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1. 发明申请

WO2012151389A1 ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS 审中-公开
标题翻译：评估心脏内膜激活模式
公开(公告)号：WO2012151389A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036302
申请日：2012-05-03
申请人： MEDTRONIC, INC. , GHOSH, Subham , GILLBERG, Jeffrey M , STADLER, Robert W.
发明人： GHOSH, Subham , GILLBERG, Jeffrey M , STADLER, Robert W.
IPC分类号： A61B5/0402 , A61B5/0408 , A61N1/362 , A61N1/368
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译：描述了评估心脏电气不同步的技术。在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

2. 发明申请

WO2012003284A3 MULTI-CHANNEL SENSING METHODS IN IMPLANTABLE CARDIOVERTER DEFIBRILLATORS 审中-公开
标题翻译：可植入式心脏起搏器除颤器的多通道检测方法
公开(公告)号：WO2012003284A3
公开(公告)日：2012-02-23
申请号：PCT/US2011042541
申请日：2011-06-30
申请人： MEDTRONIC INC , CAO JIAN , GILLBERG JEFFREY M
发明人： CAO JIAN , GILLBERG JEFFREY M
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3704 , A61B5/7203 , A61N1/3962
摘要： An implantable medical device uses an implantable sensor for acquiring a physiological signal that is received by a digital signal processor. The digital signal processor is a multi-channel signal processor including a first signal processing channel having a first sensitivity for sensing the physiological signal and a second signal processing channel having a second sensitivity different than the first sensitivity for sensing the physiological signal.
摘要翻译：可植入医疗设备使用可植入传感器来获取由数字信号处理器接收的生理信号。数字信号处理器是多通道信号处理器，其包括具有用于感测生理信号的第一灵敏度的第一信号处理通道和具有与用于感测生理信号的第一灵敏度不同的第二灵敏度的第二信号处理通道。

3. 发明申请

WO2012003284A2 MULTI-CHANNEL SENSING METHODS IN IMPLANTABLE CARDIOVERTER DEFIBRILLATORS 审中-公开
标题翻译：多通道传感器解调器中的多通道感测方法
公开(公告)号：WO2012003284A2
公开(公告)日：2012-01-05
申请号：PCT/US2011/042541
申请日：2011-06-30
申请人： MEDTRONIC, INC. , CAO, Jian , GILLBERG, Jeffrey, M.
发明人： CAO, Jian , GILLBERG, Jeffrey, M.
IPC分类号： A61B5/046
CPC分类号： A61N1/3704 , A61B5/7203 , A61N1/3962
摘要： An implantable medical device uses an implantable sensor for acquiring a physiological signal that is received by a digital signal processor. The digital signal processor is a multi-channel signal processor including a first signal processing channel having a first sensitivity for sensing the physiological signal and a second signal processing channel having a second sensitivity different than the first sensitivity for sensing the physiological signal.
摘要翻译：可植入医疗装置使用可植入传感器来获取由数字信号处理器接收的生理信号。数字信号处理器是包括具有用于感测生理信号的第一灵敏度的第一信号处理通道和具有与用于感测生理信号的第一灵敏度不同的第二灵敏度的第二信号处理通道的多通道信号处理器。

4. 发明申请

WO2011041147A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：使用心房透明膜的斑马鱼的鉴别
公开(公告)号：WO2011041147A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049448
申请日：2010-09-20
申请人： MEDTRONIC, INC. , BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
发明人： BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3716 , A61N1/3962
摘要： A cardiac medical device and associated method control delivery of dual chamber burst pacing pulses in response to detecting tachycardia. In one embodiment, a single chamber pacing pulse is delivered in response to detecting a tachycardia. Dual chamber pacing pulses are delivered subsequent to the single chamber pacing pulse. An intrinsic depolarization is sensed subsequent to delivering the dual chamber pacing pulses. The tachycardia episode is classified in response to the sensed intrinsic depolarization.
摘要翻译：响应于检测到心动过速，心脏医疗装置和相关联的方法控制双室脉冲起搏脉冲的传递。在一个实施例中，响应于检测到心动过速而递送单室起搏脉冲。双室起搏脉冲在单室起搏脉冲之后传递。在递送双室起搏脉冲之后感测到固有去极化。心动过速发作根据感觉到的内在去极化进行分类。

5. 发明申请

WO2011002535A1 HEART SOUND SENSING TO REDUCE INAPPROPRIATE TACHYARRHYTHMIA THERAPY 审中-公开
标题翻译：心脏感觉减少不明显的TACHYARRHYTHMIA治疗
公开(公告)号：WO2011002535A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/030268
申请日：2010-04-07
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , ANDERSON, David, A. , HUSTON, Jeffrey, M. , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xusheng , ANDERSON, David, A. , HUSTON, Jeffrey, M. , GILLBERG, Jeffrey, M.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/36528 , A61N1/36535
摘要： Techniques for detecting heart sounds to reduce inappropriate tachyarrhythmia therapy are described. In some examples, a medical device determines that a cardiac rhythm of the patient is treatable with a therapy, such as a defibrillation pulse, based on a cardiac electrogram (EGM). The medical device analyzes detected heart sounds, and withholds or allows the therapy based on the analysis of the heart sounds.
摘要翻译：描述了用于检测心音以减少不适当的快速性心律失常治疗的技术。在一些示例中，医疗装置通过基于心电图（EGM）的治疗，例如除颤脉冲来确定患者的心律是可治疗的。医疗器械分析检测到的心脏声音，并根据对心脏声音的分析，保留或允许进行治疗。

6. 发明申请

WO2010085391A1 HYBRID SINGLE-CHAMBER TO SIMULTANEOUS PACING METHOD FOR DISCRIMINATION OF TACHYCARDIAS 审中-公开
标题翻译：混合单室同时分离TACHYCARDIAS的方法
公开(公告)号：WO2010085391A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/020702
申请日：2010-01-12
申请人： MEDTRONIC, INC. , GILLBERG, Jeffrey, M. , BROWN, Mark, L. , JACKSON, Troy, E.
发明人： GILLBERG, Jeffrey, M. , BROWN, Mark, L. , JACKSON, Troy, E.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/39 , A61B5/0464 , A61B5/046 , A61N1/368
CPC分类号： A61N1/3622
摘要： A cardiac medical device and associated method control delivery of anti- tachycardia pacing (ATP) in response to detecting tachycardia. In one embodiment, an initial set of single chamber pacing pulses are delivered in a single one of the atrium and the ventricle, the other one of the atrium and the ventricle being a non-paced chamber during the initial set of single chamber pacing pulses. The device detects simultaneity between a sensed event in the non-paced chamber and one of the single chamber pacing pulses and delivers ATP in both the atrium and the ventricle in response to detecting the simultaneity.
摘要翻译：一种心脏医疗器械和相关方法控制抗心动过速起搏（ATP）响应于检测心动过速的传递。在一个实施例中，在初始的单室起搏脉冲组中，单室起搏脉冲的初始组被传送到心房和心室中的单个心房中，心房和心室中的另一个是非调节腔室。该装置检测非节奏室中的感测事件与单室起搏脉冲之间的同时性，并且响应于检测到同时性而在心房和心室中输送ATP。

7. 发明申请

WO2008134210A1 MORPHOLOGY BASED ARRHYTHMIA DETECTION 审中-公开
标题翻译：基于形态学的ARRHYTHMIA检测
公开(公告)号：WO2008134210A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/059699
申请日：2008-04-09
申请人： MEDTRONIC, INC. , ZHANG, Xin , GILLBERG, Jeffrey, M.
发明人： ZHANG, Xin , GILLBERG, Jeffrey, M.
IPC分类号： A61B5/046
CPC分类号： A61B5/0464 , A61B5/0205 , A61B5/0215 , A61B5/7239 , A61N1/3621
摘要： A medical device system and associated method sample an EGM signal over a processing window having a predetermined time duration. A number of morphology metrics are determined from the sampled EGM signal, and a heart rhythm is detected in response to the morphology metrics without determining depolarization intervals. The morphology metrics include metrics determined from a slope signal derived from the EGM signal in one embodiment.
摘要翻译：医疗设备系统和相关方法在具有预定持续时间的处理窗口中对EGM信号进行采样。从采样的EGM信号确定多个形态度量，并且响应于形态学量度检测心律，而不确定去极化间隔。在一个实施例中，形态度量包括从从EGM信号导出的斜率信号确定的度量。

8. 发明申请

WO2008079797A1 GRADUALLY SYNCHRONIZED SIMULTANEOUS ATRIAL AND VENTRICULAR PACING FOR CARDIAC RHYTHM DISCRIMINATION 审中-公开
标题翻译：同时同步同步心律失常和心血管疾病
公开(公告)号：WO2008079797A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/087848
申请日：2007-12-18
申请人： MEDTRONIC, INC , JACKSON, Troy Edward , BROWN, Mark L. , GILLBERG, Jeffrey M.
发明人： JACKSON, Troy Edward , BROWN, Mark L. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/368
CPC分类号： A61N1/3622
摘要： A cardiac medical device used for delivering anti-tachycardia pacing in both the atrial and ventricular regions in a simultaneous manner, while preventing potential of inducing atrial arrhythmia. The pacing pulses may be synchronized in a gradual manner so that simultaneous delivery of the pulses is ultimately achieved at reduced risk of inducing atrial arrhythmia. The pacing pulses may also be synchronized immediately after a determination is made whether simultaneous pacing pulses will be delivered in the vulnerable regions of the cardiac cycle.
摘要翻译：一种用于以同时方式在心房和心室区域递送抗心动过速起搏的心脏医疗装置，同时防止引起心房心律失常的可能性。起搏脉冲可以以逐步的方式同步，从而最终以减少诱导心房心律失常的风险实现脉冲的同时传递。在确定是否在心动周期的脆弱区域中是否同时起搏脉冲将被递送之后，起搏脉冲也可以立即同步。

9. 发明申请

WO2005105204A1 AUTOMATED TEMPLATE GENERATION ALGORITHM FOR IMPLANTABLE DEVICE 审中-公开
标题翻译：用于可植入设备的自动模板生成算法
公开(公告)号：WO2005105204A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/011937
申请日：2005-04-08
申请人： MEDTRONIC, INC. , GILLBERG, Jeffrey, M. , CAO, Jian
发明人： GILLBERG, Jeffrey, M. , CAO, Jian
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61B5/02405 , A61B5/0456 , A61N1/3702
摘要： A method and device for generating a template that includes identifying events of a plurality of sensed events having predetermined characteristics as first selected events and generating the template from the first selected events. Events of the plurality of events having the predetermined characteristics are identified as second selected events, and a determination is made as to whether the template is valid in response to the second selected events. The template is updated from the second selected events in response to the template not being valid.
摘要翻译：一种用于生成模板的方法和装置，包括将具有预定特征的多个感测事件的事件识别为第一选定事件，并从第一选定事件生成模板。具有预定特性的多个事件的事件被识别为第二选定事件，并且确定该模板是否响应于第二选定事件而有效。响应于模板无效，从第二个选定的事件更新模板。

10. 发明申请

WO2011136926A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136926A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032265
申请日：2011-04-13
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/7203 , A61N1/3622 , A61N1/36507 , A61N1/37264
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation with the non-treatable event, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. A determination is made as to whether a second match score and a third match score are within the first match zone, the second match zone, the third match zone and the fourth match zone to generate a first adjusting factor, and cardiac event evidence is accumulated in response to the first adjusting factor for discriminating cardiac events.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于与不可治疗事件的第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。确定第二匹配分数和第三匹配分数是否在第一匹配区域，第二匹配区域，第三匹配区域和第四匹配区域内，以产生第一调整因子，并且累积心脏事件证据响应于用于区分心脏事件的第一调整因子。

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