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1. 发明申请

WO2011041147A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：使用心房透明膜的斑马鱼的鉴别
公开(公告)号：WO2011041147A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049448
申请日：2010-09-20
申请人： MEDTRONIC, INC. , BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
发明人： BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3716 , A61N1/3962
摘要： A cardiac medical device and associated method control delivery of dual chamber burst pacing pulses in response to detecting tachycardia. In one embodiment, a single chamber pacing pulse is delivered in response to detecting a tachycardia. Dual chamber pacing pulses are delivered subsequent to the single chamber pacing pulse. An intrinsic depolarization is sensed subsequent to delivering the dual chamber pacing pulses. The tachycardia episode is classified in response to the sensed intrinsic depolarization.
摘要翻译：响应于检测到心动过速，心脏医疗装置和相关联的方法控制双室脉冲起搏脉冲的传递。在一个实施例中，响应于检测到心动过速而递送单室起搏脉冲。双室起搏脉冲在单室起搏脉冲之后传递。在递送双室起搏脉冲之后感测到固有去极化。心动过速发作根据感觉到的内在去极化进行分类。

2. 发明申请

WO2011041117A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：心房扑动心动过速对心动过速的辨别
公开(公告)号：WO2011041117A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049026
申请日：2010-09-16
申请人： MEDTRONIC, INC. , BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
发明人： BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3702 , A61N1/3962
摘要： A cardiac medical device and associated method control delivery of dual chamber burst pacing pulses in response to detecting tachycardia. In one embodiment, a single chamber pacing pulse is delivered in response to detecting a tachycardia. Dual chamber pacing pulses are delivered subsequent to the single chamber pacing pulse. An intrinsic depolarization is sensed subsequent to delivering the dual chamber pacing pulses. The tachycardia episode is classified in response to the sensed intrinsic depolarization.
摘要翻译：心脏医疗装置和相关方法响应于检测到心动过速而控制双腔脉冲起搏脉冲的输送。在一个实施例中，响应于检测到心动过速而输送单腔起搏脉冲。双腔起搏脉冲在单腔起搏脉冲之后递送。在递送双腔起搏脉冲之后感测内在的去极化。心动过速发作是根据感觉到的内在去极化进行分类的。

3. 发明申请

WO2008127374A2 SYSTEM AND METHOD FOR ARRHYTHMIA DISCRIMINATION WITH ATRIALVENTRICULAR DISSOCIATION 审中-公开
标题翻译： ARRHYTHMIA与ATRIALVENTRICULAR DISSOCITION的系统和方法
公开(公告)号：WO2008127374A2
公开(公告)日：2008-10-23
申请号：PCT/US2007/081575
申请日：2007-10-17
申请人： MEDTRONIC, INC. , CAO, Jian , GILLBERG, Jeffrey M. , JACKSON, Troy E. , BROWN, Mark L.
发明人： CAO, Jian , GILLBERG, Jeffrey M. , JACKSON, Troy E. , BROWN, Mark L.
IPC分类号： A61B5/0464
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3621 , A61N1/3624 , A61N1/395 , A61N1/3956
摘要： Ventricular arrhythmias are monitored and classified based upon various criteria. One criterion is PR dissociation which is determined by comparing the PR interval in a current RR cycle to a median PR value. If the current PR interval varies too far from the median, then dissociation is indicated. Often, there are multiple atrial events in a given RR interval and the PR value has been based upon the last atrial event in the cycle. An algorithm determines whether to use the last atrial event in a cycle or whether an earlier atrial event occurred and would provide a more accurate PR value.
摘要翻译：根据各种标准监测和分类室性心律失常。一个标准是PR解离，其通过将当前RR周期中的PR间隔与中值PR值进行比较来确定。如果当前PR间隔与中位数变化太远，则表示解离。通常，在给定的RR间期内存在多个心房事件，并且PR值基于该周期中的最后心房事件。算法确定是否在一个周期中使用最后一次心房事件，或者是否发生较早的心房事件，并提供更准确的PR值。

4. 发明申请

WO2010111207A1 COMBINED HEMODYNAMIC AND EGM-BASED ARRHYTHMIA DETECTION 审中-公开
标题翻译：联合HEMODYNAMIC和基于EGM的ARRHYTHMIA检测
公开(公告)号：WO2010111207A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028213
申请日：2010-03-23
申请人： MEDTRONIC, INC. , WHITMAN, Teresa A. , KUMAR, Arun , KLECKNER, Karin J. , GILLBERG, Jeffrey M. , JACKSON, Troy E. , SHRIVASTAV, Maneesh , BROWN, Mark L.
发明人： WHITMAN, Teresa A. , KUMAR, Arun , KLECKNER, Karin J. , GILLBERG, Jeffrey M. , JACKSON, Troy E. , SHRIVASTAV, Maneesh , BROWN, Mark L.
IPC分类号： A61N1/39 , A61B5/0205 , A61B5/046 , A61B5/0464 , A61B5/0215 , A61N1/365
CPC分类号： A61N1/3621 , A61B5/0215 , A61B5/0464 , A61N1/36564 , A61N1/36571 , A61N1/36578
摘要： A medical device for detecting arrhythmias that includes sensing cardiac electrical signals and cardiac hemodynamic signals, determining a long-term baseline hemodynamic measurement in response to a plurality of the sensed cardiac hemodynamic signals, detecting a period of increased metabolic demand in response to the sensed cardiac electrical signals, determining a sinus tachycardia baseline hemodynamic measurement in response to sensing of cardiac hemodynamic signals during the detected period of increased metabolic demand, and detecting the arrhythmia and delivering therapy in response to one of only the sensed cardiac electrical signals and the sensed cardiac electrical signals in combination with one or both of the determined long-term baseline hemodynamic measurement and the sinus tachycardia baseline hemodynamic measurement.
摘要翻译：一种用于检测心律失常的医疗装置，其包括感测心脏电信号和心脏血液动力学信号，响应于多个所感测到的心脏血流动力信号确定长期基线血液动力学测量，响应于感测的心脏检测增加的代谢需求的时期电信号，响应于在增加的代谢需求的检测期间响应于心脏血液动力学信号的感测而确定窦性心动过速基线血液动力学测量，以及响应于仅感测的心电信号和感测到的心脏电信之一检测心律失常并递送治疗信号与确定的长期基线血液动力学测量和窦性心动过速基线血液动力学测量中的一个或两个相结合。

5. 发明申请

WO2010088026A1 IMPLANTABLE MEDICAL DEVICE FOR DISCRIMINATING TACHYCARDIAS BASED ON A RETURN CYCLE LENGTH 审中-公开
标题翻译：基于返回循环长度识别TACHYCARDIAS的可植入医疗装置
公开(公告)号：WO2010088026A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/020697
申请日：2010-01-12
申请人： MEDTRONIC, INC. , JACKSON, Troy E. , BROWN, Mark L. , BELK, Paul A.
发明人： JACKSON, Troy E. , BROWN, Mark L. , BELK, Paul A.
IPC分类号： A61N1/362
CPC分类号： A61N1/3621
摘要： A medical device (10) for classifying a tachycardia according to a site of origin of the tachycardia. Cardiac signals are sensed and a tachycardia event is detected in response to the sensed cardiac signals. Pacing pulses are delivered and a time interval corresponding to a distance traversed by a depolarization associated with the last one of the pacing pulses from a site of delivery of the plurality of pacing pulses is determined. The tachycardia event is classified according to a site of origin in response to the determined time interval.
摘要翻译：一种用于根据心动过速起源地点对心动过速进行分类的医疗装置（10）。感测心脏信号，并且响应于感测的心脏信号检测到心动过速事件。递送起搏脉冲，并且确定与由多个起搏脉冲的递送位置与最后一个起搏脉冲相关联的去极化所穿过的距离所对应的时间间隔。响应于确定的时间间隔，根据起始点对心动过速事件进行分类。

6. 发明申请

WO2010088025A1 EVENT DISCRIMINATION USING UNIPOLAR AND BIPOLAR SIGNAL DIFFERENCES 审中-公开
标题翻译：使用单极和双极信号差异的事件歧视
公开(公告)号：WO2010088025A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/020696
申请日：2010-01-12
申请人： MEDTRONIC, INC. , JACKSON, Troy E.
发明人： JACKSON, Troy E.
IPC分类号： A61N1/37
CPC分类号： A61N1/3621 , A61N1/37
摘要： A medical device and associated method discriminate near-field and far-field events by sensing a bipolar signal and a unipolar signal at a tissue site, detecting an event in response to one of the bipolar and unipolar signals, and comparing an event feature determined from the bipolar signal to an event feature determined from the unipolar signal.
摘要翻译：医疗装置和相关方法通过在组织部位感测双极信号和单极信号来区分近场和远场事件，响应于双极和单极信号之一检测事件，并且比较从将双极性信号转换为从单极性信号确定的事件特征。

7. 发明申请

WO2023084339A1 MEDICAL DEVICE AND METHOD FOR DETECTING ARRHYTHMIA 审中-公开
公开(公告)号：WO2023084339A1
公开(公告)日：2023-05-19
申请号：PCT/IB2022/059880
申请日：2022-10-14
申请人： MEDTRONIC, INC.
发明人： ARANDA HERNANDEZ, Alfonso , EBELING, Timothy A. , GREENHUT, Saul E. , JACKSON, Troy E. , LIU, Yuanzhen , SANCHEZ, Irving J. , VANDER HEYDEN, James A. , ZHANG, Xusheng
IPC分类号： A61N1/365 , A61N1/39 , A61B5/363
摘要： A medical device is configured to determine an amplitude metric from a cardiac signal segment sensed over a predetermined time interval and determine if the amplitude metric meets an amplitude threshold. The medical device is configured to perform a first analysis of the cardiac electrical signal segment for detecting a first arrhythmia when the amplitude metric does not meet the amplitude threshold and perform a second analysis of the cardiac electrical signal segment for detecting a second arrhythmia different than the first arrhythmia in response to the amplitude metric meeting the amplitude threshold.

8. 发明申请

WO2019036258A1 ANTI-TACHYCARDIA PACING CONTROL IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM 审中-公开
公开(公告)号：WO2019036258A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/045898
申请日：2018-08-09
申请人： MEDTRONIC, INC.
发明人： ZHANG, Xusheng , GRINBERG, Yanina , SOLHEIM, Paul R. , JACKSON, Troy E. , EBELING, Timothy A. , NIKOLSKI, Vladimir P.
IPC分类号： A61N1/362 , A61N1/39 , A61N1/375
摘要： An implantable medical device system is configured to detect a tachyarrhythmia from a cardiac electrical signal and start an ATP therapy delay period. The implantable medical device determines whether the cardiac electrical signal received during the ATP therapy delay period satisfies ATP delivery criteria. A therapy delivery module is controlled to cancel the delayed ATP therapy if the ATP delivery criteria are not met and deliver the delayed ATP therapy if the ATP delivery criteria are met.

9. 发明申请

WO2016126661A1 DETERMINING PACED CARDIAC DEPOLARIZATION WAVEFORM MORPHOLOGICAL TEMPLATES 审中-公开
标题翻译：确定过滤心脏分离波形态模式
公开(公告)号：WO2016126661A1
公开(公告)日：2016-08-11
申请号：PCT/US2016/016099
申请日：2016-02-02
申请人： MEDTRONIC, INC.
发明人： JACKSON, Troy E.
IPC分类号： A61N1/362 , A61N1/37 , A61N1/372 , A61N1/05
CPC分类号： A61B5/0464 , A61B5/1118 , A61B5/686 , A61N1/0587 , A61N1/3622 , A61N1/371 , A61N1/37205 , A61N1/3937
摘要： Techniques for determining paced cardiac depolarization waveform morphological templates are described. For example, an implantable medical device (IMD) may sense a cardiac electrogram of a heart, identify cardiac depolarizations within the cardiac electrogram, and determine that the cardiac depolarizations are paced cardiac depolarizations resulting from delivery of a pacing pulse to the heart by another IMD without detecting the pacing pulse and without communicating with the other IMD. The IMD may identify paced cardiac depolarization waveforms of the paced cardiac depolarizations, determine a paced cardiac depolarization waveform morphological template based on the identified paced cardiac depolarization waveforms, determine a normal cardiac depolarization waveform morphological template based on the paced cardiac depolarization waveform morphological template, and compare the normal cardiac depolarization waveform morphological template to subsequent cardiac depolarization waveforms. The IMD may detect a cardiac tachyarrhythmia based on the above comparison.
摘要翻译：描述了用于确定起搏心脏去极化波形形态模板的技术。例如，可植入医疗装置（IMD）可以感测心脏的心脏电图，识别心脏电图中的心脏去极化，并且确定心脏去极化是由心脏去极化而产生的，由心脏由另一个IMD递送而不检测起搏脉冲，而不与其他IMD通信。 IMD可以鉴定节奏心脏去极化的节奏心脏去极化波形，基于所识别的起搏心脏去极化波形确定起搏心脏去极化波形形态模板，基于节奏心脏去极化波形态模板确定正常心脏去极化波形态模板，以及将正常心脏去极化波形态模板与随后的心脏去极化波形进行比较。基于上述比较，IMD可以检测心脏快速性心律失常。

10. 发明申请

WO2022115416A1 GUIDING ANTI-TACHYARRHYTHMIA PACING TRAIN DESIGN AND ELECTRODE SELECTION WITH ELECTROGRAMS 审中-公开
公开(公告)号：WO2022115416A1
公开(公告)日：2022-06-02
申请号：PCT/US2021/060483
申请日：2021-11-23
申请人： MEDTRONIC, INC.
发明人： JACKSON, Troy E.
IPC分类号： A61N1/362 , A61N1/365
摘要： An example medical device system includes therapy delivery circuitry configured to deliver anti-tachycardia pacing (ATP) therapy to a heart of a patient via electrodes communicatively coupled to the therapy delivery circuitry. The ATP therapy includes one or more ATP trains. The medical device system also includes processing circuitry configured determine a first propagation time based on a comparison of features in a local electrogram and a far-field electrogram, such as the time from a fiducial point in the local electrogram and QRS onset in the far-field electrogram. The processing circuitry is also configured to determine, based on the first propagation time, a number of pulses to achieve a second propagation time and control the therapy delivery circuitry to deliver the ATP train of at least the number of pulses.

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