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1. 发明申请

WO0249763A3 DEVICE FOR RECEIVING AND DISCHARGING LIQUID SUBSTANCES 审中-公开
标题翻译：设备用于接收和液体物的分布
公开(公告)号：WO0249763A3
公开(公告)日：2002-10-10
申请号：PCT/EP0114953
申请日：2001-12-18
申请人： INST PHYSIKALISCHE HOCHTECH EV , ALBERT JENS , HENKEL THOMAS , MAYER GUENTER , SCHOBER ANDREAS , SCHLINGLOFF GREGOR
发明人： ALBERT JENS , HENKEL THOMAS , MAYER GUENTER , SCHOBER ANDREAS , SCHLINGLOFF GREGOR
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , B81B1/00 , B81B3/00 , C40B60/14 , G01N1/02
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00369 , B01J2219/00423 , B01J2219/00585 , B01J2219/00659 , B01L3/021 , B01L3/50255 , C40B60/14 , Y10T137/8593
摘要： The invention relates to a device for controlling the amount of liquid substances received and discharged. The aim of the invention is to produce a device, enabling a plurality of different liquid substances to be received and discharged from micro or nano titer plates. According to the invention, it is possible to carry out one or more chemical or biological reactions in said device and to receive liquid substances with differing viscosities, as a result of capillary channels (1) which are arranged at an equal distance from each other and are provided in a row, said channels being brought together in a communicative link with a chamber (2) which is impinged upon by high and low pressure, whereby the capillary channels (1) are embedded in the plate (3) and one sieve-type membrane (4) is associated with the ends of the capillary channels (11) on the inner side of the pressure chamber. According to the invention, an area (5) is provided above each end of the capillary channels for receiving a liquid substance. Said areas (5) are arranged separately from each other and are disposed inside the chamber (2) which can be impinged upon by high and low pressure.
摘要翻译：本发明涉及一种用于控制吸收和液体物质的释放的装置。本发明的目的是通过其来提供一个设备从微或nanotiter板还多个不同的液体物质的同时拾取，并且再次释放，其特征在于，提供给执行一个或在装置中多种化学或本身生物反应和机会不同粘度的液体物质的同时吸收成为可能的实现在于在一个有一排彼此等距Kapillarkanülen提供（1），其连同可加压的压力或真空腔室（2）被带入一个通信连接，其中Kapillarkanülen（1）嵌入的板（3）和至少内部Kapillarkanülenenden压力室（11）具有一个筛状隔膜（4）与各Kapillarkanülenendes上述每一种情况下的空间（5），用于容纳液体物质的能力VORG相关联被esehen，其空间（5）彼此分离的和所有的空间（5）将联合内的加压的压力或真空室，其设置（2）。

2. 发明申请

WO02052277A2 MAGNETIC GRIP/HOLD SYSTEM FOR HANDLING MAGNETIC OBJECTS THAT ARE ARRANGED IN A MATRIX 审中-公开
标题翻译：处理MATRIXFOERMIG磁抓斗HOLD安排ARRANGED磁性的物体
公开(公告)号：WO02052277A2
公开(公告)日：2002-07-04
申请号：PCT/EP0114948
申请日：2001-12-18
申请人： INST PHYSIKALISCHE HOCHTECH EV , ALBERT JENS , ALBRECHT ARNE , HENKEL THOMAS , KALLENBACH MATTHIAS , MAYER GUENTER , SCHOBER ANDREAS , WURMUS HELMUT
发明人： ALBERT JENS , ALBRECHT ARNE , HENKEL THOMAS , KALLENBACH MATTHIAS , MAYER GUENTER , SCHOBER ANDREAS , WURMUS HELMUT
IPC分类号： G01N35/00 , G01N33/53 , G01N33/543
CPC分类号： G01N35/0098
摘要： The invention relates to a magnetic grip/hold system for handling magnetic objects that are arranged in a matrix, especially for handling particles that carry chemically samples. At least one part of the magnetic objects can be simultaneously displaced to a new position without changing its association with the matrix by producing a magnetic force that partially acts upon to the matrix. The aim of the invention is to provide a system that is economic in operation and that prevents the formation of global local interference of magnetic fields as well as the reduction of useful magnetic force. To this end, every magnetic object is associated with a holding magnetic field that is overlayered by a movable gripping magnetic field that partially acts upon the matrix.
摘要翻译：本发明涉及一种磁性拾取器保持器组件用于处理配置成矩阵状磁性物体，特别是轴承颗粒化学样品的方法，其中至少所述的磁特性的一部分，而不改变部分地由相对于同时产生的磁力的矩阵它们的基质有条件分配可移动到一个新的位置。你应该避免全球空间磁场叠加，以及可使用的磁力，而在经济工作的减少。这得以实现，每个所述磁性物体与保持磁场是由一个矩阵叠加相对于所述局部横便携式磁场有关。

3. 发明申请

WO0219437A3 MULTICRYSTALLINE LASER-CRYSTALLIZED SILICON THIN LAYER SOLAR CELL DEPOSITED ON A GLASS SUBSTRATE 审中-公开
标题翻译：玻璃基板上的多层激光晶化硅薄膜太阳能电池
公开(公告)号：WO0219437A3
公开(公告)日：2002-06-27
申请号：PCT/EP0109571
申请日：2001-08-20
申请人： INST PHYSIKALISCHE HOCHTECH EV , FALK FRITZ , ANDRAE GUDRUN
发明人： FALK FRITZ , ANDRAE GUDRUN
IPC分类号： H01L31/0224 , H01L31/0392 , H01L31/056 , H01L31/18 , H01L31/052
CPC分类号： H01L31/03921 , H01L31/022466 , H01L31/056 , H01L31/1872 , Y02E10/52 , Y02P70/521
摘要： The invention relates to a multicrystalline laser-crystallized silicon thin layer solar cell deposited on a glass substrate (a), which is configured for illuminating from the substrate side, and to a production method for the cell. Said solar cell comprises a laser-crystallized multicrystalline silicon layer (b1, b2) whose lower layer region (b1), which is situated on the substrate (a) and provided as a nucleation layer and, at the same time, as a lower transparent electrode, is p-doped (alternatively, n-doped). The silicon layer's second layer region (b2), which faces away from the substrate is p-doped (alternatively, n-doped) less than the nucleation layer and serves as an absorber layer. The edge lengths of the crystallites in the multicrystalline layer (b1, b2) are longer than the layer is thick. The inventive solar cell also comprises a laser-crystallized, n-doped (alternatively, p-doped) silicon layer (c), which is located on the silicon layer (b1, b2) and which serves as an emitter layer, and comprises a back-reflecting contact layer (A1) that serves as an upper electrode on the emitter layer (c).
摘要翻译：的玻璃基板的（a），其被设计为从衬底侧照射，并且电池的制造方法，包括在多晶硅激光结晶硅薄膜太阳能电池：激光结晶的多晶硅层（B1，B2），所述底部（基板一）B1卧，作为籽晶层，并在同一时间（如服务层区，或者n型掺杂）（p掺杂的，并且其第二从基材层区域（b2）的背向弱p掺杂（或备选地更弱n型掺杂）是作为下部透明电极）籽晶层，并且用作吸收层，其中，在所述多晶硅层中的微晶的边缘长度（B1，B2）比该层的厚度大，在硅层上（B1，B2）卧激光结晶和n型掺杂（或可选地p型掺杂）作为发射极层的硅层（c）和作为E上的上部电极的背反射接触层（Al）中间层（c）。

4. 发明申请

WO2004103565A3 DEVICE AND METHOD FOR STRUCTURING LIQUIDS AND FOR DOSING REACTION LIQUIDS INTO LIQUID COMPARTMENTS IMMERSED IN A SEPARATION MEDIUM 审中-公开
标题翻译： DEVICE AND METHOD FOR结构和液体计量反应在分离介质液体的嵌入式流体室
公开(公告)号：WO2004103565A3
公开(公告)日：2005-04-21
申请号：PCT/DE2004001056
申请日：2004-05-18
申请人： KNOELL HANS FORSCHUNG EV , INST PHYSIKALISCHE HOCHTECH EV , INST BIOPROZESS UND ANALYSENTE , UNIV ILMENAU TECH , GASTROCK GUNTER , GRODRIAN ANDREAS , HENKEL THOMAS , KIELPINSKI MARK , KOEHLER MICHAEL , LEMKE KAREN , MARTIN KARIN , METZE JOSEF , ROTH MARTIN , SCHOEN THORE , BAIER VOLKER
发明人： GASTROCK GUNTER , GRODRIAN ANDREAS , HENKEL THOMAS , KIELPINSKI MARK , KOEHLER MICHAEL , LEMKE KAREN , MARTIN KARIN , METZE JOSEF , ROTH MARTIN , SCHOEN THORE , BAIER VOLKER
IPC分类号： B01F13/00 , B01F15/02 , B01L3/00 , G01N35/08 , B01D17/02
CPC分类号： B01F13/0071 , B01F15/0201 , B01F15/0237 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2200/16 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/086 , G01N35/08
摘要： The invention relates to a device and a method for structuring liquids and for dosing reaction liquids into liquid compartments immersed in a separation medium. The aim of the invention is to provide a device and a method for structuring liquids for analytical, microbiological, cell biological and (bio)chemical combinatory applications, said device and method structuring liquids guided in microcapillaries in such a way that they can be addressed in defined concentration regions in a liquid flow, and supplying reagents to said concentration regions (liquid compartments) in a targeted manner. To this end, the inventive device consists of pre-determined liquid paths into which at least one dosing device opens up, and/or at least one merger and/or at least one separator are arranged in the liquid paths.
摘要翻译：本发明涉及一种在液体室的装置和方法，用于结构化的液体和用于计量加入反应液体的嵌入式分离介质。表示化学组合应用，本发明的目的是直接液体和试剂将这些浓度区域流内提供结构化的液体以供分析，微量，细胞生物学和（生物），所述可寻址的结构的装置和方法在微毛细管引导流体以空格确定浓度执行（液体室）的实现在于该装置由预定Flüssigkeitsleitwegen，其中通向所述Flüssigkeitsleitwege至少一个定量给料装置和/或至少一个fusionator和/或至少一个Spaltator布置在Flüssigkeitsleitwegen的。

5. 发明申请

WO0248399A3 METHOD FOR THE SIMULTANEOUS DISSECTION IN SPECIFIC POSITIONS OF FILIFORM ORGANIC MOLECULAR CHAINS, IN PARTICULAR DNA 审中-公开
标题翻译：方法用于同时特异位置的切削螺纹状的有机分子链，INSBESONERE DNA
公开(公告)号：WO0248399A3
公开(公告)日：2003-08-21
申请号：PCT/EP0114591
申请日：2001-12-12
申请人： INST PHYSIKALISCHE HOCHTECH EV , FRITZSCHE WOLFGANG , KOEHLER JOHANN MICHAEL , KOENIG KARSTEN
发明人： FRITZSCHE WOLFGANG , KOEHLER JOHANN MICHAEL , KOENIG KARSTEN
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/10 , C12Q1/68 , Y10S977/81 , C12Q2563/155 , C12Q2523/313
摘要： The invention relates to a method for the simultaneous dissection in specific positions of filiform organic molecular chains, in particular DNA. The aim of the invention is to provide a method, by which a highly specific dissection can take place on certain sequences that can be freely selected and simultaneously on numerous filiform molecules. To achieve this, nanoparticles (1) are provided with a molecular chain (11) of any predeterminable sequence, which is selected to be complementary to a sequence of a molecule (2) that is to be dissected, said molecular chain(s) (11) is/are hybridised in the usual manner with the molecule, or specifically linked to said molecule in another manner and the nanoparticles (1) are subsequently subjected to a high-energy radiation of at least one wavelength, which can be absorbed by said nanoparticles (1).
摘要翻译：本发明涉及一种用于同时位置特异性切割丝状有机分子链的，特别是DNA的方法。本发明的目的是提供其wählbaren-在某些-free序列可以和与助剂解决了该纳米颗粒（1）具有的分子链被提供（11）中任指定序列同时在具有高特异性许多线状分子切割的方法，这是在以某种其他方式特异性结合的常规方式选择互补（2）到切分子的序列，该分子链（一个或多个）（11）杂交或与该分子（2），然后将纳米颗粒（1）的高能量，由纳米颗粒（1）至少可吸收辐射将被暴露于波长。

6. 发明申请

WO03079062A8 OPTICAL ELEMENT, METHOD FOR THE PRODUCTION THEREOF AND FOR DETERMINING ITS OPTICAL PROPERTIES 审中-公开
标题翻译：光学元件，生产方法和它的光学性能的测定
公开(公告)号：WO03079062A8
公开(公告)日：2003-12-11
申请号：PCT/DE0300810
申请日：2003-03-07
申请人： FRAUNHOFER GES FORSCHUNG , INST PHYSIKALISCHE HOCHTECH EV , HEBER JOERG , KAISER NORBERT , MUEHLIG CHRISTIAN , TRIEBEL WOLFGANG
发明人： HEBER JOERG , KAISER NORBERT , MUEHLIG CHRISTIAN , TRIEBEL WOLFGANG
IPC分类号： G02B5/28 , G02B5/20
CPC分类号： G02B5/283
摘要： The invention relates to optical elements, methods for the production of these optical elements and for determining the attained optical properties. These optical elements are, in particular, ones used for reflecting, transmitting, guiding and/or filtering electromagnetic radiation in a wavelength range of 100 to 400 nm. At least one layer consisting of a metallic fluoride is formed on a substrate. The inventive solution should improve the optical properties and, in particular, prevent the interfering influence of luminescence to the greatest possible extent. Following the layer formation, the optical elements produced in this manner can be irradiated with electromagnetic radiation of a preset wavelength, and the luminescence intensity can be determined by using optical detectors.
摘要翻译：本发明涉及一种光学元件，用于产生这样的光学元件和所取得的光学特性的测定方法。光学元件特别是那些用于反射，透射，管理和/或在过滤100和400nm之间的波长范围内的电磁辐射。在基板是形成的金属氟化物的至少一种的层。本发明的方案是，以改善光学性能，特别是发光的干扰影响可以大大避免。在膜形成之后，由此制得的光学元件可以通过暴露于预定波长和发光强度的电磁辐射可以与光学检测器来确定照射。

7. 发明申请

WO03056335A2 MICRO-RECESS ARRAY FOR SIZE-DEPENDENT SORTING OR SEPARATION OF CELLS SUSPENDED IN A FLOWING MEDIUM AND METHOD FOR ANALYSING THE FUNCTIONAL ACTIVITY OF INDIVIDUAL CELLS 审中-公开
标题翻译：微孔阵列，用于依赖尺寸的分选或分离，流动的液体悬浮细胞和方法单个细胞的功能活动的考试
公开(公告)号：WO03056335A2
公开(公告)日：2003-07-10
申请号：PCT/EP0214762
申请日：2002-12-27
申请人： INST PHYSIKALISCHE HOCHTECH EV , LASSNER DIRK , UHLIG HOLM , KOEHLER JOHANN MICHAEL , MAYER GUENTER
发明人： LASSNER DIRK , UHLIG HOLM , KOEHLER JOHANN MICHAEL , MAYER GUENTER
IPC分类号： B01L3/00 , C40B60/14 , G01N15/14 , G01N33/50 , G01N33/543
CPC分类号： G01N15/1456 , B01J2219/00317 , B01J2219/00333 , B01J2219/005 , B01J2219/00511 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00743 , B01L3/502746 , B01L3/502753 , B01L2200/0668 , C40B60/14 , G01N33/5005 , G01N33/543 , G01N2015/149 , G01N2015/1493
摘要： The invention relates to a micro-recess array for size-dependent sorting or separation of cells suspended in a flowing medium in individual reaction chambers, and to a method for analysing the functional activity of individual cells which are separated by said micro-recess array. The micro-recess array is characterised in that it comprises a cell array made of a microstructured solid phase with a plurality of recesses (10).
摘要翻译：本发明涉及一种微孔阵列，用于依赖于大小的分选或悬浮在单独的反应室中的流动的液体的细胞颗粒的分离，以及用于测定已经由微孔阵列/分离的方式来分类的各个单元的功能活性的方法。微孔阵列的特征在于，它包括一个微结构化的固相的具有多个凹部（10）的单元阵列。

8. 发明申请

WO0039325A3 AFFINITY SENSOR FOR DETECTING SPECIFIC MOLECULAR BINDING EVENTS AND USE THEREOF 审中-公开
标题翻译：用于检测特定分子结合事件的亲和力传感器及其用途
公开(公告)号：WO0039325A3
公开(公告)日：2000-11-16
申请号：PCT/EP9910334
申请日：1999-12-22
申请人： INST PHYSIKALISCHE HOCHTECH EV , GENETRIX B V I O , FRITZSCHE WOLFGANG , CZAKI ANDREA , KOEHLER JOHANN MICHAEL , OOSTING LOUIS , SCHUT FREDERIK , TAN PARIS SOM TJWAN , WIEGAND ANTJE
发明人： FRITZSCHE WOLFGANG , CZAKI ANDREA , KOEHLER JOHANN MICHAEL , OOSTING LOUIS , SCHUT FREDERIK , TAN PARIS SOM TJWAN , WIEGAND ANTJE
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/04 , C12Q1/68 , G01N1/28 , G01N27/02 , G01N27/04 , G01N33/483 , G01N33/543 , G01N33/566 , G01N37/00 , C12Q1/00 , G01N27/00 , G01N33/53
CPC分类号： G01N33/5438 , B01J2219/00653
摘要： The invention relates to an affinity sensor for detecting specific molecular binding events, for use in the field of molecular biology, e.g., in medical diagnostics, especially in biosensor technology or in DNA microarray tests. The aim of the invention is to provide an affinity sensor of this type for rapidly, sensitively, specifically, economically and routinely detecting the presence of molecules, especially bioactive molecules, and to provide special applications for an affinity sensor of this type. To this end, the inventive affinity sensor consists of a support substrate (1) which is provided with at least two electrodes (2). Said electrodes are situated equidistantly from each other and cover an area (4) on both sides, at least this area (4) being provided for receiving immobilised specific binding partners (5) which are capable of coupling complementary corresponding binding partners (6) directly or with other specific binding molecules (7). The area (4) is established with a minimum width b, in such a way that at least one complementary corresponding binding partner (6) which is provided with an electroconductive particle (62) can be received in said area in such a way as to guarantee the possibility of a tunnel-type contact junction forming between the particle (62) and the electrodes (2) in each case. The affinity sensor is used for biomonitoring.
摘要翻译：本发明涉及一种用于检测特定分子结合事件的亲和力传感器，特别是在分子生物学领域，例如分子生物学领域。医学诊断，特别是在生物传感器技术或DNA微阵列测试中。本发明的目的是提供用于检测特定分子结合事件的亲和传感器，其检测在快速，灵敏，特异，资源少和例程，分子的存在，特别是生物活性分子，以及用于这样的亲和传感器提供特殊用途的，从而实现了包括载体基材的亲和性传感器（1），其设有以等距间隔的电极（2），其检测两个布置成彼此至少两个端部部分（4），其中，至少该区域（4），用于接收固定特异性结合配偶体（5）被提供，其能够联接互补相关结合伙伴（6）直接或通过另外的特定结合分子（7）和（4）具有最小宽度b的区域被设置为使得至少一个互补相关联b的的，上述范围是设置有导电粒子（62）indungspartner（6），以便容纳，所述微粒（62）和电极（2）之间的每个形成隧道接触过渡的可能性得到保证，并且该亲和力传感器用于生物监测。

9. 发明申请

WO03056330A3 CELL SORTING SYSTEM FOR THE SIZE-BASED SORTING OR SEPARATION OF CELLS SUSPENDED IN A FLOWING FLUID 审中-公开
标题翻译：细胞分选系统技术依赖尺寸的分选或分离，流动的液体悬浮细胞
公开(公告)号：WO03056330A3
公开(公告)日：2003-10-09
申请号：PCT/EP0214764
申请日：2002-12-27
申请人： INST PHYSIKALISCHE HOCHTECH EV , LASSNER DIRK , UHLIG HOLM , KOEHLER JOHANN MICHAEL , MAYER GUENTER
发明人： LASSNER DIRK , UHLIG HOLM , KOEHLER JOHANN MICHAEL , MAYER GUENTER
IPC分类号： G01N15/00 , G01N15/10 , G01N33/50 , G01N33/543 , B01J19/00 , B01L3/00 , G01N33/552
CPC分类号： G01N33/5094 , G01N15/1484 , G01N2015/0065 , G01N2015/149
摘要： The invention relates to a cell sorting system for sorting or separating cells suspended in a flowing fluid according to the size thereof. Said cell sorting system comprises at least one chip (10, 40, 42) provided with a base plate (12) which is overflowed by the fluid and encompasses a plurality of indentations (31, 60, 62, 70, 80).
摘要翻译：本发明涉及细胞分选系统用于分拣或悬浮在流动的液体细胞颗粒的尺寸相关的分离。所述细胞分拣系统的特征在于，它包括至少一个芯片（10，40，42）包括一个由具有多个凹部（31，60，62，70，80）将液体基体板（12）溢出。

10. 发明申请

WO03025113A3 METHODS FOR CULTIVATING AND ANALYZING MICROBIAL INDIVIDUAL CELL CULTURES 审中-公开
标题翻译：培养方法及微生物单细胞培养分析
公开(公告)号：WO03025113A3
公开(公告)日：2003-06-26
申请号：PCT/DE0203451
申请日：2002-09-13
申请人： KNOELL HANS FORSCHUNG EV , INST BIOPROZESS ANALYSENMESST , INST PHYSIKALISCHE HOCHTECH EV , MUELLER PETER-JUERGEN , ROTH MARTIN , HILLIGER MONIKA HF , HILLIGER STEPHAN HM , GROTH INGRID , KUMMER CHRISTEL , MARTIN KARIN , SCHROECKH VOLKER , METZE JOSEF , KOEHLER MICHAEL , HENKEL THOMAS , GASTROCK GUNTER , LEMKE KAREN
发明人： MUELLER PETER-JUERGEN , ROTH MARTIN , GROTH INGRID , KUMMER CHRISTEL , MARTIN KARIN , SCHROECKH VOLKER , METZE JOSEF , KOEHLER MICHAEL , HENKEL THOMAS , GASTROCK GUNTER , LEMKE KAREN , HILLIGER MATTHIAS DI
IPC分类号： C12N1/00 , C12M1/00 , C12N1/02 , C12M1/20 , C12M1/26 , C12M1/34
CPC分类号： C12M21/16 , C12M41/36
摘要： The invention relates to methods for individually separating microorganisms from a suspension or culture, parallel cultivation of individual cells and analyzing the metabolic performances thereof. The invention enables basic microbial operations such as media optimization, screening according to images of novel natural substances and special metabolic performances, qualitative and quantitative detection of the effects of nutrient substrates, effectors and active substances including the media optimization and selection of microorganism clones with specific properties from large populations according to mutagenesis, transformation, transfection and genetic processing in addition to the detection of microbial contaminations to be carried out. One advantage of the invention is that it can be applied when microorganisms having outstanding properties can be respectively obtained as individual cells or individual organisms from a large population and can be characterized as pure cultures or when the effect of influencing variables can be examined in many fully comparable cultures.
摘要翻译：本发明涉及用于从悬浮液或培养，分离的细胞的平行培养和它们的代谢活动的分析分离微生物的方法。与诸如媒体优化的微生物的基本操作的发明中，筛选的新的天然产品和特殊代谢性能，的营养基质，效应物和试剂，包括媒体优化和微生物与通过诱变，转化，转染从hochzahligen群体的某些特征的克隆的选择的效果的定性和定量证据的图像可以和基因工程的处理以及检测由微生物污染进行。本发明特别有利地总是使用在每种情况下为单细胞或单生物体从具有突出的特征的许多发育人口微生物获得和表征为纯培养物或是否应该检查在许多影响因素，与每个完全可比培养物的效果时，必须。

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