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1. 发明申请

WO2015094770A2 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING AN ELASTOMERIC OPTICAL ELEMENT 审中-公开
标题翻译：使用弹性光学元件的成像探针和相关设备，系统和方法
公开(公告)号：WO2015094770A2
公开(公告)日：2015-06-25
申请号：PCT/US2014/069101
申请日：2014-12-08
申请人： NOVARTIS AG , WHEATLEY, Barry L. , PARTO, Kambiz
发明人： WHEATLEY, Barry L. , PARTO, Kambiz
IPC分类号： A61B3/10 , A61B5/00
CPC分类号： A61B3/102 , A61B3/12 , A61B5/0084 , G02B3/0087 , G02B26/10
摘要： The imaging probe can comprise a housing, having a proximal region configured to be coupled to an optical cable; a cannula, extending from a distal region of the housing; an optical guide, positioned partially in the housing and partially in the cannula, configured to receive an imaging light from the cable in the proximal region of the housing, and to guide the imaging light towards a distal end of the cannula; an optical focusing element, configured to receive the imaging light from the optical guide, and to emit a focused imaging light; an elastomeric optical element, configured to receive the focused imaging light from the optical focusing element, and to be deformable to redirect the focused imaging light; and an actuator system, configured to deform the elastomeric optical element to redirect the focused imaging light.
摘要翻译：成像探针可以包括壳体，其具有被配置为耦合到光缆的近端区域; 套管，其从所述壳体的远侧区域延伸; 光学引导件，部分地定位在壳体中并且部分地定位在套管中，被配置为在壳体的近侧区域中接收来自电缆的成像光，并且将成像光导向套管的远端; 光学聚焦元件，被配置为从所述光学引导件接收成像光，并且发射聚焦的成像光; 弹性体光学元件，被配置为从所述光学聚焦元件接收所聚焦的成像光，并且可变形以使所聚焦的成像光重定向; 以及致动器系统，其构造成使弹性体光学元件变形以重定向聚焦的成像光。

2. 发明申请

WO2015094725A1 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING ELECTROACTIVE POLYMER ACTUATORS 审中-公开
标题翻译：使用电动聚合物致动器的成像探针和相关设备，系统和方法
公开(公告)号：WO2015094725A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/068894
申请日：2014-12-05
申请人： NOVARTIS AG , WHEATLEY, Barry L.
发明人： WHEATLEY, Barry L.
IPC分类号： A61B3/00
CPC分类号： A61B3/102 , A61B3/1208 , A61B5/0084 , G01B9/0205 , G01B9/02091 , G02B6/3624 , G02B23/26 , G02B26/103
摘要： Devices, systems, and methods that utilize electroactive polymer actuators to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging apparatus comprises an optical probe having a handle sized and shaped for handheld grasping by a user; and a cannula coupled to the handle, the cannula sized and shaped for insertion into an eye to be treated; an optical fiber positioned at least partially within the optical probe, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within the cannula of the optical probe; and an actuator system configured to impart motion to the optical fiber, the actuator system including an electroactive polymer (EAP) actuator positioned within the optical probe.
摘要翻译：提供了利用电活性聚合物致动器向位于成像探针内的光纤赋予运动的装置，系统和方法。在一些实施例中，眼科成像设备包括具有尺寸和形状的手柄的光学探针，用于由用户手持握持; 以及联接到所述手柄的套管，所述套管的尺寸和形状用于插入待治疗的眼睛中; 至少部分地位于光学探针内的光纤，所述光纤被配置为从成像光源接收成像光并将成像光引导到位于所述光学探针的套管内的光学元件; 以及致动器系统，被配置为向所述光纤传递运动，所述致动器系统包括位于所述光学探针内的电活性聚合物（EAP）致动器。

3. 发明申请

WO2014160691A1 DEVICES, SYSTEMS, AND METHODS FOR CALIBRATING AN OCT IMAGING SYSTEM IN A LASER SURGICAL SYSTEM 审中-公开
标题翻译：用于在激光外科系统中校准OCT成像系统的装置，系统和方法
公开(公告)号：WO2014160691A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031696
申请日：2014-03-25
申请人： NOVARTIS AG , PARTO, Kambiz , WHEATLEY, Barry L. , LIN, Dean , HEEREN, Tammo , YU, Lingfeng
发明人： PARTO, Kambiz , WHEATLEY, Barry L. , LIN, Dean , HEEREN, Tammo , YU, Lingfeng
IPC分类号： G01N21/45
CPC分类号： A61B3/102 , A61F9/00821 , A61F2009/00863 , A61F2009/00868
摘要： An adjustment system for an Optical Coherence Tomography (OCT) imaging system includes an OCT light source; a beam splitter, splitting the OCT light beam into an imaging beam to an imaging arm, and a reference beam to a reference arm; a probe, guiding the imaging beam onto a target and receiving a returned imaging beam from the target; the beam splitter generating an interference beam from the returned imaging beam and a returned reference beam from the reference arm.
摘要翻译：光学相干断层扫描（OCT）成像系统的调整系统包括OCT光源; 分束器，将OCT光束分解成成像束到成像臂，以及将参考光束分配到参考臂; 探针，将成像光束引导到目标上并从目标接收返回的成像光束; 分束器从返回的成像光束产生干涉光束和从参考臂返回的参考光束。

4. 发明申请

WO2015175422A1 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING LEVER ARM ACTUATORS 审中-公开
标题翻译：成像探针和相关设备，系统和使用杠杆臂执行器的方法
公开(公告)号：WO2015175422A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030188
申请日：2015-05-11
申请人： NOVARTIS AG , WHEATLEY, Barry L.
发明人： WHEATLEY, Barry L. , PARTO, Kambiz
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B1/00133 , A61B1/00149 , A61B1/0016 , A61B1/00165 , A61B3/0008 , A61B3/0025 , A61B3/0075 , A61B3/10 , A61B3/14 , G02B3/0087
摘要： Devices, systems, and methods that utilize a mechanical structure, such as a lever arm or a flexure mechanism, and an electrically energizable member, such as an actuator, to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging probe can include a handle; a cannula coupled to the handle; an optical fiber positioned at least partially within the handle and the cannula, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within a distal portion of the cannula; and an actuator system configured to impart motion to the optical fiber, the actuator system including a mechanical structure and an electrically energizable member configured to selectively impart motion to the mechanical structure upon the electrically energizable member being electrically energized.
摘要翻译：提供了利用机械结构的装置，系统和方法，例如杠杆臂或挠曲机构，以及诸如致动器的电激励构件，以向位于成像探针内的光纤赋予运动。在一些实施例中，眼科成像探针可以包括手柄; 联接到手柄的套管; 至少部分地位于手柄和套管内的光纤，所述光纤被配置为从成像光源接收成像光并将成像光引导到位于套管的远端部分内的光学元件; 以及致动器系统，被配置为向光纤施加运动，所述致动器系统包括机械结构和电可激励构件，所述电激励构件被构造成在所述电激励构件被电通电时选择性地向所述机械结构施加运动。

5. 发明申请

WO2015094770A3 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING AN ELASTOMERIC OPTICAL ELEMENT 审中-公开
标题翻译：使用弹性光学元件的成像探针和相关装置，系统和方法
公开(公告)号：WO2015094770A3
公开(公告)日：2015-11-12
申请号：PCT/US2014069101
申请日：2014-12-08
申请人： NOVARTIS AG , WHEATLEY BARRY L , PARTO KAMBIZ
发明人： WHEATLEY BARRY L , PARTO KAMBIZ
IPC分类号： A61B5/00
CPC分类号： A61B3/102 , A61B3/12 , A61B5/0084 , G02B3/0087 , G02B26/10
摘要： The imaging probe can comprise a housing, having a proximal region configured to be coupled to an optical cable; a cannula, extending from a distal region of the housing; an optical guide, positioned partially in the housing and partially in the cannula, configured to receive an imaging light from the cable in the proximal region of the housing, and to guide the imaging light towards a distal end of the cannula; an optical focusing element, configured to receive the imaging light from the optical guide, and to emit a focused imaging light; an elastomeric optical element, configured to receive the focused imaging light from the optical focusing element, and to be deformable to redirect the focused imaging light; and an actuator system, configured to deform the elastomeric optical element to redirect the focused imaging light.
摘要翻译：成像探针可以包括外壳，该外壳具有被配置为耦合到光缆的近端区域; 套管，其从壳体的远侧区域延伸; 光导，所述光导部分地定位在所述壳体中并且部分地定位在所述套管中，所述光导被配置为在所述壳体的所述近侧区域中接收来自所述光缆的成像光并且将所述成像光引导到所述套管的远端; 光学聚焦元件，被配置为接收来自所述光导的成像光并且发射聚焦的成像光; 弹性体光学元件，其被配置为接收来自所述光学聚焦元件的所述聚焦的成像光，并且能够变形以重新导向所述聚焦的成像光; 以及致动器系统，其被配置成使弹性体光学元件变形以重定向聚焦的成像光。

6. 发明申请

WO2015094775A1 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING FERROFLUID-IMPREGNATED ACTUATORS 审中-公开
标题翻译：成像探针和相关设备，系统和使用流体动力学印刷机构的方法
公开(公告)号：WO2015094775A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/069144
申请日：2014-12-08
申请人： NOVARTIS AG , WHEATLEY, Barry L.
发明人： WHEATLEY, Barry L.
IPC分类号： A61B5/00
CPC分类号： A61B3/102 , A61B3/1208 , A61B5/0084 , G01B9/0205 , G01B9/02091 , G02B6/3572 , G02B6/3624 , G02B23/2469 , G02B23/26 , G02B26/103
摘要： Devices, systems, and methods that utilize a ferrofluid-impregnated medium to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging probe can include a housing having a proximal portion and a distal portion; an optical fiber positioned within the housing, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within the distal portion of the housing; and an actuator system configured to impart motion to the optical fiber, the actuator system including a ferrofluid-impregnated medium (FIM) and an electrically energizable coil positioned within the housing.
摘要翻译：提供了利用浸渍有铁介质的介质对位于成像探针内的光纤进行运动的装置，系统和方法。在一些实施例中，眼科成像探针可以包括具有近端部分和远端部分的壳体; 定位在所述壳体内的光纤，所述光纤被配置为从成像光源接收成像光并将成像光引导到位于所述壳体的远侧部分内的光学元件; 以及致动器系统，被配置为向所述光纤传递运动，所述致动器系统包括被置于所述壳体内的含氟铁流体介质（FIM）和可电激励的线圈。

7. 发明申请

WO2015094727A1 FORWARD SCANNING-OPTICAL PROBES, CIRCULAR SCAN PATTERNS, OFFSET FIBERS 审中-公开
标题翻译：前向扫描光学探测器，圆形扫描模式，偏移光纤
公开(公告)号：WO2015094727A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/068912
申请日：2014-12-05
申请人： NOVARTIS AG , PARTO, Kambiz , WHEATLEY, Barry, L. , SCHMIDTLIN, Edouard , HEEREN, Tammo , JOCHINSEN, Mauricio , YU, Lingfeng
发明人： PARTO, Kambiz , WHEATLEY, Barry, L. , SCHMIDTLIN, Edouard , HEEREN, Tammo , JOCHINSEN, Mauricio , YU, Lingfeng
IPC分类号： A61B1/07 , A61B18/22 , G01N21/01
CPC分类号： A61B18/20 , A61B5/0066 , A61B5/0084 , A61B18/201 , A61B18/22 , A61B2018/00577 , A61B2018/00589 , A61B2018/00982 , A61B2018/20357 , A61B2560/0431
摘要： An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region; and a fiber actuator, housed at least partially in the handle, configured to move the distal fiber-portion to scan the deflected light along a scanning curve in the target region.
摘要翻译：提供了一种光学扫描探针，该探针包括一个被用户抓握的手柄; 套管，其从所述手柄的远端突出，外径小于20号; 光纤，其远离光纤部分离开探针轴，被配置为在近端光纤部分处接收来自光源的光，并在远端光纤部分发射接收的光; 固定光束形成单元，设置在所述套管的远端部分处，被配置为接收来自所述远端纤维部分的光，并将接收的光偏转到目标区域; 以及纤维致动器，其至少部分地容纳在所述把手中，所述纤维致动器被构造成移动所述远端光纤部分以沿着所述目标区域中的扫描曲线扫描所述偏转的光。

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