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1. 发明申请

WO0141835A3 SYRINGES, SYRINGE TUBING AND FLUID TRANSFER SYSTEMS 审中-公开
标题翻译：灌注，灌注管和流体传输系统
公开(公告)号：WO0141835A3
公开(公告)日：2002-01-03
申请号：PCT/US0033009
申请日：2000-12-06
申请人： MEDRAD INC
发明人： COWAN KEVIN P , TROMBLEY FREDERICK W III , TROCKI MARK , REILLY DAVID M
IPC分类号： A61M5/178 , A61M5/14 , A61M5/145 , A61M5/38
CPC分类号： A61M5/14546 , A61M5/385 , A61M2005/1403
摘要： A syringe includes a body and a plunger disposed therein. The body includes a nozzle formed therein and at least one hub member connected thereto or integrally formed thereon for holding an end of a connector tube. The connector tube includes two ends, each end preferably being connected to a respective hub member to retain the connector tube in contact with the syringe. Preferably, the syringe and the connector tube are packaged in a pre-connected condition for ease of use by the customer. Furthermore, flexible inlet tubing for connection to a syringe for filling the syringe with contrast media, for example, is described. The inlet tubing permits filling of the syringe from either a bag or a bottle and may remain attached to the syringe so that it forms at least a part of the connection to the patient. In addition, an apparatus for facilitating the purge of air from a connector tube that will ultimately be connected between a syringe and a patient is described. The apparatus includes a purging tube connected to the distal end of the connector tubing from the syringe. The purging tube includes a venting cap at its distal end. A flow inhibitor is positioned under the venting cap to cooperate with the venting cap by discouraging the discharge of fluid from the distal end of the purging tube while permitting the discharge of air therefrom.
摘要翻译：注射器包括主体和设置在其中的柱塞。主体包括形成在其中的喷嘴和与其连接或一体地形成在其上的至少一个毂构件，用于保持连接器管的端部。连接器管包括两个端部，每个端部优选地连接到相应的毂部件，以将连接器管保持与注射器接触。优选地，注射器和连接管被包装在预连接状态中，以便客户易于使用。此外，描述了用于连接到注射器的柔性入口管，用于例如用造影剂填充注射器。入口管允许从袋或瓶中填充注射器，并且可以保持附接到注射器，使得其形成与患者的连接的至少一部分。此外，描述了一种便于从最终连接在注射器和患者之间的连接管吹扫空气的装置。该装置包括从注射器连接到连接管的远端的清洗管。吹扫管在其远端包括通气盖。流动抑制剂位于排气盖下面，以与通气帽配合，通过阻止从清洗管的远端排出流体，同时允许排出空气。

2. 发明申请

WO2007056247A3 DELIVERY OF AGENTS SUCH AS CELLS TO TISSUE 审中-公开
标题翻译：递送代理作为细胞组织
公开(公告)号：WO2007056247A3
公开(公告)日：2009-05-07
申请号：PCT/US2006043133
申请日：2006-11-06
申请人： MEDRAD INC , UBER ARTHUR E III , HIRSCHMAN ALAN D , FACHER EVAN , GELBLUM EUGENE A , GRIFFITHS DAVID M , RHINEHART EDWARD J , REILLY DAVID M , COWAN KEVIN P , CEDARHOLM PAGE , TUCKER BARRY L , TROCKI MARK , MISHLER DAVID , BARTONY HENRY E JR , PARKS ROBERT
发明人： UBER ARTHUR E III , HIRSCHMAN ALAN D , FACHER EVAN , GELBLUM EUGENE A , GRIFFITHS DAVID M , RHINEHART EDWARD J , REILLY DAVID M , COWAN KEVIN P , CEDARHOLM PAGE , TUCKER BARRY L , TROCKI MARK , MISHLER DAVID , BARTONY HENRY E JR , PARKS ROBERT
IPC分类号： A61M31/00 , B65D25/04
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be progenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是祖细胞或干细胞。

3. 发明申请

WO2006078817A8 INJECTORS, INJECTOR SYSTEMS AND METHODS FOR INJECTING FLUIDS 审中-公开
标题翻译：注射器，注射器系统和注射液的方法
公开(公告)号：WO2006078817A8
公开(公告)日：2007-12-27
申请号：PCT/US2006001896
申请日：2006-01-21
申请人： MEDRAD INC , COWAN KEVIN P , REILLY DAVID M , FULARZ JOSEPH J , SWARTZ PAUL J , TROCKI MARK , MISHLER DAVID A
发明人： COWAN KEVIN P , REILLY DAVID M , FULARZ JOSEPH J , SWARTZ PAUL J , TROCKI MARK , MISHLER DAVID A
IPC分类号： A61B6/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/16827 , A61M2005/14506
摘要： An injector for injection a fluid into a patient, including: a first pressurizing mechanism adapted to operatively connect with a first fluid container to pressurize fluid therein; at least a second pressurizing mechanism to operatively connect with a second fluid container to pressurize a fluid therein; a single drive; and a transmission to control how power from the drive is distributed to the first pressurizing mechanism of the first container and to the second pressurizing mechanism of the second container to control injection of fluid from the first container and from the second container. The drive can, for example, be an electric motor or other drive.
摘要翻译：一种用于将流体注入患者体内的注射器，包括：第一加压机构，其适于与第一流体容器可操作地连接以对其中的流体加压; 至少第二加压机构，其与第二流体容器可操作地连接以对其中的流体加压; 一个驱动器; 以及传动装置，用于控制来自驱动装置的动力如何分配给第一容器的第一加压机构和第二容器的第二加压机构，以控制来自第一容器和第二容器的流体的注入。例如，该驱动器可以是电动机或其他驱动器。

4. 发明申请

WO2007053779A3 DELIVERY OF AGENTS TO TISSUE 审中-公开
标题翻译：药剂运送到组织
公开(公告)号：WO2007053779A3
公开(公告)日：2007-11-08
申请号：PCT/US2006043134
申请日：2006-11-06
申请人： MEDRAD INC , UBER ARTHUR E III , TROMBLEY FREDERICK W III , GELBLUM EUGENE A , RHINEHART EDWARD J , REILLY DAVID M , CEDARHOLM PAGE , COWAN KEVIN P , TROCKI MARK , HIRSCHMAN ALAN D
发明人： UBER ARTHUR E III , TROMBLEY FREDERICK W III , GELBLUM EUGENE A , RHINEHART EDWARD J , REILLY DAVID M , CEDARHOLM PAGE , COWAN KEVIN P , TROCKI MARK , HIRSCHMAN ALAN D
IPC分类号： A61M5/30 , A61M31/00
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：一种用于将注射剂注入患者体内的系统包括用于保持注射剂的第一可加压容器; 与第一可加压容器流体连接的患者接口，患者接口适于将注射液传递到患者的组织; 动力注射器，其与第一可加压容器可操作地连接以对注射物加压; 与动力注射器可操作连接的控制器系统; 以及立体定位框架，适于与患者接口操作连接，以帮助控制患者接口的定位。用于处理细胞（和/或其他注射组分）的系统包括容器和适于可滑动地定位在容器内的柱塞。该系统包括流体可以通过其进入系统的至少一个入口和至少一个流出物可以通过其流出系统的流出口。柱塞部分与容器的内壁形成密封接合，使得柱塞的向后运动适于经由入口将流体吸入系统中，并且柱塞的向前运动适于通过流出物将流出物排出系统港口。

5. 发明申请

WO2006078817A3 INJECTORS, INJECTOR SYSTEMS AND METHODS FOR INJECTING FLUIDS 审中-公开
标题翻译：注射器，注射器系统和注射流体的方法
公开(公告)号：WO2006078817A3
公开(公告)日：2007-11-01
申请号：PCT/US2006001896
申请日：2006-01-21
申请人： MEDRAD INC , COWAN KEVIN P , REILLY DAVID M , FULARZ JOSEPH J , SWARTZ PAUL J , TROCKI MARK , MISHLER DAVID A
发明人： COWAN KEVIN P , REILLY DAVID M , FULARZ JOSEPH J , SWARTZ PAUL J , TROCKI MARK , MISHLER DAVID A
IPC分类号： A61B6/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/16827 , A61M2005/14506
摘要： An injector for injection a fluid into a patient, including: a first pressurizing mechanism adapted to operatively connect with a first fluid container to pressurize fluid therein; at least a second pressurizing mechanism to operatively connect with a second fluid container to pressurize a fluid therein; a single drive; and a transmission to control how power from the drive is distributed to the first pressurizing mechanism of the first container and to the second pressurizing mechanism of the second container to control injection of fluid from the first container and from the second container. The drive can, for example, be an electric motor or other drive.
摘要翻译：一种用于将流体注射到患者体内的注射器，包括：适于与第一流体容器可操作地连接以对其中的流体加压的第一加压机构; 至少第二加压机构，用于与第二流体容器可操作地连接以对其中的流体加压; 单一驱动器以及变速器，用于控制来自驱动器的动力如何分配到第一容器的第一加压机构和第二容器的第二加压机构，以控制来自第一容器和第二容器的流体的喷射。驱动器可以例如是电动机或其他驱动器。

6. 发明申请

WO2007140085A2 VALVE SYSTEMS AND INJECTOR SYSTEM INCLUDING SUCH VALVE SYSTEMS 审中-公开
标题翻译：阀门系统和喷油器系统，包括这种阀门系统
公开(公告)号：WO2007140085A2
公开(公告)日：2007-12-06
申请号：PCT/US2007068458
申请日：2007-05-08
申请人： MEDRAD INC , TROCKI MARK , REILLY DAVID M , NEILL JAMES R , CAPONE CHRISTOPHER D
发明人： TROCKI MARK , REILLY DAVID M , NEILL JAMES R , CAPONE CHRISTOPHER D
IPC分类号： F16K21/04
CPC分类号： A61M39/24 , A61M5/14546 , A61M5/16827 , A61M39/223 , A61M39/228 , A61M2039/2473 , A61M2039/2486 , A61M2039/2493 , Y10T137/2567 , Y10T137/2569 , Y10T137/2572 , Y10T137/2622 , Y10T137/7838 , Y10T137/7843 , Y10T137/7849 , Y10T137/86726 , Y10T137/87338 , Y10T137/87555
摘要： A valve system for use in a system including a first source of a first pressurized fluid and a second source of a second pressurized fluid includes a valve housing including a first inlet port adapted to be placed in fluid connection with the first source, a second inlet port adapted to be placed in fluid connection with the second source and an outlet port. The valve system further includes a backflow prevention system to prevent flow of the first pressurized fluid through the second inlet and to prevent flow of the second pressurized fluid through the first inlet port. The valve system is adapted to provide a fluid path between at least the first inlet port and the outlet port to enable fluid to be drawn from the outlet port to the first inlet port. Several of the valve systems of the present invention provide for flow from the first inlet port to the outlet port and concurrent flow from the second inlet port to the outlet port.
摘要翻译：一种用于包括第一加压流体的第一源和第二加压流体的第二源的系统的阀系统包括阀壳体，其包括适于与第一源流体连接的第一入口端口，第二入口端口适于与第二源和出口端口流体连接。阀系统还包括防止流体流动的第一加压流体通过第二入口并防止第二加压流体流过第一入口的回流防止系统。阀系统适于在至少第一入口和出口之间提供流体路径，以使流体能够从出口被抽出到第一入口端口。本发明的几个阀门系统提供从第一入口到出口的流动以及从第二入口到出口的并流。

7. 发明申请

WO2007002154A3 MEDICAL FLUID INJECTION AND INFLATION SYSTEM 审中-公开
标题翻译：医用流体注射和灌注系统
公开(公告)号：WO2007002154A3
公开(公告)日：2007-04-05
申请号：PCT/US2006024081
申请日：2006-06-21
申请人： MEDRAD INC , GRIFFITHS DAVID M , ALMON-MARTIN ROSEMARY , HIRSCHMAN ALAN D , REILLY DAVID M , TROCKI MARK , TROMBLEY FREDERICK W , WEICH THOMAS R , JAECKLEIN WILLIAM J , SPOHN MICHAEL A , JOYCE THOMAS P
发明人： GRIFFITHS DAVID M , ALMON-MARTIN ROSEMARY , HIRSCHMAN ALAN D , REILLY DAVID M , TROCKI MARK , TROMBLEY FREDERICK W , WEICH THOMAS R , JAECKLEIN WILLIAM J , SPOHN MICHAEL A , JOYCE THOMAS P
IPC分类号： A61M31/00
CPC分类号： A61M25/10184 , A61M5/007 , A61M5/14566 , A61M5/16827 , A61M5/16854 , A61M25/007 , A61M25/104 , A61M2025/102 , A61M2025/1022
摘要： A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.
摘要翻译：公开了组合的流体注入和充气系统，并且包括包括至少一个加压装置，流体路径和控制单元的流体递送系统。流体路径适于经由包括球囊并且插入患者体内的导管将加压装置连接到患者。控制单元可操作以控制流体输送系统。在操作中，控制单元选择性地致动流体输送系统以流体注射模式或气球充气模式操作。在流体注射模式中，加压装置将流体输送到流体路径用于流体注射程序。在球囊膨胀模式中，加压装置将流体输送到流体路径，用于使与导管相关联的球囊膨胀。操作员控制可以连接到控制单元以控制流体输送系统，并且可以是手持装置。

8. 发明申请

WO0137903A3 FRONT-LOADING MEDICAL INJECTOR AND SYRINGE 审中-公开
标题翻译：前装医用注射器和注射器
公开(公告)号：WO0137903A3
公开(公告)日：2002-01-17
申请号：PCT/US0031991
申请日：2000-11-21
申请人： MEDRAD INC
发明人： TROCKI MARK , RHINEHART EDWARD J , HITCHINS MARK W , FUCHS LARRY , DEDIG JAMES A , PARKS ROBERT D , COWAN KEVIN P , SCIULLI FRANCIS J , RYGG STEVEN C
IPC分类号： A61M5/145
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2005/14553
摘要： Embodiments of an injector, syringe, syringe interface, and piston/plunger assembly for an injector (of contrast medium, for example) are described. Preferably, the syringe is adapted to engage a syringe interface mechanism such that the syringe may be connected to an injector without regard to any particular orientation of the syringe to the injector or to the piston/plunger assembly.
摘要翻译：描述了用于注射器（例如造影剂）的注射器，注射器，注射器接口和活塞/柱塞组件的实施例。优选地，注射器适于接合注射器接口机构，使得注射器可以连接到注射器，而不考虑注射器对于注射器或活塞/柱塞组件的任何特定取向。

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