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1. 发明申请

WO2004098704A1 METHOD FOR ELIMINATION OF VENTRICULAR PRO-ARRHYTHMIC EFFECT CAUSED BY ATRIAL THERAPY 审中-公开
标题翻译：消除由ATRIAL治疗引起的心房性心律失常效应的方法
公开(公告)号：WO2004098704A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/013328
申请日：2004-04-29
申请人： MEDTRONIC, INC. , GILLBERG, jeffrey, M. , RITSCHER, David, E. , BROWN, Mark, L.
发明人： RITSCHER, David, E. , BROWN, Mark, L.
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A system and method are provided for controlling atrial anti-tachycardia pacing (ATP) delivery based on detection of ventricular pro-arrhythmia during or immediately after atrial ATP. Ventricular pro-arrhythmia is detected based on one or more criteria relating to pro-arrhythmic changes including, but not limited to, ventricular rate changes, R-wave morphology changes, and/or 1:1 or nearly 1:1 atrial-ventricular conduction patterns persisting at high ventricular rates. Upon detecting ventricular pro-arrhythmia, a current atrial ATP sequence is aborted. Atrial ATP therapies may subsequently be temporarily or permanently disabled.
摘要翻译：提供了一种系统和方法，用于基于在心房ATP期间或之后立即检测心室心律失常来控制心房抗心动过速起搏（ATP）递送。基于与心律失常变化相关的一个或多个标准检测心室心律失常，包括但不限于心室率变化，R波形态变化和/或1：1或接近1：1心房 - 心室传导模式持续高心率。当检测到心室心律失常时，当前的心房ATP序列被中止。心房ATP疗法随后可能被暂时或永久禁用。

2. 发明申请

WO2010085391A1 HYBRID SINGLE-CHAMBER TO SIMULTANEOUS PACING METHOD FOR DISCRIMINATION OF TACHYCARDIAS 审中-公开
标题翻译：混合单室同时分离TACHYCARDIAS的方法
公开(公告)号：WO2010085391A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/020702
申请日：2010-01-12
申请人： MEDTRONIC, INC. , GILLBERG, Jeffrey, M. , BROWN, Mark, L. , JACKSON, Troy, E.
发明人： GILLBERG, Jeffrey, M. , BROWN, Mark, L. , JACKSON, Troy, E.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/39 , A61B5/0464 , A61B5/046 , A61N1/368
CPC分类号： A61N1/3622
摘要： A cardiac medical device and associated method control delivery of anti- tachycardia pacing (ATP) in response to detecting tachycardia. In one embodiment, an initial set of single chamber pacing pulses are delivered in a single one of the atrium and the ventricle, the other one of the atrium and the ventricle being a non-paced chamber during the initial set of single chamber pacing pulses. The device detects simultaneity between a sensed event in the non-paced chamber and one of the single chamber pacing pulses and delivers ATP in both the atrium and the ventricle in response to detecting the simultaneity.
摘要翻译：一种心脏医疗器械和相关方法控制抗心动过速起搏（ATP）响应于检测心动过速的传递。在一个实施例中，在初始的单室起搏脉冲组中，单室起搏脉冲的初始组被传送到心房和心室中的单个心房中，心房和心室中的另一个是非调节腔室。该装置检测非节奏室中的感测事件与单室起搏脉冲之间的同时性，并且响应于检测到同时性而在心房和心室中输送ATP。

3. 发明申请

WO2010111209A1 COMBINED HEMODYNAMIC AND EGM-BASED ARRHYTHMIA DETECTION 审中-公开
标题翻译：联合HEMODYNAMIC和基于EGM的ARRHYTHMIA检测
公开(公告)号：WO2010111209A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028217
申请日：2010-03-23
申请人： MEDTRONIC, INC. , WHITMAN, Teresa, A. , KUMAR, Arun , KLECKNER, Karin, J. , GILLBERG, Jeffrey, M. , JACKSON, Troy, E. , SHRIVASTAV, Maneesh , BROWN, Mark, L.
发明人： WHITMAN, Teresa, A. , KUMAR, Arun , KLECKNER, Karin, J. , GILLBERG, Jeffrey, M. , JACKSON, Troy, E. , SHRIVASTAV, Maneesh , BROWN, Mark, L.
IPC分类号： A61N1/39 , A61B5/0205 , A61B5/046 , A61B5/0464 , A61N1/365
CPC分类号： A61N1/3621 , A61B5/0215 , A61B5/0464 , A61N1/36564 , A61N1/36571 , A61N1/36578
摘要： A medical device for detecting arrhythmias that includes electrodes for sensing cardiac electrical signals and a hemodynamic sensor for sensing a hemodynamic signal. An episode of cardiac electrical event intervals meeting cardiac arrhythmia detection criteria is detected from the sensed electrical signals. Cardiac mechanical events and/or cardiac mechanical event intervals are measured from the hemodynamic signal and used to withhold or confirm a cardiac arrhythmia detection of the episode.
摘要翻译：一种用于检测心律失常的医疗装置，其包括用于感测心脏电信号的电极和用于感测血液动力学信号的血液动力学传感器。从感测到的电信号中检测到满足心律失常检测标准的心脏电活动间隔的发作。从血液动力学信号测量心脏机械事件和/或心脏机械事件间隔，并用于抑制或确认发作的心律失常检测。

4. 发明申请

WO2004103470A1 MEDICAL SYSTEM INCLUDING A NOVEL BIPOLAR PACING PAIR 审中-公开
标题翻译：医疗系统包括一个新的双极板对
公开(公告)号：WO2004103470A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015152
申请日：2004-05-13
申请人： MEDTRONIC, INC. , BROWN, Mark, L. , WARMAN, Eduardo, N. , GILLBERG, Jeffrey, M. , BONNER, Matthew, D. , MARSHALL, Mark, T. , WHITMAN, Teresa, A.
发明人： BROWN, Mark, L. , WARMAN, Eduardo, N. , GILLBERG, Jeffrey, M. , BONNER, Matthew, D. , MARSHALL, Mark, T. , WHITMAN, Teresa, A.
IPC分类号： A61N1/39
CPC分类号： A61N1/057 , A61N1/0568 , A61N1/0573 , A61N1/368 , A61N1/3702 , A61N2001/0585
摘要： An implantable electrical medical system comprises a low voltage cathode electrode assembly, including a cathode surface adapted for intimate contact with electrically active tissue, and a low voltage anode electrode assembly, including an anode surface and a porous layer extending over the anode surface. The cathode surface and the anode surface function as a bipolar pair for pacing and the porous layer extending over the anode surface allows conduction therethrough and prevents the anode surface from contacting the electrically active tissue in order to prevent anodal stimulation.
摘要翻译：可植入电气医疗系统包括低压阴极电极组件，其包括适于与电活性组织紧密接触的阴极表面，以及包括阳极表面和在阳极表面上延伸的多孔层的低压阳极电极组件。阴极表面和阳极表面用作用于起搏的双极对，并且在阳极表面上延伸的多孔层允许通过其传导，并且防止阳极表面接触电活性组织以防止阳极刺激。

5. 发明申请

WO2011041149A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：使用心房透明膜的斑马鱼的鉴别
公开(公告)号：WO2011041149A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049456
申请日：2010-09-20
申请人： MEDTRONIC, INC. , BROWN, Mark, L. , JACKSON, Troy, E. , GILLBERG, Jeffrey, M.
发明人： BROWN, Mark, L. , JACKSON, Troy, E. , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0245 , A61B5/0464 , A61N1/39 , A61N1/368
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7264 , A61B2560/0209 , A61N1/3622 , A61N1/3624 , A61N1/3702 , A61N1/3962
摘要： A cardiac medical device controls delivery of dual chamber burst pacing pulses in response to detecting tachycardia. A number of cardiac cycles occurring in a first cardiac chamber are identified subsequent to the dual chamber pacing pulses. The number of sensed intrinsic events occurring in a second cardiac chamber during the first chamber cardiac cycles is determined as a number of second chamber events. The tachycardia episode is classified in response to the number of second chamber events.
摘要翻译：响应于检测到心动过速，心脏医疗装置控制双腔爆发起搏脉冲的传递。在双室起搏脉冲之后，识别在第一心室中发生的许多心动周期。在第一室心脏周期期间在第二心室中发生的感测内在事件的数量被确定为第二腔室事件的数量。根据第二次腔室事件的数量分类心动过速。

6. 发明申请

WO2010085524A1 A "BLURRED TEMPLATE" APPROACH FOR ARRHYTHMIA DETECTION 审中-公开
标题翻译：一种用于ARRHYTHMIA检测的“BLEDED TEMPLATE”方法
公开(公告)号：WO2010085524A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021580
申请日：2010-01-21
申请人： MEDTRONIC, INC. , ZHANG, Xin , BROWN, Mark, L. , ZHANG, Xusheng , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xin , BROWN, Mark, L. , ZHANG, Xusheng , GILLBERG, Jeffrey, M.
IPC分类号： A61B5/0452 , A61N1/39 , A61B5/046 , A61B5/0464 , A61N1/362
CPC分类号： A61N1/3956 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable medical device and associated method sense cardiac signals for deriving a template representing a known EGM waveform morphology and for classifying an unknown waveform morphology. A boundary of the template, offset from the template, is computed and compared to an unknown waveform morphology for classifying the unknown waveform morphology.
摘要翻译：可植入医疗装置和相关联的方法感测用于导出表示已知EGM波形形态的模板并用于分类未知波形形态的心脏信号。计算与模板偏移的模板的边界，并将其与未知波形形态进行比较，以对未知波形形态进行分类。

7. 发明申请

WO2006104849A1 IMPLANTABLE CARDIOVERTER DEFIBRILLATOR WITH AUTOMATICALLY ADAPTABLE SENSING CONFIGURATION 审中-公开
标题翻译：具有自动适应感应配置的可移动式卡式除颤器
公开(公告)号：WO2006104849A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/010594
申请日：2006-03-23
申请人： MEDTRONIC, INC. , CASAVANT, David, A. , COLLINS, Robert, F. , BROWN, Mark, L. , GUNDERSON, Bruce, D.
发明人： CASAVANT, David, A. , COLLINS, Robert, F. , BROWN, Mark, L. , GUNDERSON, Bruce, D.
IPC分类号： A61N1/39 , A61N1/37
CPC分类号： A61N1/3925 , A61N1/3622 , A61N1/3704 , A61N1/3962
摘要： An implantable cardioverter defibrillator (ICD) automatically determines whether to use electrogram (EGM) signals sensed by a true bipolar electrode pair or those sensed by an integrated bipolar electrode pair. EGM signals from both the true bipolar pair and the integrated bipolar pair are simultaneously sensed and compared to determine which pair produced more accurate sensing of cardiac events. The more accurate source of EGM signals is selected and used in determining the therapy to be delivered.
摘要翻译：植入式心律转复除颤器（ICD）自动确定是否使用由真正双极电极对或由集成双极电极对感测到的电摄影（EGM）信号。同时检测和比较来自真实双极对和集成双极对的EGM信号，以确定哪一对产生更准确的心脏事件感测。选择更准确的EGM信号源，并用于确定要传递的治疗。

8. 发明申请

WO2005107865A1 DISCRIMINATION OF VENTRICULAR TACHYARRHYTHMIAS IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：在可植入医疗器械中鉴别胸腔积液性紫癜
公开(公告)号：WO2005107865A1
公开(公告)日：2005-11-17
申请号：PCT/US2005/015616
申请日：2005-05-05
申请人： MEDTRONIC, INC. , BROWN, Mark, L.
发明人： BROWN, Mark, L.
IPC分类号： A61N1/39
CPC分类号： A61N1/3621 , A61N1/3925 , A61N1/3962
摘要： A method and medical device for discriminating an arrhythmia that includes an input circuit (110) sensing cardiac signals and a microprocessor (100) identifying an event associated with the sensed cardiac signals as a first arrhythmia event. A first circuit (107) delivers a first therapy, substantially simultaneous with coupling of a charging circuit (111) and an energy storage device (109) to generate stored energy on the energy storage device, in response to the first arrhythmia event, and a control circuit (106) controls delivery of the first therapy by the first circuit. The microprocessor evaluates a physiologic response to the delivered first therapy and determines the event is other than the first arrhythmia event in response to the evaluated physiologic response.
摘要翻译：一种用于区分心律失常的方法和医疗装置，其包括感测心脏信号的输入电路（110）和识别与感测到的心脏信号相关联的事件的微处理器（100）作为第一心律失常事件。第一电路（107）响应于第一心律失常事件，传送第一疗法，其基本上与充电电路（111）和能量存储装置（109）的耦合同时产生存储在能量存储装置上的能量，并且控制电路（106）控制第一电路的第一次治疗的传送。微处理器评估对所递送的第一疗法的生理反应，并且确定事件不是响应于所评估的生理反应的第一心律失常事件。

9. 发明申请

WO2009126434A1 METHOD AND APPARATUS FOR DETECTING AND TREATING TACHYARRHYTHMIAS INCORPORATING DIAGNOSTIC/THERAPEUTIC PACING TECHNIQUES 审中-公开
标题翻译：检测和治疗加入诊断/治疗方法的TACHYARRHYTHMIMIAS的方法和装置
公开(公告)号：WO2009126434A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/038159
申请日：2009-03-25
申请人： MEDTRONIC, INC. , BROWN, Mark, L.
发明人： BROWN, Mark, L.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61N1/3622 , A61B5/0464 , A61B5/7264 , A61N1/3962
摘要： An implantable medical device (IMD) and methods of operating the same to treat a tachyarrhythmia are disclosed herein. In accordance with this method, an arrhythmia of the heart is classified based on one or more supraventricular tachycardia (SVT) rejection rules, which differentiate between a first group of heart rhythms that do not require treatment and a second group of heart rhythms that possibly require treatment. Diagnostic/therapeutic pacing can then be performed to further discriminate the second group of heart rhythms as being within a first sub-group of heart rhythms and a second sub-group of heart rhythms which are to be treated by applying a ventricular tachycardia (VT)/ventricular fibrillation (VF) therapy sequence. In another implementation, the order in which the IMD performs diagnostic/therapeutic pacing and analyzes passive detection and classification criteria can be reversed.
摘要翻译：本文公开了可植入医疗装置（IMD）及其操作方法来治疗快速性心律失常。根据该方法，基于一种或多种室性心动过速（SVT）排斥规则对心脏的心律失常进行分类，该规则区分不需要治疗的第一组心律和可能需要治疗的第二组心律治疗。然后可以进行诊断/治疗起搏，以进一步区分第二组心脏节律，使其处于通过应用室性心动过速（VT）治疗的心律的第一子组和心律的第二子组中， /心室颤动（VF）治疗方案。在另一个实施中，可以逆转IMD执行诊断/治疗起搏并分析被动检测和分类标准的顺序。

10. 发明申请

WO2006113698A1 METHOD AND APPARATUS FOR IDENTIFYING OVERSENSING USING FAR-FIELD INTRACARDIAC ELECTROGRAMS AND MARKER CHANNELS 审中-公开
标题翻译：用于识别使用FAR-FIELD INTRACARDIAC电子和标记通道进行过滤的方法和装置
公开(公告)号：WO2006113698A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/014539
申请日：2006-04-17
申请人： MEDTRONIC, INC. , GUNDERSON, Bruce, D. , PATEL, Amisha, S. , BOUNDS, Chad, A. , BROWN, Mark, L. , XAVIER, Ravi
发明人： GUNDERSON, Bruce, D. , PATEL, Amisha, S. , BOUNDS, Chad, A. , BROWN, Mark, L. , XAVIER, Ravi
IPC分类号： A61N1/37 , A61B5/0456 , A61N1/362
CPC分类号： A61B5/0456 , A61B5/0464 , A61B5/7217 , A61B5/7239 , A61B5/7264 , A61N1/3622 , A61N1/3702 , A61N1/3704
摘要： A method for identifying and classifying various types of oversensing in implantable medical devices (IMDs), such as implantable cardioverter defibrillators (ICDs), to assist a physician in choosing corrective action to reduce the likelihood of oversensing and inappropriate therapy delivery. Far-field electrogram (EGM) signals are analyzed to detect the occurrence of R-waves, and the result is compared to the number and pattern of R-waves sensed by the IMD and indicated on the marker channel. A marker channel with more sensed R-waves than indicated by analysis of the far-field EGM indicates the presence of oversensing, including double-counting of R-waves, T-wave oversensing, lead malfunction or failure, poor lead connections, noise associated with electromagnetic interference, non-cardiac myopotentials, etc.. Identification of the type of oversensing may be determined by analysis of the number and pattern of marker channel sensed R-waves with respect to the timing of the R-waves detected from the far-field EGM.
摘要翻译：一种用于识别和分类可植入医疗装置（IMD）中的各种类型的过度感染的方法，例如可植入的心律转复除颤器（ICD），以协助医生选择矫正动作以减少过度感染和不适当的治疗递送的可能性。分析远场电描记图（EGM）信号以检测R波的出现，并将结果与由IMD感测并在标记通道上指示的R波的数量和图案进行比较。具有比远场EGM分析所指示的更多的感测R波的标记通道表示存在过敏，包括R波的双重计数，T波超检测，导线故障或故障，导线连接不良，噪声相关具有电磁干扰，非心脏神经障碍等。过敏类型的识别可以通过分析相对于从远端检测到的R波的定时的标记信道感测R波的数量和模式来确定，现场EGM。

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