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1. 发明申请

WO2016203405A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开
标题翻译：化合物和组合物抑制SHP2的活性
公开(公告)号：WO2016203405A1
公开(公告)日：2016-12-22
申请号：PCT/IB2016/053549
申请日：2016-06-15
申请人： NOVARTIS AG , CHEN, Zhuoliang , FORTANET, Jorge Farcia , LAMARCHE, Matthew J. , SENDZIK, Martin , TAMEZ, JR., Victoriano , YU, Bing
发明人： CHEN, Zhuoliang , FORTANET, Jorge Farcia , LAMARCHE, Matthew J. , SENDZIK, Martin , TAMEZ, JR., Victoriano , YU, Bing
IPC分类号： C07D401/04 , C07D401/14 , C07D491/107 , A61K31/537 , A61K31/513 , A61K31/4545 , A61P35/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P25/28
CPC分类号： C07D491/107 , C07D401/04 , C07D401/14
摘要： The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.
摘要翻译：本发明涉及式I化合物。该化合物是Src Homolgy-2磷酸酶（SHP2）的抑制剂，因此可用于治疗Noonan综合征，豹综合征和癌症。

2. 发明申请

WO2016203406A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开
标题翻译：抑制SHP2活性的化合物和组合物
公开(公告)号：WO2016203406A1
公开(公告)日：2016-12-22
申请号：PCT/IB2016/053550
申请日：2016-06-15
申请人： NOVARTIS AG , CHEN, Zhuoliang , FORTANET, Jorge Farcia , JOUK, Andriana , KARKI, Rajesh , LAMARCHE, Matthew J. , LIU, Gang , PALERMO, Mark G. , PEREZ, Lawrence Blas , SARVER, Patrick James , SHULTZ, Michael David , SENDZIK, Martin , TOURE, Bakary-Barry , YU, Bing
发明人： CHEN, Zhuoliang , FORTANET, Jorge Farcia , JOUK, Andriana , KARKI, Rajesh , LAMARCHE, Matthew J. , LIU, Gang , PALERMO, Mark G. , PEREZ, Lawrence Blas , SARVER, Patrick James , SHULTZ, Michael David , TOURE, Bakary-Barry , YU, Bing
IPC分类号： C07D401/14 , C07D401/04 , C07D471/10 , C07D491/107 , C07D498/10 , A61K31/506 , A61K31/537 , A61P35/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P25/28
CPC分类号： C07D401/14 , C07D401/04 , C07D471/10 , C07D491/107 , C07D498/10
摘要： The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.
摘要翻译：本发明涉及式I化合物。该化合物是Src Homolgy-2磷酸酶（SHP2）的抑制剂，因此可用于治疗Noonan综合征，Leopard综合征和癌症。 >

3. 发明申请

WO2014130310A1 BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS 审中-公开
标题翻译：作为选择性雌激素受体降解剂的苯并噻吩衍生物及其组合物
公开(公告)号：WO2014130310A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/015938
申请日：2014-02-12
申请人： NOVARTIS AG , BURKS, Heather Elizabeth , DECHANTSREITER, Michael A. , HE, Guo , NUNEZ, Jill , PEUKERT, Stefan , SPRINGER, Clayton , SUN, Yingchuan , THOMSEN, Noel Marie-France , TRIA, George Scott , YU, Bing
发明人： BURKS, Heather Elizabeth , DECHANTSREITER, Michael A. , HE, Guo , NUNEZ, Jill , PEUKERT, Stefan , SPRINGER, Clayton , SUN, Yingchuan , THOMSEN, Noel Marie-France , TRIA, George Scott , YU, Bing
IPC分类号： C07D333/64 , C07D333/66 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , A61K31/381 , A61P35/00
CPC分类号： A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/4436 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P35/00 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I: in which n, m, X, Y 1 , R 1 , R 2 , R 3 , R 4 and R 5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
摘要翻译：本发明涉及式I化合物：其中n，m，X，Y 1，R 1，R 2，R 3，R 4和R 5在发明概述中定义; 能够成为雌激素受体的有效拮抗剂和降解物。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂以及使用这些化合物和组合物来管理与异常雌激素受体活性相关的疾病或病症的方法。

4. 发明申请

WO2012104776A1 NOVEL HETEROCYCLIC DERIVATIVES 审中-公开
标题翻译：新型杂环衍生物
公开(公告)号：WO2012104776A1
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050428
申请日：2012-01-30
申请人： NOVARTIS AG , RADETICH, Branko , YU, Bing , ZHU, Yanyi
发明人： RADETICH, Branko , YU, Bing , ZHU, Yanyi
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5377 , C07D519/00
摘要： The invention relates to novel heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenrative disorders, and to medicaments comprising them.
摘要翻译：本发明涉及式（I）的新型杂环化合物，其中所有变量如说明书中所定义，其制备，其医疗用途，特别是其在治疗癌症和神经发生性疾病中的用途，以及包括它们的药物。

5. 发明申请

WO2009043045A1 SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE, AND A MONTE CARLO OR A DIFFUSION ALGORITHM 审中-公开
标题翻译：使用仪器，光学探头和蒙特卡罗或扩散算法对组织质量进行光谱分析的系统和方法
公开(公告)号：WO2009043045A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/078186
申请日：2008-09-29
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , YU, Bing , BROWN, J., Quincy , SHANG, Allan, B.
发明人： RAMANUJAM, Nirmala , YU, Bing , BROWN, J., Quincy , SHANG, Allan, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/0091 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/413 , A61B5/4312
摘要： Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.
摘要翻译：提供了使用仪器，光学探针和蒙特卡洛算法或扩散算法对组织块进行光谱分析的系统和方法。根据一种方法，将器械插入组织块中。通过仪器将光纤探头施加到组织块中。使用光纤探针测量组织块的浊度光谱数据。通过蒙特卡罗算法或扩散算法将浊度光谱数据转换为吸收，散射和/或固有荧光光谱数据。使用吸收，散射和/或固有的荧光光谱数据来量化组织块中的生物标志物浓度。

6. 发明申请

WO2016019235A1 A SMARTPHONE ENDOSCOPE SYSTEM 审中-公开
标题翻译：精神内窥镜系统
公开(公告)号：WO2016019235A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/043100
申请日：2015-07-31
申请人： THE UNIVERSITY OF AKRON , YU, Bing , NAGARAJAN, Vivek Krishna
发明人： YU, Bing , NAGARAJAN, Vivek Krishna
IPC分类号： A61B1/005 , A61B1/07 , A61B10/04 , G01B9/02 , G01J3/16 , G01J3/18
CPC分类号： A61B1/07 , A61B1/00 , A61B1/00105 , A61B1/04 , A61B1/043 , A61B1/0638 , A61B1/0684 , G01J3/0218 , G01J3/0291 , G01J3/36 , G01J3/4406
摘要： A smartphone endoscope system includes a smartphone with first and second imaging sensors, and an imaging optics attachment. The imaging optics attachment includes a first and second imaging apparatus, the first imaging apparatus including a first light source, a beam splitter, an objective lens, and a fiber optic imaging bundle, wherein the fiber optic imaging bundle delivers excitation light to a target which emits a fluorescence emission and a reflectance emission both collected by the fiber optic imaging bundle and transmitted to the first imaging sensor. The second imaging apparatus includes a second light source, a DRS source fiber delivering broadband light to the target which produces a diffuse reflectance emission, a DRS detection fiber, a collimator, a slit, and a transmission grating wherein the transmission grating diffracts diffuse reflectance emission and creates diffracted light which is transmitted to a second imaging sensor.
摘要翻译：智能手机内窥镜系统包括具有第一和第二成像传感器的智能手机以及成像光学元件附件。成像光学装置包括第一和第二成像装置，第一成像装置包括第一光源，分束器，物镜和光纤成像束，其中光纤成像束将激发光传递到目标，发射由光纤成像束收集并传输到第一成像传感器的荧光发射和反射率发射。第二成像装置包括第二光源，向目标产生宽带光的DRS光纤，产生漫反射发射，DRS检测光纤，准直仪，狭缝和透射光栅，其中透射光栅衍射漫反射发射并产生被传输到第二成像传感器的衍射光。

7. 发明申请

WO2009132360A2 SYSTEMS AND METHODS FOR PERFORMING OPTICAL SPECTROSCOPY USING A SELF-CALIBRATING FIBER OPTIC PROBE 审中-公开
标题翻译：使用自校准光纤探头执行光学光谱的系统和方法
公开(公告)号：WO2009132360A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041857
申请日：2009-04-27
申请人： DUKE UNIVERSITY , YU, Bing , RAMANUJAM, Nirmala
发明人： YU, Bing , RAMANUJAM, Nirmala
IPC分类号： G01N13/10 , G01B11/00 , G01N21/00 , G12B21/02
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
摘要： Systems and methods for performing optical spectroscopy using a self- calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
摘要翻译：公开了使用自校准光纤探针执行光谱的系统和方法。一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。光谱数据包括在一个或多个波长处从样本漫反射的照明光。自校准光纤探针还可以包括用于传送校准光的校准通道。校准光和照明光从公共光源同时产生。校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。

8. 发明申请

WO2010042249A2 A DIFFUSE REFLECTANCE SPECTROSCOPY DEVICE FOR QUANTIFYING TISSUE ABSORPTION AND SCATTERING 审中-公开
标题翻译：用于定量组织吸收和散射的差分反射光谱仪
公开(公告)号：WO2010042249A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/041732
申请日：2009-04-24
申请人： DUKE UNIVERSITY , YU, Bing , RAMANUJAM, Nirmala , LO, Justin, Y.
发明人： YU, Bing , RAMANUJAM, Nirmala , LO, Justin, Y.
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/0059
摘要： A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, wherein the optical probe includes at least one entity for emitting light that interacts with a tissue mass and then is remitted to a collecting entity, for collecting the light that has interacted with the tissue mass, wherein the collecting entity comprises a detector comprising one or more photodiodes; measuring turbid spectral data of the tissue mass using the optical probe; converting the turbid spectral data to at least one of absorption and scattering spectral data via a Monte Carlo algorithm or a diffusion algorithm; and quantifying tissue compositions and scatterer size in a tissue mass using the at least one of absorption and scattering spectral data.
摘要翻译：提供了用于量化组织中的电磁吸收和散射的漫反射光谱系统。还提供了用于成像组织块的光学探针和方法。在一些实施例中，所述方法包括使组织块与光学探针接触的步骤，其中所述光学探针包括用于发射与组织块相互作用的光的至少一个实体，然后被传送到收集实体，用于收集光其与所述组织块相互作用，其中所述收集实体包括检测器，所述检测器包括一个或多个光电二极管; 使用光学探针测量组织块的混浊光谱数据; 通过蒙特卡罗算法或扩散算法将混浊光谱数据转换成吸收和散射光谱数据中的至少一个; 以及使用吸收和散射光谱数据中的至少一个来定量组织块中的组织组成和散射体大小。

9. 发明申请

WO2009043050A2 OPTICAL ASSAY SYSTEM WITH A MULTI-PROBE IMAGING ARRAY 审中-公开
标题翻译：具有多探针成像阵列的光学测定系统
公开(公告)号：WO2009043050A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/078194
申请日：2008-09-29
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , YU, Bing , BROWN, Quincy, J. , SHANG, Allan, B.
发明人： RAMANUJAM, Nirmala , YU, Bing , BROWN, Quincy, J. , SHANG, Allan, B.
IPC分类号： A61B8/00 , G01N21/27
CPC分类号： G01N21/4795 , A61B5/0059 , G01N21/6456 , G01N21/6486 , G01N2021/4747 , G01N2021/6484
摘要： The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According to one aspect, the subject matter described herein includes a multi-probe imaging array for contacting biological samples and simultaneously illuminating a plurality of locations on the biological sample and collecting the reflected radiation from the locations. The multi-probe imaging array can be used for the rapid imaging of biological samples, for example, during surgery.
摘要翻译：这里描述的主题涉及具有多探针成像阵列的光学测定系统，该多探针成像阵列将多个探针相对于彼此和样本定向。根据一个方面，本文描述的主题包括用于接触生物样本并且同时照射生物样本上的多个位置并从这些位置收集反射的辐射的多探针成像阵列。多探头成像阵列可用于生物样本的快速成像，例如在手术过程中。

10. 发明申请

WO2007117166A1 PREPARATION OF ESLICARBAZEPINE AND RELATED COMPOUNDS BY ASYMMETRIC HYDROGENATION 审中-公开
标题翻译：通过不对称氢化法制备苯胺卡必定及相关化合物
公开(公告)号：WO2007117166A1
公开(公告)日：2007-10-18
申请号：PCT/PT2007/000017
申请日：2007-04-11
申请人： PORTELA & C.A., S.A. , YU, Bing , LI, Wenge , LEARMONTH, David
发明人： YU, Bing , LI, Wenge , LEARMONTH, David
IPC分类号： C07D223/22
CPC分类号： C07D223/22
摘要： A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic gτoup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.
摘要翻译：制备式IA或IB化合物的方法，其中R是烷基，氨基烷基，卤代烷基，芳烷基，环烷基，环烷基烷基，烷氧基，苯基或取代的苯基或吡啶基; 术语烷基是指含有1至18个碳原子的直链或支链的碳链; 术语卤素表示氟，氯，溴或碘; 术语环烷基表示具有3至6个碳原子的饱和脂环族基团; 术语芳基表示未取代的苯基或被烷氧基，卤素或硝基取代的苯基，该方法包括使用手性催化剂和氢源的式II化合物的不对称氢化，其中R具有与上述相同的含义。

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