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1. 发明申请

WO2010085391A1 HYBRID SINGLE-CHAMBER TO SIMULTANEOUS PACING METHOD FOR DISCRIMINATION OF TACHYCARDIAS 审中-公开
标题翻译：混合单室同时分离TACHYCARDIAS的方法
公开(公告)号：WO2010085391A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/020702
申请日：2010-01-12
申请人： MEDTRONIC, INC. , GILLBERG, Jeffrey, M. , BROWN, Mark, L. , JACKSON, Troy, E.
发明人： GILLBERG, Jeffrey, M. , BROWN, Mark, L. , JACKSON, Troy, E.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/39 , A61B5/0464 , A61B5/046 , A61N1/368
CPC分类号： A61N1/3622
摘要： A cardiac medical device and associated method control delivery of anti- tachycardia pacing (ATP) in response to detecting tachycardia. In one embodiment, an initial set of single chamber pacing pulses are delivered in a single one of the atrium and the ventricle, the other one of the atrium and the ventricle being a non-paced chamber during the initial set of single chamber pacing pulses. The device detects simultaneity between a sensed event in the non-paced chamber and one of the single chamber pacing pulses and delivers ATP in both the atrium and the ventricle in response to detecting the simultaneity.
摘要翻译：一种心脏医疗器械和相关方法控制抗心动过速起搏（ATP）响应于检测心动过速的传递。在一个实施例中，在初始的单室起搏脉冲组中，单室起搏脉冲的初始组被传送到心房和心室中的单个心房中，心房和心室中的另一个是非调节腔室。该装置检测非节奏室中的感测事件与单室起搏脉冲之间的同时性，并且响应于检测到同时性而在心房和心室中输送ATP。

2. 发明申请

WO2010111209A1 COMBINED HEMODYNAMIC AND EGM-BASED ARRHYTHMIA DETECTION 审中-公开
标题翻译：联合HEMODYNAMIC和基于EGM的ARRHYTHMIA检测
公开(公告)号：WO2010111209A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028217
申请日：2010-03-23
申请人： MEDTRONIC, INC. , WHITMAN, Teresa, A. , KUMAR, Arun , KLECKNER, Karin, J. , GILLBERG, Jeffrey, M. , JACKSON, Troy, E. , SHRIVASTAV, Maneesh , BROWN, Mark, L.
发明人： WHITMAN, Teresa, A. , KUMAR, Arun , KLECKNER, Karin, J. , GILLBERG, Jeffrey, M. , JACKSON, Troy, E. , SHRIVASTAV, Maneesh , BROWN, Mark, L.
IPC分类号： A61N1/39 , A61B5/0205 , A61B5/046 , A61B5/0464 , A61N1/365
CPC分类号： A61N1/3621 , A61B5/0215 , A61B5/0464 , A61N1/36564 , A61N1/36571 , A61N1/36578
摘要： A medical device for detecting arrhythmias that includes electrodes for sensing cardiac electrical signals and a hemodynamic sensor for sensing a hemodynamic signal. An episode of cardiac electrical event intervals meeting cardiac arrhythmia detection criteria is detected from the sensed electrical signals. Cardiac mechanical events and/or cardiac mechanical event intervals are measured from the hemodynamic signal and used to withhold or confirm a cardiac arrhythmia detection of the episode.
摘要翻译：一种用于检测心律失常的医疗装置，其包括用于感测心脏电信号的电极和用于感测血液动力学信号的血液动力学传感器。从感测到的电信号中检测到满足心律失常检测标准的心脏电活动间隔的发作。从血液动力学信号测量心脏机械事件和/或心脏机械事件间隔，并用于抑制或确认发作的心律失常检测。

3. 发明申请

WO2011041149A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：使用心房透明膜的斑马鱼的鉴别
公开(公告)号：WO2011041149A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049456
申请日：2010-09-20
申请人： MEDTRONIC, INC. , BROWN, Mark, L. , JACKSON, Troy, E. , GILLBERG, Jeffrey, M.
发明人： BROWN, Mark, L. , JACKSON, Troy, E. , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0245 , A61B5/0464 , A61N1/39 , A61N1/368
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7264 , A61B2560/0209 , A61N1/3622 , A61N1/3624 , A61N1/3702 , A61N1/3962
摘要： A cardiac medical device controls delivery of dual chamber burst pacing pulses in response to detecting tachycardia. A number of cardiac cycles occurring in a first cardiac chamber are identified subsequent to the dual chamber pacing pulses. The number of sensed intrinsic events occurring in a second cardiac chamber during the first chamber cardiac cycles is determined as a number of second chamber events. The tachycardia episode is classified in response to the number of second chamber events.
摘要翻译：响应于检测到心动过速，心脏医疗装置控制双腔爆发起搏脉冲的传递。在双室起搏脉冲之后，识别在第一心室中发生的许多心动周期。在第一室心脏周期期间在第二心室中发生的感测内在事件的数量被确定为第二腔室事件的数量。根据第二次腔室事件的数量分类心动过速。

4. 发明申请

WO2011139686A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011139686A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/033933
申请日：2011-04-26
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert, W. , GREENHUT, Saul, E. , BROWN, Mark, L. , JACKSON, Troy, E. , WHITMAN, Teresa, A.
发明人： ZHANG, Xusheng , STADLER, Robert, W. , GREENHUT, Saul, E. , BROWN, Mark, L. , JACKSON, Troy, E. , WHITMAN, Teresa, A.
IPC分类号： A61B5/0452 , A61N1/39 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/7203 , A61N1/3621
摘要： A medical device and associated method obtaining cardiac event intervals corresponding to a tachycardia interval. Evidence of a rhythm breaking point is obtained in response to sensing a cardiac event having a morphology corresponding to a supraventricular beat. A non-treatable rhythm is detected in response to the plurality of cardiac event intervals and the evidence of the rhythm breaking point.
摘要翻译：获得对应于心动过速间隔的心脏事件间隔的医疗装置和相关方法。响应于感测具有对应于室上搏动的形态的心脏事件而获得节律断点的证据。响应于多个心脏事件间隔和节律断点的证据来检测不可治疗的节律。

5. 发明申请

WO2007095612A2 METHOD AND DEVICE FOR DELIVERING ANTI-TACHYCARDIA PACING THERAPY 审中-公开
标题翻译：用于递送抗惊厥药治疗的方法和装置
公开(公告)号：WO2007095612A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/062215
申请日：2007-02-15
申请人： MEDTRONIC, INC. , BELK, Paul, A. , JACKSON, Troy, E.
发明人： BELK, Paul, A. , JACKSON, Troy, E.
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3621 , A61N1/3962
摘要： A method and device for delivering anti-tachycardia pacing (ATP) therapy that includes an electrode to sense cardiac signals and to deliver the therapy, sensing circuitry, electrically coupled to the electrode, to detect the tachycardia event in response to the sensed cardiac signals, and a processor to control delivery of the therapy. The processor determines whether a return cycle length generated subsequent to the delivery of a first plurality of pacing pulses is less than or equal to a cycle length associated with the tachycardia event, and adjusts delivery of a second plurality of pacing pulses in response to the return cycle length being less than or equal to the cycle length associated with the tachycardia event.
摘要翻译：一种用于递送抗心动过速起搏（ATP）治疗的方法和装置，其包括用于感测心脏信号的电极和递送电耦合到所述电极的所述治疗，感测电路，以响应于所感测到的心脏信号来检测心动过速事件，以及用于控制治疗递送的处理器。处理器确定在第一组多个起搏脉冲的递送之后产生的返回周期长度是否小于或等于与心动过速事件相关联的周期长度，并且响应于返回来调整第二组起搏脉冲的递送循环长度小于或等于与心动过速事件相关联的周期长度。

6. 发明申请

WO2007131176A2 METHOD AND APPARATUS FOR DISCRIMINATING CARDIAC SIGNALS IN A MEDICAL DEVICE BASED ON WAVELET DECOMPOSITION ANALYSIS 审中-公开
标题翻译：基于小波分解分析的医疗设备鉴别心脏信号的方法与装置
公开(公告)号：WO2007131176A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/068255
申请日：2007-05-04
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , JACKSON, Troy, E.
发明人： GHANEM, Raja, N. , JACKSON, Troy, E.
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/0424 , A61B5/046 , A61B5/726 , A61N1/362 , A61N1/3706 , G06K9/00536 , G06K9/527
摘要： A method and device for detecting cardiac signals in a medical device that includes decomposing sensed cardiac signals using a wavelet function to form a corresponding wavelet transform, generating a first wavelet representation corresponding to the wavelet transform that is responsive to RR intervals of the sensed cardiac signals, generating a second wavelet representation that is not responsive to RR intervals associated with the sensed cardiac signals, and determining a device failure in response to the first wavelet representation and the second wavelet representation. The method and device may also include decomposing sensed cardiac signals using a wavelet function to form a corresponding wavelet transform, generating a wavelet representation that is not responsive to RR intervals of the sensed cardiac signals, determining RR intervals associated with the sensed cardiac signals, and determining a device failure in response to the first wavelet representation and the determined RR intervals.
摘要翻译：一种用于检测医疗装置中的心脏信号的方法和装置，包括使用小波函数分解感测到的心脏信号以形成相应的小波变换，产生对应于小波变换的第一小波表示，所述小波变换响应于感测的心脏信号的RR间隔产生不响应于与感测到的心脏信号相关联的RR间隔的第二小波表示，以及响应于第一小波表示和第二小波表示来确定设备故障。所述方法和装置还可以包括使用小波函数分解感测到的心脏信号以形成相应的小波变换，产生不响应感测的心脏信号的RR间隔的小波表示，确定与感测到的心脏信号相关联的RR间隔，以及响应于第一小波表示和所确定的RR间隔来确定设备故障。

7. 发明申请

WO2007131173A2 METHOD AND APPARATUS FOR DISCRIMINATING CARDIAC SIGNALS IN A MEDICAL DEVICE BASED ON WAVELET DECOMPOSITION ANALYSIS 审中-公开
标题翻译：基于小波分解分析的医疗设备鉴别心脏信号的方法与装置
公开(公告)号：WO2007131173A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/068249
申请日：2007-05-04
申请人： MEDTRONIC, INC. , GHANEM, Raja, N. , JACKSON, Troy, E.
发明人： GHANEM, Raja, N. , JACKSON, Troy, E.
IPC分类号： A61B5/04 , A61B5/0402 , A61N1/362 , G06F17/00
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/0424 , A61B5/046 , A61B5/726 , A61N1/362 , A61N1/3706 , G06K9/00536 , G06K9/527
摘要： A method of detecting cardiac signals in a medical device that includes decomposing a cardiac signal using a wavelet function at a plurality of scales to form a corresponding wavelet transform, determining approximation coefficients in response to the plurality of scales, reconstructing a first wavelet representation of the wavelet transform using predetermined approximation coefficients of the determined approximation coefficients, and evaluating the detected cardiac signals in response to the reconstructing.
摘要翻译：一种检测医疗装置中的心脏信号的方法，包括使用多个尺度的小波函数分解心脏信号以形成对应的小波变换，响应于所述多个标度确定近似系数，重建所述多个尺度的第一小波表示使用所确定的近似系数的预定近似系数的小波变换，以及响应于重建来评估检测到的心脏信号。

8. 发明申请

WO2006118846A3 SUPPRESSION OF HIGH RATE PACING FOR REDUCING MYOCARDIAL ISCHEMIC IRRITABILITY 审中-公开
公开(公告)号：WO2006118846A3
公开(公告)日：2006-11-09
申请号：PCT/US2006/015397
申请日：2006-04-24
申请人： MEDTRONIC, INC. , JACKSON, Troy, E.
发明人： JACKSON, Troy, E.
IPC分类号： A61N1/362 , A61N1/39
摘要： An implantable cardiac stimulation device capable of delivering automatic rate-adjusting pacing therapies is provided having an adjustable upper rate limit responsive to an indication of myocardial irritability. The implantable device, which may be embodied as a pacemaker, a pacemaker/cardioverter/defibrillator, or the like, responds to the detection of an arrhythmia as an indicator of myocardial irritability by adjusting an upper rate limit. The adjusted upper rate limit is applied as the maximum allowable pacing rate during delivery of any pacing therapies previously defined as "long-term" pacing therapies.

9. 发明申请

WO2005056107A1 METHOD AND APPARATUS FOR PREDICTING ARRHYTHMIAS USING DIURNAL HEART RATE 审中-公开
标题翻译：方法和装置预测使用心脏心率的ARRHYTHMIAS
公开(公告)号：WO2005056107A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/040522
申请日：2004-12-03
申请人： MEDTRONIC, INC. , BELK, Paul, A. , JACKSON, Troy, E.
发明人： BELK, Paul, A. , JACKSON, Troy, E.
IPC分类号： A61N1/365
CPC分类号： A61B5/7275 , A61B5/0031 , A61B5/0215 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/0464 , A61N1/3622 , A61N1/365 , G06F19/00
摘要： A method of predicting an arrhythmia, such as ventricular tachycardia, for example, in a medical device using a quantitative measure in order to allow assessment of patient risk and to enable preventative interventions by the device and clinicians. The trending of day and night average heart rates, along with patient physical activity can be analyzed to provide prediction of impending arrhythmia within weeks. By examining day and night average heart rate for crossover points, where the night heart rate equals or exceeds the day rate, and monitoring for a concomitant elevation in the night heart rate from a reference value, specific days heralding an increased risk of arrhythmia can be determined and therapy can be updated accordingly.
摘要翻译：一种预测心律失常（例如室性心动过速）的方法，例如在使用定量测量的医疗装置中，以便允许评估患者风险并使得设备和临床医师能够进行预防性干预。可以分析昼夜平均心率的趋势以及患者的身体活动，以便在几周内提供即将发生的心律失常的预测。通过检查夜间心率等于或超过日间率的交叉点的日夜平均心率，并从参考值监测夜间心率的伴随升高，预测心律失常风险增加的特定天数可以是确定和治疗可以相应更新。

10. 发明申请

WO2022026171A1 PACING THERAPY SELECTION FOR HEART FAILURE TREATMENT 审中-公开
公开(公告)号：WO2022026171A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/041405
申请日：2021-07-13
申请人： MEDTRONIC, INC.
发明人： KORNET, Lilian , JACKSON, Troy, E.
IPC分类号： A61N1/362 , A61B5/366 , A61B5/361
摘要： A method for heart failure management includes monitoring one or more sensor-based parameters for a patient to determine a pacing therapy. If the one or more parameters indicate atrial tachycardia or atrial fibrillation, a first pacing therapy is delivered. If the one or more parameters do not indicate atrial tachycardia or atrial fibrillation, it is determined whether the patient is asleep. If the patient is asleep, a second pacing therapy is delivered. If the one or more parameters do not indicate atrial tachycardia, atrial fibrillation, or that the patient is asleep, the patient's P-wave duration is evaluated with respect to a P-wave duration threshold value. When the patient's P-wave duration is determined to exceed the P-wave duration threshold value, a third pacing therapy is delivered, and when the patient's P-wave duration is determined to not exceed the P-wave duration threshold value, a fourth pacing therapy is delivered.

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