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1. 发明申请

WO2006110405A2 METHODS AND APPARATUS FOR THERMAL REGULATION OF A BODY 审中-公开
标题翻译：一种身体温度调节的方法和装置
公开(公告)号：WO2006110405A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/012561
申请日：2006-04-03
申请人： MEDCOOL, INC. , LENNOX, Charles, D. , ALLAIRE, Kevin , RADZIUNAS, Jeffrey , THOMPSON, John , DICESARE, Paul , HIRES, Greg , MELSKY, Gerald
发明人： LENNOX, Charles, D. , ALLAIRE, Kevin , RADZIUNAS, Jeffrey , THOMPSON, John , DICESARE, Paul , HIRES, Greg , MELSKY, Gerald
IPC分类号： H04L9/00
CPC分类号： A61F7/02 , A61F2007/0002 , A61F2007/0011 , A61F2007/0056
摘要： A thermal regulation system includes a thermal exchange collar for application to a neck of a patient, a thermal regulation pad for application to a body region, such as an axilla region of the patient, and a thermal regulation cap for application to a head of the patient.
摘要翻译：热调节系统包括用于应用于患者颈部的热交换套环，用于应用于身体区域（例如患者的腋窝区域）的热调节垫，以及用于应用于患者的头部的热调节帽患者。

2. 发明申请

WO2011041635A3 CARDIAC ABLATION SYSTEM WITH INFLATABLE MEMBER HAVING MULTIPLE INFLATION SETTINGS 审中-公开
公开(公告)号：WO2011041635A3
公开(公告)日：2011-04-07
申请号：PCT/US2010/051054
申请日：2010-10-01
申请人： CARDIOFOCUS, INC. , MELSKY, Gerald , ESTABROOK, Brian , STANCAMPIANO, Alfred
发明人： MELSKY, Gerald , ESTABROOK, Brian , STANCAMPIANO, Alfred
IPC分类号： A61B18/18 , A61B18/24 , A61M25/10 , A61M29/00 , A61N5/06
摘要： A cardiac tissue ablation system includes an elongate catheter configured to deliver a distal end thereof to a patient's heart and an expandable member formed at the distal portion of the catheter. The expandable member has an elastic portion configured to conform to the shape of a target tissue region upon expansion. The expandable member has a plurality of inflation settings that correspond to different levels of inflation of the expandable member. The system also includes a controller for selecting an inflation setting for the expandable member and an energy emitter movably disposed within a lumen of the catheter. The energy emitter is configured to deliver radiant ablative energy to the target tissue region.

3. 发明申请

WO2011041629A2 CARDIAC ABLATION SYSTEM WITH PULSED AIMING LIGHT 审中-公开
标题翻译：心脏吸收系统与脉冲瞄准灯
公开(公告)号：WO2011041629A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/051047
申请日：2010-10-01
申请人： CARDIOFOCUS, INC. , MELSKY, Gerald , OSTROWSKI, Susan
发明人： MELSKY, Gerald , OSTROWSKI, Susan
IPC分类号： A61B18/18 , A61B18/24 , A61M25/10 , A61M29/00 , A61N5/06
CPC分类号： A61B18/24 , A61B90/361 , A61B2017/22051 , A61B2017/22059 , A61B2018/2025 , A61B2090/3618
摘要： A method for treating a cardiac condition with visual inspection of a tissue treatment site includes the step of delivering an expanding member formed on a distal end of a catheter to a position adjacent a tissue treatment area within a patient's heart. The expandable member has an elastic portion configured to conform to the tissue treatment area. The method further includes the steps of expanding the expandable member thereby allowing the elastic portion of the expandable member to conform to the tissue treatment area and positioning an energy emitter at a first location within an inner lumen of the catheter. A visible aiming beam is projected during positioning of the energy emitter and ablative energy is delivered from the energy emitter to the tissue treatment area thereby resulting in a first spot lesion. The ablative energy is coincident with the aiming beam and the aiming beam is in the form of pulsed visible light to allow intermittent visual inspection of the first spot lesion at times when the arming beam is not projected onto the tissue treatment area, thereby allowing visual inspection of the ablative characteristics and sufficiency of the first spot lesion.
摘要翻译：用于通过目视检查组织治疗部位来治疗心脏病状的方法包括将形成在导管的远端上的扩张部件输送到患者心脏内的组织治疗区域附近的位置的步骤。可膨胀构件具有构造成符合组织处理区域的弹性部分。该方法还包括以下步骤：使可膨胀构件膨胀，从而允许可膨胀构件的弹性部分与组织处理区域一致，并将能量发射器定位在导管的内腔内的第一位置处。在能量发射器的定位期间投射可见的瞄准光束，并且烧蚀能量从能量发射器传送到组织处理区域，从而导致第一斑点损伤。烧蚀能量与瞄准光束重合，瞄准光束是脉冲可见光的形式，以允许在布防光束未投射到组织治疗区域时的第一斑点损伤的间歇性目视检查，从而允许目视检查的烧蚀特征和充足的第一斑点病变。

4. 发明申请

WO2010120881A2 SYSTEM AND METHOD FOR VISUALIZING TISSUE DURING ABLATION PROCEDURES 审中-公开
标题翻译：系统和方法，用于在组织过程中可视化组织
公开(公告)号：WO2010120881A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031032
申请日：2010-04-14
申请人： CARDIO FOCUS, INC. , MELSKY, Gerald , SAGON, Stephen, W. , SINOFSKY, Edward, L. , FARR, Norman, E.
发明人： MELSKY, Gerald , SAGON, Stephen, W. , SINOFSKY, Edward, L. , FARR, Norman, E.
IPC分类号： A61B1/05 , A61B1/06 , A61B17/125
CPC分类号： A61B18/24 , A61B1/00087 , A61B1/00165 , A61B1/0638 , A61B1/07 , A61B5/0044 , A61B5/0075 , A61B5/0084 , A61B5/4836 , A61B5/7264 , A61B5/743 , A61B2017/00057 , A61B2018/00011 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/0069 , A61B2018/00904 , A61B2018/00982 , A61B2576/023
摘要： Systems for visualizing cardiac tissue during an ablation procedure are provided. In general, the systems include an imaging module configured to measure absorbance data at first and second wavelengths wherein the ratio of these absorbance values identifies the nature of the tissue (e.g., lesion, de novo tissue, etc.). The imaging module can also include a video system having at least two chips with corresponding bandpass filters centered at the first and second target wavelengths. The system can also include a processor and/or video monitor for combining the images produced by the various chips, determining treated and non-treated tissue based on the ratio of absorbance values at the target wavelengths, and displaying images of the treatment area. Methods of visualizing cardiac treatment areas during ablation procedures are also provided herein.
摘要翻译：提供了在消融过程中可视化心脏组织的系统。通常，该系统包括成像模块，该成像模块被配置为测量第一和第二波长处的吸光度数据，其中这些吸光度值的比率识别组织的性质（例如病变，从头组织等）。成像模块还可以包括具有至少两个具有以第一和第二目标波长为中心的带通滤波器的芯片的视频系统。该系统还可以包括用于组合由各种芯片产生的图像的处理器和/或视频监视器，基于目标波长处的吸光度值的比率和显示处理区域的图像来确定处理和未处理的组织。本文还提供了在消融过程中可视化心脏治疗区域的方法。

5. 发明申请

WO2004110258A2 GUIDED CARDIAC ABLATION CATHETERS 审中-公开
标题翻译：指导性戒毒导管
公开(公告)号：WO2004110258A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/018471
申请日：2004-06-10
申请人： CARDIOFOCUS, INC. , MELSKY, Gerald , ARNOLD, Jeffrey, M. , SINOFSKY, Edward, L. , FARR, Norman, E.
发明人： MELSKY, Gerald , ARNOLD, Jeffrey, M. , SINOFSKY, Edward, L. , FARR, Norman, E.
IPC分类号： A61B
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/0022 , A61B2018/00982 , A61B2018/0212 , A61B2090/3937 , A61N7/02
摘要： Guided ablation instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias, including atrial fibrillation. In one aspect of the invention, a percutaneous catheter is disclosed with an endoscope positionable in the instrument's distal end region to obtain an image. The image allows the clinician to determine whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) before ablation begins or while ablation is occurring. In one embodiment, percutaneous ablation catheters are disclosed having at least one central lumen and one or more balloon structures at the distal end region of the instrument. Also disposed in the distal end region are an illuminating light source and an endoscope capable of collecting sufficient light to relay an image to the user. The instruments can further include an ablation element. The ablation element can be a contact ablation element, or a radiant energy emitter, which is preferably independently positionable within the lumen of the instrument and adapted to project ablative energy through a transmissive region of the instrument body (and/or balloon) to a target tissue site proximate to the pulmonary veins. The energy can delivered without the need for contact between the energy emitter and the target tissue so long as a clear transmission pathway is established. The endoscope element of the instrument allows the clinician to determine the position of the instrument and, if radiant energy is to be employed, see if such a pathway is clear. Moreover, because the position of the radiant energy emitter can be varied, endoscopic guidance permits the clinician to select a desired location and dose for the lesion.
摘要翻译：公开了引导消融器械用于在组织中产生损伤，特别是用于治疗心律失常的心脏组织，包括房颤。在本发明的一个方面，公开了一种经皮导管，其具有可置于仪器的远端区域中的内窥镜，以获得图像。图像允许临床医生确定在消融开始之前还是在消融期间已经实现了接触（或者从消融能量传递路径中清除血液）。在一个实施例中，公开了经皮消融导管，其在器械的远端区域具有至少一个中心腔和一个或多个气囊结构。还设置在远端区域中的是能够收集足够的光以将图像中继给用户的照明光源和内窥镜。仪器还可以包括消融元件。消融元件可以是接触消融元件或辐射能发射器，其优选地可独立地定位在器械的内腔内并且适于将烧蚀能量穿过器械主体（和/或气囊）的透射区域投射到靶靠近肺静脉的组织部位。只要建立清晰的传输路径，能量可以传送而不需要能量发射器和目标组织之间的接触。仪器的内窥镜元件允许临床医生确定仪器的位置，并且如果要使用辐射能量，看看这样的通路是否清晰。此外，由于辐射能发射器的位置可以改变，所以内窥镜引导允许临床医生选择病变的期望位置和剂量。

6. 发明申请

WO2011044248A2 CARDIAC ABLATION IMAGE ANALYSIS SYSTEM AND PROCESS 审中-公开
标题翻译： CARDIAC消融图像分析系统与过程
公开(公告)号：WO2011044248A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051648
申请日：2010-10-06
申请人： CARDIOFOCUS, INC. , MELSKY, Gerald
发明人： MELSKY, Gerald
IPC分类号： A61B18/18 , A61B18/24 , A61B17/94 , A61B1/04 , A61B19/00
CPC分类号： A61B18/24 , A61B34/25 , A61B2017/0046 , A61B2018/00982 , A61B2018/2025 , A61B2090/306 , A61B2090/365
摘要： A system is provided for identifying the sufficiency of lesions formed during a tissue ablation procedure. The system captures live and still images from the surgical site and provides composite imaging to the operator. Through the use of the system, the aiming light used to direct ablative energy is captured on the still images and used to indicate locations in a surgical site where energy has been directed. Through the use of processing modules, the system can analyze the lesions and determine the sufficiency thereof.
摘要翻译：提供了一种用于识别在组织消融手术期间形成的损伤的充分性的系统。该系统从手术部位捕捉活动和静止图像，并向操作员提供复合成像。通过使用该系统，用于引导消融能量的瞄准光被捕获在静止图像上并用于指示能量已被引导的手术部位的位置。通过使用处理模块，系统可以分析病变并确定其充分性。

7. 发明申请

WO2010120883A2 CARDIAC ABLATION CATHETERS FOR FORMING OVERLAPPING LESIONS 审中-公开
标题翻译：用于形成超重力的心脏吸收管
公开(公告)号：WO2010120883A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031034
申请日：2010-04-14
申请人： CARDIOFOCUS, INC. , MELSKY, Gerald , SAGON, Stephen W. , STANCAMPIANO, Alfred , ARNOLD, Jeffrey M. , BAXTER, Lincoln S.
发明人： MELSKY, Gerald , SAGON, Stephen W. , STANCAMPIANO, Alfred , ARNOLD, Jeffrey M. , BAXTER, Lincoln S.
IPC分类号： A61B18/24
CPC分类号： A61B18/245 , A61B2017/00057 , A61B2017/00061 , A61B2018/0097 , A61B2018/2261 , A61B2018/2266 , A61B2018/2272 , A61B2090/065 , A61N7/02
摘要： Methods and instruments are disclosed for creating lesions in tissue, especially cardiac tissue, for treatment of arrhythmias and the like, by employing an elastic balloon and an energy emitter, which is independently positionable within the lumen of the instrument and adapted to project a series of spots of ablative energy through a transmissive region of the balloon to a target tissue site. The energy emitter preferably is configured such the spots of energy result in a series of lesions formed in the target tissue region when the emitter is activated, the lesions having an average area ranging from about 5 mm 2 to about 100 mm 2 . In one aspect of the invention, percutaneous ablation instruments are disclosed in the form of catheter bodies having one or more balloon structures at the distal end region of the instrument and an energy emitting element, which is independently positionable and rotatable within a lumen of the instrument and adapted to project ablative energy through a transmissive region of the balloon to a target tissue site in contact with, or proximal to, the balloon surface.
摘要翻译：公开了用于通过使用弹性球囊和能量发射器在组织，特别是心脏组织中产生损伤来治疗心律不齐等的方法和仪器，所述弹性球囊和能量发射器可独立地定位在所述仪器的内腔内并适于投射一系列通过球囊的透射区域到目标组织部位的烧蚀能量的斑点。能量发射体优选配置成当发射体被激活时，能量斑点导致在靶组织区域中形成的一系列病变，病变的平均面积范围为约5mm 2至约100mm 2。在本发明的一个方面，经皮消融器具以在仪器的远端区域具有一个或多个球囊结构的导管主体的形式被公开，并且能量发射元件可在仪器的内腔内独立地定位和旋转并且适于将消融能量通过球囊的透射区域投射到与球囊表面接触或接近的目标组织部位。

8. 发明申请

WO2003105636A1 LIMITED FLOW CUPS 审中-公开
标题翻译：有限公司
公开(公告)号：WO2003105636A1
公开(公告)日：2003-12-24
申请号：PCT/US2002/032785
申请日：2002-10-16
申请人： RELIANT MEDICAL PRODUCTS, INC. , BURKE, Andrea , DAVIS, Richard, M. , MELSKY, Gerald , PORAT, David , PORTER, Jerry
发明人： BURKE, Andrea , DAVIS, Richard, M. , MELSKY, Gerald , PORAT, David , PORTER, Jerry
IPC分类号： A47G19/22
CPC分类号： A47G19/2272 , G01F11/262
摘要： Limited flow cups (14) are provided which deliver a metered amount of fluid to a user during a drinking motion.
摘要翻译：提供有限的流动杯（14），其在饮酒运动期间向使用者输送计量的流体。

9. 发明申请

WO2011041638A2 CARDIAC ABLATION SYSTEM WITH AUTOMATIC SAFETY SHUT-OFF FEATURE 审中-公开
标题翻译：具有自动安全关闭功能的CARDIAC消融系统
公开(公告)号：WO2011041638A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/051057
申请日：2010-10-01
申请人： CARDIOFOCUS, INC. , MELSKY, Gerald , SAGON, Stephen, W.
发明人： MELSKY, Gerald , SAGON, Stephen, W.
IPC分类号： A61B18/18 , A61B18/24 , A61M25/10 , A61M29/00 , A61N5/06
CPC分类号： A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00123 , A61B2017/0046 , A61B2018/00196 , A61B2018/00982 , A61B2018/1861 , A61B2018/2025 , A61B2018/2261 , A61B2018/2272 , A61B2090/306 , A61N7/022
摘要： A cardiac tissue ablation system according to one embodiment includes an elongate catheter configured to deliver a distal end thereof to a patient's heart and an expandable member formed at the distal portion of the catheter. The expandable member has an elastic portion configured to conform to the shape of a target tissue region upon expansion. The system further includes an energy emitter movably disposed within a lumen of the catheter. The energy emitter is configured to deliver radiant ablative energy to the target tissue region. The system further includes a controller that includes a safety shut-off feature for automatically shutting off power to the energy emitter when a prescribed event occurs resulting in power to the energy emitter being stopped.
摘要翻译：根据一个实施例的心脏组织消融系统包括构造成将其远端递送至患者心脏的细长导管和形成于导管远端部分处的可扩张构件。可扩张部件具有弹性部分，该弹性部分被配置为在扩张时符合目标组织区域的形状。该系统还包括可移动地设置在导管的管腔内的能量发射器。能量发射器被配置为将辐射消融能量递送至目标组织区域。该系统还包括控制器，该控制器包括安全切断特征，用于在发生规定事件时自动切断能量发射器的电力，从而导致能量发射器的电力停止。

10. 发明申请

WO2006091597A1 DEFLECTABLE SHEATH CATHETERS 审中-公开
标题翻译：防水护目镜
公开(公告)号：WO2006091597A1
公开(公告)日：2006-08-31
申请号：PCT/US2006/006115
申请日：2006-02-21
申请人： CARDIOFOCUS, INC. , BAXTER, Lincoln, S. , ARNOLD, Jeffrey, M. , MELSKY, Gerald
发明人： BAXTER, Lincoln, S. , ARNOLD, Jeffrey, M. , MELSKY, Gerald
IPC分类号： A61M25/01 , A61B18/14
CPC分类号： A61M25/1002 , A61B18/1492 , A61B18/24 , A61B2018/00375 , A61M25/0054 , A61M25/0141 , A61M25/0147 , A61M29/02 , A61M2025/0004 , A61M2025/0037 , A61M2025/0681 , A61M2025/1015
摘要： The present invention provides devices and methods for the treatment of atrial fibrillation. In one embodiment a deflectable sheath catheter includes an elongate catheter body having proximal and distal ends, and a deflectable distal end section at the distal end of the catheter body. The deflectable distal end section can be adapted to deflect along a compound curve or has a bent tip oriented in a direction that is out of the plane of deflection to direct an ablation instrument to a target site within a heart.
摘要翻译：本发明提供了用于治疗房颤的装置和方法。在一个实施例中，可偏转护套导管包括具有近端和远端的细长导管本体和位于导管主体远端的可偏转的远端部分。可偏转的远端部分可以适于沿着复合曲线偏转或者具有沿着偏离平面的方向定向的弯曲尖端，以将消融器械引导到心脏内的目标部位。

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