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1. 发明申请

WO2014160691A1 DEVICES, SYSTEMS, AND METHODS FOR CALIBRATING AN OCT IMAGING SYSTEM IN A LASER SURGICAL SYSTEM 审中-公开
标题翻译：用于在激光外科系统中校准OCT成像系统的装置，系统和方法
公开(公告)号：WO2014160691A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031696
申请日：2014-03-25
申请人： NOVARTIS AG , PARTO, Kambiz , WHEATLEY, Barry L. , LIN, Dean , HEEREN, Tammo , YU, Lingfeng
发明人： PARTO, Kambiz , WHEATLEY, Barry L. , LIN, Dean , HEEREN, Tammo , YU, Lingfeng
IPC分类号： G01N21/45
CPC分类号： A61B3/102 , A61F9/00821 , A61F2009/00863 , A61F2009/00868
摘要： An adjustment system for an Optical Coherence Tomography (OCT) imaging system includes an OCT light source; a beam splitter, splitting the OCT light beam into an imaging beam to an imaging arm, and a reference beam to a reference arm; a probe, guiding the imaging beam onto a target and receiving a returned imaging beam from the target; the beam splitter generating an interference beam from the returned imaging beam and a returned reference beam from the reference arm.
摘要翻译：光学相干断层扫描（OCT）成像系统的调整系统包括OCT光源; 分束器，将OCT光束分解成成像束到成像臂，以及将参考光束分配到参考臂; 探针，将成像光束引导到目标上并从目标接收返回的成像光束; 分束器从返回的成像光束产生干涉光束和从参考臂返回的参考光束。

2. 发明申请

WO2015094770A2 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING AN ELASTOMERIC OPTICAL ELEMENT 审中-公开
标题翻译：使用弹性光学元件的成像探针和相关设备，系统和方法
公开(公告)号：WO2015094770A2
公开(公告)日：2015-06-25
申请号：PCT/US2014/069101
申请日：2014-12-08
申请人： NOVARTIS AG , WHEATLEY, Barry L. , PARTO, Kambiz
发明人： WHEATLEY, Barry L. , PARTO, Kambiz
IPC分类号： A61B3/10 , A61B5/00
CPC分类号： A61B3/102 , A61B3/12 , A61B5/0084 , G02B3/0087 , G02B26/10
摘要： The imaging probe can comprise a housing, having a proximal region configured to be coupled to an optical cable; a cannula, extending from a distal region of the housing; an optical guide, positioned partially in the housing and partially in the cannula, configured to receive an imaging light from the cable in the proximal region of the housing, and to guide the imaging light towards a distal end of the cannula; an optical focusing element, configured to receive the imaging light from the optical guide, and to emit a focused imaging light; an elastomeric optical element, configured to receive the focused imaging light from the optical focusing element, and to be deformable to redirect the focused imaging light; and an actuator system, configured to deform the elastomeric optical element to redirect the focused imaging light.
摘要翻译：成像探针可以包括壳体，其具有被配置为耦合到光缆的近端区域; 套管，其从所述壳体的远侧区域延伸; 光学引导件，部分地定位在壳体中并且部分地定位在套管中，被配置为在壳体的近侧区域中接收来自电缆的成像光，并且将成像光导向套管的远端; 光学聚焦元件，被配置为从所述光学引导件接收成像光，并且发射聚焦的成像光; 弹性体光学元件，被配置为从所述光学聚焦元件接收所聚焦的成像光，并且可变形以使所聚焦的成像光重定向; 以及致动器系统，其构造成使弹性体光学元件变形以重定向聚焦的成像光。

3. 发明申请

WO2015175422A1 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING LEVER ARM ACTUATORS 审中-公开
标题翻译：成像探针和相关设备，系统和使用杠杆臂执行器的方法
公开(公告)号：WO2015175422A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030188
申请日：2015-05-11
申请人： NOVARTIS AG , WHEATLEY, Barry L.
发明人： WHEATLEY, Barry L. , PARTO, Kambiz
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B1/00133 , A61B1/00149 , A61B1/0016 , A61B1/00165 , A61B3/0008 , A61B3/0025 , A61B3/0075 , A61B3/10 , A61B3/14 , G02B3/0087
摘要： Devices, systems, and methods that utilize a mechanical structure, such as a lever arm or a flexure mechanism, and an electrically energizable member, such as an actuator, to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging probe can include a handle; a cannula coupled to the handle; an optical fiber positioned at least partially within the handle and the cannula, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within a distal portion of the cannula; and an actuator system configured to impart motion to the optical fiber, the actuator system including a mechanical structure and an electrically energizable member configured to selectively impart motion to the mechanical structure upon the electrically energizable member being electrically energized.
摘要翻译：提供了利用机械结构的装置，系统和方法，例如杠杆臂或挠曲机构，以及诸如致动器的电激励构件，以向位于成像探针内的光纤赋予运动。在一些实施例中，眼科成像探针可以包括手柄; 联接到手柄的套管; 至少部分地位于手柄和套管内的光纤，所述光纤被配置为从成像光源接收成像光并将成像光引导到位于套管的远端部分内的光学元件; 以及致动器系统，被配置为向光纤施加运动，所述致动器系统包括机械结构和电可激励构件，所述电激励构件被构造成在所述电激励构件被电通电时选择性地向所述机械结构施加运动。

4. 发明申请

WO2015094775A1 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING FERROFLUID-IMPREGNATED ACTUATORS 审中-公开
标题翻译：成像探针和相关设备，系统和使用流体动力学印刷机构的方法
公开(公告)号：WO2015094775A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/069144
申请日：2014-12-08
申请人： NOVARTIS AG , WHEATLEY, Barry L.
发明人： WHEATLEY, Barry L.
IPC分类号： A61B5/00
CPC分类号： A61B3/102 , A61B3/1208 , A61B5/0084 , G01B9/0205 , G01B9/02091 , G02B6/3572 , G02B6/3624 , G02B23/2469 , G02B23/26 , G02B26/103
摘要： Devices, systems, and methods that utilize a ferrofluid-impregnated medium to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging probe can include a housing having a proximal portion and a distal portion; an optical fiber positioned within the housing, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within the distal portion of the housing; and an actuator system configured to impart motion to the optical fiber, the actuator system including a ferrofluid-impregnated medium (FIM) and an electrically energizable coil positioned within the housing.
摘要翻译：提供了利用浸渍有铁介质的介质对位于成像探针内的光纤进行运动的装置，系统和方法。在一些实施例中，眼科成像探针可以包括具有近端部分和远端部分的壳体; 定位在所述壳体内的光纤，所述光纤被配置为从成像光源接收成像光并将成像光引导到位于所述壳体的远侧部分内的光学元件; 以及致动器系统，被配置为向所述光纤传递运动，所述致动器系统包括被置于所述壳体内的含氟铁流体介质（FIM）和可电激励的线圈。

5. 发明申请

WO2015094725A1 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING ELECTROACTIVE POLYMER ACTUATORS 审中-公开
标题翻译：使用电动聚合物致动器的成像探针和相关设备，系统和方法
公开(公告)号：WO2015094725A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/068894
申请日：2014-12-05
申请人： NOVARTIS AG , WHEATLEY, Barry L.
发明人： WHEATLEY, Barry L.
IPC分类号： A61B3/00
CPC分类号： A61B3/102 , A61B3/1208 , A61B5/0084 , G01B9/0205 , G01B9/02091 , G02B6/3624 , G02B23/26 , G02B26/103
摘要： Devices, systems, and methods that utilize electroactive polymer actuators to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging apparatus comprises an optical probe having a handle sized and shaped for handheld grasping by a user; and a cannula coupled to the handle, the cannula sized and shaped for insertion into an eye to be treated; an optical fiber positioned at least partially within the optical probe, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within the cannula of the optical probe; and an actuator system configured to impart motion to the optical fiber, the actuator system including an electroactive polymer (EAP) actuator positioned within the optical probe.
摘要翻译：提供了利用电活性聚合物致动器向位于成像探针内的光纤赋予运动的装置，系统和方法。在一些实施例中，眼科成像设备包括具有尺寸和形状的手柄的光学探针，用于由用户手持握持; 以及联接到所述手柄的套管，所述套管的尺寸和形状用于插入待治疗的眼睛中; 至少部分地位于光学探针内的光纤，所述光纤被配置为从成像光源接收成像光并将成像光引导到位于所述光学探针的套管内的光学元件; 以及致动器系统，被配置为向所述光纤传递运动，所述致动器系统包括位于所述光学探针内的电活性聚合物（EAP）致动器。

6. 发明申请

WO2017009745A1 VITREOUS CUTTER WITH INTEGRATED ILLUMINATION SYSTEM 审中-公开
标题翻译：具有集成照明系统的VITREOUS CUTTER
公开(公告)号：WO2017009745A1
公开(公告)日：2017-01-19
申请号：PCT/IB2016/054058
申请日：2016-07-06
申请人： NOVARTIS AG
发明人： KERN, Thomas , PAPAC, Michael J. , SMITH, Ronald T. , WHEATLEY, Barry L. , MIRSEPASSI, Alireza
IPC分类号： A61F9/007 , A61B18/00 , A61B90/30
CPC分类号： A61F9/00736 , A61B90/30 , A61B2017/00973 , A61B2090/306 , A61B2217/005 , A61B2217/007
摘要： An illuminated microsurgical instrument is provided herein that includes a microsurgical instrument having a tubular member arranged to treat patient tissue at a surgical site, the tubular member having a distal tip, an inner surface, and an outer surface. The inner surface defines a lumen. The outer surface has a notch formed therein. The illuminated microsurgical instrument further includes an optical fiber arranged to deliver light to the surgical site. The optical fiber includes a proximal end arranged to receive a light beam from a light source and also includes a curved distal end arranged to emit light adjacent to the distal tip. A portion of the curved distal end is positioned within the notch and curves away from the tubular member.
摘要翻译：本文提供了一种照明显微外科器械，其包括显微外科器械，其具有布置成在外科手术部位处理患者组织的管状构件，所述管状构件具有远端尖端，内表面和外表面。内表面限定内腔。外表面具有形成在其中的凹口。照明的显微外科器械还包括布置成将光传送到手术部位的光纤。该光纤包括近端，该近端布置成接收来自光源的光束，并且还包括被布置为发射与远侧末端相邻的光的弯曲远端。弯曲的远端的一部分定位在凹口内并且远离管状构件弯曲。

7. 发明申请

WO2018073665A1 SCANNING OPTICAL PROBE WITH FLEXING MECHANISM 审中-公开
标题翻译：用弯曲机构扫描光学探针
公开(公告)号：WO2018073665A1
公开(公告)日：2018-04-26
申请号：PCT/IB2017/055406
申请日：2017-09-07
申请人： NOVARTIS AG
发明人： WHEATLEY, Barry L. , PARTO, Kambiz , SCHMIDTLIN, Edouard G.
IPC分类号： A61B3/10
摘要： A scanning optical probe includes a cannula, optical fiber, lens, and an actuating mechanism for tilting the optical fiber back and forth within the cannula. An actuator in the probe handle is coupled to various flexing and guide components extending through the cannula and towards the distal end of the scanning optical probe. Reciprocating motion from the actuator is transmitted to the components thereby causing the optical fiber at the distal end of the scanning optical probe to aim across target surfaces. The light emitted from the optical fiber is processed to generate a scan of the target area.
摘要翻译：扫描光学探头包括套管，光纤，透镜以及用于在套管内来回倾斜光纤的致动机构。探针手柄中的致动器联接到延伸穿过套管并且朝向扫描光学探针的远端的各种挠曲和引导部件。来自致动器的往复运动被传递到部件，从而使扫描光学探头远端处的光纤瞄准目标表面。处理从光纤发出的光以产生目标区域的扫描。

8. 发明申请

WO2018092002A1 MEDICAL INSTRUMENT WITH AN INTEGRATED OPTICAL FIBER 审中-公开
公开(公告)号：WO2018092002A1
公开(公告)日：2018-05-24
申请号：PCT/IB2017/056965
申请日：2017-11-07
申请人： NOVARTIS AG
发明人： MIRSEPASSI, Alireza , WHEATLEY, Barry L. , SMITH, Ronald T. , PAPAC, Michael J. , DIAO, Chenguang , PARTO, Kambiz , MCDONELL, Brian William , FARLEY, Mark Harrison
IPC分类号： A61F9/007 , A61B18/00 , A61B90/30
摘要： Provided herein is an illuminated microsurgical instrument system and an illuminated microsurgical instrument. In one implementation, the system includes a microsurgical instrument having a distally projecting tubular member arranged to perform a medical procedure at an interventional site. The tubular member has a distal tip and an outer surface, the outer surface having a flat surface formed therein. The instrument includes a sheath member surrounding a portion of the tubular member and extending toward the distal tip of the tubular member and an optical fiber extending along a length of the flat surface between the tubular member and the sheath member. The instrument may further include a slack chamber, collar structure, and fiber guard member to support and guide the optical fiber to the distal tip.

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