A1
公开(公告)日：1992-10-15
申请号：PCT/JP1992000363
申请日：1992-03-26
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , OTSUKA PHARMACEUTICAL CO., LTD , SEKIGUCHI, Kiyotoshi , ASAKAWA, Kaneji , SAKASHITA, Eiji , HINO, Kazuo , SHIN, Sadahito , TACHIKAWA, Tetsuya , HIRANO, Hisanobu
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC. , OTSUKA PHARMACEUTICAL CO., LTD
IPC分类号： C12P21/08
CPC分类号： C07K16/18 , C07K14/78 , C07K2319/00
摘要： An anti-EDA monoclonal antibody which recognizes the amino acid sequence part in the EDA region of fibronection (FN). It has a reaction specificity for EDA, in particular, EDA-FN (the FN wherein the EDA region is expressed), so that it can be utilized in establishing the techniques of high-sensitivity, high-accuracy and convenient immunoassay of EDA-FN, screening and diagnosis of EDA-FN-related inflammatory diseases, etc.

7. 发明申请

WO1991013855A1 PHENANTHRENE DERIVATIVE 审中-公开
标题翻译： PHANANTHRENE DERIVATIVE
公开(公告)号：WO1991013855A1
公开(公告)日：1991-09-19
申请号：PCT/JP1991000289
申请日：1991-03-05
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC. , TAKAISHI, Yoshihisa , GOTO, Kiyoto , UESAKO, Takuji , KUWAHARA, Toshiko , TAKAI, Masaaki , ONO, Yukihisa , TANIGUCHI, Yoshihiro , MANABE, Sachiko , ASAKUNI, Takahiro
发明人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： C07C49/747
CPC分类号： C07D307/77 , C07C49/747 , C07C50/34 , C07C50/38 , C07C62/32 , C07C62/34 , C07C62/38 , C07C69/007 , C07C69/013 , C07C69/757 , C07C2603/26
摘要： A novel phenanthrene derivative of general formula (1), its salt, a compound further derived therefrom, and its salt; a process for the production thereof; and an interleukin 1 (IL-1) inhibitor containing the derivative as the active ingredient, wherein (a) represents (b) wherein R' represents hydrogen or lower alkyl, (c) wherein R2 represents hydrogen or lower alkanoyl, or (d) wherein R2 is as defined above.

8. 发明申请

WO1996017578A1 METHOD OF SUPPRESSING ADSORPTION OF SUBSTANCES DERIVED FROM CONTAINER MATERIAL ON DRUGS AND CONTAINER 审中-公开
标题翻译：抑制从容器中吸收的物质对药物和容器的吸附的方法
公开(公告)号：WO1996017578A1
公开(公告)日：1996-06-13
申请号：PCT/JP1995002487
申请日：1995-12-04
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , INOUE, Fujio , IZUMI, Masamitsu , HAYASHI, Satoru , YOSHIDA, Chieko
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： A61J01/00
CPC分类号： B65D81/2069 , A61J1/00 , B65D81/24 , Y10S206/828 , Y10T428/1314 , Y10T428/1352 , Y10T428/292
摘要： A method of suppressing adsorption of various substances derived from a drug container material on a powdery or solid drug in putting the same into a drug container that is partially or wholly constituted of a rubbery or plastic material, wherein the inside of the container is put in an atmosphere of a lower alcohol. This method enables a powdery or solid drug to be preserved safely for long without generating fine insoluble particles or muddy substances (poor liquefaction) due to the container material in preparing solutions and without the loss of the active ingredients caused by the decomposition, denaturation or degradation thereof and the generation of toxic substances caused thereby.
摘要翻译：抑制由药物容器材料衍生的各种物质吸附在粉状或固体药物上的方法，将其放入部分或全部由橡胶或塑料材料构成的药物容器中，其中将容器的内部放入低级酒精的气氛。该方法使得粉末状或固态药物长时间保存而不会由于容器材料在制备溶液中而产生细小的不溶性颗粒或泥质物质（液化不良），而且不会由于分解，变性或降解而导致活性成分的损失。并且由此引起的有毒物质的产生。

9. 发明申请

WO1994018212A1 PHOSPHONIC DIESTER DERIVATIVE 审中-公开
公开(公告)号：WO1994018212A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000209
申请日：1994-02-10
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , SHOJI, Yasuo , TSUDA, Yoshihiko , TSUTSUMI, Kazuhiko , INOUE, Yasuhide
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： C07F09/650
CPC分类号： C07F9/6561 , C07F9/6541
摘要： A phosphonic diester derivative represented by general formula (I), which is excellent is hypolipidemic and hypoglycemic effects, reduced in the side effects, and hence useful for treating and preventing hyperlipidemia, treating cataract, and treating and preventing diabetes, wherein R , R , R and R represent each independently hydrogen, lower alkyl, lower alkoxy, halogenated lower alkyl, nitro, halogen, cyano, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylated lower alkoxy, phenylated lower alkylthio or benzoyloxy substituted by di(lower alkoxy)phosphorylated lower alkyl, provided R and R may be combined together to form -CH = CH-CH = CH-; R represents hydrogen, lower alkyl or phenyl; R and R represent each independently lower alkoxy, phenyl or phenylated lower alkoxy; A represents optionally phenylated lower alkylene; B represents a benzene or thiophene ring; D represents -CO-, -CS- or -SO2-; E represents (a), (b) or (c) wherein R represents lower alkyl; Z represents a single bond or -O-; Y represents optionally phenylated lower alkylene or vinylene; and n represents 0 or 1.
摘要翻译：由通式（I）表示的膦酸二酯衍生物是优异的降血脂和降血糖作用，副作用降低，因此可用于治疗和预防高脂血症，治疗白内障和治疗和预防糖尿病，其中R 1， R 2，R 3和R 4各自独立地表示氢，低级烷基，低级烷氧基，卤代低级烷基，硝基，卤素，氰基，苯硫基，苯基亚磺酰基，苯基磺酰基，苯基低级烷氧基，苯基低级烷硫基或由二（低级烷氧基）磷酸化低级烷基取代的苯甲酰氧基，只要R 3和R 4可以组合在一起形成-CH = CH-CH = CH-; R 5表示氢，低级烷基或苯基; R 6和R 7各自独立地表示低级烷氧基，苯基或苯基低级烷氧基; A代表任选地是苯基的低级亚烷基; B代表苯或噻吩环; D表示-CO - ， - CS-或-SO 2 - ; E表示（a），（b）或（c）其中R 8表示低级烷基; Z表示单键或-O-; Y代表任选地是苯基的低级亚烷基或亚乙烯基; n表示0或1。

10. 发明申请

WO1994017772A1 MULTILAYERED MEDICAL FILM AND DOUBLE-COMPARTMENT CONTAINER 审中-公开
标题翻译：多层医用膜和双层容器
公开(公告)号：WO1994017772A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000143
申请日：1994-02-02
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , INOUE, Fujio , IZUMI, Masamitsu , KASHIYAMA, Shigetoshi
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： A61J01/05
CPC分类号： B32B27/08 , A61J1/10 , A61J1/2024 , A61J1/2093 , B32B27/32 , B32B2250/242 , B32B2307/72 , B32B2439/80 , Y10T428/1359 , Y10T428/24992 , Y10T428/31909
摘要： A multilayered medical film mainly used for forming a double-compartment medical container and excellent in heat resistance, transparency, flexibility, impact resistance, and easiness in peeling and sealing, which film is composed of: an inner layer formed from a resin mixture composed of an ethylene/ alpha -olefin copolymer having a density of 0.930-0.945 g/cm and polypropylene, an intermediate layer containing at least one mixed resin layer formed from a resin mixture, in a ratio of 1:5 to 2:1 by weight, of an ethylene/ alpha -olefin copolymer having a density of 0.920-0.945 g/cm and an ethylene/ alpha -olefin elastomer having a density of 0.880-0.890 g/cm , wherein the mixed resin layer accounts for at least 85 % of the whole intermediate layer in thickness, and an outer layer formed from an ethylene/ alpha -olefin copolymer having a density of 0.930-0.945 g/cm .
摘要翻译：一种主要用于形成双室医疗容器的多层医用膜，其耐热性，透明性，柔韧性，耐冲击性和易剥离密封性优异，该膜由以下组成的树脂混合物构成的内层：由密度为0.930-0.945g / cm 3的乙烯/α-烯烃共聚物和聚丙烯，含有至少一种由树脂混合物形成的混合树脂层的中间层，其比例为1:5至2:1 的密度为0.920-0.945g / cm 3的乙烯/α-烯烃共聚物和密度为0.880-0.890g / cm 3的乙烯/α-烯烃弹性体，其中混合树脂层占整个中间层厚度的至少85％，外层由密度为0.930-0.945g / cm 3的乙烯/α-烯烃共聚物形成。

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