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1. 发明申请

WO2009043050A2 OPTICAL ASSAY SYSTEM WITH A MULTI-PROBE IMAGING ARRAY 审中-公开
标题翻译：具有多探针成像阵列的光学测定系统
公开(公告)号：WO2009043050A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/078194
申请日：2008-09-29
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , YU, Bing , BROWN, Quincy, J. , SHANG, Allan, B.
发明人： RAMANUJAM, Nirmala , YU, Bing , BROWN, Quincy, J. , SHANG, Allan, B.
IPC分类号： A61B8/00 , G01N21/27
CPC分类号： G01N21/4795 , A61B5/0059 , G01N21/6456 , G01N21/6486 , G01N2021/4747 , G01N2021/6484
摘要： The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According to one aspect, the subject matter described herein includes a multi-probe imaging array for contacting biological samples and simultaneously illuminating a plurality of locations on the biological sample and collecting the reflected radiation from the locations. The multi-probe imaging array can be used for the rapid imaging of biological samples, for example, during surgery.
摘要翻译：这里描述的主题涉及具有多探针成像阵列的光学测定系统，该多探针成像阵列将多个探针相对于彼此和样本定向。根据一个方面，本文描述的主题包括用于接触生物样本并且同时照射生物样本上的多个位置并从这些位置收集反射的辐射的多探针成像阵列。多探头成像阵列可用于生物样本的快速成像，例如在手术过程中。

2. 发明申请

WO2009043045A1 SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE, AND A MONTE CARLO OR A DIFFUSION ALGORITHM 审中-公开
标题翻译：使用仪器，光学探头和蒙特卡罗或扩散算法对组织质量进行光谱分析的系统和方法
公开(公告)号：WO2009043045A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/078186
申请日：2008-09-29
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , YU, Bing , BROWN, J., Quincy , SHANG, Allan, B.
发明人： RAMANUJAM, Nirmala , YU, Bing , BROWN, J., Quincy , SHANG, Allan, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/0091 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/413 , A61B5/4312
摘要： Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.
摘要翻译：提供了使用仪器，光学探针和蒙特卡洛算法或扩散算法对组织块进行光谱分析的系统和方法。根据一种方法，将器械插入组织块中。通过仪器将光纤探头施加到组织块中。使用光纤探针测量组织块的浊度光谱数据。通过蒙特卡罗算法或扩散算法将浊度光谱数据转换为吸收，散射和/或固有荧光光谱数据。使用吸收，散射和/或固有的荧光光谱数据来量化组织块中的生物标志物浓度。

3. 发明申请

WO2010042249A2 A DIFFUSE REFLECTANCE SPECTROSCOPY DEVICE FOR QUANTIFYING TISSUE ABSORPTION AND SCATTERING 审中-公开
标题翻译：用于定量组织吸收和散射的差分反射光谱仪
公开(公告)号：WO2010042249A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/041732
申请日：2009-04-24
申请人： DUKE UNIVERSITY , YU, Bing , RAMANUJAM, Nirmala , LO, Justin, Y.
发明人： YU, Bing , RAMANUJAM, Nirmala , LO, Justin, Y.
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/0059
摘要： A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, wherein the optical probe includes at least one entity for emitting light that interacts with a tissue mass and then is remitted to a collecting entity, for collecting the light that has interacted with the tissue mass, wherein the collecting entity comprises a detector comprising one or more photodiodes; measuring turbid spectral data of the tissue mass using the optical probe; converting the turbid spectral data to at least one of absorption and scattering spectral data via a Monte Carlo algorithm or a diffusion algorithm; and quantifying tissue compositions and scatterer size in a tissue mass using the at least one of absorption and scattering spectral data.
摘要翻译：提供了用于量化组织中的电磁吸收和散射的漫反射光谱系统。还提供了用于成像组织块的光学探针和方法。在一些实施例中，所述方法包括使组织块与光学探针接触的步骤，其中所述光学探针包括用于发射与组织块相互作用的光的至少一个实体，然后被传送到收集实体，用于收集光其与所述组织块相互作用，其中所述收集实体包括检测器，所述检测器包括一个或多个光电二极管; 使用光学探针测量组织块的混浊光谱数据; 通过蒙特卡罗算法或扩散算法将混浊光谱数据转换成吸收和散射光谱数据中的至少一个; 以及使用吸收和散射光谱数据中的至少一个来定量组织块中的组织组成和散射体大小。

4. 发明申请

WO2009132360A2 SYSTEMS AND METHODS FOR PERFORMING OPTICAL SPECTROSCOPY USING A SELF-CALIBRATING FIBER OPTIC PROBE 审中-公开
标题翻译：使用自校准光纤探头执行光学光谱的系统和方法
公开(公告)号：WO2009132360A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041857
申请日：2009-04-27
申请人： DUKE UNIVERSITY , YU, Bing , RAMANUJAM, Nirmala
发明人： YU, Bing , RAMANUJAM, Nirmala
IPC分类号： G01N13/10 , G01B11/00 , G01N21/00 , G12B21/02
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
摘要： Systems and methods for performing optical spectroscopy using a self- calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
摘要翻译：公开了使用自校准光纤探针执行光谱的系统和方法。一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。光谱数据包括在一个或多个波长处从样本漫反射的照明光。自校准光纤探针还可以包括用于传送校准光的校准通道。校准光和照明光从公共光源同时产生。校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。

5. 发明申请

WO2011068998A2 SYSTEMS AND METHODS FOR DETERMINING HEMOGLOBIN CONCENTRATION UTILIZING DIFFUSE REFLECTANCE AT ISOSBESTIC WAVELENGTHS 审中-公开
标题翻译：确定利用异烟波散射反射的血红蛋白浓度的系统和方法
公开(公告)号：WO2011068998A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/058771
申请日：2010-12-02
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , PHELPS, Janelle, E.
发明人： RAMANUJAM, Nirmala , PHELPS, Janelle, E.
IPC分类号： G01N33/49 , G01N21/47 , G01N33/72 , A61B5/1455
CPC分类号： G01N21/49 , A61B5/0059 , A61B5/0077 , G01N21/314 , G01N21/4738 , G01N2201/129
摘要： Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths are provided. In one embodiment, the method includes emitting light onto a tissue mass, measuring diffuse reflectance from the tissue mass, and calculating a ratio of diffuse reflectance intensities at two isosbestic wavelengths using the measured diffuse reflectance. The method also includes determining a hemoglobin concentration associated with the tissue mass by applying the calculated ratio to a predefined analytical expression associated with the two isosbestic wavelengths.
摘要翻译：提供了利用等吸收波长漫反射确定血红蛋白浓度的系统和方法。在一个实施例中，该方法包括将光发射到组织块上，测量来自组织块的漫反射率，并且使用测量的漫反射率计算两个等吸收波长处的漫反射强度的比率。该方法还包括通过将计算的比率应用于与两个等吸收波长相关联的预定义的分析表达式来确定与组织质量相关联的血红蛋白浓度。

6. 发明申请

WO2007126827A2 OPTICAL ASSAY SYSTEM FOR INTRAOPERATIVE ASSESSMENT OF TUMOR MARGINS 审中-公开
标题翻译：用于肿瘤标志物进行评估的光学测定系统
公开(公告)号：WO2007126827A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007586
申请日：2007-03-29
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , WILKE, Lee, G.
发明人： RAMANUJAM, Nirmala , WILKE, Lee, G.
IPC分类号： G01N33/53
CPC分类号： G01N21/4738
摘要： The subject matter described herein includes an optical assay system for intraoperative assessment of tumor margins. According to one aspect, the subject matter described herein includes a biological sample containment and illumination apparatus for holding a biological sample for illumination by a plurality of electromagnetic radiation probes. The biological sample containment and illumination apparatus includes a plurality of frame members positioned with respect to each other to form an interior space for receiving a biological sample. At least one of the plurality of frame members includes a plurality of probe receiving locations for receiving a plurality of electromagnetic radiation probes. The probe receiving locations position the probes with respect to the biological sample to allow illumination of plural locations of the biological sample by the probes.
摘要翻译：本文所述的主题包括用于术中评估肿瘤边缘的光学测定系统。根据一个方面，本文所述的主题包括用于通过多个电磁辐射探针保持用于照明的生物样品的生物样品容纳物和照明装置。生物样品容纳和照明装置包括相对于彼此定位的多个框架构件，以形成用于接收生物样品的内部空间。多个框架构件中的至少一个包括用于接收多个电磁辐射探针的多个探针接收位置。探针接收位置使探针相对于生物样品定位，以允许通过探针照射生物样品的多个位置。

7. 发明申请

WO2007109126A2 MONTE CARLO BASED MODEL OF FLUORESCENCE IN TURBID MEDIA AND METHODS AND SYSTEMS FOR USING SAME TO DETERMINE INTRINSIC FLUORESCENCE OF TURBID MEDIA 审中-公开
标题翻译：基于MONTE CARLO的涡轮介质中的荧光模型及其使用方法和系统来确定涡轮介质的内在荧光
公开(公告)号：WO2007109126A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006624
申请日：2007-03-16
申请人： DUKE UNIVERSITY , PALMER, Gregory, M. , RAMANUJAM, Nirmala
发明人： PALMER, Gregory, M. , RAMANUJAM, Nirmala
IPC分类号： A61B6/00 , G01J3/30
CPC分类号： G01J3/4406 , A61B5/0071 , A61B5/0084 , G01N21/49 , G01N21/6486 , G01N2021/6417
摘要： The subject matter described herein includes a method for modeling fluorescence in turbid media and methods and systems for using the model to determine intrinsic fluorescence of turbid media. According to one aspect, a method for modeling fluorescence of a turbid medium and for using the model to determine intrinsic fluorescence in the turbid medium is provided. The method includes illuminating a turbid medium of interest with an electromagnetic radiation source using a probe of a particular geometry and detecting measured fluorescence for the turbid medium using the probe. At least one set of Monte Carlo simulations is run to determine an escape energy probability map and an absorbed energy density map for the turbid medium. An indication of the intrinsic fluorescence of the turbid medium is determined using the escape probability density map and the absorbed energy density map in a manner that accounts for the geometry of the probe.
摘要翻译：本文描述的主题包括用于对混浊介质中的荧光进行建模的方法以及使用该模型确定混浊介质的固有荧光的方法和系统。根据一个方面，提供了一种用于对浑浊介质的荧光进行建模和使用该模型来确定混浊介质中的固有荧光的方法。该方法包括使用特定几何形状的探针用电磁辐射源照射感兴趣的混浊介质，并使用探针检测浊度介质的测量荧光。运行至少一组蒙特卡罗模拟来确定浑浊介质的逃逸能量概率图和吸收的能量密度图。使用逃避概率密度图和吸收的能量密度图以考虑探针的几何形状的方式确定混浊介质的固有荧光的指示。

8. 发明申请

WO2008103486A1 SCALING METHOD FOR FAST MONTE CARLO SIMULATION OF DIFFUSE REFLECTANCE SPECTRA 审中-公开
标题翻译：扩展方法用于快速蒙特卡洛仿真的差分反射谱
公开(公告)号：WO2008103486A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/002431
申请日：2008-02-25
申请人： DUKE UNIVERSITY , WISCONSIN ALUMNI RESEARCH FOUNDATION , RAMANUJAM, Nirmala , LIU, Quan
发明人： RAMANUJAM, Nirmala , LIU, Quan
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , G01N21/49 , G06F17/5009 , G06F2217/10 , G06F2217/16
摘要： The presently disclosed subject matter relates to multilayered scaling methods that allow for implementation of fast Monte Carlo simulations of diffuse reflectance from multilayered turbid media. The disclosed methods employ photon trajectory information provided by only a single baseline simulation, from which the diffuse reflectance can be computed for a wide range of optical properties in a multilayered turbid medium. A convolution scheme is also incorporated to calculate diffuse reflectance for specific fiber optic probe geometries. Also provided are systems for fast Monte Carlo simulation of diffuse reflectance of a multilayered turbid medium to rapidly determine diffuse reflectance for the multilayered turbid medium with known optical properties and for using the scaled diffuse reflectance to determine optical properties of a turbid medium having unknown optical properties.
摘要翻译：目前公开的主题涉及允许从多层混浊介质实施漫反射的快速蒙特卡罗模拟的多层缩放方法。所公开的方法使用仅由单个基线模拟提供的光子轨迹信息，可以从多层基础模拟中计算多层混浊介质中宽范围的光学性质的漫反射。还结合卷积方案来计算特定光纤探针几何形状的漫反射。还提供了用于快速蒙特卡罗模拟多层混浊介质的漫反射的系统，以快速确定具有已知光学性质的多层混浊介质的漫反射，并且使用缩放漫反射度来确定具有未知光学特性的混浊介质的光学特性。

9. 发明申请

WO2015077684A1 COLPOSCOPES HAVING LIGHT EMITTERS AND IMAGE CAPTURE DEVICES AND ASSOCIATED METHODS 审中-公开
标题翻译：具有发光体和图像捕获装置及相关方法的构图
公开(公告)号：WO2015077684A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/067038
申请日：2014-11-24
申请人： DUKE UNIVERSITY , RAMANUJAM, Nirmala , HU, Fangyao , LAM, Christopher
发明人： RAMANUJAM, Nirmala , HU, Fangyao , LAM, Christopher
IPC分类号： A61B1/303 , A61B1/06
CPC分类号： A61B1/0676 , A61B1/00045 , A61B1/00082 , A61B1/00087 , A61B1/00089 , A61B1/00091 , A61B1/012 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0684 , A61B1/303
摘要： Colposcopes having light emitters and image capture devices and associated methods are disclosed. According to an aspect, a colposcope includes an elongate body having a distal end, a proximate end, and an axis extending between the distal end and the proximate end. The colposcope also includes a balloon attached to the elongate body and configured to be inflated to expand in a direction away from the axis of the elongate body. Further the colposcope includes an image capture device attached to the distal end of the elongate body and positioned to capture images of an area outside the elongate body. The colposcope also includes one or more light emitters attached to the distal end of the elongate body and positioned to generate and direct light towards the area outside of the elongate body.
摘要翻译：公开了具有发光体和图像捕获装置及相关方法的阴道镜。根据一个方面，阴道镜包括细长体，其具有远端，近端和在远端和近端之间延伸的轴线。阴道镜还包括附接到细长主体并被配置为膨胀以在远离细长主体的轴线的方向上膨胀的气囊。此外，阴道镜包括附接到细长主体的远端并定位成捕获细长体外部的区域的图像的图像捕获装置。阴道镜还包括附接到细长主体的远端的一个或多个光发射器，并被定位成产生并引导朝向细长主体外部区域的光。

10. 发明申请

WO2005087092A1 SIDE-FIRING PROBE FOR PERFORMING OPTICAL SPECTROSCOPY DURING CORE NEEDLE BIOPSY 审中-公开
标题翻译：核心针刺生物实验光学光谱的扫描探针
公开(公告)号：WO2005087092A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/005781
申请日：2005-02-22
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , RAMANUJAM, Nirmala , ZHU, Changfang , LUBAWY, Carmalyn
发明人： RAMANUJAM, Nirmala , ZHU, Changfang , LUBAWY, Carmalyn
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/0091 , A61B5/4312 , A61B5/6848 , A61B10/0275 , A61B90/36 , A61B2017/00061 , A61B2090/3614
摘要： A needle biopsy includes the step of inserting an optical spectroscopy in the needle and gathering optical information through a window formed in the side of the needle at its distal end. The optical probe (16) includes an illumination optical fiber (12) which conveys light to the tissues adjacent the side window (27) and a detection optical fiber (20) which collects light from the same tissues and conveys it to an optical spectroscopy instrument (18). Based on the results of the optical spectroscopy measurement, the optical probe may be withdrawn from the needle and a cutter advanced to acquire a sample of the tissues adjacent the sidewindow.
摘要翻译：针穿刺活检包括将光学光谱插入针中并通过在其侧端形成的窗口收集光学信息的步骤。光探头（16）包括向邻近侧窗（27）的组织传送光的照明光纤（12）和从相同组织收集光并将其传送到光谱仪器的检测光纤（20）（18）。基于光谱测量的结果，可以从针中取出光学探针，并且切割器前进以获取邻近侧窗的组织的样品。

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