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1. 发明申请

WO0146388A2 PATHOLOGICALLY MODIFIED MYOCARDIAL CELL, PRODUCTION AND USE THEREOF 审中-公开
标题翻译：病理改变的心脏肌肉细胞，生产和使用
公开(公告)号：WO0146388A2
公开(公告)日：2001-06-28
申请号：PCT/EP0013101
申请日：2000-12-21
申请人： MEDIGENE AG , ROENICKE VOLKER , NAVE BARBARA , HENKEL THOMAS
发明人： ROENICKE VOLKER , NAVE BARBARA , HENKEL THOMAS
IPC分类号： C12N15/09 , C12N5/077 , C12Q1/02 , G01N33/50 , C12N5/06 , A61K35/34 , C12N5/08 , C12N5/10
CPC分类号： C12N5/0657 , C12N2501/235 , C12N2501/365 , C12N2501/999 , C12N2503/02 , G01N33/5014 , G01N2500/10
摘要： The invention relates to a pathologically modified myocardial cell which can be produced from healthy cardiac tissue by providing or isolating at least one healthy myocardial cell, by stimulating said isolated myocardial cell using the appropriate hormones, hormone analogues and/or zytokines and by detecting the pathologically modified myocardial cell(s) by localising at least one signal molecule. The invention also relates to a method for producing said pathologically modified myocardial cell and to the use thereof, including a method for detecting or identifying cardioactive substances.
摘要翻译：患病的心脏肌肉细胞，从健康的心脏组织制备通过提供或分离至少一种健康的心脏肌肉细胞，刺激通过适当的激素，激素类似物和/或细胞因子的分离的心脏肌细胞; 通过确定至少一个信号分子的位置，以及它们的制备方法和它们的用途，包括用于检测或鉴定的活性物质心脏的方法的至少一个患病的心肌细胞检测。

2. 发明申请

WO02097128A3 METHOD FOR IDENTIFYING SUBSTANCES DIRECTED AGAINST MYOCARDIAL CELL HYPERTROPHY 审中-公开
标题翻译：一种用于识别物质的侵害心肌肥大
公开(公告)号：WO02097128A3
公开(公告)日：2003-09-12
申请号：PCT/EP0205924
申请日：2002-05-29
申请人： MEDIGENE AG , HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
发明人： HENKEL THOMAS , ROENICKE VOLKER , NAVE BARBARA
IPC分类号： C12N5/077 , C12Q1/68 , C12N5/10
CPC分类号： C12N5/0657 , C12N2510/00 , C12Q1/6897
摘要： The invention relates to a method for the in vitro examination of myocardial cell hypertrophy characterized in that at least one parameter for myocardial cell hypertrophy can be measured by using the expression rate of a heterologous marker protein in at least one myocardial cell containing a nucleic acid that codes for the heterologous marker protein.
摘要翻译：本发明的一个目的是一种用于心肌细胞肥大的体外研究中，其特征在于，用于在异源标志物蛋白的表达的至少一种心肌细胞的速率心肌细胞肥大的至少一个参数的方法中，核酸是异源标记蛋白可测量含有编码。

3. 发明申请

WO03037323A2 INHIBITORS OF THE FATTY ACID OXIDATION FOR PROPHYLAXIS AND TREATMENT OF DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION 审中-公开
标题翻译：抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病
公开(公告)号：WO03037323A2
公开(公告)日：2003-05-08
申请号：PCT/EP0211913
申请日：2002-10-24
申请人： MEDIGENE AG GES FUER MOLEKULAR , HENKEL THOMAS , REHFUESS CHRISTOPH
发明人： HENKEL THOMAS , REHFUESS CHRISTOPH
IPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495 , A61K31/197
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substitued oxirane carboxylic acid.
摘要翻译：描述了通过抑制生物体的一种或多种细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。特别地，脂肪酸氧化通过借助于芳烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉毒碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性而被抑制的芳基烷基取代的环氧乙烷羧酸。

4. 发明申请

WO0192567A3 NOVEL TARGET GENES FOR DISEASES OF THE HEART 审中-公开
标题翻译：心脏疾病的新目标基因
公开(公告)号：WO0192567A3
公开(公告)日：2003-02-13
申请号：PCT/EP0106165
申请日：2001-05-30
申请人： MEDIGENE AG , BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
发明人： BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , C07K14/47 , C12N15/09 , C12N15/85 , C12Q1/50 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K49/00 , C07K16/18
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A01K2267/0375 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans for a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may also be used as lead compounds for the development of medicaments having an improved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comprising the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aforementioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
摘要翻译：本发明涉及在心脏组织中异常表达的各种基因以及这些基因的片段。这些基因的表达水平的评估可以用于测试哺乳动物和优选人心脏病或这种疾病的急性状态的倾向。根据本发明的优选疾病是充血性心力衰竭，扩张性心肌病，肥厚性心肌病和缺血性心肌病。本发明还涉及鉴定能够使上述基因的表达水平正常化的化合物和受异常表达影响的其它基因的方法。鉴定的化合物可用于配制组合物，优选用于预防或治疗疾病的药物组合物。它们也可以用作开发具有改善的效率，更长的半衰期，降低的毒性等等并且用于治疗心脏病的药物的铅化合物。本发明还包括体细胞基因治疗方法，其包括将任何上述基因的至少一个功能拷贝引入合适的细胞中。最后，本发明涉及在其种系中包含至少一个上述基因的非人转基因动物。本发明的转基因动物可用于开发用于治疗心脏病的药物。

5. 发明申请

WO03006687A3 NOVEL TARGET GENES FOR DISEASES OF THE HEART 审中-公开
标题翻译：心脏疾病的新目标基因
公开(公告)号：WO03006687A3
公开(公告)日：2003-08-28
申请号：PCT/EP0207704
申请日：2002-07-10
申请人： MEDIGENE AG , REUNER BIRGIT , BUNK DANIELA , HENKEL THOMAS
发明人： REUNER BIRGIT , BUNK DANIELA , HENKEL THOMAS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans of a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may be used as lead compounds for the development of medicament having an inproved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comparing the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aformentioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
摘要翻译：本发明涉及在心脏组织中异常表达的各种基因以及这些基因的片段。这些基因的表达水平的评估可以用于测试哺乳动物，优选人心脏病或这种疾病的急性状态的倾向。根据本发明的优选疾病是充血性心力衰竭，扩张性心肌病，肥厚性心肌病和缺血性心肌病。本发明还涉及鉴定能够使上述基因的表达水平正常化的化合物和受异常表达影响的其它基因的方法。鉴定的化合物可用于配制组合物，优选用于预防或治疗疾病的药物组合物。它们可以用作开发具有提高的效率，更长的半衰期，降低的毒性等等并用于治疗心脏病的药物的铅化合物。本发明中还包括体细胞基因治疗方法，比较将任何上述基因的至少一个功能拷贝引入合适的细胞中。最后，本发明涉及在其种系中包含至少一个上述基因的非人转基因动物。本发明的转基因动物可用于开发用于治疗心脏病的药物。

6. 发明申请

WO02052277A2 MAGNETIC GRIP/HOLD SYSTEM FOR HANDLING MAGNETIC OBJECTS THAT ARE ARRANGED IN A MATRIX 审中-公开
标题翻译：处理MATRIXFOERMIG磁抓斗HOLD安排ARRANGED磁性的物体
公开(公告)号：WO02052277A2
公开(公告)日：2002-07-04
申请号：PCT/EP0114948
申请日：2001-12-18
申请人： INST PHYSIKALISCHE HOCHTECH EV , ALBERT JENS , ALBRECHT ARNE , HENKEL THOMAS , KALLENBACH MATTHIAS , MAYER GUENTER , SCHOBER ANDREAS , WURMUS HELMUT
发明人： ALBERT JENS , ALBRECHT ARNE , HENKEL THOMAS , KALLENBACH MATTHIAS , MAYER GUENTER , SCHOBER ANDREAS , WURMUS HELMUT
IPC分类号： G01N35/00 , G01N33/53 , G01N33/543
CPC分类号： G01N35/0098
摘要： The invention relates to a magnetic grip/hold system for handling magnetic objects that are arranged in a matrix, especially for handling particles that carry chemically samples. At least one part of the magnetic objects can be simultaneously displaced to a new position without changing its association with the matrix by producing a magnetic force that partially acts upon to the matrix. The aim of the invention is to provide a system that is economic in operation and that prevents the formation of global local interference of magnetic fields as well as the reduction of useful magnetic force. To this end, every magnetic object is associated with a holding magnetic field that is overlayered by a movable gripping magnetic field that partially acts upon the matrix.
摘要翻译：本发明涉及一种磁性拾取器保持器组件用于处理配置成矩阵状磁性物体，特别是轴承颗粒化学样品的方法，其中至少所述的磁特性的一部分，而不改变部分地由相对于同时产生的磁力的矩阵它们的基质有条件分配可移动到一个新的位置。你应该避免全球空间磁场叠加，以及可使用的磁力，而在经济工作的减少。这得以实现，每个所述磁性物体与保持磁场是由一个矩阵叠加相对于所述局部横便携式磁场有关。

7. 发明申请

WO0072544A3 METHOD FOR SECURELY TRANSMITTING PROTECTED DATA 审中-公开
标题翻译：方法数据安全传输而得到保护
公开(公告)号：WO0072544A3
公开(公告)日：2001-09-07
申请号：PCT/EP0004351
申请日：2000-05-15
申请人： SMARTRING GMBH GES FUER SICHER , REIF HOLGER , HENKEL THOMAS
发明人： REIF HOLGER , HENKEL THOMAS
IPC分类号： H04L29/06 , H04W88/02 , G07F7/10 , H04Q7/38
CPC分类号： H04W12/10 , H04L63/0442 , H04L63/0853 , H04L63/12 , H04W88/02
摘要： The invention relates to a method for the secure transmission of protected data from a first terminal (1) within a first security area (6) to a second terminal (2) within a second security area (10), which is different from the first security area. The inventive method comprises the following steps: providing useful data in the first terminal; generating the protected data in the first terminal by adding first security characteristics (8a) to the useful data; transmitting the protected data within the first security area to an area transformer (9), by a first communications connection (4), said area transformer being integrated into both the first and the second security areas; transforming at least some of the first security characteristics into second security characteristics (11a) by means of the area transformer; transmitting the protected data within the second security area to a second terminal, by a second communications connection (7). The protected data can then be converted back into useful data in said second terminal.
摘要翻译：本发明涉及一种用于从一个第一安全区（6）的第二终端（2）内的第一终端（1）的第二安全区域（10）内的保护的数据的安全传输的方法，其是从所述第一安全区域不同。该方法包括以下步骤：在第一终端的用户数据的提供; 生成通过加入第一安全特征（8a）的用户数据中的第一终端的受保护的数据; 经由第一通信链路（4）连接到域变换器（9），其集成在所述第一以及到第二安全域的第一安全区域内的受保护数据的传输; 将至少一些所述第一单元安全特性到第二安全功能（11A）由域变换器的; 通过第二通信链路（7）至所述第二终端，其中所述受保护的数据可以被转换回有效载荷中的第二安全区域内的受保护数据的传输。

8. 发明申请

WO2004103565A3 DEVICE AND METHOD FOR STRUCTURING LIQUIDS AND FOR DOSING REACTION LIQUIDS INTO LIQUID COMPARTMENTS IMMERSED IN A SEPARATION MEDIUM 审中-公开
标题翻译： DEVICE AND METHOD FOR结构和液体计量反应在分离介质液体的嵌入式流体室
公开(公告)号：WO2004103565A3
公开(公告)日：2005-04-21
申请号：PCT/DE2004001056
申请日：2004-05-18
申请人： KNOELL HANS FORSCHUNG EV , INST PHYSIKALISCHE HOCHTECH EV , INST BIOPROZESS UND ANALYSENTE , UNIV ILMENAU TECH , GASTROCK GUNTER , GRODRIAN ANDREAS , HENKEL THOMAS , KIELPINSKI MARK , KOEHLER MICHAEL , LEMKE KAREN , MARTIN KARIN , METZE JOSEF , ROTH MARTIN , SCHOEN THORE , BAIER VOLKER
发明人： GASTROCK GUNTER , GRODRIAN ANDREAS , HENKEL THOMAS , KIELPINSKI MARK , KOEHLER MICHAEL , LEMKE KAREN , MARTIN KARIN , METZE JOSEF , ROTH MARTIN , SCHOEN THORE , BAIER VOLKER
IPC分类号： B01F13/00 , B01F15/02 , B01L3/00 , G01N35/08 , B01D17/02
CPC分类号： B01F13/0071 , B01F15/0201 , B01F15/0237 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2200/16 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/086 , G01N35/08
摘要： The invention relates to a device and a method for structuring liquids and for dosing reaction liquids into liquid compartments immersed in a separation medium. The aim of the invention is to provide a device and a method for structuring liquids for analytical, microbiological, cell biological and (bio)chemical combinatory applications, said device and method structuring liquids guided in microcapillaries in such a way that they can be addressed in defined concentration regions in a liquid flow, and supplying reagents to said concentration regions (liquid compartments) in a targeted manner. To this end, the inventive device consists of pre-determined liquid paths into which at least one dosing device opens up, and/or at least one merger and/or at least one separator are arranged in the liquid paths.
摘要翻译：本发明涉及一种在液体室的装置和方法，用于结构化的液体和用于计量加入反应液体的嵌入式分离介质。表示化学组合应用，本发明的目的是直接液体和试剂将这些浓度区域流内提供结构化的液体以供分析，微量，细胞生物学和（生物），所述可寻址的结构的装置和方法在微毛细管引导流体以空格确定浓度执行（液体室）的实现在于该装置由预定Flüssigkeitsleitwegen，其中通向所述Flüssigkeitsleitwege至少一个定量给料装置和/或至少一个fusionator和/或至少一个Spaltator布置在Flüssigkeitsleitwegen的。

9. 发明申请

WO03025113A3 METHODS FOR CULTIVATING AND ANALYZING MICROBIAL INDIVIDUAL CELL CULTURES 审中-公开
标题翻译：培养方法及微生物单细胞培养分析
公开(公告)号：WO03025113A3
公开(公告)日：2003-06-26
申请号：PCT/DE0203451
申请日：2002-09-13
申请人： KNOELL HANS FORSCHUNG EV , INST BIOPROZESS ANALYSENMESST , INST PHYSIKALISCHE HOCHTECH EV , MUELLER PETER-JUERGEN , ROTH MARTIN , HILLIGER MONIKA HF , HILLIGER STEPHAN HM , GROTH INGRID , KUMMER CHRISTEL , MARTIN KARIN , SCHROECKH VOLKER , METZE JOSEF , KOEHLER MICHAEL , HENKEL THOMAS , GASTROCK GUNTER , LEMKE KAREN
发明人： MUELLER PETER-JUERGEN , ROTH MARTIN , GROTH INGRID , KUMMER CHRISTEL , MARTIN KARIN , SCHROECKH VOLKER , METZE JOSEF , KOEHLER MICHAEL , HENKEL THOMAS , GASTROCK GUNTER , LEMKE KAREN , HILLIGER MATTHIAS DI
IPC分类号： C12N1/00 , C12M1/00 , C12N1/02 , C12M1/20 , C12M1/26 , C12M1/34
CPC分类号： C12M21/16 , C12M41/36
摘要： The invention relates to methods for individually separating microorganisms from a suspension or culture, parallel cultivation of individual cells and analyzing the metabolic performances thereof. The invention enables basic microbial operations such as media optimization, screening according to images of novel natural substances and special metabolic performances, qualitative and quantitative detection of the effects of nutrient substrates, effectors and active substances including the media optimization and selection of microorganism clones with specific properties from large populations according to mutagenesis, transformation, transfection and genetic processing in addition to the detection of microbial contaminations to be carried out. One advantage of the invention is that it can be applied when microorganisms having outstanding properties can be respectively obtained as individual cells or individual organisms from a large population and can be characterized as pure cultures or when the effect of influencing variables can be examined in many fully comparable cultures.
摘要翻译：本发明涉及用于从悬浮液或培养，分离的细胞的平行培养和它们的代谢活动的分析分离微生物的方法。与诸如媒体优化的微生物的基本操作的发明中，筛选的新的天然产品和特殊代谢性能，的营养基质，效应物和试剂，包括媒体优化和微生物与通过诱变，转化，转染从hochzahligen群体的某些特征的克隆的选择的效果的定性和定量证据的图像可以和基因工程的处理以及检测由微生物污染进行。本发明特别有利地总是使用在每种情况下为单细胞或单生物体从具有突出的特征的许多发育人口微生物获得和表征为纯培养物或是否应该检查在许多影响因素，与每个完全可比培养物的效果时，必须。

10. 发明申请

WO0249763A3 DEVICE FOR RECEIVING AND DISCHARGING LIQUID SUBSTANCES 审中-公开
标题翻译：设备用于接收和液体物的分布
公开(公告)号：WO0249763A3
公开(公告)日：2002-10-10
申请号：PCT/EP0114953
申请日：2001-12-18
申请人： INST PHYSIKALISCHE HOCHTECH EV , ALBERT JENS , HENKEL THOMAS , MAYER GUENTER , SCHOBER ANDREAS , SCHLINGLOFF GREGOR
发明人： ALBERT JENS , HENKEL THOMAS , MAYER GUENTER , SCHOBER ANDREAS , SCHLINGLOFF GREGOR
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , B81B1/00 , B81B3/00 , C40B60/14 , G01N1/02
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00369 , B01J2219/00423 , B01J2219/00585 , B01J2219/00659 , B01L3/021 , B01L3/50255 , C40B60/14 , Y10T137/8593
摘要： The invention relates to a device for controlling the amount of liquid substances received and discharged. The aim of the invention is to produce a device, enabling a plurality of different liquid substances to be received and discharged from micro or nano titer plates. According to the invention, it is possible to carry out one or more chemical or biological reactions in said device and to receive liquid substances with differing viscosities, as a result of capillary channels (1) which are arranged at an equal distance from each other and are provided in a row, said channels being brought together in a communicative link with a chamber (2) which is impinged upon by high and low pressure, whereby the capillary channels (1) are embedded in the plate (3) and one sieve-type membrane (4) is associated with the ends of the capillary channels (11) on the inner side of the pressure chamber. According to the invention, an area (5) is provided above each end of the capillary channels for receiving a liquid substance. Said areas (5) are arranged separately from each other and are disposed inside the chamber (2) which can be impinged upon by high and low pressure.
摘要翻译：本发明涉及一种用于控制吸收和液体物质的释放的装置。本发明的目的是通过其来提供一个设备从微或nanotiter板还多个不同的液体物质的同时拾取，并且再次释放，其特征在于，提供给执行一个或在装置中多种化学或本身生物反应和机会不同粘度的液体物质的同时吸收成为可能的实现在于在一个有一排彼此等距Kapillarkanülen提供（1），其连同可加压的压力或真空腔室（2）被带入一个通信连接，其中Kapillarkanülen（1）嵌入的板（3）和至少内部Kapillarkanülenenden压力室（11）具有一个筛状隔膜（4）与各Kapillarkanülenendes上述每一种情况下的空间（5），用于容纳液体物质的能力VORG相关联被esehen，其空间（5）彼此分离的和所有的空间（5）将联合内的加压的压力或真空室，其设置（2）。

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