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1. 发明申请

WO2012166980A2 PRESSURE MEASUREMENT DEVICES, METHODS, AND SYSTEMS 审中-公开
标题翻译：压力测量装置，方法和系统
公开(公告)号：WO2012166980A2
公开(公告)日：2012-12-06
申请号：PCT/US2012040298
申请日：2012-05-31
申请人： NXSTAGE MEDICAL INC , BRUGGER JAMES M , TREU DENNIS M , BURBANK JEFFREY H , NEWELL SCOTT W , SCHNELL WILLIAM J , BUCKLER KENNETH E
发明人： BRUGGER JAMES M , TREU DENNIS M , BURBANK JEFFREY H , NEWELL SCOTT W , SCHNELL WILLIAM J , BUCKLER KENNETH E
IPC分类号： G01L9/00
CPC分类号： G01L9/006 , A61M1/3639 , A61M1/3641 , A61M1/3653 , A61M1/3659 , A61M2205/3331 , A61M2205/75 , A61M2207/00 , G01L9/0041 , G01L19/0023 , G01L19/003 , G01L19/0046
摘要： A pressure measurement system for use in blood circuits comprised of a pressure sensing pod and a force measurement device. The pressure sensing pod can include a flexible, moveable, fluid-impermeable diaphragm and can be formed via either a one-shot or a two-shot molding process. A mechanical engagement member of the force measurement device engages with a mechanical engagement feature of the diaphragm, and the engagement member is operative to move in concert with movement of the engagement feature of the diaphragm based on pressure variations with the pressure sensing pod. The force measurement device generates and outputs to a processor a signal based on detected force associated with movement of the engagement member.
摘要翻译：一种用于血液回路的压力测量系统，包括压力感测盒和力测量装置。压力传感盒可以包括柔性的，可移动的，不透液体的隔膜，并且可以通过单次或两次成型工艺形成。力测量装置的机械接合构件与隔膜的机械接合构件接合，并且接合构件可操作以基于与压力感测盒的压力变化而与隔膜的接合特征的移动一致地移动。力测量装置基于与接合构件的运动相关联的检测力产生并输出到处理器的信号。

2. 发明申请

WO2012129501A3 PERITONEAL DIALYSIS SYSTEMS, DEVICES, AND METHODS 审中-公开
标题翻译： PERITONEAL DIALYSIS SYSTEMS，DEVICES和METHODS
公开(公告)号：WO2012129501A3
公开(公告)日：2012-11-15
申请号：PCT/US2012030350
申请日：2012-03-23
申请人： NXSTAGE MEDICAL INC , BURBANK JEFFREY H , BRUGGER JAMES M , TREU DENNIS M , WYETH MARK T
发明人： BURBANK JEFFREY H , BRUGGER JAMES M , TREU DENNIS M , WYETH MARK T
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/1656 , A61M1/166 , A61M1/1664 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/281 , A61M1/282 , A61M1/285 , A61M1/287 , A61M1/288 , A61M2025/0002 , A61M2205/12 , A61M2205/123 , A61M2205/128 , A61M2205/14 , A61M2205/18 , A61M2205/33 , A61M2205/3331 , A61M2205/3334 , A61M2205/3351 , A61M2205/3355 , A61M2205/52 , A61M2230/005
摘要： An automated peritoneal dialysis system provides various features including prescription-driven dialysis fluid preparation, an integrated disposable fluid circuit, and sensor capabilities that allow accurate filing and draining control with high safety margins. Features include a peritoneal fluid circuit with a pressure sensor at either end and methods and devices for using the pressure signals. Other features and embodiments are disclosed.
摘要翻译：自动腹膜透析系统提供各种功能，包括处方驱动的透析液制备，集成的一次性液体回路和传感器功能，可以在高安全裕度下进行准确的排放和排水控制。特征包括腹膜液回路，其两端有压力传感器，以及使用压力信号的方法和装置。公开了其它特征和实施例。

3. 发明申请

WO2007118235A3 FILTRATION SYSTEM FOR PREPARATION OF FLUIDS FOR MEDICAL APPLICATIONS. 审中-公开
标题翻译：用于制备医用液体的过滤系统。
公开(公告)号：WO2007118235A3
公开(公告)日：2008-12-04
申请号：PCT/US2007066251
申请日：2007-04-09
申请人： NXSTAGE MEDICAL INC , BURBANK JEFFREY H , BRUGGER JAMES M , GREEN BRIAN C , MCDOWELL CHRISTOPHER S , TREU DENNIS M , FREIDERICHS GOETZ
发明人： BURBANK JEFFREY H , BRUGGER JAMES M , GREEN BRIAN C , MCDOWELL CHRISTOPHER S , TREU DENNIS M , FREIDERICHS GOETZ
IPC分类号： B01D61/02 , A61M5/00 , B67D7/76 , C02F1/44
CPC分类号： A61M1/1668 , A61J1/05 , A61J1/1468 , A61J1/1475 , A61J1/2003 , A61M1/14 , A61M1/1656 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/3413 , A61M1/342 , A61M1/3462 , A61M39/1011 , A61M39/288 , A61M2205/273 , B01D61/14 , B01D61/142 , B01D61/145 , B01D63/00 , B01L3/502 , B01L2200/026 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0864 , B65B3/28 , B65B3/30 , B65B55/04 , C02F1/444 , C02F2103/026 , F16K7/068 , F16L55/00 , F16L55/07 , Y10T137/8593
摘要： Systems, methods, and devices for preparation of purified water and medicaments for various uses including blood treatment are described. Methods, devices, and systems for creating multiple-treatment batches are described.
摘要翻译：描述了用于制备用于包括血液处理在内的各种用途的纯净水和药物的系统，方法和装置。描述了用于创建多个处理批次的方法，设备和系统。

4. 发明申请

WO2007051118A3 SAFETY FEATURES FOR MEDICAL DEVICES REQUIRING ASSISTANCE AND SUPERVISION 审中-公开
标题翻译：医疗设备的安全特性需要协助和监督
公开(公告)号：WO2007051118A3
公开(公告)日：2007-11-29
申请号：PCT/US2006060218
申请日：2006-10-25
申请人： NXSTAGE MEDICAL INC , BURBANK JEFFREY H , TREU DENNIS , BRUGGER JAMES M
发明人： BURBANK JEFFREY H , TREU DENNIS , BRUGGER JAMES M
IPC分类号： H04K1/00 , H04L9/00
CPC分类号： G06F19/3406 , A61B5/0077 , A61B5/015 , A61B5/0816 , A61B5/117 , A61B5/746 , A61B5/7475 , A61M1/14 , A61M1/36 , A61M1/367 , A61M2205/18 , A61M2205/3553 , A61M2205/6009 , G05B1/01 , G05B9/02 , G06F19/328 , G08B21/182 , G08B21/22 , G16H40/63
摘要： An automatic locking system for a medical treatment device helps to ensure that an assistant is present during treatment of a patient. Among the features disclosed biometric authentication to verify that a trained assistant is present, a presence detector to ensure the assistant is continuously present during treatment, and warning and recovery processes that allow intermittent lapses in the continuous presence of the assistant.
摘要翻译：用于医疗设备的自动锁定系统有助于确保在患者治疗期间存在助理。在所公开的生物特征认证特征中，用于验证训练有素的助理是否存在，存在检测器以确保助理在治疗过程中持续存在，以及警告和恢复过程允许持续存在助手间歇性失误。

5. 发明申请

WO0137900A3 HEMOFILTRATION SYSTEMS AND METHODS THAT MAINTAIN STERILE EXTRACORPOREAL PROCESSING CONDITIONS 审中-公开
标题翻译：保持无菌体外加工条件的血液滤过系统和方法
公开(公告)号：WO0137900A3
公开(公告)日：2002-02-14
申请号：PCT/US0042386
申请日：2000-11-29
申请人： NXSTAGE MEDICAL INC
发明人： BURBANK JEFFREY H , BRUGGER JAMES , TREU DENNIS M , FINCH DAVID C
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , A61M39/02 , A61M37/00 , A61M1/14 , B01D35/00 , C02F1/00 , C02F9/00
CPC分类号： A61M1/34 , A61M1/1639 , A61M1/3403 , A61M1/341 , A61M1/342 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3458 , A61M1/361 , A61M1/3612 , A61M1/3626 , A61M1/3639 , A61M1/3646 , A61M1/367 , A61M39/0208 , A61M2205/126 , A61M2205/128 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/35 , A61M2205/3553 , A61M2205/3569 , A61M2205/502 , A61M2205/505 , A61M2205/60 , A61M2205/6018 , A61M2205/6072
摘要： Hemofiltration systems and methods circulate blood from an individual through a hemofilter (34) to remove waste and to return blood and replacement fluid to the individual after removal of waste. The systems and methods maintain sterile extracorporeal processing conditions during and between therapy sessions. For example, the systems and methods include a waste discharge path in the extracorporeal circuit to convey waste fluid to a waste receiving unit. The waste discharge path (66) includes an air break (170). The air break prevents back flow of waste contaminants into the extracorporeal circuit from the waste receiving unit. As another example, the systems and methods include a replacement fluid path (68) in the extracorporeal circuit to convey replacement fluid from a source to the extracorporeal circuit. The replacement fluid path includes a sterilizing filter (178) to avoid contamination of the extracorporeal circuit.
摘要翻译：血液过滤系统和方法通过血液过滤器（34）使个体血液循环以去除废物并在去除废物后将血液和置换液返回给个体。该系统和方法在治疗期间和治疗期间保持无菌的体外处理条件。例如，该系统和方法包括体外回路中的废物排放路径，以将废液输送到废物接收单元。废物排放路径（66）包括空气断裂（170）。空气阻断防止废物接收单元将废物污染物回流到体外回路中。作为另一个例子，该系统和方法包括体外回路中的替代流体路径（68），以将替代流体从源输送到体外回路。替代流体路径包括消毒过滤器（178）以避免体外回路的污染。

6. 发明申请

WO0137895A3 SYNCHRONIZED VOLUMETRIC FLUID BALANCING SYSTEMS AND METHODS 审中-公开
标题翻译：同步体积流量平衡系统和方法
公开(公告)号：WO0137895A3
公开(公告)日：2002-01-03
申请号：PCT/US0032477
申请日：2000-11-29
申请人： NXSTAGE MEDICAL INC
发明人： TREU DENNIS M , BURBANK JEFFREY H , BRUGGER JAMES , FINCH CHARLES D , THOMAS ROBERT
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , A61M39/02 , A61M37/00 , B01D35/00 , B01D61/00 , C02F1/44 , C02F9/00
CPC分类号： A61M1/342 , A61M1/1639 , A61M1/34 , A61M1/3403 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3458 , A61M1/361 , A61M1/3612 , A61M1/3626 , A61M1/3639 , A61M1/3646 , A61M1/367 , A61M39/0208 , A61M2205/126 , A61M2205/128 , A61M2205/15 , A61M2205/3331 , A61M2205/3334 , A61M2205/35 , A61M2205/3553 , A61M2205/3569 , A61M2205/505 , A61M2205/60 , A61M2205/6018 , A61M2205/6072
摘要： System and methods balance fluid in a fluid processing procedure during which an outgoing fluid is removed from an individual and an ingoing fluid is supplied to the individual. The systems and methods supply a volume of the outgoing fluid and a volume of the ingoing fluid into a volumetric chamber. The systems and methods discharge a volume of the outgoing fluid and a volume of the ingoing fluid from the volumetric chamber. The systems and methods synchronizes the supply and discharge of fluid to affect a concurrent discharge of the outgoing and ingoing fluids from the volumetric chamber in volumetric balance with a concurrent supply of outgoing and ingoing fluids into the volumetric chamber. The volumetric chamber can include at least one chamber including an interior wall dividing the chamber into first and second compartments. The first and second compartments retain a volume of outgoing and ingoing fluids respectively.
摘要翻译：系统和方法在流体处理过程中平衡流体，在该过程期间将流出的流体从个体移出，并且将流入的流体供应给个体。系统和方法将输出流体的体积和进入流体的体积提供到容积室中。系统和方法从体积腔排出一定体积的输出流体和一定体积的流入流体。系统和方法使流体的供应和排放同步，以体积平衡的方式影响来自体积室的输出和进入流体的同时排放，同时将排出和进入流体供应到容积室中。容积室可以包括至少一个室，其包括将室分成第一和第二室的内壁。第一和第二隔室分别保留一定体积的输出和流入流体。

7. 发明申请

WO02070042B1 METHODS, SYSTEMS, AND KITS FOR THE EXTRACORPOREAL PROCESSING OF BLOOD 审中-公开
标题翻译：用于体外血液处理的方法，系统和试剂盒
公开(公告)号：WO02070042B1
公开(公告)日：2002-10-31
申请号：PCT/US0106906
申请日：2001-03-01
申请人： NXSTAGE MEDICAL INC
发明人： BRUGGER JAMES M , FINCH CHARLES DAVID , BURBANK JEFFREY H
IPC分类号： A61M1/10 , A61M1/36
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/1037 , A61M1/1039 , A61M1/1086 , A61M1/3663 , A61M2205/3334
摘要： Methods, systems, and kits for extracorporeally circulating and processing blood are described. The systems include a pump, a processing unit, and blood drawn return lines for accessing a patient's vasculature. Blood flow through the return line is measured and pump speed controlled to maintain a desired blood flow rate. Alarm conditions can be initiated when expected pump performance differs from that needed to maintain the control point flow rate. By using an ultrasonic flow detector, gas bubbles in the blood flow can be detected.
摘要翻译：描述了用于体外循环和处理血液的方法，系统和试剂盒。该系统包括一个泵，一个处理单元，以及用于进入患者脉管系统的抽血返回管线。测量通过返回线的血液流量并控制泵速度以保持期望的血液流速。当预期的泵性能与维持控制点流量所需的性能不同时，可以启动报警条件。通过使用超声波流量检测器，可以检测血流中的气泡。

8. 发明申请

WO0137786A2 FLUID PROCESSING SYSTEMS AND METHODS USING EXTRACORPOREAL FLUID FLOW PANELS ORIENTED WITHIN A CARTRIDGE 审中-公开
标题翻译：流体加工系统和使用面向圆盘的流体流动面板的方法
公开(公告)号：WO0137786A2
公开(公告)日：2001-05-31
申请号：PCT/US0042356
申请日：2000-11-29
申请人： NXSTAGE MEDICAL INC
发明人： BURBANK JEFFREY H , BRUGGER JAMES M , TREU DENNIS M
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , A61M39/02 , A61K
CPC分类号： A61M1/34 , A61M1/1639 , A61M1/341 , A61M1/342 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3458 , A61M1/361 , A61M1/3612 , A61M1/3626 , A61M1/3639 , A61M1/3646 , A61M1/367 , A61M39/0208 , A61M2205/126 , A61M2205/128 , A61M2205/15 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/35 , A61M2205/3553 , A61M2205/3569 , A61M2205/502 , A61M2205/505 , A61M2205/60 , A61M2205/6018 , A61M2205/6072
摘要： A first flow path (78) is defined within a first panel that forms part of an extracorporeal fluid circuit (56). A second flow path is defined within a second panel that also forms a part of the extracorporeal fluid circulation. The first and second panels are oriented in a fluid processing cartridge (18) for mounting as an integrated unit on a fluid processing machine (16) and for removal as an integrated unit from the fluid processing machine.
摘要翻译：第一流路78限定在形成体外流体回路（56）的一部分的第一面板内。第二流路限定在也形成体外流体循环的一部分的第二面板内。第一和第二面板定位在流体处理盒（18）中，用于作为集成单元安装在流体处理机器（16）上并且用于从流体处理机器移除作为集成单元。

9. 发明申请

WO03058608A2 METHOD AND APPARATUS FOR LEAK DETECTION IN BLOOD CIRCUITS COMBINING EXTERNAL FLUID DETECTION AND AIR INFILTRATION DETECTION 审中-公开
标题翻译：组合外部流体检测和空气浸润检测的血液循环中漏液检测的方法和装置
公开(公告)号：WO03058608A2
公开(公告)日：2003-07-17
申请号：PCT/US0300147
申请日：2003-01-03
申请人： NXSTAGE MEDICAL INC
发明人： BURBANK JEFFREY H
IPC分类号： A61M1/36 , G01M3/26 , G11B
CPC分类号： A61M1/367 , A61M1/3659 , A61M2205/15 , G01M3/26
摘要： One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be catastrophic. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. According to the present invention, the probability of a leak, its seriousness, the amount of time the leak condition has persisted without a response, and other factors may be used to control escalation of multiple types of alarms. In a simple embodiment, for example, there may be a staged audio signal that has a certain loudness and tonal quality when a leak is first detected and becomes more conspicuous as time goes by without a reset response from a user.
摘要翻译：体外血液治疗如透析自动化中最重要的安全问题之一是出现血液渗漏的风险。体外血液处理系统以如此高的速度吸取血液，使得血液回路中完整性的丧失可能是灾难性的。有一些检测和防止泄漏的机制，但没有一个是完美的。根据本发明，可以使用泄漏的可能性，其严重性，泄漏条件持续的时间没有响应等因素来控制多种类型的报警的升级。在简单的实施例中，例如，当首次检测到泄漏时，可能存在具有一定响度和音调质量的分级音频信号，并且随着时间的流逝而变得更显眼，而没有来自用户的复位响应。

10. 发明申请

WO0137786A9 FLUID PROCESSING SYSTEMS AND METHODS USING EXTRACORPOREAL FLUID FLOW PANELS ORIENTED WITHIN A CARTRIDGE 审中-公开
标题翻译：流体加工系统和使用面向圆盘的流体流动面板的方法
公开(公告)号：WO0137786A9
公开(公告)日：2002-12-12
申请号：PCT/US0042356
申请日：2000-11-29
申请人： NXSTAGE MEDICAL INC
发明人： BURBANK JEFFREY H , BRUGGER JAMES M , TREU DENNIS M
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , A61M39/02 , A61M37/00 , B01D35/00 , B01D61/00 , C02F1/44 , C02F9/00
CPC分类号： A61M1/34 , A61M1/1639 , A61M1/341 , A61M1/342 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3458 , A61M1/361 , A61M1/3612 , A61M1/3626 , A61M1/3639 , A61M1/3646 , A61M1/367 , A61M39/0208 , A61M2205/126 , A61M2205/128 , A61M2205/15 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/35 , A61M2205/3553 , A61M2205/3569 , A61M2205/502 , A61M2205/505 , A61M2205/60 , A61M2205/6018 , A61M2205/6072
摘要： A first flow path (78) is defined within a first panel that forms part of an extracorporeal fluid circuit (56). A second flow path is defined within a second panel that also forms a part of the extracorporeal fluid circulation. The first and second panels are oriented in a fluid processing cartridge (18) for mounting as an integrated unit on a fluid processing machine (16) and for removal as an integrated unit from the fluid processing machine.
摘要翻译：第一流路78限定在形成体外流体回路（56）的一部分的第一面板内。第二流路限定在也形成体外流体循环的一部分的第二面板内。第一和第二面板定位在流体处理盒（18）中，用于作为集成单元安装在流体处理机器（16）上并且用于从流体处理机器移除作为集成单元。

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