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1. 发明申请

WO2013167985A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗神经疾病的组合物和方法
公开(公告)号：WO2013167985A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/050711
申请日：2013-01-28
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07D223/20 , C07D223/22 , A61K31/55 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D409/12 , A61K31/55 , A61K45/06 , A61K47/543 , A61K47/55 , C07D223/28
摘要： The invention relates to the compounds of formula (I) and formula (1A) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I) and formula (IA); and methods for treating or preventing neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment, of epilepsy, bipolar disorder, trigeminal neuralgia, attention-deficit, hyperactivity disorder (ADHD), schizophrenia, neuropathic pain, seizures, bipolar disorder, mania, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotonia, intermittent explosive disorder, borderline personality disorder. Myotonia congenita and post-traumatic stress disorder.
摘要翻译：本发明涉及式（I）和式（1A）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映异构体，立体异构体和水合物。包含有效量的式（I）和式（IA）的化合物的药物组合物; 并且可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射的治疗或预防神经疾病的方法。这些组合物可用于治疗癫痫，双相性精神障碍，三叉神经痛，注意力缺陷，多动症（ADHD），精神分裂症，神经性疼痛，癫痫发作，双相情感障碍，躁狂症，幻肢综合征，复杂性局部疼痛综合征，阵发性极限疼痛障碍，神经性肌张力障碍，间歇性爆发性疾病，边缘性人格障碍。先天性肌强直和创伤后应激障碍。

2. 发明申请

WO2013146437A1 ３－デセン酸誘導体およびその用途审中-公开
标题翻译： 3-十二酸衍生物及其用途
公开(公告)号：WO2013146437A1
公开(公告)日：2013-10-03
申请号：PCT/JP2013/057723
申请日：2013-03-18
申请人：飯沼宗和 , 赤尾幸博 , シーシーアイ株式会社
发明人：飯沼　宗和 , 赤尾　幸博 , 村瀬　博宣
IPC分类号： C07C69/533 , A61K31/155 , A61K31/16 , A61K31/165 , A61K31/231 , A61K31/265 , A61K31/341 , A61K31/395 , A61K31/403 , A61K31/426 , A61K31/4409 , A61K31/444 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/538 , A61K31/5415 , A61K31/55 , A61P35/00 , C07C69/65 , C07C233/09 , C07C233/36 , C07C233/44 , C07C243/30 , C07C251/02 , C07C251/28 , C07C327/10 , C07D209/86 , C07D211/16 , C07D213/40 , C07D213/74 , C07D223/22 , C07D239/42 , C07D241/04 , C07D265/38 , C07D277/16 , C07D277/20 , C07D277/46 , C07D279/30 , C07D295/18 , C07D295/22 , C07D307/64 , C07D317/58
CPC分类号： C07C251/08 , C07C69/533 , C07C69/65 , C07C233/09 , C07C243/30 , C07C327/10 , C07C2601/14 , C07C2601/18 , C07C2603/18 , C07D209/86 , C07D211/16 , C07D213/40 , C07D213/50 , C07D213/74 , C07D223/22 , C07D239/42 , C07D241/04 , C07D265/38 , C07D277/16 , C07D277/82 , C07D279/30 , C07D295/185 , C07D295/32 , C07D317/58
摘要：【課題】がんの予防・治療剤として有用な、新規な化合物を提供する。【解決手段】本発明の一形態によれば、下記化学式１で表される化合物またはその製薬上許容されうる塩が提供される：化学式１におけるＡは、明細書において定義されているとおりである。また、本発明の他の形態は、上述した化合物の用途として、上述した化合物またはその製薬上許容されうる塩を有効成分として含有する医薬に関する。さらに、本発明のさらに他の形態によれば、当該医薬からなるがんの予防および／または治療剤が提供される。
摘要翻译： [问题]提供可用作预防/治疗癌症的药剂的新型化合物。 [解决方案]本发明的一个方面提供由化学式（1）表示的化合物或其药学上可允许的盐; 化学式（1）中的A如说明书中所定义。此外，本发明的另一方面涉及作为上述化合物的用途的含有上述化合物或其药学上可允许的盐作为活性成分的药物。本发明的另一方面提供了包含该药物的用于预防和/或治疗癌症的药剂。

3. 发明申请

WO2011132171A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药物的氮氧化物释放制剂（NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS）
公开(公告)号：WO2011132171A1
公开(公告)日：2011-10-27
申请号：PCT/IB2011/051751
申请日：2011-04-21
申请人： PIRAMAL LIFE SCIENCES LIMITED , SATYAM, Apparao
发明人： SATYAM, Apparao
IPC分类号： A61K31/21 , A61P9/00 , A61P29/00 , C07C203/04 , C07C229/42 , C07C233/25 , C07C233/63 , C07C317/18 , C07C323/12 , C07D207/34 , C07D209/28 , C07D209/52 , C07D211/90 , C07D213/80 , C07D223/22
CPC分类号： C07C203/04 , C07C229/42 , C07C233/25 , C07C233/63 , C07C317/18 , C07C323/12 , C07C2601/14 , C07D207/27 , C07D207/34 , C07D209/28 , C07D209/52 , C07D213/30 , C07D213/80 , C07D223/26 , C07D223/28 , C07D233/91 , C07D295/088 , C07D305/14 , C07D307/20 , C07D401/12 , C07D403/10 , C07D493/04 , C07J41/005 , C07J71/0031
摘要： The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them. The present invention also relates to use of the compounds of formula (I) for the treatment of diseases or disorders for which the known drugs or therapeutic agents are used. The present invention also relates to method of treatment of diseases or disorders in humans or mammals by administering therapeutically effective amount of the compounds of formula (I) to said humans or mammals.
摘要翻译：本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在本文中表示为式（I）化合物，其中药物或治疗剂含有一个或多个独立地选自羧酸，氨基，羟基的官能团和巯基。本发明还涉及制备一氧化氮释放前体药物（式（I）化合物）的方法，含有它们的药物组合物。本发明还涉及式（I）化合物用于治疗已知药物或治疗剂的疾病或病症的用途。本发明还涉及通过向所述人或哺乳动物施用治疗有效量的式（I）化合物来治疗人或哺乳动物疾病或病症的方法。

4. 发明申请

WO2006053674A3 A PROCESS FOR THE PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ[B,F]AZEPINE-5-CARBOXYAMIDE 审中-公开
公开(公告)号：WO2006053674A3
公开(公告)日：2006-05-26
申请号：PCT/EP2005/012047
申请日：2005-11-10
申请人： FARCHEMIA S.R.L. , PANUNZIO, Mauro , CAMPANA, Eileen , BREVIGLIERI, Gabriele
发明人： PANUNZIO, Mauro , CAMPANA, Eileen , BREVIGLIERI, Gabriele
IPC分类号： C07D223/22
摘要： A process for the preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide by hydrolysis of 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine with peroxy compounds in alkali medium and in the presence of solvents. (I) (II) (III)

5. 发明申请

WO2005122671A2 AN IMPROVED PROCESS FOR THE PREPARATION OF OXCARBAZEPINE AND RELATED INTERMEDIATES 审中-公开
标题翻译：改进奥沙利铂及相关中间体的制备方法
公开(公告)号：WO2005122671A2
公开(公告)日：2005-12-29
申请号：PCT/CA2005/000932
申请日：2005-06-16
申请人： APOTEX PHARMACHEM INC. , CHE, Daqing , CORELLI-RENNIE, Nadia , GUNTOORI, Bhaskar, Reddy , FAUGHT, Jody
发明人： CHE, Daqing , CORELLI-RENNIE, Nadia , GUNTOORI, Bhaskar, Reddy , FAUGHT, Jody
IPC分类号： A61K31/55 , C07D223/18 , C07D223/22 , C07D223/26 , C07D223/28 , C07D223/30
CPC分类号： C07D223/26 , C07D223/28
摘要： A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifying oxcarbazepine.
摘要翻译：一种制备奥卡西平III的方法，包括：a）使肟基芪Ⅳ与氯代磺酰基异氰酸酯在惰性有机溶剂中反应并分离化合物Ⅴb）水解化合物V以形成粗制的奥卡西平III，c）纯化奥卡西平。

6. 发明申请

WO2002096881A1 METHOD FOR PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND 10,11-DIHYDRO-10-0X0-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE 审中-公开
标题翻译：制备10,11-二氢-10-羟基-5H-二苯并噻吩/ B，F /亚胺-5-羧酰胺和10,11-二氢-10-0X0-5H-二苯并/ B，F / AZEPINE-5- 羧酰胺
公开(公告)号：WO2002096881A1
公开(公告)日：2002-12-05
申请号：PCT/GB2002/002356
申请日：2002-05-22
申请人： PORTELA & CA SA , LEARMONTH, David, Alexander
发明人： LEARMONTH, David, Alexander
IPC分类号： C07D223/22
CPC分类号： C07D491/04 , C07D223/22
摘要： A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step process involving (i) epoxidation of carbamazepine; (ii) ring-opening of the resulting epoxide and (iii) oxidation of the resulting alcohol.
摘要翻译：制备10,11-二氢-10-羟基-5H-二苯并/ b，f /氮杂-5-甲酰胺和10,11-二氢-10-氧代-5H-二苯并/ b，f /氮杂 - 通过三步法从卡马西平引入5-甲酰胺，其涉及（i）卡马西平的环氧化; （ii）所得环氧化物的开环和（iii）所得醇的氧化。

7. 发明申请

WO02064557A2 NEW CRYSTAL FORMS OF OXCARBAZEPINE AND PROCESSES FOR THEIR PREPARATION 审中-公开
公开(公告)号：WO02064557A2
公开(公告)日：2002-08-22
申请号：PCT/US0204065
申请日：2002-02-12
申请人： TEVA PHARMA , TEVA PHARMA , ARONHIME JUDITH , DOLITZKY BEN-ZION , BERKOVICH YANA , GARTH NISSIM
发明人： ARONHIME JUDITH , DOLITZKY BEN-ZION , BERKOVICH YANA , GARTH NISSIM
IPC分类号： A61K9/10 , A61K9/20 , A61K9/44 , A61K31/55 , A61P25/08 , A61P25/16 , A61P43/00 , C07D223/22 , C07D
CPC分类号： C07D223/22
摘要： The present invention provides for new crystal forms of oxcarbazepine, more particularly oxcarbazepine Forms B, C, D and E. The present invention further provides processes for preparation of these forms. Form B is prepared by evaporating the solvents from a solution of oxcarbazepine in toluene and dichloromethane. Form B is also obtained by immediately cooling the solution of oxcarbazepine and toluene. Cooling the same solution at a slower rate, but still fairly rapidly, results in oxcarbazepine Form C. Cooling th same solution at even a slower rate results in another Form, oxcarbazepine Form D. Oxcarbazepine Form E, a solvate of chloroform, is obtained by precipitating a solution of oxcarbazepine and chloroform. The present invention also provides processes for converting one of the newly discovered crystal forms of oxcarbazepine into another crystal form, including Form A, which is in the prior art. These conversions may occur by storage at ambient temperature, by heating one particular Form or treatment with a protic solvent.

8. 发明申请

WO01056992A2 DIBENZO [B,F]AZEPINE DERIVATIVES AND THEIR PREPARATION 审中-公开
标题翻译： DIBENZO [B，F] AZEPINE DERIVATIVES AND THEPROPARATION
公开(公告)号：WO01056992A2
公开(公告)日：2001-08-09
申请号：PCT/EP2001/001330
申请日：2001-02-07
IPC分类号： C07D223/26 , A61K31/55 , A61P25/28 , C07D223/22 , C07D223/28
CPC分类号： C07D223/22
摘要： The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine as well as novel intermediates (I), (V), (VI), (VII), (IX) prepared by or used for said processes, and the preparation of said intermediates. R1, R3, R4 = C(1-4) alkyl, R2 = C(1-4) alkyl or phenyl.
摘要翻译：本发明涉及制备奥卡西平药物的新方法以及通过或用于所述方法制备的新型中间体（I），（V），（VI），（VII），（IX）和所述中间体。 R1，R3，R4 = C（1-4）烷基，R2 = C（1-4）烷基或苯基。

9. 发明申请

WO2012121701A1 PROCESS FOR THE RESOLUTION OF RACEMIC (±)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE 审中-公开
标题翻译：（±）-10,11-二氢-10-羟基-5H-二苯并[b，F]亚胺-5-羧酰胺的分解方法
公开(公告)号：WO2012121701A1
公开(公告)日：2012-09-13
申请号：PCT/US2011/027406
申请日：2011-03-07
申请人： WATSON LABORATORIES, INC. , CRASTA, Santosh Richard Fredric , JOSHI, Ashutosh Vijay , BHANU, Manjunath Narayan
发明人： CRASTA, Santosh Richard Fredric , JOSHI, Ashutosh Vijay , BHANU, Manjunath Narayan
IPC分类号： C07D223/24 , C07D223/22 , A61K31/55 , B01J31/02
CPC分类号： C07D223/28 , B01J31/0244 , B01J31/0247 , B01J2231/49 , C07B57/00
摘要： A process for resolving racemic (±)-10,l l-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5- carboxamide comprising reacting (±)-10,l l-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5- carboxamide with S-ibuprofen or a pharmaceutically acceptable salt thereof to form a mixture of the SS and SR diastereomer esters of 10,l l-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5- carboxamide, followed by separating the SS-ibuprofen ester from the SR ibuprofen ester, and removal of the S-ibuprofen moiety to form S-(+)-10,l l-dihydro-10-hydroxy-5H- dibenz[b,f]azepine-5-carboxamide with a chiral purity greater than 90%.
摘要翻译：一种用于拆分外消旋（±）-10,11-二氢-10-羟基-5H-二苯并[b，f]吖庚因-5-甲酰胺的方法，包括使（±）-10,11-二氢-10-羟基 - 5H-二苯并[b，f]吖庚因-5-甲酰胺与S-布洛芬或其药学上可接受的盐形成10,11-二氢-10-羟基-5H-二苯并[ b] f]吖庚因-5-甲酰胺，然后从SR布洛芬酯中分离SS-布洛芬酯，除去S-布洛芬部分以形成S - （+） - 10,11-二氢-10-羟基 -5H-二苯并[b，f]吖庚因-5-甲酰胺，手性纯度大于90％。

10. 发明申请

WO2011115378A1 NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME 审中-公开
标题翻译：新型有机电致发光化合物和使用该有机电致发光化合物的有机电致发光器件
公开(公告)号：WO2011115378A1
公开(公告)日：2011-09-22
申请号：PCT/KR2011/001435
申请日：2011-03-02
申请人： ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. , AHN, Hee Choon , SEO, Mi Ran , CHO, Young Jun , KWON, Hyuck Joo , KIM, Bong Ok , KIM, Sung Min
发明人： AHN, Hee Choon , SEO, Mi Ran , CHO, Young Jun , KWON, Hyuck Joo , KIM, Bong Ok , KIM, Sung Min
IPC分类号： C07C13/66 , C07C211/43 , C07D307/91 , C07D209/86 , C07D213/16 , C07D215/06 , C07D209/02 , C07D223/22 , C07D333/76 , C07F7/08 , C07F9/6564 , C09K11/06 , H01L51/54
CPC分类号： C07F5/027 , C07B2200/05 , C07C13/66 , C07C13/72 , C07C25/22 , C07C43/21 , C07C49/792 , C07C211/54 , C07C211/61 , C07C321/30 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/42 , C07C2603/50 , C07C2603/52 , C07C2603/94 , C07D209/86 , C07D213/16 , C07D215/06 , C07D223/22 , C07D235/18 , C07D277/66 , C07D279/22 , C07D307/91 , C07D333/76 , C07F7/0818 , C07F9/65683 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1037 , H01L51/0052 , H01L51/0055 , H01L51/0058 , H01L51/006 , H01L51/5012 , H05B33/10
摘要： Disclosed are organic electroluminescent compounds and organic electroluminescent devices employing said compounds. The organic electroluminescent compounds of the invention are defined by chemical formula [1], Chemical Formula 1 The compounds, when used in an electron transport layer of an organic electroluminescent device, reduce power consumption and operation voltage of said device. Provided are novel organic electroluminescent compounds and an organic electroluminescent device using the same. Since the organic electroluminescent compound exhibits good luminous efficiency and excellent life property, it may be used to manufacture OLED devices having very superior operation life and consuming less power due to improved power efficiency.
摘要翻译：公开了使用所述化合物的有机电致发光化合物和有机电致发光器件。本发明的有机电致发光化合物由化学式[1]化学式1定义。当用于有机电致发光器件的电子传输层时，该化合物降低了所述器件的功耗和操作电压。提供新颖的有机电致发光化合物和使用其的有机电致发光器件。由于有机电致发光化合物具有良好的发光效率和优异的寿命性质，因此可以用于制造具有非常优异的使用寿命的OLED器件，并且由于提高的功率效率而消耗较少的功率。

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