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1. 发明申请

WO2016109015A1 OCT SURGICAL VISUALIZATION SYSTEM WITH MACULAR CONTACT LENS 审中-公开
标题翻译： OCT手术视觉系统与MACULAR接触透镜
公开(公告)号：WO2016109015A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/058653
申请日：2015-11-02
申请人： NOVARTIS AG , YU, Lingfeng , SHOFMAN, Vadim
发明人： YU, Lingfeng , SHOFMAN, Vadim
IPC分类号： A61B3/125
CPC分类号： A61B3/102 , A61B3/0008 , A61B3/1025 , A61B3/13 , A61B3/14 , A61B3/18 , A61B90/20 , A61F9/00821 , A61F9/00823 , A61F2009/00851 , A61F2009/00863 , A61N5/06 , A61N5/062
摘要： An ophthalmic visualization system can include an ocular lens positioned between a macular contact lens coupled to a procedure eye and a surgical microscope. The ocular lens can guide a light beam through the macular contact lens and into the procedure eye, and in combination with the macular contact lens generate an intermediate image of the procedure eye at an image plane between the procedure eye and the surgical microscope. The system can include a reduction lens positioned in the optical path between the surgical microscope and the ocular lens. The reduction lens and/or ocular lens can align a focus plane of the surgical microscope with the image plane. A method of visualizing a procedure eye in an ophthalmic procedure can include positioning an ocular lens and a reduction lens between a macular contact lens and a surgical microscope; and scanning the procedure eye with a light beam.
摘要翻译：眼科可视化系统可以包括定位在联接到手术眼的黄斑隐形眼镜和手术显微镜之间的眼透镜。眼透镜可引导光束通过黄斑隐形眼镜进入手术眼，并与黄斑隐形眼镜组合，在手术眼和手术显微镜之间的图像平面处产生手术眼的中间图像。该系统可以包括位于手术显微镜和眼透镜之间的光路中的减速透镜。还原透镜和/或眼透镜可以将外科显微镜的焦平面与图像平面对准。在眼科手术中可视化手术眼的方法可包括将眼透镜和还原透镜定位在黄斑隐形眼镜和手术显微镜之间; 并用光束扫描手术眼。

2. 发明申请

WO2015094727A1 FORWARD SCANNING-OPTICAL PROBES, CIRCULAR SCAN PATTERNS, OFFSET FIBERS 审中-公开
标题翻译：前向扫描光学探测器，圆形扫描模式，偏移光纤
公开(公告)号：WO2015094727A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/068912
申请日：2014-12-05
申请人： NOVARTIS AG , PARTO, Kambiz , WHEATLEY, Barry, L. , SCHMIDTLIN, Edouard , HEEREN, Tammo , JOCHINSEN, Mauricio , YU, Lingfeng
发明人： PARTO, Kambiz , WHEATLEY, Barry, L. , SCHMIDTLIN, Edouard , HEEREN, Tammo , JOCHINSEN, Mauricio , YU, Lingfeng
IPC分类号： A61B1/07 , A61B18/22 , G01N21/01
CPC分类号： A61B18/20 , A61B5/0066 , A61B5/0084 , A61B18/201 , A61B18/22 , A61B2018/00577 , A61B2018/00589 , A61B2018/00982 , A61B2018/20357 , A61B2560/0431
摘要： An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region; and a fiber actuator, housed at least partially in the handle, configured to move the distal fiber-portion to scan the deflected light along a scanning curve in the target region.
摘要翻译：提供了一种光学扫描探针，该探针包括一个被用户抓握的手柄; 套管，其从所述手柄的远端突出，外径小于20号; 光纤，其远离光纤部分离开探针轴，被配置为在近端光纤部分处接收来自光源的光，并在远端光纤部分发射接收的光; 固定光束形成单元，设置在所述套管的远端部分处，被配置为接收来自所述远端纤维部分的光，并将接收的光偏转到目标区域; 以及纤维致动器，其至少部分地容纳在所述把手中，所述纤维致动器被构造成移动所述远端光纤部分以沿着所述目标区域中的扫描曲线扫描所述偏转的光。

3. 发明申请

WO2015042305A1 INTEGRATED OCT-REFRACTOMETER SYSTEM FOR OCULAR BIOMETRY 审中-公开
标题翻译：用于眼科生物测定的集成OCT-压力计系统
公开(公告)号：WO2015042305A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/056381
申请日：2014-09-18
申请人： NOVARTIS AG , ARTSYUKHOVICH, Alexander N. , ASLAN, Z. Aras , YU, Lingfeng , BOUKHNY, Mikhail
发明人： ARTSYUKHOVICH, Alexander N. , ASLAN, Z. Aras , YU, Lingfeng , BOUKHNY, Mikhail
IPC分类号： A61B3/14
CPC分类号： A61B3/0025 , A61B3/0041 , A61B3/1015 , A61B3/102 , A61B3/103 , A61B3/135 , A61F2009/00851 , A61F2009/00887 , A61F2240/002
摘要： A Slit-lamp-or-Microscope-Integrated-OCT-Refractometer system includes an eye-visualization system, configured to provide a visual image of an imaged region in an eye; an Optical Coherence Tomographic (OCT) imaging system, configured to generate an OCT image of the imaged region; a refractometer, configured to generate a refractive mapping of the imaged region; and an analyzer, configured to determine refractive characteristics of the eye based on the OCT image and the refractive mapping, wherein the refractometer and the OCT imaging system are integrated into the eye visualization system.
摘要翻译：狭缝灯或显微镜集成OCT折射仪系统包括眼睛可视化系统，其被配置为提供眼睛中的成像区域的视觉图像; 光学相干断层扫描（OCT）成像系统，被配置为产生所述成像区域的OCT图像; 折射计，被配置为产生所述成像区域的折射映射; 以及分析器，被配置为基于所述OCT图像和所述折射映射来确定所述眼睛的折射特性，其中所述折射计和所述OCT成像系统被集成到所述眼睛可视化系统中。

4. 发明申请

WO2016010725A1 MOVABLE WIDE-ANGLE OPHTHALMIC SURGICAL SYSTEM 审中-公开
标题翻译：可移动宽角度手术系统
公开(公告)号：WO2016010725A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/038613
申请日：2015-06-30
申请人： NOVARTIS AG , YU, Lingfeng
发明人： YU, Lingfeng
IPC分类号： G01B9/02 , A61B3/10 , A61B3/13
CPC分类号： A61F9/009 , A61B3/102 , A61B3/1176 , A61B5/0095 , A61B5/4836 , A61B90/20 , A61B90/50 , A61B2090/3735 , A61F9/00821 , A61F2009/00851 , A61F2009/00874 , A61F2009/00891 , A61F2009/00897 , G02B21/0012
摘要： A surgical imaging system can include at least one light source, configured to generate a light beam; a beam guidance system, configured to guide the light beam from the light source; a beam scanner, configured to receive the light from the beam guidance system, and to generate a scanned light beam; a beam coupler, configured to redirect the scanned light beam; and a wide field of view (WFOV) lens, configured to guide the redirected scanned light beam into a target region of a procedure eye; wherein the beam coupler is movably positioned relative to the procedure eye such that the beam coupler is selectively movable to change at least one of an incidence angle of the redirected scanned light beam into the procedure eye and the target region of the procedure eye.
摘要翻译：手术成像系统可以包括被配置为产生光束的至少一个光源; 光束引导系统，被配置为引导来自光源的光束; 光束扫描器，被配置为接收来自光束引导系统的光并产生扫描光束; 光束耦合器，被配置为重定向扫描的光束; 和宽视野（WFOV）透镜，被配置为将重定向的扫描光束引导到过程眼睛的目标区域中; 其中所述光束耦合器相对于过程眼可移动地定位，使得所述光束耦合器选择性地可移动以将重定向的扫描光束的入射角中的至少一个改变为过程眼睛和过程眼睛的目标区域中的至少一个。

5. 发明申请

WO2015094773A1 TWO DIMENSIONAL FORWARD SCANNING PROBE 审中-公开
标题翻译：两维前向扫描探测器
公开(公告)号：WO2015094773A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/069127
申请日：2014-12-08
申请人： NOVARTIS AG , YU, Lingfeng , YU, Xiaoyu , AULD, Jack
发明人： YU, Lingfeng , YU, Xiaoyu , AULD, Jack
IPC分类号： A61B1/07
CPC分类号： A61B1/07 , A61B1/00112 , A61B1/00172 , A61B1/00188 , A61B3/102 , A61B5/0062 , A61B5/0066 , A61B5/0084
摘要： An optical scanning probe comprises a handle to receive a light beam from a light guide; a cannula, extending from a distal end of the handle; a fiber, positioned partially inside the handle and partially inside the cannula, to guide the received light beam toward a distal end of the cannula; a rotating scanner, rotatably positioned at least partially inside the cannula and configured to house a proximal portion of the fiber; and a deflecting scanner, movably coupled to a distal end of the rotating scanner, configured to deflect a distal portion of the fiber, wherein the distal portion of the fiber is configured to emit and scan the guided light in a target region.
摘要翻译：光学扫描探针包括用于接收来自光导的光束的手柄; 从手柄的远端延伸的插管; 纤维，其部分地位于手柄内并且部分地位于套管内部，以将接收的光束引导到套管的远端; 旋转扫描器，至少部分地可旋转地定位在套管内部并且被配置为容纳纤维的近端部分; 以及可移动地联接到所述旋转扫描器的远端的偏转扫描器，被配置为偏转所述光纤的远端部分，其中所述光纤的远端部分被配置为发射和扫描目标区域中的被引导光。

6. 发明申请

WO2016204833A1 TRACKING SYSTEM FOR SURGICAL OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：手术光学相干坐标跟踪系统
公开(公告)号：WO2016204833A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/020567
申请日：2016-03-03
申请人： NOVARTIS AG , HEEREN, Tammo , YU, Lingfeng
发明人： HEEREN, Tammo , YU, Lingfeng
IPC分类号： A61B3/10 , A61B3/13 , A61F9/007 , G02B21/00
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0033 , A61B3/10 , A61B3/12 , A61B3/13 , A61B3/132 , A61B3/14 , A61F9/007 , G02B21/0012
摘要： An OCT tracking system includes an imaging unit operable to generate a fundus image of a patient's eye and a tracking system operable to process the fundus image to determine a location of a surgical instrument inserted into the patient's eye. The OCT tracking system further includes an OCT system including an OCT light source operable to generate an OCT imaging beam and a beam scanner. Based at least in part on the determined location of the surgical instrument, the beam scanner directs the OCT imaging beam to a particular region within the patient's eye, the particular region within the patient's eye including the determined location of the surgical instrument inserted into the patient's eye.
摘要翻译： OCT跟踪系统包括可操作以产生患者眼睛的眼底图像的成像单元和可操作以处理眼底图像以确定插入到患者眼睛中的外科器械的位置的跟踪系统。 OCT跟踪系统还包括OCT系统，其包括可操作以产生OCT成像束和束扫描器的OCT光源。至少部分地基于所确定的外科器械的位置，束扫描器将OCT成像束引导到患者眼睛内的特定区域，患者眼睛内的特定区域包括被插入到患者眼睛中的确定的外科器械的位置眼。

7. 发明申请

WO2016133762A1 SYSTEMS AND METHODS FOR DUAL VITREOUS AND RETINA IMAGING 审中-公开
标题翻译：用于双维和反射成像的系统和方法
公开(公告)号：WO2016133762A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/017382
申请日：2016-02-10
申请人： NOVARTIS AG , YU, Lingfeng
发明人： YU, Lingfeng , REN, Hugang
IPC分类号： G06T5/50
CPC分类号： A61B3/0025 , A61B3/0058 , A61B3/102 , A61B3/12 , A61B3/14 , G06T5/50 , G06T2207/10101 , G06T2207/30041
摘要： A system and method for using optical coherence tomography (OCT) to image both the vitreous and the retina in the eye. The image of both tissues may be created sequentially, simultaneously, or near-simultaneously from at least one OCT image.
摘要翻译：一种使用光学相干断层扫描（OCT）来对眼睛中的玻璃体和视网膜进行成像的系统和方法。可以从至少一个OCT图像顺序地，同时地或几乎同时地创建两个组织的图像。

8. 发明申请

WO2015026414A1 SYSTEMS AND METHODS FOR INTRA-OPERATIVE EYE BIOMETRY OR REFRACTIVE MEASUREMENT 审中-公开
标题翻译：用于手术眼睛生物测定或折射测量的系统和方法
公开(公告)号：WO2015026414A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/039579
申请日：2014-05-27
申请人： NOVARTIS AG , ARTSYUKHOVICH, Alexander N. , ASLAN, Aras , YU, Lingfeng
发明人： ARTSYUKHOVICH, Alexander N. , ASLAN, Aras , YU, Lingfeng
IPC分类号： A61F9/007
CPC分类号： A61B3/16 , A61B3/103 , A61F9/00736 , A61F9/00781
摘要： Systems and methods for capturing intraoperative biometry and/or refractive measurements include a sensor or valve associated with the eye and configured to detect a pressure of the eye. The system also includes an intra-op diagnostics device including a control unit arranged to actuate the intra-op diagnostics device to capture the intraoperative biometry and/or refractive measurements when the sensor or valve detects pressure within a predetermined pressure range.
摘要翻译：用于捕获术中生物测定和/或折射测量的系统和方法包括与眼睛相关联并被配置为检测眼睛压力的传感器或瓣膜。该系统还包括操作内诊断装置，其包括控制单元，该控制单元被布置成当传感器或阀检测到预定压力范围内的压力时致动操作内诊断装置以捕获术中生物测定和/或折射测量。

9. 发明申请

WO2014160691A1 DEVICES, SYSTEMS, AND METHODS FOR CALIBRATING AN OCT IMAGING SYSTEM IN A LASER SURGICAL SYSTEM 审中-公开
标题翻译：用于在激光外科系统中校准OCT成像系统的装置，系统和方法
公开(公告)号：WO2014160691A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031696
申请日：2014-03-25
申请人： NOVARTIS AG , PARTO, Kambiz , WHEATLEY, Barry L. , LIN, Dean , HEEREN, Tammo , YU, Lingfeng
发明人： PARTO, Kambiz , WHEATLEY, Barry L. , LIN, Dean , HEEREN, Tammo , YU, Lingfeng
IPC分类号： G01N21/45
CPC分类号： A61B3/102 , A61F9/00821 , A61F2009/00863 , A61F2009/00868
摘要： An adjustment system for an Optical Coherence Tomography (OCT) imaging system includes an OCT light source; a beam splitter, splitting the OCT light beam into an imaging beam to an imaging arm, and a reference beam to a reference arm; a probe, guiding the imaging beam onto a target and receiving a returned imaging beam from the target; the beam splitter generating an interference beam from the returned imaging beam and a returned reference beam from the reference arm.
摘要翻译：光学相干断层扫描（OCT）成像系统的调整系统包括OCT光源; 分束器，将OCT光束分解成成像束到成像臂，以及将参考光束分配到参考臂; 探针，将成像光束引导到目标上并从目标接收返回的成像光束; 分束器从返回的成像光束产生干涉光束和从参考臂返回的参考光束。

10. 发明申请

WO2015195247A1 OPHTHALMIC IMAGING SYSTEM WITH AUTOMATIC RETINAL FEATURE DETECTION 审中-公开
标题翻译：具有自动反射特征检测的眼底成像系统
公开(公告)号：WO2015195247A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/031070
申请日：2015-05-15
申请人： NOVARTIS AG , REN, Hugang , YU, Lingfeng
发明人： REN, Hugang , YU, Lingfeng
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/12 , G06T7/0012 , G06T2207/10101 , G06T2207/30041
摘要： A method of automatically detecting a retinal feature using an ophthalmic imaging system can include: acquiring an optical coherence tomography (OCT) image of a retina; segmenting the OCT image; generating a metric based on the segmented OCT image; detecting the retinal feature based on the metric; and providing an indication of the detected retinal feature to a user. An ophthalmic imaging system can include: an OCT system configured to acquire an image of a retina; a computing device coupled to the OCT system and configured to segment the image, generate a metric based on the segmented image, and detect a retinal feature based on the metric; and an audio/visual/tactile device in communication with the computing device and configured to provide at least one of an audio, visual, and tactile indication of the detected retinal feature to a user.
摘要翻译：使用眼科成像系统自动检测视网膜特征的方法可以包括：获取视网膜的光学相干断层摄影（OCT）图像; 分割OCT图像; 基于分割的OCT图像生成度量; 基于度量检测视网膜特征; 以及向用户提供检测到的视网膜特征的指示。眼科成像系统可以包括：OCT系统，被配置为获取视网膜的图像; 耦合到所述OCT系统并被配置为分割所述图像的计算设备，基于所述分割的图像生成度量，并且基于所述度量来检测视网膜特征; 以及与所述计算设备通信并被配置为向用户提供检测到的视网膜特征的音频，视觉和触觉指示中的至少一个的音频/视觉/触觉设备。

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